Gut, ISSN 0017-5749, 01/2018, Volume 67, Issue 1, pp. 108 - 119
ObjectivePatients with IBD display substantial heterogeneity in clinical characteristics. We hypothesise that individual differences in the complex interaction...
BACTERIA | CROHNS-DISEASE | VARIANTS | RARE | GENOTYPE | ULCERATIVE-COLITIS | RISK | LOCI | ASSOCIATION | BACTERIAL INTERACTIONS | INFLAMMATORY BOWEL DISEASE | GENETICS | INTESTINAL BACTERIA | CROHNS | GASTROENTEROLOGY & HEPATOLOGY | Severity of Illness Index | Crohn Disease - genetics | Risk Assessment - methods | Genetic Predisposition to Disease | Humans | Middle Aged | Colitis, Ulcerative - genetics | Male | Colitis, Ulcerative - pathology | Dysbiosis - complications | Dysbiosis - microbiology | Gastrointestinal Microbiome - genetics | Case-Control Studies | Feces - microbiology | Colitis, Ulcerative - microbiology | Dysbiosis - genetics | Host-Pathogen Interactions - genetics | Crohn Disease - pathology | Inflammatory Bowel Diseases - pathology | Inflammatory Bowel Diseases - genetics | Adult | Crohn Disease - microbiology | Female | Inflammatory Bowel Diseases - microbiology | Inflammatory bowel diseases | Care and treatment | Genetic aspects | Research | Microbiota (Symbiotic organisms) | Genetic variation | Phenotypes | Bacterial infections | Breastfeeding & lactation | rRNA 16S | Pathogenesis | Genomes | Inflammation | Crohn's disease | Family medical history | Crohns disease | Inflammatory bowel disease | Genetic variance | Microbiota | Antibiotics | Intestine | Gastroenterology | Peripheral blood | Genetics | Gene loci | Colon | Endoscopy | Acetic acid | NOD2 protein | Gut microbiota | Healthy controls | Host genetics
BACTERIA | CROHNS-DISEASE | VARIANTS | RARE | GENOTYPE | ULCERATIVE-COLITIS | RISK | LOCI | ASSOCIATION | BACTERIAL INTERACTIONS | INFLAMMATORY BOWEL DISEASE | GENETICS | INTESTINAL BACTERIA | CROHNS | GASTROENTEROLOGY & HEPATOLOGY | Severity of Illness Index | Crohn Disease - genetics | Risk Assessment - methods | Genetic Predisposition to Disease | Humans | Middle Aged | Colitis, Ulcerative - genetics | Male | Colitis, Ulcerative - pathology | Dysbiosis - complications | Dysbiosis - microbiology | Gastrointestinal Microbiome - genetics | Case-Control Studies | Feces - microbiology | Colitis, Ulcerative - microbiology | Dysbiosis - genetics | Host-Pathogen Interactions - genetics | Crohn Disease - pathology | Inflammatory Bowel Diseases - pathology | Inflammatory Bowel Diseases - genetics | Adult | Crohn Disease - microbiology | Female | Inflammatory Bowel Diseases - microbiology | Inflammatory bowel diseases | Care and treatment | Genetic aspects | Research | Microbiota (Symbiotic organisms) | Genetic variation | Phenotypes | Bacterial infections | Breastfeeding & lactation | rRNA 16S | Pathogenesis | Genomes | Inflammation | Crohn's disease | Family medical history | Crohns disease | Inflammatory bowel disease | Genetic variance | Microbiota | Antibiotics | Intestine | Gastroenterology | Peripheral blood | Genetics | Gene loci | Colon | Endoscopy | Acetic acid | NOD2 protein | Gut microbiota | Healthy controls | Host genetics
Journal Article
Gastroenterology, ISSN 0016-5085, 05/2019, Volume 156, Issue 6
Journal Article
JOURNAL OF PATHOLOGY, ISSN 0022-3417, 01/2017, Volume 241, Issue 2, pp. 146 - 158
Recent studies have greatly improved our insight into the genetic background of inflammatory bowel disease (IBD). New high-throughput technologies and...
