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1. Full Text Glypican‐3: a marker and a therapeutic target in hepatocellular carcinoma
by Filmus, Jorge and Capurro, Mariana
The FEBS Journal, ISSN 1742-464X, 05/2013, Volume 280, Issue 10, pp. 2471 - 2476
Glypican‐3 (GPC3) is a member of the glypican family. Glypicans are proteoglycans that are attached to the cell surface by a glycosyl‐phosphatidylinositol... 
Wnt signaling | glypican‐3 | tumor marker | hepatocellular carcinoma | immunotherapy | glypican-3 | DIAGNOSTIC-VALUE | PROGNOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIVER BIOPSIES | IDENTIFICATION | CONVERTASES | DYSPLASTIC NODULES | GROWTH | DYSREGULATION | GLUTAMINE-SYNTHETASE | EXPRESSION | Liver - pathology | Humans | Liver - metabolism | Frizzled Receptors - metabolism | Clinical Trials as Topic | Glypicans - metabolism | Disease Progression | Multiprotein Complexes - metabolism | T-Lymphocytes, Cytotoxic - metabolism | Antibodies, Monoclonal, Humanized - pharmacology | Carcinoma, Hepatocellular - pathology | Biomarkers, Tumor - metabolism | Protein Binding | Carcinoma, Hepatocellular - therapy | Wnt Signaling Pathway | Carcinoma, Hepatocellular - metabolism | Monoclonal antibodies | Development and progression | Hepatoma | Health aspects | Liver cirrhosis | Immunotherapy
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2. Full Text The role of glypicans in Hedgehog signaling
by Filmus, Jorge and Capurro, Mariana
Matrix Biology, ISSN 0945-053X, 04/2014, Volume 35, pp. 248 - 252
Glypicans (GPCs) are a family of proteoglycans that are bound to the cell surface by a glycosylphosphatidylinositol anchor. Six glypicans have been found in... 
Glypicans | Hedgehog | Proteoglycans | RECEPTOR-RELATED PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | GOLABI-BEHMEL-SYNDROME | CELL-SURFACE | INDIAN HEDGEHOG | DROSOPHILA | CELL BIOLOGY | OVERGROWTH | MOUSE MODEL | DALLY-LIKE | HEPARAN-SULFATE PROTEOGLYCANS | GPI-ANCHORED PROTEINS | Arrhythmias, Cardiac - metabolism | Gigantism - metabolism | Humans | Rhabdomyosarcoma - metabolism | Hedgehog Proteins - metabolism | Genetic Diseases, X-Linked - metabolism | Glypicans - genetics | Glypicans - metabolism | Intellectual Disability - metabolism | Animals | Models, Biological | Signal Transduction - physiology | Heart Defects, Congenital - metabolism | Drosophila melanogaster
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3. Full Text Glypicans
by Filmus, Jorge and Capurro, Mariana and Rast, Jonathan
Genome Biology, ISSN 1474-7596, 05/2009, Volume 9, Issue 5, pp. 224 - 224
Glypicans are heparan sulfate proteoglycans that are bound to the outer surface of the plasma membrane by a glycosyl-phosphatidylinositol anchor. Homologs of... 
GASTRULATION MOVEMENTS | NERVOUS-SYSTEM | HEPATOCELLULAR-CARCINOMA | DROSOPHILA GLYPICAN | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MORPHOGEN GRADIENT FORMATION | GENETICS & HEREDITY | CELL-SURFACE | CONVERGENT EXTENSION | DALLY-LIKE | HEPARAN-SULFATE PROTEOGLYCANS | GPI-ANCHORED PROTEINS | Cell Membrane - chemistry | Glypicans - physiology | Animals | Humans | Glypicans - chemistry | Glypicans - genetics | Evolution, Molecular | Protein Family Review
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4. Full Text Glypicans in growth control and cancer
by Filmus, Jorge
Glycobiology, ISSN 0959-6658, 2001, Volume 11, Issue 3, pp. 19R - 23R
The name glypican has been assigned to a family of heparan sulfate (HS) proteoglycans that are linked to the cell membrane by a glycosyl-phosphatidylinositol... 
