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Nature Genetics, ISSN 1061-4036, 02/2015, Volume 47, Issue 3, pp. 250 - 256
Resistance to RAF-and MEK-targeted therapy is a major clinical challenge(1-4). RAF and MEK inhibitors are initially but only transiently effective in some but... 
COLON-CANCER | SURVIVAL | LUNG | ACTIVATION | INHIBITION | MELANOMA | SIGNALING PATHWAY | TRANSCRIPTION | GENETICS & HEREDITY | BRAF | KRAS | Humans | Molecular Targeted Therapy | Phosphoproteins - metabolism | Gene Knockdown Techniques | Heterografts | MAP Kinase Signaling System - genetics | HEK293 Cells | Female | MAP Kinase Kinase Kinases - antagonists & inhibitors | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins B-raf - metabolism | MAP Kinase Kinase Kinases - genetics | Protein-Serine-Threonine Kinases - genetics | MAP Kinase Kinase Kinases - metabolism | Phosphoproteins - genetics | Mice, SCID | HT29 Cells | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Drug Resistance, Neoplasm - genetics | Animals | MAP Kinase Signaling System - drug effects | Proto-Oncogene Proteins B-raf - genetics | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Mice, Inbred NOD | Biomarkers, Tumor - genetics | Mice | Protein Kinase Inhibitors - pharmacology | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Genes, ras | Antimitotic agents | Gene mutations | Genetic aspects | Research | Antineoplastic agents | Drug resistance | Health aspects | Thyroid cancer | Lung cancer | Colorectal cancer | Melanoma | Kinases | Charitable foundations | Cancer therapies | Design of experiments | Tumors
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2014, Volume 9, Issue 8, p. e103883
Introduction: Assessment of EGFR mutation in non-small cell lung cancer (NSCLC) patients is mandatory for optimization of pharmacologic treatment. In this... 
BREAST-CANCER | MOLECULAR CHARACTERIZATION | SURVIVAL | THERAPY | DNA | MULTIDISCIPLINARY SCIENCES | PROGRESSION-FREE | FACTOR-RECEPTOR MUTATIONS | DISCORDANCE | EXPRESSION | Erlotinib Hydrochloride | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Neoplastic Cells, Circulating - pathology | Exons | Humans | Molecular Sequence Data | Neoplastic Cells, Circulating - metabolism | Lung Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Carcinoma, Non-Small-Cell Lung - diagnosis | Case-Control Studies | Base Sequence | Sensitivity and Specificity | Carcinoma, Non-Small-Cell Lung - pathology | Gene Expression | Biomarkers, Tumor - blood | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Carcinoma, Non-Small-Cell Lung - blood | Biomarkers, Tumor - genetics | High-Throughput Nucleotide Sequencing | Lung Neoplasms - blood | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Lung Neoplasms - diagnosis | Care and treatment | Genetic aspects | Lung cancer, Non-small cell | Analysis | Tumors | Lung cancer | Medical services | Oncology | Metastasis | Kinases | Cancer therapies | Nuclei | Blood | Optimization | Aging | Deoxyribonucleic acid--DNA | Sequences | Epidermal growth factor receptors | Tumor cells | Non-small cell lung carcinoma | Breast cancer | Pharmacology | Real time | Patients | Medicine | Chemotherapy | Hospitals | Biopsy | Experimental design | Diagnostic software | Diagnostic systems | Prostate cancer | Cancer | Deoxyribonucleic acid
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 04/2009, Volume 27, Issue 10, pp. 1667 - 1674
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