Nature Genetics, ISSN 1061-4036, 04/2013, Volume 45, Issue 4, pp. 385 - 391
Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we...
VARIANTS | PREDISPOSITION | MEN | GENETICS & HEREDITY | MUTATIONS | HOXB13 | GENOME-WIDE ASSOCIATION | Prostatic Neoplasms - pathology | Genetic Predisposition to Disease | Genome-Wide Association Study | Meta-Analysis as Topic | Oligonucleotide Array Sequence Analysis | Humans | Risk Factors | Genetic Loci - genetics | Prostatic Neoplasms - etiology | Cooperative Behavior | Genotype | Male | Case-Control Studies | Polymorphism, Single Nucleotide - genetics | Quantitative trait loci | Genetic susceptibility | Genetic aspects | Research | Prostate cancer | Identification and classification | Risk factors | Studies | Confidence intervals | Genotype & phenotype | Genealogy | Quality control | Cell cycle | Genomes | DNA repair | Deoxyribonucleic acid--DNA | Klinisk medicin | Medicin och hälsovetenskap | Cancer och onkologi
VARIANTS | PREDISPOSITION | MEN | GENETICS & HEREDITY | MUTATIONS | HOXB13 | GENOME-WIDE ASSOCIATION | Prostatic Neoplasms - pathology | Genetic Predisposition to Disease | Genome-Wide Association Study | Meta-Analysis as Topic | Oligonucleotide Array Sequence Analysis | Humans | Risk Factors | Genetic Loci - genetics | Prostatic Neoplasms - etiology | Cooperative Behavior | Genotype | Male | Case-Control Studies | Polymorphism, Single Nucleotide - genetics | Quantitative trait loci | Genetic susceptibility | Genetic aspects | Research | Prostate cancer | Identification and classification | Risk factors | Studies | Confidence intervals | Genotype & phenotype | Genealogy | Quality control | Cell cycle | Genomes | DNA repair | Deoxyribonucleic acid--DNA | Klinisk medicin | Medicin och hälsovetenskap | Cancer och onkologi
Journal Article
Cancer Epidemiology Biomarkers and Prevention, ISSN 1055-9965, 01/2017, Volume 26, Issue 1, pp. 126 - 135
Background: Common cancers develop through a multistep process often including inherited susceptibility. Collaboration among multiple institutions, and funding...
BREAST-CANCER | LUNG | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | VARIANTS | RARE | ONCOLOGY | ENVIRONMENT INTERACTIONS | PROSTATE-CANCER | SUSCEPTIBILITY LOCI | RISK | MENDELIAN RANDOMIZATION | GENOME-WIDE ASSOCIATION | Causation | Health risks | Principal components analysis | Genomes | Pharmacology | Mapping | Single-nucleotide polymorphism | Environmental impact | Loci | Ethnic factors | Impact analysis | Ecological risk assessment | Consortia | Genetic variance | Genotyping | Etiology | Risk assessment | Quality control | Tagging | Biomarkers | Gene mapping | Cancer | Ancestry | Epistasis | Genetic Susceptibility | Genetic Epidemiology
BREAST-CANCER | LUNG | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | VARIANTS | RARE | ONCOLOGY | ENVIRONMENT INTERACTIONS | PROSTATE-CANCER | SUSCEPTIBILITY LOCI | RISK | MENDELIAN RANDOMIZATION | GENOME-WIDE ASSOCIATION | Causation | Health risks | Principal components analysis | Genomes | Pharmacology | Mapping | Single-nucleotide polymorphism | Environmental impact | Loci | Ethnic factors | Impact analysis | Ecological risk assessment | Consortia | Genetic variance | Genotyping | Etiology | Risk assessment | Quality control | Tagging | Biomarkers | Gene mapping | Cancer | Ancestry | Epistasis | Genetic Susceptibility | Genetic Epidemiology
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 17778 - 9
The HOXB13 G84E variant is associated with risk of prostate cancer (PCa), however the role this variant plays in PCa development is unknown. This study...
