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Nature Genetics, ISSN 1061-4036, 2015, Volume 47, Issue 3, pp. 291 - 295
Both polygenicity (many small genetic effects) and confounding biases, such as cryptic relatedness and population stratification, can yield an inflated... 
Journal Article
American Journal of Human Genetics, ISSN 0002-9297, 2015, Volume 97, pp. 576 - 592
Polygenic risk scores have shown great promise in predicting complex disease risk and will become more accurate as training sample sizes increase. The standard... 
Journal Article
by Day, F.R and Ruth, K.S and Thompson, D.J and Lunetta, K.L and Pervjakova, N and Chasman, D.I and Stolk, L and Finucane, H.K and Sulem, P and Bulik-Sullivan, B.K and Esko, T and Johnson, A.D and Elks, C.E and Franceschini, N and He, C and Altmaier, E and Brody, J.A and Franke, L.L and Huffman, J.E and Keller, M.F and McArdle, P.F and Nutile, T and Porcu, E and Robino, A and Rose, L.M and Schick, U.M and Smith, J.A and Teumer, A and Traglia, M and Vuckovic, D and Yao, J and Zhao, W and Albrecht, E and Amin, N and Corre, T and Hottenga, J.J and Mangino, M and Smith, A.V and Tanaka, T and Abecasis, G.R and Anulis, I.L and Anton-Culver, H and Antoniou, A.C and Arndt, V and Arnold, A.M and Barbieri, C and Beckmann, M.W and Beeghly-Fadiel, A and Benitez, J and Bernstein, L and Bielinski, S.J and Blomqvist, C and Boerwinkle, E and Bogdanova, N.V and Bojesen, S.E and Bolla, M.K and Borresen-Dale, A.L and Boutin, T.S and Brauch, H and Brenner, H and Brüning, T and Burwinkel, B and Campbell, A and Campbell, H and Chanock, S.J and Chapman, J.R and Ida Chen, Y.D and Chenevix-Trench, G and Couch, F.J and Coviello, A.D and Cox, A and Czene, K and Darabi, H and De Vivo, I and Demerath, E.W and Dennis, J and Devilee, P and Dörk, T and dos-Santos-Silva, I and Dunning, A.M and Eicher, J.D and Fasching, P.A and Faul, J.D and Figueroa, J and Flesch-Janys, D and Gandin, I and Garcia, M.E and García-Closas, M and Giles, G.G and Girotto, G.G and Goldberg, M.S and González-Neira, A and Goodarzi, M.O and Grove, M.L and Gudbjartsson, D.F and Guénel, P and Guo, X and Haiman, C.A and Hall, P and Hamann, U and ...
Nature Genetics, ISSN 1061-4036, 2015, Volume 47, Issue 11, pp. 1294 - 1303
Menopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We... 
Journal Article
by Day, F.R and Ruth, K.S and Thompson, D.J and Lunetta, K.L and Pervjakova, N and Chasman, D.I and Stolk, L and Finucane, H.K and Sulem, P and Bulik-Sullivan, B and Esko, T and Johnson, A.D and Elks, C.E and Franceschini, N and He, C and Altmaier, E and Brody, J.A and Franke, L.L and Huffman, J.E and Keller, M.F and McArdle, P.F and Nutile, T and Porcu, E and Robino, A and Rose, L.M and Schick, U.M and Smith, J.A and Teumer, A and Traglia, M and Vuckovic, D and Yao, J and Zhao, W and Albrecht, E and Amin, N and Corre, T and Hottenga, J and Mangino, M and Smith, A.V and Tanaka, T and Abecasis, G.R and Anulis, I.L and Anton-Culver, H and Antoniou, A.C and Arndt, V and Arnold, A.M and Barbieri, C and Beckmann, M.W and Beeghly-Fadiel, A and Benitez, J and Bernstein, L and Bielinski, S.J and Blomqvist, C and Boerwinkle, E and Bogdanova, N.V and Bojesen, S.E and Bolla, M.K and Borresen-Dale, A and Boutin, T.S and Brauch, H and Brenner, H and Bruening, T and Burwinkel, B and Campbell, A and Campbell, H and Chanock, S.J and Chapman, J.R and Chen, Y.I and Chenevix-Trench, G and Couch, F.J and Coviello, A.D and Cox, A and Czene, K and Darabi, H and De Vivo, I and Demerath, E.W and Dennis, J and Devilee, P and Doerk, T and dos-Santos-Silva, I and Dunning, A.M and Eicher, J.D and Fasching, P.A and Faul, J.D and Figueroa, J and Flesch-Janys, D and Gandin, I and Garcia, M.E and Garcia-Closas, M and Giles, G.G and Girotto, G.G and Goldberg, M.S and Gonzalez-Neira, A and Goodarzi, M.O and Grove, M.L and Gudbjartsson, D.F and Guenel, P and Guo, X and Haiman, C.A and Hall, P and Hamann, U and ...
