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humans (92) 92
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immunohistochemistry (27) 27
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expression (8) 8
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helicobacter-pylori (7) 7
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reproducibility of results (7) 7
stomach neoplasms - metabolism (7) 7
biomarkers, tumor - metabolism (6) 6
care and treatment (6) 6
cell biology (6) 6
esophageal ph monitoring (6) 6
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formaldehyde (6) 6
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predictive value of tests (6) 6
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proto-oncogene proteins b-raf - genetics (6) 6
risk factors (6) 6
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gastroesophageal reflux - diagnosis (5) 5
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genetic aspects (5) 5
immunoenzyme techniques (5) 5
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1. Full Text Prognostic Role of KRAS and BRAF in Stage II and III Resected Colon Cancer: Results of the Translational Study on the PETACC-3, EORTC 40993, SAKK 60-00 Trial
by Arnaud D. Roth and Sabine Tejpar and Mauro Delorenzi and Pu Yan and Roberto Fiocca and Dirk Klingbiel and Daniel Dietrich and Bart Biesmans and György Bodoky and Carlo Barone and Enrique Aranda and Bernard Nordlinger and Laura Cisar and Roberto Labianca and David Cunningham and Eric Van Cutsem and Fred Bosman
Journal of Clinical Oncology, ISSN 0732-183X, 01/2010, Volume 28, Issue 3, pp. 466 - 474
Purpose Mutations within the KRAS proto-oncogene have predictive value but are of uncertain prognostic value in the treatment of advanced colorectal cancer. We... 
CETUXIMAB | KIRSTEN RAS MUTATIONS | METAANALYSIS | K-RAS | ONCOLOGY | MICROSATELLITE INSTABILITY | POOR SURVIVAL | METHYLATOR PHENOTYPE | CARCINOMA | TP53 | METASTATIC COLORECTAL-CANCER | ras Proteins - genetics | Colonic Neoplasms - genetics | Proto-Oncogene Proteins p21(ras) | Adenocarcinoma - pathology | Prognosis | Prospective Studies | Humans | Middle Aged | Colonic Neoplasms - diagnosis | Male | Proto-Oncogene Proteins - genetics | Young Adult | Adenocarcinoma - diagnosis | Proto-Oncogene Proteins B-raf - genetics | Colonic Neoplasms - pathology | Adolescent | Adult | Female | Adenocarcinoma - genetics | Aged | Mutation
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2. Full Text Kidney Ultrastructure by Atomic Force Microscopy Imaging Directly From Formalin Fixed-Paraffin Embedded Biopsy: Is This a Dream Come True?
by Peñuela, Leonardo and Villaggio, Barbara and Raiteri, Roberto and Fiocca, Roberto and Vellone, Valerio Gaetano
International Journal of Surgical Pathology, ISSN 1066-8969, 9/2018, Volume 26, Issue 6, pp. 532 - 533
SURGERY | PATHOLOGY
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3. Full Text Microscopic esophagitis distinguishes patients with non-erosive reflux disease from those with functional heartburn
by Savarino, Edoardo and Savarino, Edoardo and Zentilin, Patrizia and Zentilin, Patrizia and Mastracci, Luca and Mastracci, Luca and Dulbecco, Pietro and Dulbecco, Pietro and Marabotto, Elisa and Marabotto, Elisa and Gemignani, Lorenzo and Gemignani, Lorenzo and Bruzzone, Luca and Bruzzone, Luca and de Bortoli, Nicola and de Bortoli, Nicola and Frigo, Anna Chiara and Frigo, Anna Chiara and Fiocca, Roberto and Fiocca, Roberto and Savarino, Vincenzo and Savarino, Vincenzo
Journal of Gastroenterology, ISSN 0944-1174, 4/2013, Volume 48, Issue 4, pp. 473 - 482
Microscopic esophagitis (ME) is common in patients with non-erosive reflux disease (NERD), and dilation of intercellular spaces (DIS) has been regarded as the... 
