American Journal of Gastroenterology, ISSN 0002-9270, 11/2012, Volume 107, Issue 11, pp. 1702 - 1712
OBJECTIVES: Linaclotide is a minimally absorbed peptide guanylate cyclase-C agonist. The objective of this trial was to determine the efficacy and safety of...
TRANSIT | IMPACT | ABDOMINAL-PAIN | DISORDERS | PATTERNS | CLINICAL IMPORTANCE | PREVALENCE | OUTCOMES | SCALE | GASTROENTEROLOGY & HEPATOLOGY | Double-Blind Method | Humans | Middle Aged | Irritable Bowel Syndrome - drug therapy | Male | Treatment Outcome | Analysis of Variance | Adolescent | Endpoint Determination | Aged, 80 and over | Placebos | Adult | Female | Aged | Constipation - drug therapy | Peptides - adverse effects | Peptides - therapeutic use
TRANSIT | IMPACT | ABDOMINAL-PAIN | DISORDERS | PATTERNS | CLINICAL IMPORTANCE | PREVALENCE | OUTCOMES | SCALE | GASTROENTEROLOGY & HEPATOLOGY | Double-Blind Method | Humans | Middle Aged | Irritable Bowel Syndrome - drug therapy | Male | Treatment Outcome | Analysis of Variance | Adolescent | Endpoint Determination | Aged, 80 and over | Placebos | Adult | Female | Aged | Constipation - drug therapy | Peptides - adverse effects | Peptides - therapeutic use
Journal Article
Book
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 139, Issue 6, pp. 1797 - 1807
Abstract Background Asthma is a heterogeneous disease in which there is a differential response to asthma treatments. This heterogeneity needs to be evaluated...
Allergy and Immunology | partition-around-medoids algorithm | clustering | Severe asthma | sputum eosinophilia | LYN | EPITHELIAL-CELLS | ALLERGY | PHENOTYPES | IMMUNOLOGY | IDENTIFICATION | EXPRESSION | DISCOVERY | Biomarkers - metabolism | Severity of Illness Index | Sputum - cytology | Asthma - metabolism | Oligonucleotide Array Sequence Analysis | Humans | Middle Aged | Male | Gene Expression Profiling | Asthma - genetics | Sputum - metabolism | Phenotype | Algorithms | Proteomics | Adult | Female | Aged | Leukocyte Count | Asthma - classification | Stock options | Asthma | Cluster analysis | Respiratory function | Immunoglobulin E | Training | Heterogeneity | Pathways | Classification | Clusters | Chronic obstructive pulmonary disease | Obesity | Management | Clustering | Patients | Eosinophilia | Diseases | Body fluids | Air flow | Lungs | Reproducibility | Respiratory diseases | Nitric oxide | Sputum | Biomarkers | Adults | Smoking | Index Medicus | Abridged Index Medicus | Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Lungmedicin och allergi | Klinisk medicin | Respiratory Medicine and Allergy
Allergy and Immunology | partition-around-medoids algorithm | clustering | Severe asthma | sputum eosinophilia | LYN | EPITHELIAL-CELLS | ALLERGY | PHENOTYPES | IMMUNOLOGY | IDENTIFICATION | EXPRESSION | DISCOVERY | Biomarkers - metabolism | Severity of Illness Index | Sputum - cytology | Asthma - metabolism | Oligonucleotide Array Sequence Analysis | Humans | Middle Aged | Male | Gene Expression Profiling | Asthma - genetics | Sputum - metabolism | Phenotype | Algorithms | Proteomics | Adult | Female | Aged | Leukocyte Count | Asthma - classification | Stock options | Asthma | Cluster analysis | Respiratory function | Immunoglobulin E | Training | Heterogeneity | Pathways | Classification | Clusters | Chronic obstructive pulmonary disease | Obesity | Management | Clustering | Patients | Eosinophilia | Diseases | Body fluids | Air flow | Lungs | Reproducibility | Respiratory diseases | Nitric oxide | Sputum | Biomarkers | Adults | Smoking | Index Medicus | Abridged Index Medicus | Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Lungmedicin och allergi | Klinisk medicin | Respiratory Medicine and Allergy
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2017, Volume 140, Issue 4, pp. 1068 - 1078.e6
Abstract Background Helminth parasites have been reported to have beneficial immune modulatory effects in allergic and autoimmune conditions and detrimental...