Genetic Predisposition to Disease - genetics | Gene Expression - genetics | Humans | Risk Factors | Tasmania | Formaldehyde - pharmacology | Genotype | Male | DNA Methylation - genetics | Case-Control Studies | Homeodomain Proteins - genetics | Paraffin Embedding - methods | Prostatic Neoplasms - genetics | Alleles | Heterozygote | Genetic Variation - genetics | Transcription, Genetic - genetics | Cohort Studies | Immunohistochemistry | Proteins | Transcription | DNA methylation | Protein expression | Paraffin | Prostate | Prostate cancer | CpG islands | Tumors | Hoxb13 gene
Genetic Predisposition to Disease - genetics | Gene Expression - genetics | Humans | Risk Factors | Tasmania | Formaldehyde - pharmacology | Genotype | Male | DNA Methylation - genetics | Case-Control Studies | Homeodomain Proteins - genetics | Paraffin Embedding - methods | Prostatic Neoplasms - genetics | Alleles | Heterozygote | Genetic Variation - genetics | Transcription, Genetic - genetics | Cohort Studies | Immunohistochemistry | Proteins | Transcription | DNA methylation | Protein expression | Paraffin | Prostate | Prostate cancer | CpG islands | Tumors | Hoxb13 gene
Journal Article
Nature Genetics, ISSN 1061-4036, 01/2019, Volume 51, Issue 1, pp. 76 - 87
To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed...
Genetics | Journal Article | COLON-CANCER | ORGAN SIZE | METAANALYSIS | LYSOPHOSPHATIDIC ACID | GENETICS & HEREDITY | SUSCEPTIBILITY LOCI | QUALITY-CONTROL | MUTATIONS | EXPRESSION | GENOME-WIDE ASSOCIATION | IDENTIFIES 6 | Genetic Predisposition to Disease - genetics | Colorectal Neoplasms - genetics | Humans | Middle Aged | Risk Factors | Genotype | Male | RNA, Long Noncoding - genetics | Signal Transduction - genetics | Case-Control Studies | Polymorphism, Single Nucleotide - genetics | Female | Aged | Genome-Wide Association Study - methods | Genetic aspects | Research | Genetic variation | Risk factors | Colorectal cancer | Haplotypes | Immune response | Nucleotide sequence | Colorectal carcinoma | Health risks | Risk | Systematic review | Genomes | Drug development | Gene expression | Epidemiology | Gene sequencing | Meta-analysis | Consortia | Yes-associated protein | Studies | Signaling | Hedgehog protein | Gastroenterology | Heritability | Mutation | Cancer | Life Sciences | Santé publique et épidémiologie | Basic Medicine | Medical Genetics | Medicinsk genetik | Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Cancer and Oncology | Klinisk medicin | Cancer och onkologi
Genetics | Journal Article | COLON-CANCER | ORGAN SIZE | METAANALYSIS | LYSOPHOSPHATIDIC ACID | GENETICS & HEREDITY | SUSCEPTIBILITY LOCI | QUALITY-CONTROL | MUTATIONS | EXPRESSION | GENOME-WIDE ASSOCIATION | IDENTIFIES 6 | Genetic Predisposition to Disease - genetics | Colorectal Neoplasms - genetics | Humans | Middle Aged | Risk Factors | Genotype | Male | RNA, Long Noncoding - genetics | Signal Transduction - genetics | Case-Control Studies | Polymorphism, Single Nucleotide - genetics | Female | Aged | Genome-Wide Association Study - methods | Genetic aspects | Research | Genetic variation | Risk factors | Colorectal cancer | Haplotypes | Immune response | Nucleotide sequence | Colorectal carcinoma | Health risks | Risk | Systematic review | Genomes | Drug development | Gene expression | Epidemiology | Gene sequencing | Meta-analysis | Consortia | Yes-associated protein | Studies | Signaling | Hedgehog protein | Gastroenterology | Heritability | Mutation | Cancer | Life Sciences | Santé publique et épidémiologie | Basic Medicine | Medical Genetics | Medicinsk genetik | Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Cancer and Oncology | Klinisk medicin | Cancer och onkologi
Journal Article
BMC Cancer, ISSN 1471-2407, 08/2008, Volume 8, Issue 1, pp. 230 - 230
Background: The presence of the TMPRSS2-ERG fusion gene in prostate tumors has recently been associated with an aggressive phenotype, as well as recurrence and...