Gastroesophageal reflux | Medicine & Public Health | Colorectal Surgery | Hepatology | Gastroenterology | Abdominal Surgery | Functional heartburn | Surgical Oncology | Dilated intercellular spaces | NERD | NONACID GASTROESOPHAGEAL-REFLUX | ACID | OMEPRAZOLE | CLASSIFICATION | HISTOLOGY | GERD | EPITHELIUM | IMPEDANCE | GASTROENTEROLOGY & HEPATOLOGY | Prospective Studies | Gastroesophageal Reflux - diagnosis | Esophageal pH Monitoring | Esophagitis, Peptic - etiology | Humans | Middle Aged | Esophagitis, Peptic - diagnosis | Male | Case-Control Studies | Esophagitis - pathology | Young Adult | Esophagus - physiopathology | Esophagitis, Peptic - pathology | Adult | Female | Endoscopy, Gastrointestinal - methods | Diagnosis, Differential | Gastroesophageal Reflux - pathology | Heartburn - diagnosis | Electric Impedance | Esophagitis - etiology | Esophagus - pathology | Gastroesophageal Reflux - complications | Biopsy | Aged | Heartburn - pathology | Esophagitis | Endoscopic surgery | Endoscopy | Heartburn
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4. Full Text Laparoscopic Antireflux Surgery vs Esomeprazole Treatment for Chronic GERD: The LOTUS Randomized Clinical Trial
by Galmiche, Jean-Paul and Hatlebakk, Jan and Attwood, Stephen and Ell, Christian and Fiocca, Roberto and Eklund, Stefan and Långström, Göran and Lind, Tore and Lundell, Lars and LOTUS Trial Collaborators, for the and LOTUS Trial Collaborators and Sahlgrenska akademin and Göteborgs universitet and Gothenburg University and Institute of Clinical Sciences, Section for Surgery and Gastrosurgical Research and Education, Department of Surgery and Institutionen för kliniska vetenskaper, sektionen för kirurgi och kirurgisk gastroforskning, Avdelningen för kirurgi and Sahlgrenska Academy
JAMA, ISSN 0098-7484, 05/2011, Volume 305, Issue 19, pp. 1969 - 1977
CONTEXT Gastroesophageal reflux disease (GERD) is a chronic, relapsing disease with symptoms that have negative effects on daily life. Two treatment options... 
HIP FRACTURE | MEDICINE, GENERAL & INTERNAL | THERAPY | NISSEN FUNDOPLICATION | GASTROESOPHAGEAL-REFLUX DISEASE | EROSIVE ESOPHAGITIS | ACID CONTROL | OMEPRAZOLE | FOLLOW-UP | PROTON-PUMP INHIBITORS | LANSOPRAZOLE 30 MG | Severity of Illness Index | Esomeprazole - administration & dosage | Humans | Middle Aged | Anti-Ulcer Agents - adverse effects | Esomeprazole - adverse effects | Male | Treatment Outcome | Digestive System Surgical Procedures - adverse effects | Remission Induction | Anti-Ulcer Agents - administration & dosage | Gastroesophageal Reflux - surgery | Laparoscopy - methods | Laparoscopy - adverse effects | Adult | Female | Gastroesophageal Reflux - drug therapy | Chronic Disease | Digestive System Surgical Procedures - methods | Gastroesophageal reflux | Gastrointestinal surgery | Drug therapy | Clinical outcomes | drug therapy | methods | Laparoscopy | Anti-Ulcer Agents | Gastroesophageal Reflux | Kirurgi | Omeprazole | Digestive System Surgical Procedures | administration & dosage | Surgery | adverse effects
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5. Full Text Clinico-pathological associations and concomitant mutations of the RAS/RAF pathway in metastatic colorectal cancer
by Isnaldi, E and Garuti, A and Cirmena, G and Scabini, S and Rimini, E and Ferrando, L and Lia, M and Murialdo, R and Tixi, L and Carminati, E and Panaro, A and Gallo, M and Grillo, F and Mastracci, L and Repetto, L and Fiocca, R and Romairone, E and Zoppoli, G and Ballestrero, A
JOURNAL OF TRANSLATIONAL MEDICINE, ISSN 1479-5876, 04/2019, Volume 17, Issue 1, pp. 137 - 10
BackgroundOver the past few years, next-generation sequencing (NGS) has become reliable and cost-effective, and its use in clinical practice has become a... 
