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Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 5286 - 13
Protein networks in all organisms comprise homologous interacting pairs. In these networks, some proteins are specific, interacting with one or a few binding... 
KINASE PATHWAYS | COLICIN E9 | BINDING-SPECIFICITY | DUAL RECOGNITION | STRUCTURAL BASIS | MULTIDISCIPLINARY SCIENCES | IMMUNITY PROTEINS | ENERGETIC BASIS | HIGH-AFFINITY | HYDROGEN-BOND NETWORK | STRUCTURE PREDICTION | Design | Proteins | Algorithms | Cellular communication | Switching theory | Homology | Affinity | Crystallography | Binding sites
Journal Article
Annual Review of Biochemistry, ISSN 0066-4154, 01/2018, Volume 87, p. 105
Proteins are increasingly used in basic and applied biomedical research. Many proteins, however, are only marginally stable and can be expressed in limited... 
Biomedical research | Stability analysis | Vaccines | Phylogeny | Thermal stability | Molecular chains | Proteins | Design | Thermodynamics | Design engineering | Thermal resistance | Computation | Computer applications | Phylogenetics | Bioinformatics
Journal Article
Protein Science, ISSN 0961-8368, 04/2017, Volume 26, Issue 4, pp. 807 - 813
Journal Article
Science, ISSN 0036-8075, 05/2016, Volume 352, Issue 6286, pp. 657 - 658
Journal Article
PLOS COMPUTATIONAL BIOLOGY, ISSN 1553-7358, 08/2019, Volume 15, Issue 8, p. e1007207
Antibodies developed for research and clinical applications may exhibit suboptimal stability, expressibility, or affinity. Existing optimization strategies... 
HETEROGENEITY | DEVELOPABILITY ASSESSMENT | MECHANISM | COMPUTATIONAL DESIGN | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | GENERATION | OPTIMIZATION | MATURATION | PROTEINS | DOMAINS | AGGREGATION | Protein Engineering - statistics & numerical data | Immunoglobulin Fragments - chemistry | Oxidoreductases Acting on Sulfur Group Donors - antagonists & inhibitors | Protein Engineering - methods | Humans | Immunoglobulin Variable Region - chemistry | Immunoglobulin Heavy Chains - chemistry | Peptide Library | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Immunoglobulin Light Chains - chemistry | Immunoglobulin Light Chains - genetics | Drug Design | HEK293 Cells | Protein Stability | Mutagenesis, Site-Directed | Computational Biology | Models, Molecular | Antibody Affinity - genetics | Vascular Endothelial Growth Factor A - immunology | Animals | Oxidoreductases Acting on Sulfur Group Donors - immunology | Immunoglobulin Fragments - genetics | Immunoglobulin Variable Region - genetics | Software | Mutation | Immunoglobulin Heavy Chains - genetics | Viral antibodies | Technology application | Usage | Drug stability | Chemical affinity | Analysis | Antibodies | Properties | Internet server software | Identification and classification | Mathematical optimization | Methods | Yeasts | Yeast | Funding | Chains | Biology | Optimization | Design | Proteins | Servers (computers) | Vascular endothelial growth factor | Supervision | Lysozyme | Antigens | Immunoglobulins | Automation | Therapeutic applications | Cloning | Immunological tolerance | Interfaces | Interface stability | Computer applications | Proteomics | Affinity | Scientific imaging | Internet | Mass spectrometry | Binding sites
Journal Article
Protein Science, ISSN 0961-8368, 07/2016, Volume 25, Issue 7, pp. 1179 - 1187
Journal Article
Analytical Chemistry, ISSN 0003-2700, 09/2018, Volume 90, Issue 17, p. 10090
A powerful method to determine the energetic coupling between amino acids is double mutant cycle analysis. In this method, two residues are mutated separately... 
Proteins | Residues | Lysates | E coli | Hydrogen bonds | Protein purification | Amino acids | Mass spectroscopy | Mutation | Mass spectrometry
Journal Article
Science (New York, N.Y.), ISSN 0036-8075, 5/2016, Volume 352, Issue 6286, pp. 657 - 658
Journal Article
Proteins: Structure, Function, and Bioinformatics, ISSN 0887-3585, 01/2017, Volume 85, Issue 1, pp. 30 - 38
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2017, Volume 114, Issue 41, p. 10900
Natural proteins must both fold into a stable conformation and exert their molecular function. To date, computational design has successfully produced stable... 
Binding | Immunoglobulins | Complementarity | Antibodies | Crystallography | Proteins | Design | Immunology | Computation | Computer applications | Catalysis | Mutation | Conformation
Journal Article
Cell, ISSN 0092-8674, 04/2012, Volume 149, Issue 2, pp. 262 - 273
Journal Article
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 01/2014, Volume 111, Issue 2, pp. 675 - 675
Computational design provides the opportunity to program protein-protein interactions for desired applications. We used de novo protein interface design to... 
Journal Article
Current Opinion in Structural Biology, ISSN 0959-440X, 08/2015, Volume 33, pp. v - vi
Journal Article
Biophysical Journal, ISSN 0006-3495, 01/2012, Volume 102, Issue 3, pp. 189a - 189a
Journal Article
Bioinformatics (Oxford, England), ISSN 1367-4803, 05/2019, Volume 35, Issue 9, pp. 1591 - 1593
Methods for antibody structure prediction rely on sequence homology to experimentally determined structures. Resulting models may be accurate but are often... 
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2017, Volume 114, Issue 5, p. 998
  Many promising vaccine candidates from pathogenic viruses, bacteria, and parasites are unstable and cannot be produced cheaply for clinical use. For... 
Proteins | Antigens | Malaria | Phylogenetics | Vaccines | Optimization
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2014, Volume 111, Issue 2, p. 675
  Computational design provides the opportunity to program protein-protein interactions for desired applications. We used de novo protein interface design to... 
Proteins | Sensitivity | Binding sites
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