Glypicans | Heparan sulfate proteoglycans | Overgrowth syndromes | OVERGROWTH SYNDROME | NERVOUS-SYSTEM | overgrowth | BIOCHEMISTRY & MOLECULAR BIOLOGY | GOLABI-BEHMEL-SYNDROME | CONTROLS CELLULAR-RESPONSES | PANCREATIC-CARCINOMA CELLS | HEPATOCELLULAR-CARCINOMA | GPC3 GENE | syndromes | HEPARAN-SULFATE PROTEOGLYCAN | heparan sulfate proteoglycans | PERINATAL LETHALITY | glypicans | DEVELOPMENTALLY-REGULATED TRANSCRIPT | Cell Division - physiology | Mice | Animals | Neoplasms - pathology | Heparan Sulfate Proteoglycans - physiology
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5. Glypican-3: a marker and a therapeutic target in hepatocellular carcinoma
by Jorge Filmus and Mariana Capurro
The FEBS Journal, ISSN 1742-464X, 05/2013, Volume 280, Issue 10, p. 2471
  Glypican-3 (GPC3) is a member of the glypican family. Glypicans are proteoglycans that are attached to the cell surface by a glycosyl-phosphatidylinositol... 
Proteins | Liver cancer | Signal transduction | Biomarkers
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6. Glypican-3: a marker and a therapeutic target in hepatocellular carcinoma
: 1
by Jorge Filmus and Mariana Capurro
The FEBS Journal, ISSN 1742-464X, 05/2013, Volume 280, Issue 10, p. 2471
  Glypican-3 (GPC3) is a member of the glypican family. Glypicans are proteoglycans that are attached to the cell surface by a glycosyl-phosphatidylinositol... 
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7. Full Text The role of glypican-3 in the regulation of body size and cancer
by Filmus, Jorge and Capurro, Mariana
Cell Cycle, ISSN 1538-4101, 09/2008, Volume 7, Issue 18, pp. 2787 - 2790
Glypicans are a family of heparan sulfate proteoglycans whose members are bound to the cell surface by a glycosylphosphatidylinositol (GPI) anchor.... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Glypicans | Hedgehog | Glypican-3 | Proteoglycans | Wnt | proteoglycans | glypican-3 | PROLIFERATION | CELL BIOLOGY | OVERGROWTH | hedgehog | GROWTH | GPC3 | MOVEMENT | HEPARAN-SULFATE | DALLY-LIKE | MUTATIONS | CARCINOMA | glypicans | Abnormalities, Multiple - metabolism | Neoplasms - metabolism | Signal Transduction | Body Size | Hedgehog Proteins - metabolism | Wnt Proteins - metabolism | Glypicans - metabolism | Heparitin Sulfate - metabolism | Abnormalities, Multiple - physiopathology | Syndrome | Animals | Glycosylphosphatidylinositols - metabolism | Mice | Neoplasms - physiopathology
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8. Full Text Glypican-3 binds to Frizzled and plays a direct role in the stimulation of canonical Wnt signaling
by Capurro, Mariana and Martin, Tonya and Shi, Wen and Filmus, Jorge
Journal of Cell Science, ISSN 0021-9533, 2014, Volume 127, Issue 7, pp. 1565 - 1575
Glypican-3 (GPC3) is a proteoglycan that is bound to the cell surface. It is expressed by most hepatocellular carcinomas (HCCs) but not by normal hepatocytes.... 
