X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (59) 59
humans (46) 46
rheumatoid arthritis (27) 27
animals (24) 24
rheumatology (21) 21
abridged index medicus (20) 20
cytokines (17) 17
arthritis, rheumatoid - immunology (15) 15
arthritis, rheumatoid - pathology (15) 15
cells, cultured (15) 15
rheumatoid-arthritis (14) 14
male (13) 13
mice (12) 12
care and treatment (10) 10
gene expression (10) 10
research (10) 10
arthritis, rheumatoid - drug therapy (9) 9
cells (9) 9
expression (9) 9
female (9) 9
fibroblasts (9) 9
immunology (9) 9
physiological aspects (9) 9
collagen-induced arthritis (8) 8
inflammation (8) 8
synovial membrane - pathology (8) 8
arthritis (7) 7
arthritis, rheumatoid - etiology (7) 7
arthritis, rheumatoid - genetics (7) 7
article (7) 7
gene-expression (7) 7
interleukin-1 - pharmacology (7) 7
middle aged (7) 7
proteins (7) 7
studies (7) 7
synovial membrane - cytology (7) 7
synovial membrane - immunology (7) 7
synovial membrane - metabolism (7) 7
arthritis, rheumatoid - metabolism (6) 6
kinases (6) 6
medicine, research & experimental (6) 6
tumor necrosis factor-tnf (6) 6
tumor-necrosis-factor (6) 6
activation (5) 5
adult (5) 5
apoptosis (5) 5
arthritis, rheumatoid - enzymology (5) 5
cell biology (5) 5
chronic disease (5) 5
lymphocyte activation (5) 5
patient outcomes (5) 5
rats (5) 5
synovial fibroblasts (5) 5
synoviocytes (5) 5
t-lymphocytes - immunology (5) 5
tumor necrosis factor-alpha - pharmacology (5) 5
adenosine - pharmacology (4) 4
aged (4) 4
antirheumatic agents - pharmacology (4) 4
antirheumatic agents - therapeutic use (4) 4
biochemistry & molecular biology (4) 4
cytokines - physiology (4) 4
drug therapy (4) 4
enzymes (4) 4
fibroblast-like synoviocytes (4) 4
fibroblasts - metabolism (4) 4
fibroblasts - pathology (4) 4
gene expression regulation (4) 4
genetic aspects (4) 4
models, biological (4) 4
musculoskeletal diseases (4) 4
phosphorylation (4) 4
ribonucleosides - pharmacology (4) 4
rna, messenger - analysis (4) 4
rna, messenger - metabolism (4) 4
rodents (4) 4
synovial membrane - drug effects (4) 4
synovial membrane - enzymology (4) 4
tumor necrosis factor (4) 4
adenosine kinase - antagonists & inhibitors (3) 3
adjuvant arthritis (3) 3
analysis (3) 3
arthritis, experimental - enzymology (3) 3
arthritis, experimental - pathology (3) 3
arthritis, rheumatoid - physiopathology (3) 3
articular-cartilage (3) 3
cell movement (3) 3
clinical trials (3) 3
collagenase (3) 3
cytokines - genetics (3) 3
cytokines - immunology (3) 3
cytokines - metabolism (3) 3
deoxyribonucleic acid--dna (3) 3
development and progression (3) 3
disease models, animal (3) 3
dose-response relationship, drug (3) 3
double-blind (3) 3
drug dosages (3) 3
enzyme inhibitors - pharmacology (3) 3
flow cytometry (3) 3
more...
Library Location Library Location
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2016, Volume 75, Issue Suppl 2, pp. 29 - 30
Kinases play a critical role in inflammatory disease and immune regulation. They are critical molecules that transduce signals from the environment, including... 
Journal Article
The journal of clinical investigation, ISSN 0021-9738, 2001, Volume 107, Issue 1, pp. 7 - 11
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2015, Volume 74, Issue 6, pp. 1311 - 1316
Objective Tofacitinib is an oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis (RA). The pathways affected by tofacitinib and the... 
