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1. Full Text Novel antibody-antibiotic conjugate eliminates intracellular S. aureus
by Lehar, Sophie M and Pillow, Thomas and Xu, Min and Staben, Leanna and Kajihara, Kimberly K and Vandlen, Richard and DePalatis, Laura and Raab, Helga and Hazenbos, Wouter L and Hiroshi Morisaki, J and Kim, Janice and Park, Summer and Darwish, Martine and Lee, Byoung-Chul and Hernandez, Hilda and Loyet, Kelly M and Lupardus, Patrick and Fong, Rina and Yan, Donghong and Chalouni, Cecile and Luis, Elizabeth and Khalfin, Yana and Plise, Emile and Cheong, Jonathan and Lyssikatos, Joseph P and Strandh, Magnus and Koefoed, Klaus and Andersen, Peter S and Flygare, John A and Wah Tan, Man and Brown, Eric J and Mariathasan, Sanjeev and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Nature, ISSN 0028-0836, 11/2015, Volume 527, Issue 7578, pp. 323 - 328
Staphylococcus aureus is considered to be an extracellular pathogen. However, survival of S. aureus within host cells may provide a reservoir relatively... 
INFECTIONS | INTERNALIZATION | PHAGOCYTOSIS | BACTEREMIA | MULTIDISCIPLINARY SCIENCES | GRANULOCYTES | PERSISTERS | STAPHYLOCOCCUS-AUREUS | MODEL | ENDOCARDITIS | REPERTOIRES | Phagosomes - microbiology | Staphylococcal Infections - pathology | Carrier State - microbiology | Bacteremia - microbiology | Microbial Sensitivity Tests | Anti-Bacterial Agents - therapeutic use | Methicillin-Resistant Staphylococcus aureus - pathogenicity | Immunoconjugates - pharmacology | Vancomycin - pharmacology | Drug Design | Immunoconjugates - therapeutic use | Female | Staphylococcal Infections - microbiology | Phagosomes - drug effects | Staphylococcal Infections - drug therapy | Intracellular Space - drug effects | Methicillin-Resistant Staphylococcus aureus - drug effects | Phagosomes - metabolism | Bacteremia - drug therapy | Immunoconjugates - chemistry | Staphylococcus aureus - pathogenicity | Animals | Intracellular Space - microbiology | Vancomycin - therapeutic use | Carrier State - drug therapy | Anti-Bacterial Agents - pharmacology | Mice | Staphylococcus aureus - drug effects | Pathogens | Bacteria | Staphylococcus infections | Antibiotics | Bacteriology
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2. Full Text A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action
by Chai, Ning and Swem, Lee R and Park, Summer and Nakamura, Gerald and Chiang, Nancy and Estevez, Alberto and Fong, Rina and Kamen, Lynn and Kho, Elviza and Reichelt, Mike and Lin, Zhonghua and Chiu, Henry and Skippington, Elizabeth and Modrusan, Zora and Stinson, Jeremy and Xu, Min and Lupardus, Patrick and Ciferri, Claudio and Tan, Man-Wah
Nature Communications, ISSN 2041-1723, 01/2017, Volume 8, Issue 1, p. 14234
Influenza B virus (IBV) causes annual influenza epidemics around the world. Here we use an in vivo plasmablast enrichment technique to isolate a human... 