HETEROGENEITY | OVEREXPRESSION | TRANSCRIPTS | ONCOLOGY | FREQUENCY | IN-SITU HYBRIDIZATION | FISH | RISK | REARRANGEMENTS | EXPRESSION | Prostatic Neoplasms - metabolism | Prostatic Neoplasms - pathology | Humans | Middle Aged | Genotype | In Situ Hybridization, Fluorescence | Male | Treatment Outcome | Oncogene Proteins, Fusion - physiology | Microarray Analysis | Oncogene Fusion | Oncogene Proteins, Fusion - genetics | Aged, 80 and over | Adult | Prostatectomy | Aged | Polymorphism, Single Nucleotide | Physiological aspects | Genetic aspects | Research | Diagnosis | Prostate cancer | Gene fusion
HETEROGENEITY | OVEREXPRESSION | TRANSCRIPTS | ONCOLOGY | FREQUENCY | IN-SITU HYBRIDIZATION | FISH | RISK | REARRANGEMENTS | EXPRESSION | Prostatic Neoplasms - metabolism | Prostatic Neoplasms - pathology | Humans | Middle Aged | Genotype | In Situ Hybridization, Fluorescence | Male | Treatment Outcome | Oncogene Proteins, Fusion - physiology | Microarray Analysis | Oncogene Fusion | Oncogene Proteins, Fusion - genetics | Aged, 80 and over | Adult | Prostatectomy | Aged | Polymorphism, Single Nucleotide | Physiological aspects | Genetic aspects | Research | Diagnosis | Prostate cancer | Gene fusion
Journal Article
Nature Genetics, ISSN 1061-4036, 01/2009, Volume 41, Issue 10, pp. 1116 - 21
Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously...
RISK | AUSTRALIAN CASE-CONTROL | VARIANTS | MULTIPLE | GENETICS & HEREDITY | ANTIGEN | Genome-Wide Association Study | Disease Susceptibility | Prostatic Neoplasms - genetics | Humans | Genotype | Male | Chromosomes, Human | Polymorphism, Single Nucleotide | Genome, Human | Disease susceptibility | Genetic aspects | Research | Diagnosis | Single nucleotide polymorphisms | Health aspects | Prostate cancer | Risk factors | Studies | Medical research | Inflation | Regression analysis | Chromosomes
RISK | AUSTRALIAN CASE-CONTROL | VARIANTS | MULTIPLE | GENETICS & HEREDITY | ANTIGEN | Genome-Wide Association Study | Disease Susceptibility | Prostatic Neoplasms - genetics | Humans | Genotype | Male | Chromosomes, Human | Polymorphism, Single Nucleotide | Genome, Human | Disease susceptibility | Genetic aspects | Research | Diagnosis | Single nucleotide polymorphisms | Health aspects | Prostate cancer | Risk factors | Studies | Medical research | Inflation | Regression analysis | Chromosomes
Journal Article
Nature Genetics, ISSN 1061-4036, 07/2018, Volume 50, Issue 7, pp. 928 - 936
Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We...
CONSORTIUM | METAANALYSIS | GENE | VARIANTS | PATHWAY | GENETICS & HEREDITY | RISK | MULTIPLE LOCI | IDENTIFICATION | GENOME-WIDE ASSOCIATION | PREDICTION | Genetic Predisposition to Disease | Prostatic Neoplasms - genetics | Humans | Genotype | Male | Risk | Polymorphism, Single Nucleotide | Genetic Loci | Genome-Wide Association Study - methods | Case-Control Studies | Case studies | Genome-wide association studies | Usage | Men | Genetic aspects | Health aspects | Prostate cancer | Risk factors | Genealogy | Data processing | Genomes | Mapping | Biology | Family medical history | Loci | Meta-analysis | Confidence intervals | Consortia | Signal transduction | Software | Gene mapping | Health risk assessment | Prostate | Genotypes | Cancer | Basic Medicine | Medical Genetics | Medicinsk genetik | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
CONSORTIUM | METAANALYSIS | GENE | VARIANTS | PATHWAY | GENETICS & HEREDITY | RISK | MULTIPLE LOCI | IDENTIFICATION | GENOME-WIDE ASSOCIATION | PREDICTION | Genetic Predisposition to Disease | Prostatic Neoplasms - genetics | Humans | Genotype | Male | Risk | Polymorphism, Single Nucleotide | Genetic Loci | Genome-Wide Association Study - methods | Case-Control Studies | Case studies | Genome-wide association studies | Usage | Men | Genetic aspects | Health aspects | Prostate cancer | Risk factors | Genealogy | Data processing | Genomes | Mapping | Biology | Family medical history | Loci | Meta-analysis | Confidence intervals | Consortia | Signal transduction | Software | Gene mapping | Health risk assessment | Prostate | Genotypes | Cancer | Basic Medicine | Medical Genetics | Medicinsk genetik | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
Journal Article