SIGNALING PATHWAYS | environmental factors | SEQUENCE VARIANTS | Crohn's disease | pathways | GUT MICROBIOTA | microbiome | ILEAL CROHNS-DISEASE | ALPHA-DEFENSIN EXPRESSION | inflammatory bowel disease | causal variants | causality | RISK LOCI | LYMPHOCYTE MIGRATION | genetics | ARYL-HYDROCARBON RECEPTOR | ulcerative colitis | ULCERATIVE-COLITIS SUSCEPTIBILITY | GENOME-WIDE ASSOCIATION | PATHOLOGY | ONCOLOGY | Crohn Disease - genetics | Genetic Predisposition to Disease | Animals | Humans | Inflammatory Bowel Diseases - genetics | Genetic Variation - genetics | Genetic Background | Genome-Wide Association Study - methods | Genetic research | Gene expression | Ulcerative colitis
SIGNALING PATHWAYS | environmental factors | SEQUENCE VARIANTS | Crohn's disease | pathways | GUT MICROBIOTA | microbiome | ILEAL CROHNS-DISEASE | ALPHA-DEFENSIN EXPRESSION | inflammatory bowel disease | causal variants | causality | RISK LOCI | LYMPHOCYTE MIGRATION | genetics | ARYL-HYDROCARBON RECEPTOR | ulcerative colitis | ULCERATIVE-COLITIS SUSCEPTIBILITY | GENOME-WIDE ASSOCIATION | PATHOLOGY | ONCOLOGY | Crohn Disease - genetics | Genetic Predisposition to Disease | Animals | Humans | Inflammatory Bowel Diseases - genetics | Genetic Variation - genetics | Genetic Background | Genome-Wide Association Study - methods | Genetic research | Gene expression | Ulcerative colitis
Journal Article
World Journal of Gastroenterology, ISSN 1007-9327, 12/2017, Volume 23, Issue 46, pp. 8182 - 8192
AIM: To determine the prevalence of work disability in inflammatory bowel disease (IBD), and to assess risk factors associated with work disability. METHODS:...
Health care costs | POPULATION | CROHNS-DISEASE | ULCERATIVE-COLITIS | PROCTOCOLECTOMY | Crohn's disease | SICK LEAVE | Work disability | Inflammatory bowel disease | THERAPY | QUALITY-OF-LIFE | EMPLOYMENT | UNEMPLOYMENT | PARTICIPATION | Ulcerative colitis
Health care costs | POPULATION | CROHNS-DISEASE | ULCERATIVE-COLITIS | PROCTOCOLECTOMY | Crohn's disease | SICK LEAVE | Work disability | Inflammatory bowel disease | THERAPY | QUALITY-OF-LIFE | EMPLOYMENT | UNEMPLOYMENT | PARTICIPATION | Ulcerative colitis
Journal Article
World Journal of Gastroenterology, ISSN 1007-9327, 12/2017, Volume 23, Issue 46, pp. 8182 - 8192
Journal Article
PLoS genetics, ISSN 1553-7390, 2011, Volume 7, Issue 1, p. e1001283
Crohn's disease (CD) and celiac disease (CelD) are chronic intestinal inflammatory diseases, involving genetic and environmental factors in their pathogenesis....
IMPUTATION | INFLAMMATORY-BOWEL-DISEASE | ULCERATIVE-COLITIS | GENETICS & HEREDITY | SUSCEPTIBILITY LOCI | GENETIC-VARIANTS | MULTIPLE | Crohn Disease - genetics | Interleukin-18 Receptor beta Subunit - genetics | Data Interpretation, Statistical | Genetic Predisposition to Disease | Genome-Wide Association Study | Celiac Disease - genetics | Humans | Risk Factors | GTPase-Activating Proteins - genetics | Hydro-Lyases - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics | Celiac disease | Genetic susceptibility | Interleukins | Crohn's disease | Genetic aspects | Research | Risk factors | Interferon gamma | Medical research | Diet | Genetics | Genomes | Small intestine | Meta-analysis
IMPUTATION | INFLAMMATORY-BOWEL-DISEASE | ULCERATIVE-COLITIS | GENETICS & HEREDITY | SUSCEPTIBILITY LOCI | GENETIC-VARIANTS | MULTIPLE | Crohn Disease - genetics | Interleukin-18 Receptor beta Subunit - genetics | Data Interpretation, Statistical | Genetic Predisposition to Disease | Genome-Wide Association Study | Celiac Disease - genetics | Humans | Risk Factors | GTPase-Activating Proteins - genetics | Hydro-Lyases - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics | Celiac disease | Genetic susceptibility | Interleukins | Crohn's disease | Genetic aspects | Research | Risk factors | Interferon gamma | Medical research | Diet | Genetics | Genomes | Small intestine | Meta-analysis
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 10/2011, Volume 20, Issue 2, pp. 206 - 213
The successes of genome-wide association (GWA) studies have mainly come from studies performed in populations of European descent. Since complex traits are...
