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Journal of the American Chemical Society, ISSN 0002-7863, 06/2011, Volume 133, Issue 24, pp. 9282 - 9285
Journal Article
Organic Letters, ISSN 1523-7060, 06/2008, Volume 10, Issue 11, pp. 2207 - 2210
The ortho arylation of anilides to form biphenyls via a twofold C−H functionalization/C−C bond-forming process is described. The oxidative coupling takes place... 
OXYGEN | ORGANIC-SYNTHESIS | ROOM-TEMPERATURE | ROUTE | ACTIVATION | TURNOVER | CHEMISTRY, ORGANIC | BOND FORMATION | OLEFINS | INDOLES | BIARYLS | Catalysis | Oxidation-Reduction | Hydrogen - chemistry | Palladium - chemistry | Carbon - chemistry | Anilides - chemistry
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 05/2009, Volume 131, Issue 19, pp. 6676 - 6677
An intramolecular enantioselective metal-catalyzed dearomatization reaction is described. This procedure allows the dearomatization of naphthalene derivatives... 
REARRANGEMENT | OXIDATIVE DEAROMATIZATION | PHENOLS | NATURAL-PRODUCTS | ALKYLATION | CARBON QUATERNARY STEREOCENTERS | ARENES | ENANTIOSELECTIVE CONSTRUCTION | BIRCH REDUCTION | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 10/2008, Volume 47, Issue 42, pp. 8108 - 8111
Phoxy ligand: The first catalytic method for the asymmetric palladium‐catalyzed intramolecular α‐arylation of α‐branched aldehydes was developed (see scheme).... 
P ligands | palladium | aldehydes | α‐arylation | asymmetric catalysis | α-arylation | Palladium | Aldehydes | Asymmetric catalysis | OXIDATION | alpha-arylation | KETONE | CARBENE LIGANDS | QUATERNARY STEREOCENTERS | CHEMISTRY, MULTIDISCIPLINARY | BULKY | ARYL BROMIDES | CONSTRUCTION | ALLYLIC SUBSTITUTION | aldehyde
Journal Article
Nature, ISSN 0028-0836, 07/2016, Volume 535, Issue 7610, pp. 148 - 152
The non-receptor protein tyrosine phosphatase SHP2, encoded by PTPN11, has an important role in signal transduction downstream of growth factor receptor... 
TARGET | POTENT | PTPN11 | PROTOONCOGENE | MULTIDISCIPLINARY SCIENCES | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Humans | Extracellular Signal-Regulated MAP Kinases - metabolism | Oncogene Protein p21(ras) - metabolism | Pyrimidines - chemistry | Piperidines - pharmacology | Inhibitory Concentration 50 | Female | Allosteric Regulation - drug effects | Piperidines - chemistry | Reproducibility of Results | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors | Models, Molecular | Neoplasms - enzymology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - chemistry | Pyrimidines - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Mice, Nude | Piperidines - therapeutic use | Pyrimidines - therapeutic use | Protein Stability - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Neoplasms - pathology | Protein Structure, Tertiary - drug effects | Phosphatases | Observations | Health aspects | Phosphotransferases | Protein-protein interactions | Signal transduction | Cell growth | Peptides | Kinases | Phosphatase | Drug dosages | Cancer | BASIC BIOLOGICAL SCIENCES
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 08/2005, Volume 127, Issue 32, pp. 11254 - 11255
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2006, Volume 4, Issue 10, pp. 2039 - 2049
5-Pyrrolidin-2-yltetrazole is a versatile organocatalyst for the asymmetric conjugate addition of nitroalkanes to enones. Using this catalyst, this... 