Proteoglycan | Hepatocellular carcinoma | Glypican-3 | Frizzled | Heparan sulphate | Wnt | GASTRULATION MOVEMENTS | LRP6 PHOSPHORYLATION | GOLABI-BEHMEL-SYNDROME | CELL-SURFACE | DROSOPHILA | CELL BIOLOGY | WNT/BETA-CATENIN | MORPHOGEN GRADIENT FORMATION | DALLY-LIKE | HEPARAN-SULFATE PROTEOGLYCANS | HUMAN HEPATOCELLULAR-CARCINOMA | Humans | HEK293 Cells | Liver Neoplasms - metabolism | Frizzled Receptors - metabolism | Wnt Signaling Pathway - physiology | Wnt Proteins - metabolism | Glypicans - metabolism | Carcinoma, Hepatocellular - metabolism
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9. Full Text Glypican-6 stimulates intestinal elongation by simultaneously regulating Hedgehog and non-canonical Wnt signaling
by Shi, Wen and Kaneiwa, Tomoyuki and Cydzik, Marzena and Gariepy, Jean and Filmus, Jorge
Matrix biology : journal of the International Society for Matrix Biology, ISSN 0945-053X, 11/2019
We report here that Glypican-6 (GPC6)-null mice display at birth small intestines that are 75% shorter than those of normal littermates. Notably, we... 
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10. Full Text Glypicans: Proteoglycans with a surprise
by Filmus, J and Selleck, S.B
Journal of Clinical Investigation, ISSN 0021-9738, 2001, Volume 108, Issue 4, pp. 497 - 501
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11. Full Text The Loss of Glypican-3 Induces Alterations in Wnt Signaling
by Howard H. Song and Wen Shi and Yun-Yan Xiang and Jorge Filmus
Journal of Biological Chemistry, ISSN 0021-9258, 01/2005, Volume 280, Issue 3, pp. 2116 - 2125
Loss-of-function mutations of the GPC3 gene are the cause of the human Simpson-Golabi-Behmel syndrome. Based on the overgrowth phenotype of the... 
GASTRULATION MOVEMENTS | CONVERGENT EXTENSION MOVEMENTS | GROWTH-RETARDATION | WNT/BETA-CATENIN | CYCLIN D1 | INSULIN-RESISTANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BEHMEL OVERGROWTH SYNDROME | HEPARAN-SULFATE PROTEOGLYCANS | CONTROLS CELLULAR-RESPONSES | TRANSGENIC MICE | Mice, Inbred C57BL | Wnt Proteins | DNA Primers | Phosphoproteins - metabolism | Mice, Knockout | Glypicans | Intercellular Signaling Peptides and Proteins - metabolism | Animals | Heparan Sulfate Proteoglycans - genetics | Base Sequence | Insulin Receptor Substrate Proteins | Signal Transduction - physiology | Mice | Heparan Sulfate Proteoglycans - physiology
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12. Therapeutic potential of targeting glypican-3 in hepatocellular carcinoma
by Allegretta, Mark and Filmus, Jorge
Anti-Cancer Agents in Medicinal Chemistry, ISSN 1871-5206, 2011, Volume 11, Issue 6, pp. 543 - 548
Glypican-3 (GPC3) is a developmentally-regulated oncofetal protein that has been established as a clinically-relevant biomarker for early hepatocellular... 
Immunohistochemistry | Wnt signaling | Therapeutic antibody | Hepatocellular carcinoma | Glypican-3 | Peptide vaccine | Oncofetal protein | CHEMISTRY, MEDICINAL | oncofetal protein | DYSPLASTIC NODULES | OVERGROWTH | GENE | ONCOLOGY | BENIGN | LIVER | GROWTH | therapeutic antibody | GPC3 | immunohistochemistry | DIFFERENTIATION | peptide vaccine | EXPRESSION | Hepatocellular Carcinoma | DEVELOPMENTALLY-REGULATED TRANSCRIPT | Carcinoma, Hepatocellular - diagnosis | Humans | Glypicans - chemistry | Liver Neoplasms - therapy | Glypicans - metabolism | Liver Neoplasms - diagnosis | Cancer Vaccines | Immunotherapy | Liver Neoplasms - metabolism | Biomarkers, Tumor - metabolism | Carcinoma, Hepatocellular - therapy | Antibodies, Monoclonal - chemistry | Carcinoma, Hepatocellular - metabolism
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13. Full Text Glypican-5 stimulates rhabdomyosarcoma cell proliferation by activating Hedgehog signaling
by Li, Fuchuan and Shi, Wen and Capurro, Mariana and Filmus, Jorge
Journal of Cell Biology, ISSN 0021-9525, 02/2011, Volume 192, Issue 4, pp. 691 - 704
Glypican-5 (GPC5) is one of the six members of the glypican family. It has been previously reported that GPC5 stimulates the proliferation of rhabdomyosarcoma... 