PATHWAYS | HEPATOCELLULAR-CARCINOMA | LINKAGE DISEQUILIBRIUM | POSITIVE SELECTION | VARIANTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISEASE | GENETICS & HEREDITY | POPULATIONS | LOCI | GENOME-WIDE ASSOCIATION | DIABETES SUSCEPTIBILITY | Genome-Wide Association Study | Disease - genetics | Continental Population Groups - ethnology | Humans | Continental Population Groups - genetics | Disease - ethnology | Quantitative Trait Loci | Reviews
PATHWAYS | HEPATOCELLULAR-CARCINOMA | LINKAGE DISEQUILIBRIUM | POSITIVE SELECTION | VARIANTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISEASE | GENETICS & HEREDITY | POPULATIONS | LOCI | GENOME-WIDE ASSOCIATION | DIABETES SUSCEPTIBILITY | Genome-Wide Association Study | Disease - genetics | Continental Population Groups - ethnology | Humans | Continental Population Groups - genetics | Disease - ethnology | Quantitative Trait Loci | Reviews
Journal Article
Journal of Crohn's and Colitis, ISSN 1873-9946, 01/2019, Volume 13, Issue 1
Background Mucosal healing is the ultimate treatment goal in inflammatory bowel disease (IBD). Endoscopic examination is the gold standard to determine disease...
Journal Article
Inflammatory Bowel Diseases, ISSN 1078-0998, 11/2016, Volume 22, Issue 11, pp. 2562 - 2570
Background:Currently, 200 genetic risk loci have been identified for inflammatory bowel disease (IBD). Although these findings have significantly advanced our...
CROHNS-DISEASE | ULCERATIVE-COLITIS | SUSCEPTIBILITY LOCI | POPULATIONS | Crohn's disease | drug identification | drug repositioning | inflammatory bowel disease | PATHOGENESIS | TRIAL | METABOLISM | candidate genes | ulcerative colitis | TOFACITINIB | GENOME-WIDE ASSOCIATION | GASTROENTEROLOGY & HEPATOLOGY | Inflammatory Bowel Diseases - drug therapy | Genetic Association Studies | Humans | Drug Repositioning - methods | Gastrointestinal Agents - therapeutic use | Inflammatory Bowel Diseases - genetics
CROHNS-DISEASE | ULCERATIVE-COLITIS | SUSCEPTIBILITY LOCI | POPULATIONS | Crohn's disease | drug identification | drug repositioning | inflammatory bowel disease | PATHOGENESIS | TRIAL | METABOLISM | candidate genes | ulcerative colitis | TOFACITINIB | GENOME-WIDE ASSOCIATION | GASTROENTEROLOGY & HEPATOLOGY | Inflammatory Bowel Diseases - drug therapy | Genetic Association Studies | Humans | Drug Repositioning - methods | Gastrointestinal Agents - therapeutic use | Inflammatory Bowel Diseases - genetics
Journal Article
Gut, ISSN 0017-5749, 08/2018, Volume 67, Issue 8, pp. 1517 - 1524
ObjectivePrimary sclerosing cholangitis (PSC) is a genetically complex, inflammatory bile duct disease of largely unknown aetiology often leading to liver...