SURVIVAL | ANTIBODIES | MEDICINE, RESEARCH & EXPERIMENTAL | Anti-EGFR | METAANALYSIS | RAS | Extended RAS | CHEMOTHERAPY | CETUXIMAB | BENEFIT | BRAF MUTATION | RAS MUTATIONS | RAF pathway | KRAS | Metastatic colorectal cancer | Concomitant mutations | PROGNOSTIC ROLE | Gene mutations | Panitumumab | Genomics | Colorectal cancer | Genetic aspects | Research | Metastasis | Formaldehyde | Paraffins | Statistical analysis | Microsatellites | Stability | Epidermal growth factor receptors | Exons | Lung cancer | Colorectal carcinoma | Sex | Raf protein | Systematic review | Genomes | Microsatellite instability | Paraffin | Cancer therapies | Metastases | Variables | Chemotherapy | Next-generation sequencing | Mutation | Tumors | Cancer | RAS/RAF pathway
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6. Full Text Long-term endoscopic surveillance of patients with Barrett's esophagus. incidence of dysplasia and adenocarcinoma: a prospective study
by Conio, Massimo and Blanchi, Sabrina and Lapertosa, Gabriella and Ferraris, Roberto and Sablich, Renato and Marchi, Santino and D'Onofrio, Vittorio and Lacchin, Teresa and Iaquinto, Gaetano and Missale, Guido and Ravelli, Paolo and Cestari, Renzo and Benedetti, Giorgio and Macrì, Giuseppe and Fiocca, Roberto and Munizzi, Francesco and Filiberti, Rosangela
American Journal of Gastroenterology, ISSN 0002-9270, 09/2003, Volume 98, Issue 9, pp. 1931 - 1939
Barrett's esophagus (BE) is a premalignant condition for which regular endoscopic follow-up is usually advised. We evaluated the incidence of esophageal... 
Adenocarcinoma - pathology | Age Distribution | Barrett Esophagus - epidemiology | Prognosis | Prospective Studies | Humans | Middle Aged | Male | Esophageal Neoplasms - epidemiology | Esophageal Neoplasms - pathology | Esophagoscopy | Incidence | Barrett Esophagus - pathology | Time Factors | Aged, 80 and over | Adult | Female | Precancerous Conditions - pathology | Risk Assessment | Monitoring, Physiologic - methods | Sex Distribution | Italy - epidemiology | Aged | Adenocarcinoma - epidemiology | Cohort Studies
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7. Full Text Integrated analysis of molecular and clinical prognostic factors in stage II/III colon cancer
by Roth, Arnaud D and Delorenzi, Mauro and Tejpar, Sabine and Yan, Pu and Klingbiel, Dirk and Fiocca, Roberto and D'Ario, Giovanni and Cisar, Laura and Labianca, Roberto and Cunningham, David and Nordlinger, Bernard and Bosman, Fred and Van Cutsem, Eric
Journal of the National Cancer Institute, ISSN 0027-8874, 11/2012, Volume 104, Issue 21, pp. 1635 - 1646
The prognostic potential of individual clinical and molecular parameters in stage II/III colon cancer has been investigated, but a thorough multivariable... 
