Journal of Clinical Oncology, ISSN 0732-183X, 05/2018, Volume 36, Issue 15_suppl, pp. 9093 - 9093
Journal Article
Journal of Biomechanics, ISSN 0021-9290, 2012, Volume 45, pp. S337 - S337
Journal Article
3.
Analysis of a rotary task following total knee arthroplasty: Stair descent with a cross-over turn
Proceedings of the Institution of Mechanical Engineers, ISSN 0954-4119, 05/2014, Volume 228, Issue 5, p. 429
Leg loading and knee angle differences have been reported in total knee replacement individuals during straight gait; however, little is known about the...
Knee | Walking | Risk assessment | Comparative analysis | Joint replacement surgery
Knee | Walking | Risk assessment | Comparative analysis | Joint replacement surgery
Journal Article
4.
Analysis of a rotary task following total knee arthroplasty: Stair descent with a cross-over turn
Proceedings of the Institution of Mechanical Engineers. Part H: Journal of Engineering in Medicine, ISSN 0954-4119, 05/2014, Volume 228, Issue 5, pp. 429 - 429
Leg loading and knee angle differences have been reported in total knee replacement individuals during straight gait; however, little is known about the impact...
Surgical implants | Biomedical materials | Knees | Gait | Grounds | Strategy | Descent | Contact
Surgical implants | Biomedical materials | Knees | Gait | Grounds | Strategy | Descent | Contact
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 05/2017, Volume 12, Issue 5, pp. 872 - 877
Chromosomal rearrangements involving the gene define a distinct molecular subset of NSCLCs with sensitivity to ROS1 inhibitors. Recent reports have suggested a...
Non–small cell lung cancer | NSCLC | ROS1 | Concurrent mutations | ADENOCARCINOMA | REARRANGEMENTS | EGFR | IMPACT | ONCOLOGY | RESPIRATORY SYSTEM | Non-small cell lung cancer | CRIZOTINIB | KRAS | MUTATIONS | CLINICOPATHOLOGICAL ANALYSIS | Lung Neoplasms - genetics | Class I Phosphatidylinositol 3-Kinases - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Middle Aged | Male | Proto-Oncogene Proteins - genetics | Proto-Oncogene Proteins c-akt - genetics | MAP Kinase Kinase 1 - genetics | Young Adult | Genes, erbB-1 | Protein-Tyrosine Kinases - genetics | Receptor Protein-Tyrosine Kinases - genetics | Genes, erbB-2 | Oncogene Fusion | Proto-Oncogene Proteins B-raf - genetics | Aged, 80 and over | Adult | Female | Aged | Retrospective Studies | Mutation | non-small cell lung cancer
Non–small cell lung cancer | NSCLC | ROS1 | Concurrent mutations | ADENOCARCINOMA | REARRANGEMENTS | EGFR | IMPACT | ONCOLOGY | RESPIRATORY SYSTEM | Non-small cell lung cancer | CRIZOTINIB | KRAS | MUTATIONS | CLINICOPATHOLOGICAL ANALYSIS | Lung Neoplasms - genetics | Class I Phosphatidylinositol 3-Kinases - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Middle Aged | Male | Proto-Oncogene Proteins - genetics | Proto-Oncogene Proteins c-akt - genetics | MAP Kinase Kinase 1 - genetics | Young Adult | Genes, erbB-1 | Protein-Tyrosine Kinases - genetics | Receptor Protein-Tyrosine Kinases - genetics | Genes, erbB-2 | Oncogene Fusion | Proto-Oncogene Proteins B-raf - genetics | Aged, 80 and over | Adult | Female | Aged | Retrospective Studies | Mutation | non-small cell lung cancer
Journal Article
Cancer Discovery, ISSN 2159-8274, 06/2018, Volume 8, Issue 6, pp. 714 - 729
The cornerstone of treatment for advanced ALK-positive lung cancer is sequential therapy with increasingly potent and selective ALK inhibitors. The...