Primary sclerosing cholangitis | liver transplantation | genetics | RISK LOCI | ACTIVATION | MALIGNANCY | HEPATIC STELLATE CELLS | CIRRHOSIS | ULCERATIVE-COLITIS | LIVER FIBROSIS | GASTROENTEROLOGY & HEPATOLOGY | MULTIPLE | EPIDEMIOLOGY | GENOME-WIDE ASSOCIATION | Animal models | Transplants & implants | Disease | Syngeneic grafts | Association analysis | Effector cells | Genomes | Single-nucleotide polymorphism | Allografts | Etiology | Gastroenterology | Genetic analysis | Gallbladder | Antigens | Stellate cells | Liver diseases | Cholangitis | Regression analysis | Gene expression | Bile duct | Inflammatory bowel disease | Genetic variance | Hepatocytes | Quality control | Liver cirrhosis | Bile | Liver transplantation | Gastroenterology and Hepatology | Gastroenterologi
Primary sclerosing cholangitis | liver transplantation | genetics | RISK LOCI | ACTIVATION | MALIGNANCY | HEPATIC STELLATE CELLS | CIRRHOSIS | ULCERATIVE-COLITIS | LIVER FIBROSIS | GASTROENTEROLOGY & HEPATOLOGY | MULTIPLE | EPIDEMIOLOGY | GENOME-WIDE ASSOCIATION | Animal models | Transplants & implants | Disease | Syngeneic grafts | Association analysis | Effector cells | Genomes | Single-nucleotide polymorphism | Allografts | Etiology | Gastroenterology | Genetic analysis | Gallbladder | Antigens | Stellate cells | Liver diseases | Cholangitis | Regression analysis | Gene expression | Bile duct | Inflammatory bowel disease | Genetic variance | Hepatocytes | Quality control | Liver cirrhosis | Bile | Liver transplantation | Gastroenterology and Hepatology | Gastroenterologi
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2019, Volume 14, Issue 1, p. e0211328
Background Gene-microbiome interactions are important in aetiology and pathogenesis of inflammatory bowel disease, a chronic inflammatory disorder of the...
INFLAMMATORY-BOWEL-DISEASE | To be checked for WOS id | GENOME | ZINC | MULTIDISCIPLINARY SCIENCES | Crohn's disease | Genetic aspects | Research | Microbiota (Symbiotic organisms) | Pediatrics | Inflammatory bowel diseases | rRNA 16S | Control methods | Pathogenesis | Microbiomes | Genomes | Gene sequencing | Microorganisms | Microbiota | Intestine | Hepatology | Gastroenterology | Peripheral blood | Population | Genetics | Digestive tract | Phenotypes | Composition | Digestive system | Health risks | Gastrointestinal tract | Disease control | Patients | Variance analysis | Zinc | Carriers | Inflammatory bowel disease | Studies | Biological warfare | Gastrointestinal system | Alleles | Sampling methods | Ulcerative colitis
INFLAMMATORY-BOWEL-DISEASE | To be checked for WOS id | GENOME | ZINC | MULTIDISCIPLINARY SCIENCES | Crohn's disease | Genetic aspects | Research | Microbiota (Symbiotic organisms) | Pediatrics | Inflammatory bowel diseases | rRNA 16S | Control methods | Pathogenesis | Microbiomes | Genomes | Gene sequencing | Microorganisms | Microbiota | Intestine | Hepatology | Gastroenterology | Peripheral blood | Population | Genetics | Digestive tract | Phenotypes | Composition | Digestive system | Health risks | Gastrointestinal tract | Disease control | Patients | Variance analysis | Zinc | Carriers | Inflammatory bowel disease | Studies | Biological warfare | Gastrointestinal system | Alleles | Sampling methods | Ulcerative colitis
Journal Article
Human molecular genetics, ISSN 0964-6906, 2010, Volume 19, Issue 17, pp. 3482 - 3488
Genome-wide association studies (GWAS) for Crohn's disease (CD) have identified loci explaining approximately 20% of the total genetic risk of CD. Part of the...