TRIAL | SURVIVAL | CHROMOSOME 18Q | SMAD4 | ONCOLOGY | MICROSATELLITE INSTABILITY | POOR-PROGNOSIS | ADJUVANT TREATMENT | MISMATCH REPAIR | FLUOROURACIL | ADVANCED COLORECTAL-CANCER | Immunohistochemistry | Leucovorin - administration & dosage | Multivariate Analysis | Predictive Value of Tests | ras Proteins - genetics | Microsatellite Instability | Proto-Oncogene Proteins p21(ras) | Prognosis | Colonic Neoplasms - drug therapy | Humans | Middle Aged | Male | Loss of Heterozygosity | Colonic Neoplasms - metabolism | Colonic Neoplasms - surgery | Fluorouracil - administration & dosage | Biomarkers, Tumor - metabolism | Adult | Camptothecin - administration & dosage | Female | Chemotherapy, Adjuvant | Camptothecin - analogs & derivatives | Drug Administration Schedule | Kaplan-Meier Estimate | Proportional Hazards Models | Proto-Oncogene Proteins - genetics | Smad4 Protein - metabolism | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Colonic Neoplasms - pathology | Aged | Biomarkers, Tumor - genetics | Mutation | Chromosomes, Human, Pair 18 - genetics | Neoplasm Staging | Research Design | Colon cancer | Gene mutations | Analysis | Physiological aspects | Genetic aspects | Research | Molecular biology
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8. Debate sobre a Constiuição de 1988
by Fiocca, Demian and Grau, Eros Roberto, 1940 and Rocha, Cármen Lúcia Antunes
2001, ISBN 8521903901, 168
Constitutional law
Book
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9. Full Text Heterogeneous Her2/Neu expression in gastric and gastroesophageal cancer
by Grillo, Federica, MD and Fassan, Matteo, MD, PhD and Fiocca, Roberto, MD and Mastracci, Luca, MD
Human Pathology, ISSN 0046-8177, 2015, Volume 48, pp. 173 - 174
  [...]both the Food and Drug Administration and the European Medicine Agency have approved the anti-Her2 drug trastuzumab (Herceptin; Hoffman-La Roche, Basel,... 
Pathology | Immunohistochemistry | Humans | Receptor, ErbB-2 - metabolism | Biomarkers, Tumor - metabolism | Female | Male | Stomach Neoplasms - pathology | Biopsy | Stomach cancer
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10. Full Text HER2 heterogeneity in gastric/gastroesophageal cancers: From benchside to practice
by Federica Grillo Matteo Fassan Francesca Sarocchi Roberto Fiocca Luca Mastracci
世界胃肠病学杂志：英文版, ISSN 1007-9327, 2016, Volume 22, Issue 26, pp. 5879 - 5887
HER2 is overexpressed in approximately 10%-20% of gastric and gastroesophageal junction carcinomas. In these types of cancer, accurate assessment of HER2... 
Gastric | cancer;HER2;Heterogeneity;Immunohistochemistry;FISH | Immunohistochemistry | FISH | Heterogeneity | HER2 | Gastric cancer | FACTOR RECEPTOR 2 | IN-SITU HYBRIDIZATION | METASTATIC SITES | ESOPHAGEAL ADENOCARCINOMA | GASTROESOPHAGEAL JUNCTION CANCER | BREAST-CANCER | ADVANCED GASTRIC-CANCER | OF-AMERICAN-PATHOLOGISTS | GENE AMPLIFICATION | TISSUE MICROARRAY | GASTROENTEROLOGY & HEPATOLOGY | Adenocarcinoma - pathology | Trastuzumab - therapeutic use | Humans | Receptor, ErbB-2 - metabolism | Stomach Neoplasms - metabolism | In Situ Hybridization, Fluorescence | Stomach Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Stomach Neoplasms - drug therapy | Adenocarcinoma - drug therapy | Carcinogenesis | Patient Selection | Esophagogastric Junction | Adenocarcinoma - metabolism | In Situ Hybridization | Biopsy | Biomarkers, Tumor - metabolism | Topic Highlight
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11. Full Text Atomic force microscopy: a promising aid in diagnosis of uterine smooth muscle neoplasms
by Peñuela, Leonardo A and Fulcheri, Ezio and Vellone, Valerio G and Fiocca, Roberto and Vigliercio, Gian M and Raiteri, Roberto and Ferrero, Simone
American Journal of Obstetrics and Gynecology, ISSN 0002-9378, 10/2019, Volume 221, Issue 4, pp. 362 - 364
OBSTETRICS & GYNECOLOGY
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12. Full Text Factors affecting immunoreactivity in long-term storage of formalin-fixed paraffin-embedded tissue sections
by Grillo, Federica and Pigozzi, Simona and Ceriolo, Paola and Calamaro, Paola and Fiocca, Roberto and Mastracci, Luca
Histochemistry and Cell Biology, ISSN 0948-6143, 7/2015, Volume 144, Issue 1, pp. 93 - 99
Antigen decay in archival formalin-fixed paraffin-embedded (FFPE) tissue sections for immunohistochemistry is a well-known phenomenon which may have... 