EML4-ALK | DRUG-COMBINATIONS | GENE | ONCOLOGY | CERITINIB | OVERCOMES CRIZOTINIB RESISTANCE | ALECTINIB | ACQUIRED-RESISTANCE | OPEN-LABEL | ROS1 | CHEMOTHERAPY | Lung Neoplasms - genetics | Lung Neoplasms - drug therapy | Lung Neoplasms - chemically induced | Humans | Ethylnitrosourea - adverse effects | Drug Resistance, Neoplasm | Lactams, Macrocyclic - pharmacology | Anaplastic Lymphoma Kinase - genetics | Whole Exome Sequencing | Xenograft Model Antitumor Assays | Protein Kinase Inhibitors - administration & dosage | Animals | Oncogene Proteins, Fusion - genetics | Crizotinib - pharmacology | Cell Line, Tumor | Crizotinib - administration & dosage | Female | Lactams, Macrocyclic - administration & dosage | Mice | Protein Kinase Inhibitors - pharmacology | Mutation | Index Medicus | ALK | brigatinib | crizotinib | lorlatinib | and NSCLC | Anaplastic lymphoma kinase | ceritinib | acquired resistance | alectinib
EML4-ALK | DRUG-COMBINATIONS | GENE | ONCOLOGY | CERITINIB | OVERCOMES CRIZOTINIB RESISTANCE | ALECTINIB | ACQUIRED-RESISTANCE | OPEN-LABEL | ROS1 | CHEMOTHERAPY | Lung Neoplasms - genetics | Lung Neoplasms - drug therapy | Lung Neoplasms - chemically induced | Humans | Ethylnitrosourea - adverse effects | Drug Resistance, Neoplasm | Lactams, Macrocyclic - pharmacology | Anaplastic Lymphoma Kinase - genetics | Whole Exome Sequencing | Xenograft Model Antitumor Assays | Protein Kinase Inhibitors - administration & dosage | Animals | Oncogene Proteins, Fusion - genetics | Crizotinib - pharmacology | Cell Line, Tumor | Crizotinib - administration & dosage | Female | Lactams, Macrocyclic - administration & dosage | Mice | Protein Kinase Inhibitors - pharmacology | Mutation | Index Medicus | ALK | brigatinib | crizotinib | lorlatinib | and NSCLC | Anaplastic lymphoma kinase | ceritinib | acquired resistance | alectinib
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 01/2019, Volume 25, Issue 1, pp. 158 - 165
Purpose: BRAF mutations are divided into functional classes distinguished by signaling mechanism and kinase activity: V600-mutant kinase-activating monomers...
DABRAFENIB PLUS TRAMETINIB | INHIBITION | ONCOLOGY | ADENOCARCINOMAS | SENSITIVITY | UNCOMMON | OPEN-LABEL | KRAS | CLINICOPATHOLOGICAL FEATURES
DABRAFENIB PLUS TRAMETINIB | INHIBITION | ONCOLOGY | ADENOCARCINOMAS | SENSITIVITY | UNCOMMON | OPEN-LABEL | KRAS | CLINICOPATHOLOGICAL FEATURES
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 2019, Volume 14, Issue 5, pp. 816 - 824
Introduction: Circulating tumor DNA analysis is an emerging genotyping strategy that can identify tumor-specific genetic alterations in plasma including...
Liquid biopsy | Targeted therapy | ROS1 | Lung cancer | VALIDATION | HETEROGENEITY | ONCOLOGY | RESPIRATORY SYSTEM | MUTATION | RESISTANCE | FUSIONS | CAPTURE | CELL-FREE DNA
Liquid biopsy | Targeted therapy | ROS1 | Lung cancer | VALIDATION | HETEROGENEITY | ONCOLOGY | RESPIRATORY SYSTEM | MUTATION | RESISTANCE | FUSIONS | CAPTURE | CELL-FREE DNA
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 01/2019, Volume 14, Issue 1, pp. 135 - 140
Introduction: Immune checkpoint inhibitors (ICIs) are standard therapies in advanced NSCLC. Although genotype-directed tyrosine kinase inhibitors represent the...
Crizotinib | Non–small cell lung cancer | Immune checkpoint inhibitor | Tyrosine kinase inhibitor | Hepatotoxicity | Immunotherapy | ONCOLOGY | SAFETY | RESPIRATORY SYSTEM | Non-small cell lung cancer | CHEMOTHERAPY | Index Medicus
Crizotinib | Non–small cell lung cancer | Immune checkpoint inhibitor | Tyrosine kinase inhibitor | Hepatotoxicity | Immunotherapy | ONCOLOGY | SAFETY | RESPIRATORY SYSTEM | Non-small cell lung cancer | CHEMOTHERAPY | Index Medicus
Journal Article
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, ISSN 1556-0864, 10/2018, Volume 13, Issue 10, pp. 1530 - 1538
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 10/2018, Volume 13, Issue 10, pp. 1530 - 1538
The second-generation anaplastic lymphoma kinase (ALK) inhibitor alectinib recently showed superior efficacy compared to the first-generation ALK inhibitor...