PATHOGENESIS | INFLAMMATORY-BOWEL-DISEASE | VARIANTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | SUSCEPTIBILITY LOCI | GENOME-WIDE ASSOCIATION | Crohn Disease - genetics | European Continental Ancestry Group - genetics | Gene Expression | Genetic Predisposition to Disease | Genome-Wide Association Study | Humans | Male | Proto-Oncogene Proteins - genetics | Ubiquitin-Conjugating Enzymes - genetics | Transcription Factors - genetics | Case-Control Studies | Female | Polymorphism, Single Nucleotide | Cohort Studies
PATHOGENESIS | INFLAMMATORY-BOWEL-DISEASE | VARIANTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | SUSCEPTIBILITY LOCI | GENOME-WIDE ASSOCIATION | Crohn Disease - genetics | European Continental Ancestry Group - genetics | Gene Expression | Genetic Predisposition to Disease | Genome-Wide Association Study | Humans | Male | Proto-Oncogene Proteins - genetics | Ubiquitin-Conjugating Enzymes - genetics | Transcription Factors - genetics | Case-Control Studies | Female | Polymorphism, Single Nucleotide | Cohort Studies
Journal Article
JAMA, ISSN 0098-7484, 02/2019, Volume 321, Issue 8, pp. 773 - 785
Importance: Use of thiopurines may be limited by myelosuppression. TPMT pharmacogenetic testing identifies only 25% of at-risk patients of European ancestry....
MEDICINE, GENERAL & INTERNAL | S-METHYLTRANSFERASE | POLYMORPHISMS | MANAGEMENT | PREDICTOR | THERAPY | ACUTE LYMPHOBLASTIC-LEUKEMIA | SUSCEPTIBILITY | AZATHIOPRINE | MERCAPTOPURINE INTOLERANCE | CHILDREN | Haplotypes | Crohn Disease - genetics | Genome-Wide Association Study | Colitis, Ulcerative - metabolism | Humans | Methyltransferases - metabolism | Colitis, Ulcerative - genetics | Methyltransferases - genetics | Pyrophosphatases - genetics | Crohn Disease - metabolism | European Continental Ancestry Group | Male | Case-Control Studies | Methyltransferases - therapeutic use | Exome | Young Adult | Crohn Disease - drug therapy | Adolescent | Adult | Female | Leukocyte Count | Polymorphism, Single Nucleotide | Colitis, Ulcerative - drug therapy | Sequence Analysis, DNA - methods | Antimitotic agents | Complications and side effects | Inflammatory bowel diseases | Genetic variation | Myelosuppression | Dosage and administration | Genetic aspects | Research | Antineoplastic agents | Drug therapy | Health aspects | Chromosome 6 | Risk | Genomes | Chromosome deletion | Pharmacology | Gene deletion | Disease control | Patients | Inflammatory bowel disease | White blood cells | Genetic variance | Genotyping | Clonal deletion | Intestine | Deletion | Chromosome 13 | Genetic testing | Genotypes | Original Investigation | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Gastroenterology and Hepatology | Gastroenterologi
MEDICINE, GENERAL & INTERNAL | S-METHYLTRANSFERASE | POLYMORPHISMS | MANAGEMENT | PREDICTOR | THERAPY | ACUTE LYMPHOBLASTIC-LEUKEMIA | SUSCEPTIBILITY | AZATHIOPRINE | MERCAPTOPURINE INTOLERANCE | CHILDREN | Haplotypes | Crohn Disease - genetics | Genome-Wide Association Study | Colitis, Ulcerative - metabolism | Humans | Methyltransferases - metabolism | Colitis, Ulcerative - genetics | Methyltransferases - genetics | Pyrophosphatases - genetics | Crohn Disease - metabolism | European Continental Ancestry Group | Male | Case-Control Studies | Methyltransferases - therapeutic use | Exome | Young Adult | Crohn Disease - drug therapy | Adolescent | Adult | Female | Leukocyte Count | Polymorphism, Single Nucleotide | Colitis, Ulcerative - drug therapy | Sequence Analysis, DNA - methods | Antimitotic agents | Complications and side effects | Inflammatory bowel diseases | Genetic variation | Myelosuppression | Dosage and administration | Genetic aspects | Research | Antineoplastic agents | Drug therapy | Health aspects | Chromosome 6 | Risk | Genomes | Chromosome deletion | Pharmacology | Gene deletion | Disease control | Patients | Inflammatory bowel disease | White blood cells | Genetic variance | Genotyping | Clonal deletion | Intestine | Deletion | Chromosome 13 | Genetic testing | Genotypes | Original Investigation | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Gastroenterology and Hepatology | Gastroenterologi
Journal Article