COOPERATE | CHONDROITIN SULFATE | PROTEOGLYCANS | PATHWAY | MOUSE MODEL | MORPHOGEN | DALLY-LIKE | STRENGTH | IDENTIFICATION | EXPRESSION | CELL BIOLOGY | NIH 3T3 Cells | Glypicans - physiology | Cell Proliferation | Signal Transduction | Humans | Rhabdomyosarcoma - metabolism | Hedgehog Proteins - metabolism | Receptors, Cell Surface - metabolism | Glypicans - metabolism | Animals | Cell Line, Tumor | Mice | Patched Receptors | Patched-1 Receptor | Histogenesis | Growth | Cancer cells | Cell division | Research | Properties | Hedgehog proteins | Membrane proteins
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14. Full Text Mammalian Notum induces the release of glypicans and other GPI-anchored proteins from the cell surface
by Traister, Alexandra and Shi, Wen and Filmus, Jorge
Biochemical Journal, ISSN 0264-6021, 03/2008, Volume 410, Issue 3, pp. 503 - 511
Glypicans are heparan sulfate proteoglycans that are attached to the cell surface by a GPI (glycosylphosphatidylinositol) anchor. Glypicans regulate the... 
Phospholipase | Glypican family of proteins | Wnt | Mammalian notum | Glycosylphosphatidylinositol (GPI) anchor | Heparan sulfate proteoglycan | GASTRULATION MOVEMENTS | NERVOUS-SYSTEM | glycosylphosphatidylinositol (GPI) anchor | PHOSPHOLIPASE-D | BIOCHEMISTRY & MOLECULAR BIOLOGY | CONVERGENT EXTENSION | WINGLESS MORPHOGEN GRADIENT | glypican family of proteins | phospholipase | HEPATOCELLULAR-CARCINOMA | mammalian Notum | UROKINASE RECEPTOR | DALLY-LIKE | HEPARAN-SULFATE PROTEOGLYCANS | heparan sulfate proteoglycan | MEMBRANE-PROTEINS | Rabbits | Humans | Drosophila Proteins - metabolism | Wnt Proteins - metabolism | Glypicans - metabolism | GPI-Linked Proteins - metabolism | Extracellular Space - metabolism | Animals | Transfection | Glycosylphosphatidylinositols - metabolism | HEK293 Cells | Cell Membrane - metabolism | Mice | Drosophila Proteins - genetics | Drosophila - genetics
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15. Full Text Glypican-3 promotes the growth of hepatocellular carcinoma by stimulating canonical Wnt signaling
by Capurro, Mariana I and Xiang, Yun-Yan and Lobe, Corrinne and Filmus, Jorge
Cancer Research, ISSN 0008-5472, 07/2005, Volume 65, Issue 14, pp. 6245 - 6254
Glypican-3 (GPC3) is a heparan sulfate proteoglycan that is bound to the cell membrane by a glycosyl-phosphatidylinositol anchor. GPC3 is expressed by most... 