Obstetrical and Gynecological Survey, ISSN 0029-7828, 2015, Volume 70, Issue 12, pp. 758 - 762
Journal Article
Nature Genetics, ISSN 1061-4036, 04/2018, Volume 50, Issue 4, pp. 621 - 629
Journal Article
by Day, Felix R and Thompson, Deborah J and Helgason, Hannes and Chasman, Daniel I and Finucane, Hilary and Sulem, Patrick and Ruth, Katherine S and Whalen, Sean and Sarkar, Abhishek K and Albrecht, Eva and Altmaier, Elisabeth and Amini, Marzyeh and Barbieri, Caterina M and Boutin, Thibaud and Campbell, Archie and Demerath, Ellen and Giri, Ayush and He, Chunyan and Hottenga, Jouke J and Karlsson, Robert and Kolcic, Ivana and Loh, Po-Ru and Lunetta, Kathryn L and Mangino, Massimo and Marco, Brumat and McMahon, George and Medland, Sarah E and Nolte, Ilja M and Noordam, Raymond and Nutile, Teresa and Paternoster, Lavinia and Perjakova, Natalia and Porcu, Eleonora and Rose, Lynda M and Schraut, Katharina E and Segrè, Ayellet V and Smith, Albert V and Stolk, Lisette and Teumer, Alexander and Anulis, Irene L and Bandinelli, Stefania and Beckmann, Matthias W and Benitez, Javier and Bergmann, Sven and Bochud, Murielle and Boerwinkle, Eric and Bojesen, Stig E and Bolla, Manjeet K and Brand, Judith S and Brauch, Hiltrud and Brenner, Hermann and Broer, Linda and Brüning, Thomas and Buring, Julie E and Campbell, Harry and Catamo, Eulalia and Chanock, Stephen and Chenevix-Trench, Georgia and Corre, Tanguy and Couch, Fergus J and Cousminer, Diana L and Cox, Angela and Crisponi, Laura and Czene, Kamila and Davey Smith, George and de Geus, Eco J C N and de Mutsert, Renée and De Vivo, Immaculata and Dennis, Joe and Devilee, Peter and Dos-Santos-Silva, Isabel and Dunning, Alison M and Eriksson, Johan G and Fasching, Peter A and Fernández-Rhodes, Lindsay and Ferrucci, Luigi and Flesch-Janys, Dieter and Franke, Lude and Gabrielson, Marike and Gandin, Ilaria and Giles, Graham G and Grallert, Harald and Gudbjartsson, Daniel F and Guénel, Pascal and Hall, Per and Hallberg, Emily and Hamann, Ute and Harris, Tamara B and Hartman, Catharina A and Heiss, Gerardo and Hooning, Maartje J and Hopper, John L and Hu, Frank and Hunter, David J and Ikram, M Arfan and Im, Hae Kyung and Järvelin, Marjo-Riitta and Joshi, Peter K and Karasik, David and Kellis, Manolis and ...
