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by Franke, Ane and McGovern, Dermot P. B and Barrett, Jeffrey C and Wang, Kai and Radford-Smith, Graham L and Ahmad, Tariq and Lees, Charlie W and Balschun, Tobias and Lee, James and Roberts, Rebecca and Anderson, Carl A and Bis, Joshua C and Bumpstead, Suzanne and Ellinghaus, David and Festen, Eleonora M and Georges, Michel and Green, Todd and Haritunians, Talin and Jostins, Luke and Latiano, Anna and Mathew, Christopher G and Montgomery, Grant W and Prescott, Natalie J and Raychaudhuri, Soumya and Rotter, Jerome I and Schumm, Philip and Sharma, Yashoda and Simms, Lisa A and Taylor, Kent D and Whiteman, David and Wijmenga, Cisca and Baldassano, Robert N and Barclay, Murray and Bayless, Theodore M and Brand, Stephan and Büning, Carsten and Cohen, Albert and Colombel, Jean-Frederick and Cottone, Mario and Stronati, Laura and Denson, Ted and de Vos, Martine and D'Inca, Renata and Dubinsky, Marla and Edwards, Cathryn and Florin, Tim and Franchimont, Denis and Gearry, Richard and Glas, Jürgen and van Gossum, Ane and Guthery, Stephen L and Halfvarson, Jonas and Verspaget, Hein W and Hugot, Jean-Pierre and Karban, Amir and Laukens, Debby and Lawrance, Ian and Lemann, Marc and Levine, Arie and Libioulle, Cecile and Louis, Edouard and Mowat, Craig and Newman, William and Panés, Julián and Phillips, Anne and Proctor, Deborah D and Regueiro, Miguel and Russell, Richard and Rutgeerts, Paul and Sanderson, Jeremy and Sans, Miquel and Seibold, Frank and Steinhart, A. Hillary and Stokkers, Pieter C. F and Torkvist, Leif and Kullak-Ublick, Gerd and Wilson, David and Walters, Thomas and Targan, Stephan R and Brant, Steven R and Rioux, John D and D'Amato, Mauro and Weersma, Rinse K and Kugathasan, Subra and Griffiths, Anne M and Mansfield, John C and Vermeire, Severine and Duerr, Richard H and Silverberg, Mark S and Satsangi, Jack and Schreiber, Stefan and Cho, Judy H and Annese, Vito and Hakonarson, Hakon and Daly, Mark J and Parkes, Miles and Hälsoakademin and Örebro universitet
Nature genetics, ISSN 1061-4036, 2010, Volume 42, Issue 12, pp. 1118 - 1125
Journal Article
Gut, ISSN 0017-5749, 01/2018, Volume 67, Issue 1, pp. 108 - 119
ObjectivePatients with IBD display substantial heterogeneity in clinical characteristics. We hypothesise that individual differences in the complex interaction... 
BACTERIAL INTERACTIONS | INFLAMMATORY BOWEL DISEASE | GENETICS | INTESTINAL BACTERIA | CROHNS | RISK | BACTERIA | LOCI | RARE | GASTROENTEROLOGY & HEPATOLOGY | Severity of Illness Index | Crohn Disease - genetics | Risk Assessment - methods | Genetic Predisposition to Disease | Humans | Middle Aged | Colitis, Ulcerative - genetics | Male | Colitis, Ulcerative - pathology | Dysbiosis - complications | Dysbiosis - microbiology | Gastrointestinal Microbiome - genetics | Case-Control Studies | Feces - microbiology | Colitis, Ulcerative - microbiology | Dysbiosis - genetics | Host-Pathogen Interactions - genetics | Crohn Disease - pathology | Inflammatory Bowel Diseases - pathology | Inflammatory Bowel Diseases - genetics | Adult | Crohn Disease - microbiology | Female | Inflammatory Bowel Diseases - microbiology | Inflammatory bowel diseases | Care and treatment | Genetic aspects | Research | Microbiota (Symbiotic organisms) | Genetic variation | Phenotypes | Bacterial infections | Breastfeeding & lactation | rRNA 16S | Pathogenesis | Genomes | Inflammation | Crohn's disease | Family medical history | Crohns disease | Inflammatory bowel disease | Genetic variance | Microbiota | Antibiotics | Intestine | Gastroenterology | Peripheral blood | Genetics | Gene loci | Colon | Endoscopy | Acetic acid | NOD2 protein | Index Medicus | Abridged Index Medicus | Gut microbiota | Healthy controls | Host genetics
Journal Article
Journal Article
by Alberts, Rudi and de Vries, Elisabeth M G and Goode, Elizabeth C and Jiang, Xiaojun and Sampaziotis, Fotis and Rombouts, Krista and Böttcher, Katrin and Folseraas, Trine and Weismüller, Tobias J and Mason, Andrew L and Wang, Weiwei and Alexander, Graeme and Alvaro, Domenico and Bergquist, Annika and Björkström, Niklas K and Beuers, Ulrich and Björnsson, Einar and Boberg, Kirsten Muri and Bowlus, Christopher L and Bragazzi, Maria C and Carbone, Marco and Chazouillères, Olivier and Cheung, Angela and Dalekos, Georgios and Eaton, John and Eksteen, Bertus and Ellinghaus, David and Färkkilä, Martti and Festen, Eleonora A M and Floreani, Annarosa and Franceschet, Irene and Gotthardt, Daniel Nils and Hirschfield, Gideon M and Hoek, Bart van and Holm, Kristian and Hohenester, Simon and Hov, Johannes Roksund and Imhann, Floris and Invernizzi, Pietro and Juran, Brian D and Lenzen, Henrike and Lieb, Wolfgang and Liu, Jimmy Z and Marschall, Hanns-Ulrich and Marzioni, Marco and Melum, Espen and