MESSENGER-RNAS | GASTRULATION MOVEMENTS | ONCOLOGY | BEHMEL OVERGROWTH SYNDROME | BETA-ESTRADIOL | MOLECULAR PATHOGENESIS | CONVERGENT EXTENSION | HEPARAN-SULFATE PROTEOGLYCANS | MCF-7 CELLS | UP-REGULATION | CANCER CELL-LINES | Immunoprecipitation | Humans | Neoplasm Proteins - physiology | Wnt Proteins | Neoplasm Proteins - metabolism | Intercellular Signaling Peptides and Proteins - physiology | Glypicans | Intercellular Signaling Peptides and Proteins - metabolism | Transfection | Membrane Proteins - physiology | Carcinoma, Hepatocellular - genetics | Liver Neoplasms - pathology | Membrane Proteins - metabolism | Neoplasm Proteins - genetics | Gene Expression | Liver Neoplasms - genetics | Signal Transduction | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Mice, SCID | Animals | Intercellular Signaling Peptides and Proteins - pharmacology | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | Mice | Carcinoma, Hepatocellular - metabolism
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16. Full Text Overgrowth of a mouse model of Simpson- Golabi-Behmel syndrome is partly mediated by Indian Hedgehog
by Capurro, Mariana I and Filmus, Jorge and Li, Fuchuan
EMBO reports, ISSN 1469-221X, 08/2009, Volume 10, Issue 8, pp. 901 - 907
Loss‐of‐function mutations of Glypican 3 (Gpc3) cause the Simpson–Golabi–Behmel overgrowth syndrome (SGBS), and developmental overgrowth is observed in... 
Glypicans | Hedgehog | Simpson–Golabi–Behmel syndrome | heparan sulphate proteoglycans | overgrowth | Simpson-Golabi-Behmel syndrome | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH-PLATE | PROLIFERATION | DIFFERENTIATION | SKELETAL DEVELOPMENT | DROSOPHILA | CELL BIOLOGY | Abnormalities, Multiple - pathology | Immunohistochemistry | Surface Plasmon Resonance | Cell Line | Glypicans - physiology | Humans | Mice, Inbred C57BL | Male | Hedgehog Proteins - physiology | Reverse Transcriptase Polymerase Chain Reaction | Glypicans - genetics | Blotting, Western | Animals | Hedgehog Proteins - genetics | RNA Interference | Mice, Mutant Strains | Female | Mice | Abnormalities, Multiple - genetics | Disease Models, Animal | Proteins | Signal transduction | Cellular biology | Rodents | Mutation | Molecular biology | Physical growth | Gene expression | Scientific Report
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17. Full Text Glypican-3 expression is silenced in human breast cancer
by Xiang, Yun-Yan and Ladeda, Virginia and Filmus, Jorge
Oncogene, ISSN 0950-9232, 11/2001, Volume 20, Issue 50, pp. 7408 - 7412
Glypican-3 (GPC3) is, a membrane-bound heparan sulfate proteoglycan that is mutated in the Simpson-Golabi-Behmel syndrome. This is an X-linked condition... 
Glypicans | DNA methylation | Breast cancer | OVERGROWTH SYNDROME | GENE | ONCOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | GPC3 | DYSPLASIA | breast cancer | GOLABI-BEHMEL-SYNDROME | glypicans | CELL BIOLOGY | Epithelial Cells - metabolism | Humans | Loss of Heterozygosity | Breast - metabolism | Promoter Regions, Genetic - genetics | DNA, Neoplasm - chemistry | Breast Neoplasms - metabolism | Heparan Sulfate Proteoglycans - genetics | Carcinoma, Hepatocellular - genetics | Female | Liver Neoplasms - pathology | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Neoplasm Proteins - genetics | Genes, Tumor Suppressor | X Chromosome - genetics | Tumor Stem Cell Assay | Liver Neoplasms - genetics | Neoplasm Proteins - biosynthesis | Gene Silencing | Azacitidine - analogs & derivatives | Reverse Transcriptase Polymerase Chain Reaction | Azacitidine - pharmacology | Dosage Compensation, Genetic | Breast Neoplasms - genetics | Carcinoma, Hepatocellular - pathology | DNA, Neoplasm - genetics | DNA Methylation - drug effects | Heparan Sulfate Proteoglycans - biosynthesis | Animal experimentation | Sulfates | Methylation | Ovarian cancer
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18. Full Text Glypican-3 Inhibits Hedgehog Signaling during Development by Competing with Patched for Hedgehog Binding
by Capurro, Mariana I and Xu, Ping and Shi, Wen and Li, Fuchuan and Jia, Angela and Filmus, Jorge
Developmental Cell, ISSN 1534-5807, 2008, Volume 14, Issue 5, pp. 700 - 711
Loss-of-function mutations in glypican-3 (GPC3), one of the six mammalian glypicans, causes the Simpson-Golabi-Behmel overgrowth syndrome (SGBS), and GPC3 null... 