D-MANNITOL | ENONES | CHEMISTRY, ORGANIC | CARBONYL-COMPOUNDS | NITRO-OLEFINS | ENANTIOSELECTIVE MICHAEL ADDITION | PHASE-TRANSFER CATALYSTS | PROLINE | NITROMETHANE | D-GLUCOSE | AZACROWN ETHERS | Ketones - chemistry | Nitro Compounds - chemistry | Catalysis
Journal Article
Tetrahedron, ISSN 0040-4020, 04/2013, Volume 69, Issue 15, pp. 3192 - 3196
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2016, Volume 59, Issue 17, pp. 7773 - 7782
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 05/2009, Volume 131, Issue 19, p. 6676
An intramolecular enantioselective metal-catalyzed dearomatization reaction is described. This procedure allows the dearomatization of naphthalene derivatives... 
Naphthalenes - chemistry | Carbazoles - chemical synthesis | Catalysis | Stereoisomerism | Palladium - chemistry | Palladium catalysts | Substitution reactions | Naphthalene | Chemical properties | Analysis
Journal Article
Tetrahedron, ISSN 0040-4020, 2007, Volume 63, Issue 49, pp. 12131 - 12137
A convergent stereoselective synthesis of the bacterial DNA primase inhibitor Sch 642305 and its non-natural epimer at C-4 is described. A key aspect was the... 
ORGANIC-SYNTHESIS | FLUORIDE-MEDIATED REACTIONS | TANDEM | HIV-1 TAT TRANSACTIVATION | MICHAEL-ADDITION | NATURAL-PRODUCTS | BOND-FORMING REACTIONS | CHEMISTRY, ORGANIC | ESCHERICHIA-COLI PRIMASE | ENANTIOSELECTIVE TOTAL-SYNTHESIS | EFFICIENT
Journal Article
Angewandte Chemie, ISSN 0044-8249, 10/2008, Volume 120, Issue 42, pp. 8228 - 8231
Schlaue Ligandenwahl: Die erste asymmetrische palladiumkatalysierte intramolekulare α‐Arylierung von α‐verzweigten Aldehyden (siehe Schema) zeichnet sich durch... 
P‐Liganden | Palladium | Asymmetrische Katalyse | Aldehyde | α‐Arylierungen | Aldehydes - chemical synthesis | Stereoisomerism | Models, Molecular | Ligands | Molecular Structure | Catalysis | Palladium - chemistry | Aldehydes - chemistry
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2019, Volume 62, Issue 4, pp. 1781 - 1792
SHP2 is a nonreceptor protein tyrosine phosphatase within the mitogen-activated protein kinase (MAPK) pathway controlling cell growth, differentiation, and... 
CHEMISTRY, MEDICINAL | PTPN11 | TYROSINE-PHOSPHATASE SHP2
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2019, Volume 62, Issue 4, pp. 1793 - 1802
Protein tyrosine phosphatase SHP2 is an oncoprotein associated with cancer as well as a potential immune modulator because of its role in the programmed cell... 
ALLOSTERIC-INHIBITION | CHEMISTRY, MEDICINAL | PTPN11 | TYROSINE-PHOSPHATASE SHP2 | MUTATIONS | IDENTIFICATION | DISCOVERY
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 10/2004, Volume 69, Issue 21, pp. 7277 - 7283
The conjugated δ-lactone passifloricin A, a natural product with antiprotozoal activity, and seven isomers thereof have been synthesized in enantiopure form.... 
CHEMISTRY, ORGANIC | CHIRAL TITANIUM COMPLEXES | ASYMMETRIC-SYNTHESIS | ACID | ENANTIOSELECTIVE ADDITION | DELTA-LACTONES | Lactones - chemical synthesis | Oxidation-Reduction | Stereoisomerism | Mass Spectrometry | Molecular Conformation | Antiprotozoal Agents - chemical synthesis | Molecular Structure | Pyrones - chemical synthesis | Isomerism | Research
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2003, Volume 44, Issue 43, pp. 7909 - 7912
The structure reported in the literature for the pharmacologically active, natural lactone passifloricin A (δ-lactone of 2Z,5R*S*... 
lactones | asymmetric allylboration | passifloricin A | ring-closing metathesis | Asymmetric allylboration | Passifloricin A | Ring-closing metathesis | Lactones | CHEMISTRY, ORGANIC | STEREOSELECTIVE-SYNTHESIS | DELTA-LACTONES
Journal Article