CELLS | FUSION | HEMAGGLUTININ | STRUCTURAL BASIS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | ELECTRON-MICROSCOPY | CONSERVED NEUTRALIZING EPITOPE | MONOCLONAL-ANTIBODY | PLASMABLAST ENRICHMENT | OSELTAMIVIR | Orthomyxoviridae Infections - therapy | Humans | Immunoglobulin G - therapeutic use | Models, Molecular | Antibodies, Monoclonal - therapeutic use | Epitopes | Influenza B virus | Oseltamivir | Antibodies, Neutralizing - immunology | Animals | Immunoglobulin G - immunology | Antibodies, Neutralizing - therapeutic use | Hemagglutinins | Protein Conformation | Mice | Orthomyxoviridae Infections - virology | Hydrogen-Ion Concentration
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3. Full Text Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability
by Lauffer, Benjamin E.L and Mintzer, Robert and Fong, Rina and Mukund, Susmith and Tam, Christine and Zilberleyb, Inna and Flicke, Birgit and Ritscher, Allegra and Fedorowicz, Grazyna and Vallero, Roxanne and Ortwine, Daniel F and Gunzner, Janet and Modrusan, Zora and Neumann, Lars and Koth, Christopher M and Kaminker, Joshua S and Heise, Christopher E and Steiner, Pascal and SLAC National Accelerator Lab., Menlo Park, CA (United States)
Journal of Biological Chemistry, ISSN 0021-9258, 09/2013, Volume 288, Issue 37, pp. 26926 - 26943
Histone deacetylases (HDACs) are critical in the control of gene expression, and dysregulation of their activity has been implicated in a broad range of... 
APOPTOSIS | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ISOFORM SELECTIVITY | PATTERNS | GENERATION | LEUKEMIA | INDUCTION | EXPRESSION | CANCER | MOLECULAR-MECHANISMS | Binding, Competitive | Cell Survival - drug effects | Oligonucleotide Array Sequence Analysis | Histones - chemistry | Pyridines - chemistry | Humans | Gene Expression Regulation, Neoplastic | Hydroxamic Acids - chemistry | Histone Deacetylase Inhibitors - chemistry | Gene Expression Regulation, Enzymologic | Vorinostat | Cell Line, Tumor | Inhibitory Concentration 50 | Protein Binding | Transcription, Genetic | Acetylation | Kinetics | Benzamides - chemistry | BIO | Gene Expression | Cell Cycle | Histone Modification | Cell Death | Binding Kinetics | Histone Deacetylase Inhibitors | Crystallography | Cell Biology | Histone Deacetylase
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4. Full Text Corrigendum: A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action
by Chai, Ning and Swem, Lee R and Park, Summer and Nakamura, Gerald and Chiang, Nancy and Estevez, Alberto and Fong, Rina and Kamen, Lynn and Kho, Elviza and Reichelt, Mike and Lin, Zhonghua and Chiu, Henry and Skippington, Elizabeth and Modrusan, Zora and Stinson, Jeremy and Xu, Min and Lupardus, Patrick and Ciferri, Claudio and Tan, Man-Wah
Nature communications, 05/2017, Volume 8, p. 15779
This corrects the article DOI: 10.1038/ncomms14234. 
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5. Full Text Eligibility, Enrollment, and Completion of Exercise-Based Cardiac Rehabilitation Following Stroke Rehabilitation: What Are the Barriers?
by Marzolini, Susan and Fong, Karen and Jagroop, David and Neirinckx, Jennifer and Liu, Jean and Reyes, Rina and Grace, Sherry L and Oh, Paul and Colella, Tracey J F
Physical Therapy, ISSN 0031-9023, 10/2019
Abstract Background People after stroke benefit from comprehensive programs for the prevention of secondary effects, including cardiac rehabilitation (CR), yet... 