TRIAL | PATHOGENESIS | CRITERIA | CYTOKINES | PLACEBO | DISEASE | GENE-EXPRESSION | METHOTREXATE | RHEUMATOLOGY | COMBINATION | CP-690,550 | Humans | Middle Aged | STAT Transcription Factors - metabolism | Chemokines - drug effects | Male | Matrix Metalloproteinase 3 - drug effects | Synovial Membrane - drug effects | Methotrexate - therapeutic use | RNA, Messenger - metabolism | STAT Transcription Factors - drug effects | Arthritis, Rheumatoid - metabolism | Janus Kinase 1 - metabolism | Piperidines - pharmacology | Arthritis, Rheumatoid - drug therapy | Adult | Female | Antirheumatic Agents - pharmacology | Drug Therapy, Combination | Pyrroles - therapeutic use | Matrix Metalloproteinase 1 - genetics | Antirheumatic Agents - therapeutic use | RNA, Messenger - drug effects | Matrix Metalloproteinase 1 - drug effects | Double-Blind Method | Matrix Metalloproteinase 3 - metabolism | Treatment Outcome | Pyrimidines - pharmacology | Chemokines - genetics | Janus Kinase 1 - drug effects | Synovial Membrane - metabolism | Pyrroles - pharmacology | Signal Transduction - drug effects | Piperidines - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Aged | Chemokines - metabolism | Protein Kinase Inhibitors - pharmacology | Matrix Metalloproteinase 1 - metabolism | Matrix Metalloproteinase 3 - genetics | Tofacitinib | Rheumatoid arthritis | Dosage and administration | Genetic aspects | Research | Gene expression | Risk factors | Index Medicus | Basic and Translational Research | 1506
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 11/2003, Volume 62, Issue 2, pp. 86 - 89
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 07/2015, Volume 74, Issue 7, pp. 1399 - 1407
ObjectivesLittle is known about targeting the metabolome in non-cancer conditions. Choline kinase (ChoKα), an essential enzyme for phosphatidylcholine... 
LUNG-CANCER | STIMULATING FACTOR PRODUCTION | MAGNETIC-RESONANCE-SPECTROSCOPY | TUMOR PROGRESSION | PHOSPHOLIPID-METABOLISM | SYNOVIAL-FLUID | GROWTH-FACTORS | CHRONIC INFLAMMATORY ARTHRITIS | NECROSIS-FACTOR-ALPHA | RHEUMATOLOGY | CELL-LINES | Butanes - pharmacology | Choline - metabolism | Choline Kinase - metabolism | Apoptosis - drug effects | Pyridinium Compounds - therapeutic use | Synovial Membrane - pathology | Synovial Membrane - drug effects | Arthritis, Rheumatoid - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Arthritis, Rheumatoid - prevention & control | Butanes - therapeutic use | Proto-Oncogene Proteins c-akt - metabolism | Choline Kinase - antagonists & inhibitors | Disease Models, Animal | Fibroblasts - metabolism | Mice, Inbred C57BL | Cells, Cultured | Enzyme Inhibitors - pharmacology | Mice, Transgenic | Fibroblasts - pathology | Enzyme Inhibitors - therapeutic use | Synovial Membrane - metabolism | Arthritis, Rheumatoid - pathology | Cell Movement - drug effects | Pyridinium Compounds - pharmacology | Animals | Fibroblasts - drug effects | Cell Proliferation - drug effects | Mice | Cell proliferation | Care and treatment | Usage | Rheumatoid arthritis | Nuclear magnetic resonance spectroscopy | Research | Phosphotransferases | Proteins | Enzymes | Metabolites | Fibroblasts | Tumor necrosis factor-TNF | Kinases | Metabolism | Laboratory animals | Variance analysis | Growth factors | Cancer | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 2001, Volume 108, Issue 1, pp. 73 - 81
Mitogen-activated protein kinase (MAPK) cascades are involved in inflammation and tissue destruction in rheumatoid arthritis (RA). In particular, c-Jun... 
RHEUMATOID-ARTHRITIS | TRANSCRIPTION FACTORS | SIGNAL-TRANSDUCTION | PATHWAYS | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATED PROTEIN-KINASE | KAPPA-B REGULATION | P38 | COLLAGENASE | GENE-EXPRESSION | JNK2 | Rats, Inbred Lew | MAP Kinase Signaling System | Arthritis, Experimental - pathology | Protein-Tyrosine Kinases - physiology | RNA, Messenger - biosynthesis | Protein-Tyrosine Kinases - genetics | Transcription Factor AP-1 - deficiency | Protein Processing, Post-Translational - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Enzyme Induction - drug effects | Flavonoids - pharmacology | Interleukin-1 - antagonists & inhibitors | Phosphorylation - drug effects | p38 Mitogen-Activated Protein Kinases | Isoenzymes - physiology | Cells, Cultured - drug effects | Collagenases - genetics | Collagenases - biosynthesis | Isoenzymes - genetics | Enzyme Inhibitors - pharmacology | Rats | Anthracenes - pharmacology | Cells, Cultured - enzymology | Interleukin-1 - pharmacology | Matrix Metalloproteinase 13 | Mice, Knockout | Transcription Factors - metabolism | Animals | Mitogen-Activated Protein Kinase 10 | Mitogen-Activated Protein Kinase 8 | Mitogen-Activated Protein Kinase 9 | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinases - physiology | Proto-Oncogene Proteins c-jun - metabolism | Activating Transcription Factor 2 | Transcription Factor AP-1 - physiology | Cyclic AMP Response Element-Binding Protein - metabolism | Mitogen-Activated Protein Kinases - genetics | Mice | Arthritis, Experimental - enzymology | Isoenzymes - antagonists & inhibitors | MAP Kinase Kinase Kinase 1 | Mitogen-Activated Protein Kinase 3 | Synovial Membrane - cytology | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Journal Article
Zeitschrift fur Rheumatologie, ISSN 0340-1855, 08/2012, Volume 71, Issue 6, pp. 460 - 467
Journal Article
Zeitschrift für Rheumatologie, ISSN 0340-1855, 8/2012, Volume 71, Issue 6, pp. 460 - 467
Biologika, häufig in Kombination mit einer konventionellen DMARD-Therapie, stellen einen wesentlichen Fortschritt in der Behandlung rheumatischer Erkrankungen... 