Allergy and Immunology | type I interferon | Respiratory syncytial virus | helminths | Heligmosomoides polygyrus | microbiome | IMMUNITY | ACTIVATION | INNATE | MECHANISMS | ALLERGIC AIRWAY INFLAMMATION | IMMUNOLOGY | PLASMACYTOID DENDRITIC CELLS | RESPONSES | ALLERGY | RSV BRONCHIOLITIS | MICE | Coinfection | Microbiota - immunology | Signal Transduction | Humans | Mice, Inbred C57BL | Respiratory Syncytial Viruses - immunology | Cells, Cultured | Immunity, Mucosal | Th2 Cells - immunology | Respiratory Syncytial Virus Infections - immunology | Intestines - immunology | Nematospiroides dubius - immunology | Mice, Knockout | Antigens, Helminth - immunology | Animals | Th2 Cells - parasitology | Strongylida Infections - immunology | Intestines - parasitology | Interferon Type I - metabolism | Female | Mice | Mice, Inbred BALB C | Receptor, Interferon alpha-beta - genetics | Lung - immunology | Virus diseases | Medical research | Tuberculosis | Microbiota (Symbiotic organisms) | Comorbidity | Medicine, Experimental | Interferon | Biological response modifiers | Health aspects | Asthma | Dendritic cells | Analysis | Gnotobiotics | Immune response | Duodenum | Laboratories | Immunomodulation | Lung diseases | Viruses | Infections | Lymphocytes T | Inflammation | Parasites | Gene expression | Patients | Viral infections
Allergy and Immunology | type I interferon | Respiratory syncytial virus | helminths | Heligmosomoides polygyrus | microbiome | IMMUNITY | ACTIVATION | INNATE | MECHANISMS | ALLERGIC AIRWAY INFLAMMATION | IMMUNOLOGY | PLASMACYTOID DENDRITIC CELLS | RESPONSES | ALLERGY | RSV BRONCHIOLITIS | MICE | Coinfection | Microbiota - immunology | Signal Transduction | Humans | Mice, Inbred C57BL | Respiratory Syncytial Viruses - immunology | Cells, Cultured | Immunity, Mucosal | Th2 Cells - immunology | Respiratory Syncytial Virus Infections - immunology | Intestines - immunology | Nematospiroides dubius - immunology | Mice, Knockout | Antigens, Helminth - immunology | Animals | Th2 Cells - parasitology | Strongylida Infections - immunology | Intestines - parasitology | Interferon Type I - metabolism | Female | Mice | Mice, Inbred BALB C | Receptor, Interferon alpha-beta - genetics | Lung - immunology | Virus diseases | Medical research | Tuberculosis | Microbiota (Symbiotic organisms) | Comorbidity | Medicine, Experimental | Interferon | Biological response modifiers | Health aspects | Asthma | Dendritic cells | Analysis | Gnotobiotics | Immune response | Duodenum | Laboratories | Immunomodulation | Lung diseases | Viruses | Infections | Lymphocytes T | Inflammation | Parasites | Gene expression | Patients | Viral infections
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 11/2014, Volume 2014, Issue 31, p. n/a
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 04/2018, Volume 141, Issue 4, pp. 1280 - 1290
Adult-onset severe asthma is characterized by highly symptomatic disease despite high-intensity asthma treatments. Understanding of the underlying pathways of...