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6. Full Text Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial
by Al-Shahi Salman, Rustam and Minks, David P and Minks, David and Mitra, Dipayan and Rodrigues, Mark A and Bhatnagar, Priya and du Plessis, Johannes and du Plessis, Johann C and Joshi, Yogish and Dennis, Martin S and Dennis, Martin and Murray, Gordon D and Newby, David E and Sandercock, Peter A G and Sprigg, Nikola and Stephen, Jacqueline and Sudlow, Cathie and Sudlow, Cathie L M and Werring, David and Werring, David J and Whiteley, William N and Whiteley, William and Wardlaw, Joanna M and White, Julie and White, Philip M and White, James and White, Susan and Baigent, Colin and Lasserson, Daniel and Sullivan, Frank and Carrie, Johanna and Rojas, Javier and Amoils, Shannon and Bamford, John and Armitage, Jane and Rinkel, Gabriel and Lowe, Gordon and Emberson, Jonathan and Innes, Karen and Dinsmore, Lynn and Drever, Jonathan and Williams, Rebecca and Williams, Carol and Perry, David and Perry, Jack and McGill, Connor and Buchanan, David and Walker, Susannah and Walker, Marion and Walker, Pauli and Walker, Allan and Hutchison, Aidan and Matthews, Christopher and Fraser, Ruth and McGrath, Aileen and Deary, Ann and Anderson, Rosemary and Hansen, Christian and Parker, Richard and Rodriguez, Aryelly and Macleod, Malcolm and Gattringer, Thomas and Palmer, Jeb and Sakka, Eleni and Adil-Smith, Jennifer and Lerpiniere, Christine and O'Brien, Eoin and O'Brien, Richard and Burgess, Seona and Burgess, Laura and Mead, Denise and Mead, Gillian and Paulton, Ruth and Doubal, Fergus and McCormick, Katrina and Hunter, Neil and Hunter, Annemarie and Taylor, Vicky and Taylor, Pat and Parakramawansha, Ruwan and Blair, Caroline and Blair, Gordon and MacRaild, Allan and Parry-Jones, Adrian and Johnes, Mary and Lee, Stephanie and Shaw, Louise and Shaw, Kelly Marie and Burger, Ilse and Punter, Martin and Ingham, Andrea and Perez, Jane and Naing, Zin and Morell, Jordi and Marsden, Tracy and Hall, Andrea and Marshall, Sally and Harrison, Thomas and Harrison, Melanie and Harrison, Louise and ... and RESTART Collaboration
The Lancet Neurology, ISSN 1474-4422, 07/2019, Volume 18, Issue 7, pp. 643 - 652
Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared... 
MICROBLEEDS | SUPERFICIAL SIDEROSIS | SIGNS | AMYLOID ANGIOPATHY | ACUTE ISCHEMIC-STROKE | ANTITHROMBOTIC THERAPY | ASPIRIN | CLINICAL NEUROLOGY | Atrophy | Neuroimaging | Anticoagulants | Stroke | Aspirin | Statistical analysis | Medical imaging | Magnetic resonance imaging | Computed tomography | Biomarkers | Hemorrhage
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7. Full Text An In Vivo Human-Plasmablast Enrichment Technique Allows Rapid Identification of Therapeutic Influenza A Antibodies
by Nakamura, Gerald and Chai, Ning and Park, Summer and Chiang, Nancy and Lin, Zhonghua and Chiu, Henry and Fong, Rina and Yan, Donghong and Kim, Janice and Zhang, Juan and Lee, Wyne P and Estevez, Alberto and Coons, Mary and Xu, Min and Lupardus, Patrick and Balazs, Mercedesz and Swem, Lee R
Cell Host & Microbe, ISSN 1931-3128, 07/2013, Volume 14, Issue 1, pp. 93 - 103
Recent advances enabling the cloning of human immunoglobulin G genes have proven effective for discovering monoclonal antibodies with therapeutic potential.... 
MORTALITY | POTENT | VIRUS | VIROLOGY | EFFICACY | HIV | SAFETY | MICROBIOLOGY | MONOCLONAL-ANTIBODIES | NEUTRALIZING EPITOPE | PARASITOLOGY | OSELTAMIVIR | Antibodies, Viral - therapeutic use | Humans | Immunoglobulin G - chemistry | Immunoglobulin G - therapeutic use | Male | Ferrets | Animals | Immunoglobulin G - genetics | Immunoglobulin G - immunology | Influenza, Human - genetics | Antibodies, Viral - chemistry | Antibodies, Viral - immunology | Female | Influenza A virus - immunology | Influenza, Human - virology | Mice, Inbred DBA | Mice | Influenza, Human - drug therapy | Influenza A virus - drug effects | Neutralization Tests - methods | Antibodies, Viral - genetics | Influenza, Human - immunology | Plasma Cells - immunology | Monoclonal antibodies | Health aspects | Influenza | Immunoglobulin G | Vaccination | Methods
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8. Full Text Characteristics of Internet Gamblers Among a Sample of Students at a Large, Public University in Southwestern United States
by Shead, N. Will and Derevensky, Jeffrey L and Fong, Timothy W and Gupta, Rina
Journal of College Student Development, ISSN 0897-5264, 2012, Volume 53, Issue 1, pp. 133 - 148
There is a current lack of descriptive information on college students who gamble on the Internet. With the increasing popularity of Internet gambling, this... 
