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animals (155) 155
dictyostelium - genetics (153) 153
cell biology (120) 120
dictyostelium - growth & development (85) 85
base sequence (82) 82
molecular sequence data (82) 82
amino acid sequence (81) 81
biochemistry & molecular biology (76) 76
dictyostelium - cytology (73) 73
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developmental biology (68) 68
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chemotaxis (59) 59
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genes, fungal (42) 42
mutation (41) 41
dictyostelium - enzymology (40) 40
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cloning, molecular (37) 37
fungal proteins - genetics (37) 37
protozoan proteins - genetics (36) 36
protozoan proteins - metabolism (35) 35
research article (34) 34
cells (33) 33
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kinetics (29) 29
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sequence homology, amino acid (28) 28
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rna, messenger - genetics (27) 27
genetics & heredity (26) 26
nucleic acid hybridization (26) 26
actins - genetics (25) 25
humans (25) 25
index medicus (25) 25
models, biological (25) 25
proteins (25) 25
protozoan proteins (24) 24
cell differentiation (23) 23
leading-edge (23) 23
biophysics (22) 22
promoter regions, genetic (22) 22
differentiation (21) 21
expression (21) 21
phosphatidylinositol 3-kinases - metabolism (21) 21
activation (20) 20
adenylyl-cyclase (20) 20
cyclic amp - physiology (20) 20
enzyme activation (20) 20
dictyostelium discoideum (19) 19
gene expression regulation, fungal (19) 19
plasmids (19) 19
protein (19) 19
cell polarity (18) 18
dictyostelium-discoideum (18) 18
gene expression (18) 18
gtp-binding proteins - genetics (18) 18
signal transduction - physiology (18) 18
kinase (17) 17
dependent protein-kinase (16) 16
genetic vectors (16) 16
physiological aspects (16) 16
protein-serine-threonine kinases - metabolism (16) 16
rna, messenger - biosynthesis (16) 16
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myxomycetes - metabolism (15) 15
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signal-transduction (15) 15
actins (14) 14
centrifugation, density gradient (14) 14
cytoskeleton - metabolism (14) 14
dna restriction enzymes (14) 14
molecular biology (14) 14
multicellular development (14) 14
protein biosynthesis (14) 14
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Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 10/2005, Volume 16, Issue 10, pp. 4572 - 4583
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2007, Volume 104, Issue 33, pp. 13343 - 13348
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 5/2001, Volume 153, Issue 4, pp. 795 - 809
We show that cells lacking two Dictyostelium class I phosphatidylinositol (PI) 3′ kinases (PI3K and pi3k1/2-null cells) or wild-type cells treated with the... 
Chemotactic factors | Phenotypes | Lymphocytes | Actins | Cell membranes | Gene expression regulation | Kinetics | Physiological regulation | Chemotaxis | Cells | Dictyostelium | Actin polymerization | PI3 kinase | PH domain | FORKHEAD TRANSCRIPTION FACTOR | SYNTHASE KINASE-3 | NEUTROPHIL CHEMOTAXIS | CELL-DEATH | CELL BIOLOGY | actin polymerization | BRUTONS TYROSINE KINASE | ADENYLYL-CYCLASE | LEADING-EDGE | MEDIATED ACTIVATION | PHOSPHOINOSITIDE 3-KINASES | chemotaxis | Protein-Serine-Threonine Kinases | Actins - metabolism | Molecular Sequence Data | Microscopy, Video | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Protozoan Proteins - genetics | Phosphoproteins - chemistry | Chemotaxis - physiology | Protozoan Proteins - metabolism | Blood Proteins - genetics | Dictyostelium - enzymology | Protozoan Proteins - chemistry | Dictyostelium - cytology | Chromones - pharmacology | Folic Acid | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Proto-Oncogene Proteins - genetics | Blood Proteins - chemistry | Chemotaxis - drug effects | Phosphoproteins - genetics | Phosphatidylinositol 3-Kinases - genetics | Proto-Oncogene Proteins c-akt | Animals | Mutagenesis, Insertional - physiology | Polymers - metabolism | Phosphatidylinositol | Cell research | Analysis | Physiological aspects | Polymerization | Proteins | Mutation | Cellular biology
Journal Article
Cell, ISSN 0092-8674, 2002, Volume 109, Issue 5, pp. 611 - 623
We have investigated the mechanisms of leading edge formation in chemotaxing Dictyostelium cells. We demonstrate that while phosphatidylinositol 3-kinase... 
SIGNAL-TRANSDUCTION | BRUTONS TYROSINE KINASE | CHEMOATTRACTANT RECEPTOR | DICTYOSTELIUM-DISCOIDEUM CELLS | PLECKSTRIN-HOMOLOGY-DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | NEUTROPHIL CHEMOTAXIS | PHOSPHOINOSITIDE 3-KINASE-GAMMA | MEMBRANE LOCALIZATION | LIVING CELLS | CELL BIOLOGY | Green Fluorescent Proteins | ras Proteins - genetics | Pseudopodia - ultrastructure | ras Proteins - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Protozoan Proteins - genetics | Chemotaxis - physiology | Protozoan Proteins - metabolism | PTEN Phosphohydrolase | Pseudopodia - enzymology | Time Factors | Isoenzymes - metabolism | Tumor Suppressor Proteins - genetics | Dictyostelium - enzymology | Phosphatidylinositols - metabolism | Dictyostelium - cytology | Phosphoric Monoester Hydrolases - genetics | Tumor Suppressor Proteins - metabolism | Isoenzymes - genetics | Cell Compartmentation - genetics | Cell Membrane - ultrastructure | Protein Structure, Tertiary - genetics | Protein Transport - genetics | Down-Regulation - physiology | Phosphatidylinositol 3-Kinases - genetics | Cell Membrane - enzymology | Cell Polarity - genetics | Indicators and Reagents - metabolism | Animals | Dictyostelium - genetics | Signal Transduction - physiology | Phosphoric Monoester Hydrolases - metabolism | Luminescent Proteins - metabolism | Physiological aspects | Phosphoinositides | Dictyostelium | Research | Cytochemistry | Chemotaxis
Journal Article
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 07/2004, Volume 5, Issue 7, pp. 531 - 541
Journal Article