ILC3 | gene set variation analysis | severe asthma | transcriptomics | eosinophils | Adult-onset asthma | mast cells | phenotyping | mechanisms | PHENOTYPES | INNATE LYMPHOID-CELLS | MODEL | IMMUNOLOGY | IL-33 | CLUSTER-ANALYSIS | ALLERGY | EOSINOPHILIC ASTHMA | INFLAMMATION | DISEASE | GENE-EXPRESSION | QUESTIONNAIRE | Severity of Illness Index | Cross-Sectional Studies | Oligonucleotide Array Sequence Analysis | Humans | Middle Aged | Male | Gene Expression Profiling | Transcriptome - immunology | Genetic Markers | Asthma - genetics | Phenotype | Age of Onset | Asthma - immunology | Adult | Female | Genetic research | Gene expression | Asthma in children | Analysis | Enrichment | Identification methods | Statistical methods | Respiratory tract | Pathways | Respiratory tract diseases | Children | Signatures | Age | Lymphoid cells | Statistical analysis | Leukocytes (eosinophilic) | Medical treatment | Neutrophils | Inflammation | Ribonucleic acid--RNA | Patients | Asthma | Quality of life | White blood cells | Lungs | Biopsy | Sputum | Quality control | Data collection | Mast cells | Eosinophils
ILC3 | gene set variation analysis | severe asthma | transcriptomics | eosinophils | Adult-onset asthma | mast cells | phenotyping | mechanisms | PHENOTYPES | INNATE LYMPHOID-CELLS | MODEL | IMMUNOLOGY | IL-33 | CLUSTER-ANALYSIS | ALLERGY | EOSINOPHILIC ASTHMA | INFLAMMATION | DISEASE | GENE-EXPRESSION | QUESTIONNAIRE | Severity of Illness Index | Cross-Sectional Studies | Oligonucleotide Array Sequence Analysis | Humans | Middle Aged | Male | Gene Expression Profiling | Transcriptome - immunology | Genetic Markers | Asthma - genetics | Phenotype | Age of Onset | Asthma - immunology | Adult | Female | Genetic research | Gene expression | Asthma in children | Analysis | Enrichment | Identification methods | Statistical methods | Respiratory tract | Pathways | Respiratory tract diseases | Children | Signatures | Age | Lymphoid cells | Statistical analysis | Leukocytes (eosinophilic) | Medical treatment | Neutrophils | Inflammation | Ribonucleic acid--RNA | Patients | Asthma | Quality of life | White blood cells | Lungs | Biopsy | Sputum | Quality control | Data collection | Mast cells | Eosinophils
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 12/2003, Volume 349, Issue 25, pp. 2387 - 2398
In this long-term trial, the combination of an alpha-blocker (doxazosin) and a 5α-reductase inhibitor (finasteride) was superior to either drug alone in...
AMERICAN-UROLOGICAL-ASSOCIATION | MEDICINE, GENERAL & INTERNAL | PLACEBO | CONTROLLED TRIAL | EFFICACY | ACUTE URINARY RETENTION | SAFETY | MEN | DOUBLE-BLIND | GOODNESS-OF-FIT | TRACT SYMPTOMS | Enzyme Inhibitors - adverse effects | Severity of Illness Index | Double-Blind Method | Humans | Middle Aged | 5-alpha Reductase Inhibitors | Adrenergic alpha-Antagonists - therapeutic use | Male | Prostatic Hyperplasia - classification | Enzyme Inhibitors - therapeutic use | Disease Progression | Prostatic Hyperplasia - surgery | Finasteride - adverse effects | Adrenergic alpha-Antagonists - adverse effects | Analysis of Variance | Doxazosin - therapeutic use | Finasteride - therapeutic use | Doxazosin - adverse effects | Drug Therapy, Combination | Prostatic Hyperplasia - drug therapy | Evaluation | Doxazosin | Finasteride | Drug therapy | Prostate | Hypertrophy | Clinical trials | Prostate cancer | Urogenital system | Older people | Men
AMERICAN-UROLOGICAL-ASSOCIATION | MEDICINE, GENERAL & INTERNAL | PLACEBO | CONTROLLED TRIAL | EFFICACY | ACUTE URINARY RETENTION | SAFETY | MEN | DOUBLE-BLIND | GOODNESS-OF-FIT | TRACT SYMPTOMS | Enzyme Inhibitors - adverse effects | Severity of Illness Index | Double-Blind Method | Humans | Middle Aged | 5-alpha Reductase Inhibitors | Adrenergic alpha-Antagonists - therapeutic use | Male | Prostatic Hyperplasia - classification | Enzyme Inhibitors - therapeutic use | Disease Progression | Prostatic Hyperplasia - surgery | Finasteride - adverse effects | Adrenergic alpha-Antagonists - adverse effects | Analysis of Variance | Doxazosin - therapeutic use | Finasteride - therapeutic use | Doxazosin - adverse effects | Drug Therapy, Combination | Prostatic Hyperplasia - drug therapy | Evaluation | Doxazosin | Finasteride | Drug therapy | Prostate | Hypertrophy | Clinical trials | Prostate cancer | Urogenital system | Older people | Men
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 07/2019, Volume 144, Issue 1, pp. 70 - 82
Stratification by eosinophil and neutrophil counts increases our understanding of asthma and helps target therapy, but there is room for improvement in our...