Internet gambling | Los Angeles | College students | California | Conduct of life | EDUCATION & EDUCATIONAL RESEARCH | GAMBLING BEHAVIOR | PSYCHOLOGY, APPLIED | Body Composition | Drug Abuse | Student Characteristics | Addictive Behavior | Drinking | At Risk Persons | Student Behavior | Gender Differences | Comparative Analysis | College Students | Behavior Problems | Internet | Smoking | Psychological aspects | Research | Behavior | Addiction | Online gambling | Drugs | Poker | University students | Online advertising | Males | Tournaments & championships | College campuses | Personal computers
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9. Full Text RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases
by Patel, Snahel and Webster, Joshua D and Varfolomeev, Eugene and Kwon, Youngsu C and Cheng, Jason H and Zhang, Juan and Dugger, Debra L and Wickliffe, Kate E and Maltzman, Allie and Sujatha-Bhaskar, Swathi and Bir Kohli, Pawan and Ramaswamy, Sreema and Deshmukh, Gauri and Liederer, Bianca M and Fong, Rina and Hamilton, Greg and Lupardus, Patrick and Caplazi, Patrick and Lee, Wyne P and van Lookeren Campagne, Menno and Johnson, Adam and McKenzie, Brent S and Junttila, Melissa R and Newton, Kim and Vucic, Domagoj
Cell Death and Differentiation, ISSN 1350-9047, 2019
The kinase RIP1 acts in multiple signaling pathways to regulate inflammatory responses and it can trigger both apoptosis and necroptosis. Its kinase activity... 
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10. Full Text Discovery of (R,E)‑N‑(7-Chloro-1-(1-[4-(dimethylamino)­but-2-enoyl]azepan-3-yl)‑1H‑benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Cell Lung Cancers
by Lelais, Gérald and Epple, Robert and Marsilje, Thomas H and Long, Yun O and McNeill, Matthew and Chen, Bei and Lu, Wenshuo and Anumolu, Jaganmohan and Badiger, Sangamesh and Bursulaya, Badry and DiDonato, Michael and Fong, Rina and Juarez, Jose and Li, Jie and Manuia, Mari and Mason, Daniel E and Gordon, Perry and Groessl, Todd and Johnson, Kevin and Jia, Yong and Kasibhatla, Shailaja and Li, Chun and Isbell, John and Spraggon, Glen and Bender, Steven and Michellys, Pierre-Yves
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2016, Volume 59, Issue 14, pp. 6671 - 6689
Over the past decade, first and second generation EGFR inhibitors have significantly improved outcomes for lung cancer patients with activating mutations in... 