Biochemistry, general | Immunohistochemistry | Paraffin section storage | Archival pathology | Biomedicine | Antigen decay | Developmental Biology | Biomedicine general | Cell Biology | BIOMARKER | IN-SITU HYBRIDIZATION | MICROSCOPY | RETRIEVAL | CELL BIOLOGY | VARIABILITY | SLIDES | IMMUNOHISTOCHEMICAL REACTIVITY | CARCINOMAS | FIXATION | ARCHIVAL TISSUE | ANTIGEN | Immunohistochemistry - methods | Paraffin Embedding | Antigens | Specimen Handling | Fixatives | Humans | Antibodies | Tissue Fixation | Formaldehyde | Tumor proteins | Muscle proteins | Intermediate filament proteins | Estrogen | Pathology | Tissue
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13. Full Text Pneumomediastinum after transbronchial cryobiopsy
by Barisione, Emanuela and Bianchi, Rita and Fiocca, Roberto and Salio, Mario
Monaldi Archives for Chest Disease, ISSN 1122-0643, 06/2018, Volume 88, Issue 2
Pneumomediastinum is defined as the presence of air or gas within the mediastinum and it rarely complicates bronchoscopy. We report, to our best knowledge, the... 
Transbronchial cryobiopsy | interstitial lung disease | pneumomediastinum
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14. Full Text Abstract 1606: Clinical routine massive parallel sequencing highlights clinicopathological associations of the RAS/RAF mutational module in metastatic colorectal cancer and reveals high frequency of concomitant RAS/RAF mutations
by Isnaldi, Edoardo and Garuti, Anna and Cirmena, Gabriella and Scabini, Stefano and Grillo, Federica and Mastracci, Luca and Ferrando, Lorenzo and Murialdo, Roberto and Gallo, Maurizio and Desmedt, Christine and Fiocca, Roberto and Romairone, Emanuele and Ballestrero, Alberto and Zoppoli, Gabriele
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 1606 - 1606
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15. Full Text Natural history of Helicobacter pylori VacA toxin in human gastric epithelium in vivo: Vacuoles and beyond
by Necchi, Vittorio and Sommi, Patrizia and Vanoli, Alessandro and Fiocca, Roberto and Ricci, Vittorio and Solcia, Enrico
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 14526 - 11
Uptake, intracellular trafficking and pathologic effects of VacA toxin from Helicobacter pylori have been widely investigated in vitro. However, no systematic... 