Signaltransduktionsinhibitoren | Transcription factors | Systemische Sklerose | Rheumatology | Transkriptionsfaktoren | Internal Medicine | Kinases | Rheumatoide Arthritis | Signaling inhibitors | Systemic lupus erythematosus | Medicine & Public Health | Systemischer Lupus erythematodes | Rheumatoid arthritis | Systemic sclerosis | Kinasen
Journal Article
Zeitschrift fur Rheumatologie, ISSN 0340-1855, 08/2012, Volume 71, Issue 6, p. 460
Biologika, haufig in Kombination mit einer konventionellen DMARD-Therapie, stellen einen wesentlichen Fortschritt in der Behandlung rheumatischer Erkrankungen... 
Lupus | Rheumatoid factor | Medical colleges | Antirheumatic agents | Systemic scleroderma | Rheumatoid arthritis | Scleroderma (Disease) | DNA binding proteins | Phosphotransferases
Journal Article
Osteoarthritis and Cartilage, ISSN 1063-4584, 04/2018, Volume 26, pp. S397 - S397
Journal Article
Plos One, ISSN 1932-6203, 2010, Volume 5, Issue 10, pp. e13416 - e13416
BACKGROUND: The use of TNF inhibitors has been a major progress in the treatment of chronic inflammation. However, not all patients respond. In addition,... 
RHEUMATOID-ARTHRITIS | CHEMOKINE EXPRESSION | MIGRATION INHIBITORY FACTOR | RETICULUM STRESS PATHWAY | BIOLOGY | NITRIC-OXIDE | PANCREATIC BETA-CELLS | ENDOPLASMIC-RETICULUM | NECROSIS FACTOR THERAPY | OXIDE-INDUCED APOPTOSIS | E3 UBIQUITIN LIGASE | In Situ Nick-End Labeling | Enzyme-Linked Immunosorbent Assay | Interleukin-17 - physiology | Ubiquitin-Protein Ligases - metabolism | Interleukin-17 - genetics | Synovial Membrane - pathology | Reverse Transcriptase Polymerase Chain Reaction | Synovial Membrane - metabolism | Blotting, Western | Arthritis, Rheumatoid - pathology | Arthritis, Rheumatoid - metabolism | Animals | RNA Interference | Mice | Chronic Disease | Ubiquitin | Rheumatoid factor | Interleukins | RNA | Tumor necrosis factor | Ligases | Arthritis | Inflammation | B cells | Tumor proteins | p53 Protein | Hyperplasia | Propidium iodide | Single-nucleotide polymorphism | Phosphatase | Proteins | Proliferating cell nuclear antigen | Fibroblasts | Deoxyribonucleic acid--DNA | Lymphatic system | Cytokines | Iodides | RNA-mediated interference | Rheumatology | Gene expression | Survival | Synoviocytes | Interleukin 17 | Polymerase chain reaction | Sodium nitroprusside | Hospitals | Ribonucleic acids | Sodium | Rheumatoid arthritis | TNF inhibitors | Genes | Interleukin | Helper cells | Antibodies | Staining | Biosynthesis | Lymphocytes T | Kinases | Clinical aspects | Immunology | Germinal centers | Rodents | Tumor necrosis factor-TNF | Rheumatism | Ubiquitin-protein ligase | Enzyme-linked immunosorbent assay | Chronic illnesses | Cell survival | Dendritic cells | Cell walls | siRNA | Immune systems | Lymphocytes B | Adenoviruses | Annexin V | Chemokines | Apoptosis | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 02/2009, Volume 68, Issue 2, pp. 257 - 263
Objectives:The IκB kinase (IKK)-related kinase IKKϵ regulates type I interferon expression and responses as well as proinflammatory mediator production. We... 
RHEUMATOID-ARTHRITIS | COLLAGEN-INDUCED ARTHRITIS | REGULATORY FACTOR-3 | TUMOR-NECROSIS-FACTOR | MULTIPLE-SCLEROSIS | IKK-EPSILON | RECEPTOR ANTAGONIST PRODUCTION | SIGNALING PATHWAY | GENE-THERAPY | RHEUMATOLOGY | ADJUVANT ARTHRITIS
Journal Article