eosinophils | proteomics | neutrophils | biomarkers | Asthma | ALLERGY | EXACERBATIONS | DEGRADATION | IMMUNOLOGY | CD44 | Phenotype | Genetic aspects | Analysis | Dehydrogenases | Metadata | Atopy | Datasets | Respiratory tract | Proteins | Granulocytes | Clusters | Signatures | Phenotypes | Data analysis | Immunoglobulins | Leukocytes (eosinophilic) | Neutrophils | Mass spectroscopy | Glycoproteins | Leukocytes (neutrophilic) | Regression analysis | Gene expression | Patients | Chromatography | DNA microarrays | Sputum | Biomarkers | Software | Scientific imaging | Leukocytes (granulocytic) | Mass spectrometry | Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Lungmedicin och allergi | Klinisk medicin | Respiratory Medicine and Allergy
eosinophils | proteomics | neutrophils | biomarkers | Asthma | ALLERGY | EXACERBATIONS | DEGRADATION | IMMUNOLOGY | CD44 | Phenotype | Genetic aspects | Analysis | Dehydrogenases | Metadata | Atopy | Datasets | Respiratory tract | Proteins | Granulocytes | Clusters | Signatures | Phenotypes | Data analysis | Immunoglobulins | Leukocytes (eosinophilic) | Neutrophils | Mass spectroscopy | Glycoproteins | Leukocytes (neutrophilic) | Regression analysis | Gene expression | Patients | Chromatography | DNA microarrays | Sputum | Biomarkers | Software | Scientific imaging | Leukocytes (granulocytic) | Mass spectrometry | Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Lungmedicin och allergi | Klinisk medicin | Respiratory Medicine and Allergy
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 02/2019, Volume 143, Issue 2, pp. 577 - 590
Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) to asthma severity and decreased lung function, the role of IL-6...
airway inflammation | IL-6 signaling | exacerbation frequency | remodeling | epithelial integrity | transcriptomics | hierarchical clustering | eosinophils | lung epithelium | Asthma | TARGET | INTERLEUKIN-6 RECEPTOR | CELLS | BARRIER FUNCTION | IMMUNOLOGY | HYPERRESPONSIVENESS | MATRIX METALLOPROTEINASES | CHITINASE-LIKE PROTEIN | ALLERGY | DISEASE | DYSFUNCTION | SEVERITY | Autoimmunity | Genetic aspects | Analysis | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin | Clinical Medicine | Lungmedicin och allergi | Respiratory Medicine and Allergy
airway inflammation | IL-6 signaling | exacerbation frequency | remodeling | epithelial integrity | transcriptomics | hierarchical clustering | eosinophils | lung epithelium | Asthma | TARGET | INTERLEUKIN-6 RECEPTOR | CELLS | BARRIER FUNCTION | IMMUNOLOGY | HYPERRESPONSIVENESS | MATRIX METALLOPROTEINASES | CHITINASE-LIKE PROTEIN | ALLERGY | DISEASE | DYSFUNCTION | SEVERITY | Autoimmunity | Genetic aspects | Analysis | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin | Clinical Medicine | Lungmedicin och allergi | Respiratory Medicine and Allergy
Journal Article