Milkiewicz, Piotr and Müller, Tobias and Pares, Albert and Rupp, Christian and Rust, Christian and Sandford, Richard N and Schramm, Christoph and Schreiber, Stefan and Schrumpf, Erik and Silverberg, Mark S and Srivastava, Brijesh and Sterneck, Martina and Teufel, Andreas and Vallier, Ludovic and Verheij, Joanne and Vila, Arnau Vich and Vries, Boudewijn de and Zachou, Kalliopi and Chapman, Roger W and Manns, Michael P and Pinzani, Massimo and Rushbrook, Simon M and Lazaridis, Konstantinos N and Franke, Andre and Anderson, Carl A and Karlsen, Tom H and Ponsioen, Cyriel Y and Weersma, Rinse K and PSC Study Grp and UK PSC Consortium and International PSC Study Group, The UK PSC Consortium and Sahlgrenska akademin and Institute of Medicine, Department of Molecular and Clinical Medicine and Institutionen för medicin, avdelningen för molekylär och klinisk medicin and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy
Gut, ISSN 0017-5749, 08/2018, Volume 67, Issue 8, pp. 1517 - 1524
Journal Article
by Walker, Gareth J and Harrison, James W and Heap, Graham A and Voskuil, Michiel D and Andersen, Vibeke and Anderson, Carl A and Ananthakrishnan, Ashwin N and Barrett, Jeffrey C and Beaugerie, Laurent and Bewshea, Claire M and Cole, Andy T and Cummings, Fraser R and Daly, Mark J and Ellul, Pierre and Fedorak, Richard N and Festen, Eleonora A. M and Florin, Timothy H and Gaya, Daniel R and Halfvarson, Jonas and Hart, Ailsa L and Heerasing, Neel M and Hendy, Peter and Irving, Peter and Jones, Samuel E and Koskela, Jukka and Lindsay, James O and Mansfield, John C and McGovern, Dermot and Parkes, Miles and Pollok, Richard C. G and Ramakrishnan, Subramaniam and Rampton, David S and Rivas, Manuel A and Russell, Richard K and Schultz, Michael and Sebastian, Shaji and Seksik, Philippe and Singh, Abhey and So, Kenji and Sokol, Harry and Subramaniam, Kavitha and Todd, Anthony and Annese, Vito and Weersma, Rinse K and Xavier, Ramnik and Ward, Rebecca and Weedon, Michael N and Goodhand, James R and Kennedy, Nicholas A and Ahmad, Tariq and Holden, Arthur L and Andrews, Jane and Auth, Marcus and Babu, Sathish and Bampton, Peter and Banim, Paul and Barnes, Theresa and Basude, Dharam and Beckly, John and Bell, Andy and Bell, Sally and Bhandari, Pradeep and Bloom, Stuart and Border, Dave and Bredin, Francesca and Brookes, Matthew J and Brown, Matthew and Calvert, Chris and Campbell, David and Chanchlani, Neil and Chaudhary, Basant and Chaudhary, Rakesh and Chung-Faye, Guy and Colleypriest, Ben and Connor, Susan and Cooney, Rachel and Cooper, Sheldon and Creed, Tom J and Croft, Nick and Cullen, Sue and D'Amato, Mauro and D'Inca, Renata and Dalal, Helen and Daneshmend, Tawfique K and Das, Debasish and Delaney, Michael and DeSilva, Shanika and Dhar, Anjan and Dharmasiri, Suranga and Direkze, Natalie and Dunckley, Paul and Elphick, David and Everett, Simon M and Feeney, Mark and Fell, John and Foley, Stephen and Franke, Andre and Gavin, Daniel and Gee, Ian and Ghosh, Deb and ... and IBD Pharmacogenetics Study Grp and IBD Pharmacogenetics Study Group and for the IBD Pharmacogenetics Study Group
JAMA - Journal of the American Medical Association, ISSN 0098-7484, 02/2019, Volume 321, Issue 8, pp. 753 - 761
IMPORTANCE Use of thiopurines may be limited by myelosuppression. TPMT pharmacogenetic testing identifies only 25% of at-risk patients of European ancestry.... 
MEDICINE, GENERAL & INTERNAL | S-METHYLTRANSFERASE | POLYMORPHISMS | MANAGEMENT | PREDICTOR | THERAPY | ACUTE LYMPHOBLASTIC-LEUKEMIA | SUSCEPTIBILITY | AZATHIOPRINE | MERCAPTOPURINE INTOLERANCE | CHILDREN | Haplotypes | Crohn Disease - genetics | Genome-Wide Association Study | Colitis, Ulcerative - metabolism | Humans | Methyltransferases - metabolism | Colitis, Ulcerative - genetics | Methyltransferases - genetics | Pyrophosphatases - genetics | Crohn Disease - metabolism | European Continental Ancestry Group | Male | Case-Control Studies | Methyltransferases - therapeutic use | Exome | Young Adult | Crohn Disease - drug therapy | Adolescent | Adult | Female | Leukocyte Count | Polymorphism, Single Nucleotide | Colitis, Ulcerative - drug therapy | Sequence Analysis, DNA - methods | Antimitotic agents | Complications and side effects | Inflammatory bowel diseases | Genetic variation | Myelosuppression | Dosage and administration | Genetic aspects | Research | Antineoplastic agents | Drug therapy | Health aspects | Chromosome 6 | Risk | Genomes | Chromosome deletion | Pharmacology | Gene deletion | Disease control | Patients | Inflammatory bowel disease | White blood cells | Genetic variance | Genotyping | Clonal deletion | Intestine | Deletion | Chromosome 13 | Genetic testing | Genotypes | Index Medicus | Abridged Index Medicus | Original Investigation
Journal Article
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