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Nucleic Acids Research, ISSN 0305-1048, 11/2013, Volume 41, Issue 20, pp. 9584 - 9592
Journal Article
Cell Reports, ISSN 2211-1247, 10/2014, Volume 7, Issue 1, pp. 293 - 305
Targeted genome editing with engineered nucleases has transformed the ability to introduce precise sequence modifications at almost any site within the genome.... 
PLURIPOTENT STEM-CELLS | RECOMBINATION | METHYLATION | TAL EFFECTORS | DNA | IN-VIVO | GENE-THERAPY | GENERATION | MEGANUCLEASES | ZINC-FINGER NUCLEASES | CELL BIOLOGY | Genetic Engineering - methods | Transfection | DNA Repair | Humans | K562 Cells | Repetitive Sequences, Nucleic Acid | Endonucleases - metabolism | Genome, Human | DNA Breaks, Double-Stranded | Sequence Analysis, DNA - methods
Journal Article
Molecular Therapy - Nucleic Acids, ISSN 2162-2531, 01/2014, Volume 3, Issue 12, pp. e214 - e214
Precise genome editing using engineered nucleases can significantly facilitate biological studies and disease treatment. In particular, clustered regularly... 
specificity | bulges | program | RISPR | off-target | bioinformatics | Specificity | Off-target | Program | Bioinformatics | Bulges | MEDICINE, RESEARCH & EXPERIMENTAL | DEFENSE | BACTERIA | DNA CLEAVAGE | SEARCHES | NUCLEASES | ADAPTIVE IMMUNITY | IMMUNE-SYSTEM | CAS9 | DELETIONS | Original
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 2014, Volume 42, Issue 6, pp. e42 - e42
Although engineered nucleases can efficiently cleave intracellular DNA at desired target sites, major concerns remain on potential 'off-target' cleavage that... 
DESIGN | SPECIFICITIES | DISRUPTION | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUTATION | SITES | EFFECTOR NUCLEASES | PROTEINS | GENOME | Zinc Fingers | Algorithms | DNA End-Joining Repair | Humans | Computational Biology | HEK293 Cells | Receptors, CCR5 - genetics | Software | Internet | DNA Cleavage | Deoxyribonucleases - metabolism | INDEL Mutation | Methods Online
Journal Article
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 2014, Volume 42, Issue 6, pp. e47 - e47
Transcription activator-like effector nucleases (TALENs) have become a powerful tool for genome editing due to the simple code linking the amino acid sequences... 
EFFECTOR | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-BINDING SPECIFICITY | DNA-Binding Proteins - metabolism | DNA - chemistry | Algorithms | Base Sequence | Humans | HEK293 Cells | Software | DNA - metabolism | Deoxyribonucleases - metabolism | Methods Online
Journal Article