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Journal Article
Cell and tissue research, ISSN 0302-766X, 09/2019, pp. 1 - 16
Considering high drug attrition rates in clinical studies and the overall complexity and challenging environment of drug development, it is increasingly... 
Pharmacodynamics | Animal models | Genetic engineering | Biology | Drug development | Pharmacokinetics | Index Medicus
Journal Article
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 10/2014, Volume 111, Issue 40, pp. E4214 - E4223
How malignant gliomas arise in a mature brain remains a mystery, hindering the development of preventive and therapeutic interventions. We previously showed... 
cancer | mTOR signaling | cellular quiescence | cellular reactivation | PROGENITOR CELLS | STEM-CELLS | WHITE-MATTER | MULTIDISCIPLINARY SCIENCES | INTEGRATED GENOMIC ANALYSIS | MTOR | MOUSE MODEL | GROWTH | NG2 CELLS | GLIAL PROGENITORS | CYCLE PROGRESSION | Immunohistochemistry | Cell Cycle - genetics | Oligodendroglia - metabolism | Oligonucleotide Array Sequence Analysis | Brain Neoplasms - pathology | Gene Expression Profiling | Neural Stem Cells - cytology | Brain Neoplasms - metabolism | Tumor Suppressor Protein p53 - genetics | Glioma - metabolism | Glioma - genetics | Cell Differentiation - genetics | Cell Transformation, Neoplastic - genetics | Glioma - pathology | Antineoplastic Agents - pharmacology | Oligodendroglia - cytology | Tumor Cells, Cultured | Neurofibromin 1 - metabolism | Cell Proliferation - genetics | Sirolimus - analogs & derivatives | Tumor Suppressor Protein p53 - metabolism | Brain Neoplasms - genetics | Mice, Transgenic | Mice, SCID | Cell Transformation, Neoplastic - metabolism | Sirolimus - pharmacology | Blotting, Western | Mice, Knockout | Animals | Cell Differentiation - drug effects | Tamoxifen - pharmacology | Mice, Inbred NOD | Cell Proliferation - drug effects | Cell Cycle - drug effects | Neural Stem Cells - metabolism | Neurofibromin 1 - genetics | Biological Sciences | PNAS Plus
Journal Article
Nature Immunology, ISSN 1529-2908, 05/2017, Volume 18, Issue 6, pp. 633 - 641
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2018, Volume 13, Issue 1, p. e0190158
The prevalence of cytotoxic tumor infiltrating lymphocytes (TILs) has demonstrated prognostic value in multiple tumor types. In particular, CD8 counts (in... 
SURVIVAL | BIOMARKERS | RESPONSES | PROGNOSTIC-FACTOR | IMMUNE CELLS | NEOADJUVANT CHEMOTHERAPY | FAVORABLE PROGNOSIS | PD-1 BLOCKADE | MULTIDISCIPLINARY SCIENCES | CD8(+) T-LYMPHOCYTES | FOXP3 | T-Lymphocyte Subsets - immunology | Biopsy - methods | CD8-Positive T-Lymphocytes - pathology | Prognosis | Breast Neoplasms - immunology | Humans | Middle Aged | Tumor Microenvironment | Male | T-Lymphocytes, Cytotoxic - pathology | Histological Techniques | Computer Simulation | Aged, 80 and over | Adult | Female | Carcinoma - pathology | T-Lymphocytes, Cytotoxic - immunology | Carcinoma - immunology | Colorectal Neoplasms - immunology | T-Lymphocyte Subsets - pathology | Image Processing, Computer-Assisted | Lymphocytes, Tumor-Infiltrating - pathology | Breast Neoplasms - pathology | Lymphocyte Count | ROC Curve | Aged | CD8-Positive T-Lymphocytes - immunology | Colorectal Neoplasms - pathology | Cytotoxicity, Immunologic | Lymphocytes, Tumor-Infiltrating - immunology | Immunohistochemistry | Breast cancer | Colon cancer | B cells | T cells | CD8 antigen | Variability | Colorectal carcinoma | Colorectal cancer | Clinical trials | Cytotoxicity | Lymphocytes T | Statistical methods | Metastasis | Paraffin | Cancer therapies | Clinical outcomes | Metastases | Breast carcinoma | Lymphocytes | Bioindicators | Colon | Statistical analysis | Mortality | Melanoma | Stroma | CD3 antigen | Patients | Statistics | Variance analysis | Studies | Pathology | Chemotherapy | Biopsy | Samples | Medical prognosis | Biomarkers | Breast | Infiltration | Tumors | Cancer
Journal Article
Nature Medicine, ISSN 1078-8956, 12/2014, Volume 20, Issue 12, pp. 1452 - 1457
Journal Article