Brigatinib | ALK | Resistance | Alectinib | NSCLC | OPEN-LABEL | PHASE-3 | SINGLE-ARM | CHEMOTHERAPY | CELL LUNG-CANCER | TRIAL | EML4-ALK | ONCOLOGY | CERITINIB | RESPIRATORY SYSTEM | CRIZOTINIB
Brigatinib | ALK | Resistance | Alectinib | NSCLC | OPEN-LABEL | PHASE-3 | SINGLE-ARM | CHEMOTHERAPY | CELL LUNG-CANCER | TRIAL | EML4-ALK | ONCOLOGY | CERITINIB | RESPIRATORY SYSTEM | CRIZOTINIB
Journal Article
Cancer discovery, ISSN 2159-8274, 12/2018, Volume 8, Issue 12, pp. 1598 - 1613
BH3 mimetic drugs, which inhibit pro-survival BCL-2 family proteins, have limited single-agent activity in solid tumor models. The potential of BH3 mimetics...
Journal Article
Cancer Discovery, ISSN 2159-8274, 12/2018, Volume 8, Issue 12, pp. 1598 - 1613
BH3 mimetic drugs, which inhibit prosurvival BCL2 family proteins, have limited single-agent activity in solid tumor models. The potential of BH3 mimetics for...
DRUG-COMBINATIONS | MEK INHIBITION | ONCOLOGY | BIM | RESISTANCE | REGULATORS | BH3 MIMETIC ABT-737 | PROTEINS | EXPRESSION | DOCETAXEL | TRAMETINIB GSK1120212
DRUG-COMBINATIONS | MEK INHIBITION | ONCOLOGY | BIM | RESISTANCE | REGULATORS | BH3 MIMETIC ABT-737 | PROTEINS | EXPRESSION | DOCETAXEL | TRAMETINIB GSK1120212
Journal Article
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 01/2019
Circulating tumor DNA analysis is an emerging genotyping strategy that can identify tumor-specific genetic alterations in plasma including mutations and...
Journal Article
12/2001, Volume 43, Issue 7
The five advertising giants profiled are David Ogilvy, Leo Burnett, Bill Bernbach, Albert Lasker and Marcel Bleustein-Blancher.
Book Chapter
JCO precision oncology, ISSN 2473-4284, 2018, Volume 2018
rearrangements predict for sensitivity to ALK tyrosine kinase inhibitors (TKIs). However, responses to ALK TKIs are generally short-lived. Serial molecular...
Journal Article
JCO precision oncology, ISSN 2473-4284, 2017, Volume 2017
The ROS1 tyrosine kinase is activated through gene rearrangements in 1-2% of non-small cell lung cancer (NSCLC), conferring sensitivity to treatment with the...
Journal Article
ELECTROPHORESIS, ISSN 0173-0835, 05/2016, Volume 37, Issue 10, pp. 1337 - 1344
Journal Article
Journal of Biomechanical Engineering, ISSN 0148-0731, 2013, Volume 135, Issue 2, pp. 021020 - 7
Functional activities in daily life can require squatting and shifting body weight during transverse plane rotations. Stability of the knee can be challenging...
rotary instability | total knee replacement | compensatory strategy | weight transfer | WALKING | INSTABILITY | MOBILITY | ENGINEERING, BIOMEDICAL | ARTHROPLASTY | GAIT ANALYSIS | ASYMMETRY | BIOPHYSICS | MOVEMENT PATTERNS | IN-VIVO | OUTCOMES | KINEMATICS | Knee Joint - surgery | Body Weight | Knee Joint - physiology | Movement | Humans | Middle Aged | Arthroplasty, Replacement, Knee | Female | Male | Weight-Bearing | Aged | Rotation | Knee | Biomechanics | Physiological aspects | Research | Health aspects | Body weight
rotary instability | total knee replacement | compensatory strategy | weight transfer | WALKING | INSTABILITY | MOBILITY | ENGINEERING, BIOMEDICAL | ARTHROPLASTY | GAIT ANALYSIS | ASYMMETRY | BIOPHYSICS | MOVEMENT PATTERNS | IN-VIVO | OUTCOMES | KINEMATICS | Knee Joint - surgery | Body Weight | Knee Joint - physiology | Movement | Humans | Middle Aged | Arthroplasty, Replacement, Knee | Female | Male | Weight-Bearing | Aged | Rotation | Knee | Biomechanics | Physiological aspects | Research | Health aspects | Body weight
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 11/2018, Volume 13, Issue 11, pp. e226 - e227
Journal Article
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