Nature Genetics, ISSN 1061-4036, 06/2017, Volume 49, Issue 6, pp. 834 - 841
The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated with various adult diseases. Using 1000 Genomes... 
reproductive disorders | genome-wide association studies | cancer
Journal Article
Nature Genetics, ISSN 1061-4036, 11/2015, Volume 47, Issue 11, pp. 1236 - 1241
Journal Article
by Day, Felix R and Thompson, Deborah J and Helgason, Hannes and Chasman, Daniel I and Finucane, Hilary and Sulem, Patrick and Ruth, Katherine S and Whalen, Sean and Sarkar, Abhishek K and Albrecht, Eva and Altmaier, Elisabeth and Amini, Marzyeh and Barbieri, Caterina M and Boutin, Thibaud and Campbell, Archie and Demerath, Ellen and Giri, Ayush and He, Chunyan and Hottenga, Jouke J and Karlsson, Robert and Kolcic, Ivana and Loh, Po-Ru and Lunetta, Kathryn L and Mangino, Massimo and Marco, Brumat and McMahon, George and Medland, Sarah E and Nolte, Ilja M and Noordam, Raymond and Nutile, Teresa and Paternoster, Lavinia and Perjakova, Natalia and Porcu, Eleonora and Rose, Lynda M and Schraut, Katharina E and Segre, Ayellet V and Smith, Albert V and Stolk, Lisette and Teumer, Alexander and Anulis, Irene L and Bandinelli, Stefania and Beckmann, Matthias W and Benitez, Javier and Bergmann, Sven and Bochud, Murielle and Boerwinkle, Eric and Bojesen, Stig E and Bolla, Manjeet K and Brand, Judith S and Brauch, Hiltrud and Brenner, Hermann and Broer, Linda and Bruning, Thomas and Buring, Julie E and Campbell, Harry and Catamo, Eulalia and Chanock, Stephen and Chenevix-Trench, Georgia and Corre, Tanguy and Couch, Fergus J and Cousminer, Diana L and Cox, Angela and Crisponi, Laura and Czene, Kamila and Smith, George Davey and de Geus, Eco J. C. N and de Mutsert, Renee and De Vivo, Immaculata and Dennis, Joe and Devilee, Peter and dos-Santos-Silva, Isabel and Dunning, Alison M and Eriksson, Johan G and Fasching, Peter A and Fernandez-Rhodes, Lindsay and Ferrucci, Luigi and Flesch-Janys, Dieter and Franke, Lude and Gabrielson, Marike and Gandin, Ilaria and Giles, Graham G and Grallert, Harald and Gudbjartsson, Daniel F and Guenel, Pascal and Hall, Per and Hallberg, Emily and Hamann, Ute and Harris, Tamara B and Hartman, Catharina A and Heiss, Gerardo and Hooning, Maartje J and Hopper, John L and Hu, Frank and Hunter, David J and Ikram, M. Arfan and Im, Hae Kyung and Jarvelin, Marjo-Riitta and Joshi, Peter K and Karasik, David and Kellis, Manolis and ... and Endometrial Canc Accoc Consortium and InterAct Consortium and PRACTICAl Consortium and kConFab AOCS Investigators and LifeLines Cohort Study and Ovarian Canc Accoc Consortium and kConFab/AOCS Investigators and Ovarian Cancer Association Consortium and PRACTICAL consortium and Endometrial Cancer Association Consortium and The InterAct Consortium and The LifeLines Cohort Study
Nature Genetics, ISSN 1061-4036, 06/2017, Volume 49, Issue 6, pp. 834 - 841
The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated with various adult diseases. Using 1000 Genomes... 
