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Annals of neurology, ISSN 0364-5134, 2011, Volume 70, Issue 6, pp. 964 - 973
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 12/2015, Volume 7, Issue 12, pp. 1529 - 1546
The epigenomic landscape of Parkinson's disease (PD) remains unknown. We performed a genomewide DNA methylation and a transcriptome studies in induced... 
DNA methylation | transcription factor | Parkinson's disease | induced pluripotent stem cell | dopaminergic neuron | Induced pluripotent stem cell | Dopaminergic neuron | Transcription factor | MEDICINE, RESEARCH & EXPERIMENTAL | PROTEIN | NEURODEGENERATION | LRRK2 MUTATION | FIBROBLASTS | EPIGENETIC-MECHANISMS | GENE | EMBRYONIC STEM-CELLS | G2019S | REVEALS | DNA Methylation | Epigenomics | Induced Pluripotent Stem Cells - physiology | Humans | Protein-Serine-Threonine Kinases - genetics | Dopaminergic Neurons - physiology | Gene Expression Profiling | Parkinson Disease - metabolism | Parkinson Disease - genetics | Protein-Serine-Threonine Kinases - metabolism | Cellular Reprogramming | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Epigenetic inheritance | RNA | Methylation | Neurons | Analysis | Stem cells | Transcription factors | Parkinsons disease | Nervous system | Regulatory sequences | Gender | Kinases | Neurogenesis | Hepatocyte nuclear factor 4 | LRRK2 protein | Deoxyribonucleic acid--DNA | Age | Movement disorders | Dopamine receptors | Dan protein | Dopamine | Neurodegenerative diseases | Ribonucleic acid--RNA | Cell differentiation | Gene expression | Patients | Studies | Enhancers | Somatic cells | Epigenetics | Skin | Mutation | Pluripotency | Inhibitory postsynaptic potentials | Stem Cells | Neuroscience | Chromatin, Epigenetics, Genomics & Functional Genomics
Journal Article
Aging, ISSN 1945-4589, 02/2019, Volume 11, Issue 4, pp. 1081 - 1082
Journal Article
Journal Article
Movement Disorders, ISSN 0885-3185, 05/2017, Volume 32, Issue 5, pp. 726 - 738
ABSTRACT Background: Asymptomatic, nonmanifesting carriers of leucine‐rich repeat kinase 2 mutations are at increased risk of developing PD. Clinical and... 
LRRK2 mutations | Parkinson's disease | nonmotor symptoms | prodromal phase | LRRK2 G2019S MUTATION | R1441G MUTATION | IDENTIFICATION | CARRIERS | CLINICAL NEUROLOGY | SLEEP BEHAVIOR DISORDER | FEATURES | PENETRANCE | DYSFUNCTION | QUESTIONNAIRE | PREMOTOR PHASE | Dopamine Plasma Membrane Transport Proteins - metabolism | Brain - diagnostic imaging | Depression - physiopathology | REM Sleep Behavior Disorder - etiology | Humans | Middle Aged | Tomography, Emission-Computed, Single-Photon | Male | Cognition | Prodromal Symptoms | Primary Dysautonomias - physiopathology | Case-Control Studies | Brain - metabolism | Depression - etiology | Young Adult | Aged, 80 and over | Adult | Female | Surveys and Questionnaires | Parkinson Disease - complications | Parkinson Disease - diagnostic imaging | Primary Dysautonomias - etiology | Parkinson Disease - genetics | Parkinson Disease - physiopathology | REM Sleep Behavior Disorder - physiopathology | Adolescent | Aged | Mutation | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - genetics | Medicine, Experimental | Medical research | Amino acids | SPECT imaging | Neuroimaging | Medical imaging | Neurodegenerative diseases | Sleep (REM) | Leucine | Dysautonomia | Mental depression | Motor task performance | Sleep | Computed tomography | Olfaction | Dopamine transporter | LRRK2 protein | Movement disorders
Journal Article
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 9/2018, Volume 55, Issue 9, pp. 7533 - 7552
Parkinson’s disease is associated with intracellular α-synuclein accumulation and ventral midbrain dopaminergic neuronal death in the Substantia Nigra of brain... 
Dopaminergic neurons | Neurology | Neurosciences | Biomedicine | Autophagy impairment | Neurobiology | RAC1/ced-10 | Alpha-synuclein accumulation | Parkinson’s disease | Cell Biology | SIGNALING PATHWAYS | STEM-CELLS | Parkinson's disease | CHAPERONE-MEDIATED AUTOPHAGY | ALZHEIMERS-DISEASE | NEUROSCIENCES | PARKINSONS-DISEASE MODEL | CELL-DEATH | CAENORHABDITIS-ELEGANS | IN-VIVO | C-ELEGANS | APOPTOTIC CELL | Humans | Caenorhabditis elegans Proteins - metabolism | rac GTP-Binding Proteins - metabolism | Autophagy - drug effects | Neuroprotection - drug effects | Caenorhabditis elegans - physiology | Amyloid - metabolism | Behavior, Animal - drug effects | Cell Death - drug effects | Inclusion Bodies - metabolism | Dopamine - metabolism | Neurites - drug effects | Induced Pluripotent Stem Cells - metabolism | Mesencephalon - pathology | Biomarkers - metabolism | Induced Pluripotent Stem Cells - pathology | Cell Survival - drug effects | Parkinson Disease - pathology | Induced Pluripotent Stem Cells - drug effects | alpha-Synuclein - toxicity | Neurites - metabolism | Mutation - genetics | Dopaminergic Neurons - enzymology | Animals | Caenorhabditis elegans - drug effects | Cell Line, Tumor | Caenorhabditis elegans - enzymology | rac1 GTP-Binding Protein - metabolism | Amyloidogenesis | Dopamine | Cell survival | Mesencephalon | Toxicity | Pathogenesis | Substantia nigra | Parkinsons disease | Rac1 protein | Neuroblastoma | Synuclein | Autophagy | Neuroblastoma cells | Accumulation | Cell death | Actin | LRRK2 protein | Phagocytosis | Dopamine receptors | Guanosinetriphosphatase | Index Medicus | RAC1 | ced-10
Journal Article