MHC CLASS-I | CYTOPLASMIC STRUCTURE | HUMAN DENDRITIC CELLS | PROTEIN | PATHWAY | VACUOLATING CYTOTOXIN | MULTIDISCIPLINARY SCIENCES | ANTIGEN PRESENTATION | AUTOPHAGY | CATHEPSIN-E | CROSS-PRESENTATION | Microscopy, Electron, Transmission | Stomach - pathology | Humans | Middle Aged | Transport Vesicles - microbiology | Helicobacter pylori - ultrastructure | Male | Helicobacter Infections - pathology | Epithelium - microbiology | Adult | Bacterial Proteins - metabolism | Female | Aged | Helicobacter pylori - physiology | Stomach - ultrastructure | Stomach - microbiology | Vacuoles | Helicobacter Infections - microbiology | Immunocytochemistry | Epithelial cells | Lysosomes | Cytotoxicity | Epithelium | Organelles | Golgi apparatus | Mitochondria | Ultrastructure | Cathepsin D | Intracellular | Localization | Endoplasmic reticulum | Cytoplasm | Endosomes
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16. Full Text Development of consensus guidelines for the histologic recognition of microscopic esophagitis in patients with gastroesophageal reflux disease: the Esohisto project
by Fiocca, Roberto, MD and Mastracci, Luca, MD and Riddell, Robert, MD and Takubo, Kaiyo, MD and Vieth, Michael, MD and Yerian, Lisa, MD and Sharma, Prateek, MD and Fernström, Paula, MSc and Ruth, Magnus, MD
Human Pathology, ISSN 0046-8177, 2010, Volume 41, Issue 2, pp. 223 - 231
Summary No gold standard test exists for gastroesophageal reflux disease (GERD). Diagnostic difficulties are greatest when reflux symptoms occur without... 
Pathology | Esophagitis | Gastroesophageal reflux disease | Consensus development | Esophageal histology | POPULATION | ESOMEPRAZOLE | CLASSIFICATION | SYMPTOMS | PREVALENCE | PATHOLOGY | SQUAMOUS EPITHELIUM | REPRODUCIBILITY | VARIABILITY | ENDOSCOPIC LESIONS | INTEROBSERVER VARIATION | Diagnosis, Differential | Reproducibility of Results | Biopsy | Esophageal pH Monitoring | Gastroesophageal Reflux - pathology | Humans | Middle Aged | Adult | Female | Male | Esophagitis - pathology | Esophagoscopy | Gastroesophageal reflux | Medical colleges | Care and treatment | Confidence intervals | Throat | Disease | Gastrointestinal diseases | Dogs | Photographs | Agreements | Clinical medicine
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17. Full Text Coping with formalin banning in pathology: under vacuum long-term tissue storage with no added formalin
by Mastracci, Luca and Gambella, Alessandro and Bragoni, Alberto and Pigozzi, Simona and Pastorino, Lorenza and Vanni, Irene and Tosi, Ilaria and Campora, Michela and Fiocca, Roberto and Grillo, Federica
Histochemistry and Cell Biology, ISSN 0948-6143, 6/2019, Volume 151, Issue 6, pp. 501 - 511
Formalin is toxic and has recently been classified as carcinogenic leading to a proposed European formalin ban. But, the pathology use of formalin has however... 
Biomedicine, general | Biochemistry, general | Formalin ban | Pathology | Biomedicine | Vacuum storage | Safety | Developmental Biology | Cell Biology | Antigens | Vacuum | Immunoreactivity | Morphology | Formaldehyde | Deoxyribonucleic acid--DNA
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18. Full Text Agar pre-embedding of small skin biopsies: real-life benefits and challenges in high throughput pathology laboratories
by Ridolfi, Mara and Paudice, Michele and Salvi, Sandra and Valle, Luca and Gualco, Marina and Perasole, Antonio and Anselmi, Luca and Fiocca, Roberto and Mastracci, Luca and Grillo, Federica
Journal of Clinical Pathology, ISSN 0021-9746, 06/2019, Volume 72, Issue 6, pp. 448 - 451
Paraffin embedding of small, thin tissue samples requires specific expertise for optimal orientation before tissue sectioning. This study evaluates the... 
SPECIMENS | PATHOLOGY | ORIENTATION | DOUBLE-EMBEDDING TECHNIQUE
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