GROWTH-FACTOR RECEPTOR | IRREVERSIBLE INHIBITORS | IN-VITRO | GEFITINIB | CHEMISTRY, MEDICINAL | METHIONINE MUTANT | BIOLOGICAL EVALUATION | TYROSINE KINASE INHIBITOR | DRUG-RESISTANCE | MUTATIONS | THREONINE | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Rats, Wistar | Antineoplastic Agents - chemical synthesis | Humans | Molecular Conformation | Crystallography, X-Ray | Lung Neoplasms - pathology | Male | Structure-Activity Relationship | Benzimidazoles - chemistry | Nicotine - pharmacology | Dose-Response Relationship, Drug | Neoplasms, Experimental - pathology | Protein Kinase Inhibitors - chemistry | Receptor, Epidermal Growth Factor - metabolism | Antineoplastic Agents - pharmacology | Carcinoma, Non-Small-Cell Lung - pathology | Protein Kinase Inhibitors - chemical synthesis | Lung Neoplasms - enzymology | Benzimidazoles - chemical synthesis | Models, Molecular | Rats | Antineoplastic Agents - chemistry | Drug Discovery | Animals | Nicotine - chemical synthesis | Mice, Nude | Nicotine - analogs & derivatives | Nicotine - chemistry | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Benzimidazoles - pharmacology | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Protein Kinase Inhibitors - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | Mutation | Neoplasms, Experimental - drug therapy | Drug Screening Assays, Antitumor | Index Medicus
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11. Full Text Erratum: Corrigendum: A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action
by Chai, Ning and Swem, Lee R and Park, Summer and Nakamura, Gerald and Chiang, Nancy and Estevez, Alberto and Fong, Rina and Kamen, Lynn and Kho, Elviza and Reichelt, Mike and Lin, Zhonghua and Chiu, Henry and Skippington, Elizabeth and Modrusan, Zora and Stinson, Jeremy and Xu, Min and Lupardus, Patrick and Ciferri, Claudio and Tan, Man-Wah
Nature Communications, ISSN 2041-1723, 08/2017, Volume 8, Issue 1
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12. Full Text Potent and selective inhibitors of receptor-interacting protein kinase 1 that lack an aromatic back pocket group
by Hamilton, Gregory L and Chen, Huifen and Deshmukh, Gauri and Eigenbrot, Charles and Fong, Rina and Johnson, Adam and Kohli, Pawan Bir and Lupardus, Patrick J and Liederer, Bianca M and Ramaswamy, Sreemathy and Wang, Haowei and Wang, Jian and Xu, Zhaowu and Zhu, Yunliang and Vucic, Domagoj and Patel, Snahel
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2019, Volume 29, Issue 12, pp. 1497 - 1501
Receptor-interacting protein kinase 1 (RIPK1), a key component of the cellular necroptosis pathway, has gained recognition as an important therapeutic target.... 
Metabolic stability | Pentafluoroethyl | RIPK1 | Necroptosis | RIPK1 inhibitor | RIP KINASES | HOMEOSTASIS | CHEMISTRY, MEDICINAL | INFLAMMATION | CHEMISTRY, ORGANIC | HIGHLY POTENT | DISCOVERY | International trade | Protein kinases | Analysis
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13. Full Text Structural investigation of human S. aureus-targeting antibodies that bind wall teichoic acid
by Fong, Rina and Kajihara, Kimberly and Chen, Matthew and Hotzel, Isidro and Mariathasan, Sanjeev and Hazenbos, Wouter L.W and Lupardus, Patrick J and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
mAbs, ISSN 1942-0862, 10/2018, Volume 10, Issue 7, pp. 979 - 991
Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are a growing health threat worldwide. Efforts to identify novel antibodies that target... 
antibody-carbohydrate interactions | WTA | antibody structure | Staphylococcus aureus | Wall Teichoic Acid | monoclonal antibodies | MEDICINE, RESEARCH & EXPERIMENTAL | RECOGNITION | VACCINE | REPERTOIRES | DLT OPERON | BIOSYNTHESIS | LINKAGES | STAPHYLOCOCCUS-AUREUS | MONOCLONAL-ANTIBODIES | PROGRAM | Methicillin-Resistant Staphylococcus aureus - physiology | Anti-Bacterial Agents - blood | Antibodies, Bacterial - chemistry | Staphylococcal Infections - immunology | Humans | Transgenes - genetics | Structure-Activity Relationship | Cell Wall - chemistry | Teichoic Acids - chemistry | Staphylococcal Infections - therapy | Crystallography, X-Ray - methods | Immunity, Humoral | Complementarity Determining Regions - chemistry | Anti-Bacterial Agents - chemistry | Cell Wall - metabolism | Teichoic Acids - metabolism | Protein Binding | Antigen-Antibody Complex - genetics | Protein Conformation | Antigen-Antibody Complex - metabolism | Antibodies, Bacterial - blood
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