REGRESSION | METAANALYSIS | METABOLISM | GROWTH | GENETICS & HEREDITY | BODY-MASS INDEX | LOCI | WIDE ASSOCIATION | MENDELIAN RANDOMIZATION | TRAITS | INHERITANCE | Body Mass Index | Genomic Imprinting | Genetic Predisposition to Disease | Genome-Wide Association Study | Age Factors | Membrane Proteins - genetics | Menarche - genetics | Humans | Risk Factors | Intercellular Signaling Peptides and Proteins - genetics | Databases, Genetic | Male | Puberty - genetics | Neoplasms - genetics | Adolescent | Female | Ribonucleoproteins - genetics | Polymorphism, Single Nucleotide | Quantitative Trait Loci | Genetic variation | Menarche | Genetic aspects | Gene expression | Health aspects | Carcinogenesis | Risk factors | Enrichment | Transcription | Laboratories | Genomics | Genes | Risk | Genomes | Tissues | Preadipocyte factor 1 | Epidemiology | Variance | Complexity | Body mass index | Mens health | Randomization | Coding | Genetics | Trends | Children | Endometrium | Public health | Age | Medical research | Puberty | Internal medicine | Gynecology | Health risks | Time measurement | Obstetrics | Diseases | Medicine | Studies | Hospitals | Body mass | Womens health | Men | Breast | Links | Heritability | Polygenic inheritance | Prostate cancer | Prostate | Endocrinology | Cancer | Index Medicus | InterAct Consortium | AOCS Investigators | PRACTICAL consortium | Endometrial Cancer Association Consortium | Ovarian Cancer Association Consortium | LifeLines Cohort Study | kConFab
Journal Article
Nature Genetics, ISSN 1061-4036, 12/2015, Volume 47, Issue 12, pp. 1385 - 1395
Journal Article
Journal Article
by Day, Felix R and Ruth, Katherine S and Thompson, Deborah J and Lunetta, Kathryn L and Pervjakova, Natalia and Chasman, Daniel I and Stolk, Lisette and Finucane, Hilary K and Sulem, Patrick and Bulik-Sullivan, Brendan and Esko, Tonu and Johnson, Anew D and Elks, Cathy E and Franceschini, Nora and He, Chunyan and Altmaier, Elisabeth and Brody, Jennifer A and Franke, Lude L and Huffman, Jennifer E and Keller, Margaux F and McArdle, Patrick F and Nutile, Teresa and Porcu, Eleonora and Robino, Antonietta and Rose, Lynda M and Schick, Ursula M and Smith, Jennifer A and Teumer, Alexander and Traglia, Michela and Vuckovic, gana and Yao, Jie and Zhao, Wei and Albrecht, Eva and Amin, Najaf and Corre, Tanguy and Hottenga, Jouke-Jan and Mangino, Massimo and Smith, Albert V and Tanaka, Toshiko and Abecasis, Goncalo R and Anulis, Irene L and Anton-Culver, Hoda and Antoniou, Antonis C and Arndt, Volker and Arnold, Alice M and Barbieri, Caterina and Beckmann, Matthias W and Beeghly-Fadiel, Alicia and Benitez, Javier and Bernstein, Leslie and Bielinski, Suzette J and Blomqvist, Carl and Boerwinkle, Eric and Bogdanova, Natalia V and Bojesen, Stig E and Bolla, Manjeet K and Borresen-Dale, Anne-Lise and Boutin, Thibaud S and Brauch, Hiltrud and Brenner, Hermann and Bruening, Thomas and Burwinkel, Barbara and Campbell, Archie and Campbell, Harry and Chanock, Stephen J and Chapman, J. Ross and Chen, Yii-Der Ida and Chenevix-Trench, Georgia and Couch, Fergus J and Coviello, Anea D and Cox, Angela and Czene, Kamila and Darabi, Hatef and De Vivo, Immaculata and Demerath, Ellen W and Dennis, Joe and Devilee, Peter and Doerk, Thilo and dos-Santos-Silva, Isabel and Dunning, Alison M and Eicher, John D and Fasching, Peter A and Faul, Jessica D and Figueroa, Jonine and Flesch-Janys, Dieter and Gandin, Ilaria and Garcia, Melissa E and Garcia-Closas, Montserrat and Giles, Graham G and Girotto, Giorgia G and Goldberg, Mark S and Gonzalez-Neira, Anna and Goodarzi, Mark O and Grove, Megan L and Gudbjartsson, Daniel F and Guenel, Pascal and Guo, Xiuqing and Haiman, Christopher A and Hall, Per and Hamann, Ute and ... and LifeLines Cohort Study and EPIC-InterAct Consortium and The PRACTICAL Consortium and AOCS Investigators and Generation Scotland and kConFab Investigators
Nature Genetics, ISSN 1061-4036, 11/2015, Volume 47, Issue 11, pp. 1294 - 303
Journal Article
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