SIGNALING | OVERGROWTH SYNDROME | CELL CARCINOMA SYNDROME | SONIC HEDGEHOG | GROWTH | SURFACE | GOLABI-BEHMEL-SYNDROME | CONVERGENT EXTENSION | DALLY-LIKE | DEVELOPMENTAL BIOLOGY | HEPARAN-SULFATE PROTEOGLYCANS | DROSOPHILA | CELL BIOLOGY | Binding, Competitive | Cell Line | Signal Transduction | Glypicans - deficiency | Humans | Hedgehog Proteins - metabolism | Receptors, Cell Surface - metabolism | Glypicans - metabolism | Embryo, Mammalian - metabolism | Endocytosis | Animals | Embryo, Mammalian - embryology | Embryo, Mammalian - cytology | Protein Binding | Fibroblasts - cytology | Mice | Protein Processing, Post-Translational | Patched Receptors | Fibroblasts - metabolism
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19. Full Text The heparan sulfate proteoglycan glypican-6 is upregulated in the failing heart, and regulates cardiomyocyte growth through ERK1/2 Signaling
by Melleby, Arne O and Strand, Mari E and Romaine, Andreas and Herum, Kate M and Skrbic, Biljana and Dahl, Christen P and Sjaastad, Ivar and Fiane, Arnt E and Filmus, Jorge and Christensen, Geir and Lunde, Ida G
PLoS ONE, ISSN 1932-6203, 10/2016, Volume 11, Issue 10, p. e0165079
Pressure overload is a frequent cause of heart failure. Heart failure affects millions of patients worldwide and is a major cause of morbidity and mortality.... 
HEPATOCELLULAR-CARCINOMA | SYNDECAN-4 | MULTIDISCIPLINARY SCIENCES | CARDIAC-HYPERTROPHY | CELL-SURFACE | PRESSURE-OVERLOADED HEART | ANGIOTENSIN-II | MICE | FAILURE | EXPRESSION | FAMILY | NIH 3T3 Cells | Up-Regulation | Rats, Wistar | Humans | Mice, Inbred C57BL | Rats | Heart Failure - metabolism | Glypicans - metabolism | MAP Kinase Signaling System | Animals | HEK293 Cells | Myocytes, Cardiac - metabolism | Mice | Heart failure | Heart | RNA | Growth | Protein biosynthesis | Sulfates | Health aspects | Phosphorylation | Transcription | Peptides | Pathogenesis | Heart surgery | mRNA | Kinases | Remodeling | Cell surface | Proteins | Evolutionary conservation | Rodents | Fibroblasts | Aorta | Growth factors | Heart diseases | Heparan sulfate | Hypertension | Medical research | Proteoglycans | Extracellular signal-regulated kinase | Cardiomyocytes | Biophysics | Gene expression | Patients | Pressure | Morbidity | Signaling | Hospitals | Banding | Cellular biology | Lungs | Protein synthesis | Coronary vessels | Heparan sulfate proteoglycans | Myocardium | Flow velocity | Ventricle | Sulfate | Laboratory animals | Hypertrophy | Ejection | Apoptosis
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