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1. Full Text Antibody-dependent cellular cytotoxicity in HIV infection
by Forthal, Donald N and Finzi, Andrés
AIDS, ISSN 0269-9370, 11/2018, Volume 32, Issue 17, pp. 2439 - 2451
Interactions between the Fc segment of IgG and its receptors (FcγRs) found on cells such as natural killer cells, monocytes, macrophages and neutrophils can... 
Development and progression | Care and treatment | Cell receptors | Genetic aspects | HIV infection | Health aspects
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2. Functions of antibodies
by Forthal, Donald N
Microbiology Spectrum, 2014, Volume 2, Issue 4
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3. Full Text Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition
by Vaccari, Monica and Gordon, Shari N and Fourati, Slim and Schifanella, Luca and Liyanage, Namal P.M and Cameron, Mark and Keele, Brandon F and Shen, Xiaoying and Tomaras, Georgia D and Billings, Erik and Rao, Mangala and Chung, Amy W and Dowell, Karen G and Bailey-Kellogg, Chris and Brown, Eric P and Ackerman, Margaret E and Vargas-Inchaustegui, Diego A and Whitney, Stephen and Doster, Melvin N and Binello, Nicolo and Pegu, Poonam and Montefiori, David C and Foulds, Kathryn and Quinn, David S and Donaldson, Mitzi and Liang, Frank and Loré, Karin and Roederer, Mario and Koup, Richard A and McDermott, Adrian and Ma, Zhong-Min and Miller, Christopher J and Phan, Tran B and Forthal, Donald N and Blackburn, Matthew and Caccuri, Francesca and Bissa, Massimiliano and Ferrari, Guido and Kalyanaraman, Vaniambadi and Ferrari, Maria G and Thompson, DeVon and Robert-Guroff, Marjorie and Ratto-Kim, Silvia and Kim, Jerome H and Michael, Nelson L and Phogat, Sanjay and Barnett, Susan W and Tartaglia, Jim and Venzon, David and Stablein, Donald M and Alter, Galit and Sekaly, Rafick-Pierre and Franchini, Genoveffa
Nature Medicine, ISSN 1078-8956, 07/2016, Volume 22, Issue 7, pp. 762 - 770
A recombinant vaccine containing Aventis Pasteur's canarypox vector (ALVAC)-HIV and gp120 alum. decreased the risk of HIV acquisition in the RV144 vaccine... 
ANTIBODIES | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | PROTECTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | HIV-1 VACCINE EFFICACY | CELL BIOLOGY | TRIAL | IMMUNOGENICITY | NK CELLS | SIMIAN IMMUNODEFICIENCY VIRUS | NITRIC-OXIDE | INFECTION | Alum Compounds - therapeutic use | Immunogenicity, Vaccine | Viral Vaccines - therapeutic use | Signal Transduction | Immunity, Mucosal | Interleukin-17 - immunology | Transcriptome | Macaca mulatta | Random Allocation | ras Proteins - immunology | Simian Acquired Immunodeficiency Syndrome - prevention & control | Immunity, Innate - immunology | SAIDS Vaccines - therapeutic use | Animals | Simian Acquired Immunodeficiency Syndrome - immunology | Immunoglobulin G - immunology | Lymphocytes | Viral Envelope Proteins - immunology | Membrane Glycoproteins - immunology | Adaptive Immunity - immunology | Adjuvants, Immunologic - therapeutic use | Simian Immunodeficiency Virus - immunology | Human immunodeficiency virus--HIV | Vaccines | Immune system
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4. Functions of Antibodies
by Forthal, Donald N
Microbiology spectrum, 08/2014, Volume 2, Issue 4, p. AID
Antibodies can impact pathogens in the presence or in the absence of effector cells or effector molecules such as complement, and experiments can often sort... 
Antibodies - therapeutic use | Animals | Humans | Communicable Diseases - immunology | Antibodies - immunology | Vaccines - immunology | Vaccines - administration & dosage
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5. Full Text Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys
by Barouch, Dan H and Liu, Jinyan and Li, Hualin and Maxfield, Lori F and Abbink, Peter and Lynch, Diana M and Iampietro, M. Justin and Sanmiguel, Adam and Seaman, Michael S and Ferrari, Guido and Forthal, Donald N and Ourmanov, Ilnour and Hirsch, Vanessa M and Carville, Angela and Mansfield, Keith G and Stablein, Donald and Pau, Maria G and Schuitemaker, Hanneke and Sadoff, Jerald C and Billings, Erik A and Rao, Mangala and Robb, Merlin L and Kim, Jerome H and Marovich, Mary A and Goudsmit, Jaap and Michael, Nelson L
Nature, ISSN 0028-0836, 2012, Volume 482, Issue 7383, pp. 89 - 93
Preclinical studies of human immunodeficiency virus type 1 (HIV-1) vaccine candidates have typically shown post-infection virological control, but protection... 
ANTIBODIES | MEMORY | MULTIDISCIPLINARY SCIENCES | CELLULAR IMMUNE-RESPONSES | INFECTION | MACAQUES | LOW-DOSE CHALLENGE | VECTORS | BREADTH | Enzyme-Linked Immunosorbent Assay | AIDS Vaccines - immunology | Macaca mulatta - immunology | Male | Neutralization Tests | Antibodies, Neutralizing - immunology | HIV-1 - immunology | Animals | SAIDS Vaccines - immunology | Adenoviridae - genetics | Female | Adenoviridae - immunology | Viral Vaccines - immunology | Simian Immunodeficiency Virus - immunology | Prevention | Rhesus monkey | AIDS vaccines | Product development | Simian immunodeficiency virus | Diseases | Confidence intervals | Cytotoxicity | Immunization | Vaccines | Adenoviruses | Deoxyribonucleic acid--DNA
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6. Glycan modulation and sulfoengineering of anti-HIV-1 monoclonal antibody PG9 in plants
by Andreas Loos and Johannes S Gach and Thomas Hackl and Daniel Maresch and Theresa Henkel and Andreas Porodko and Duc Bui-Minh and Wolfgang Sommeregger and Gordana Wozniak-Knopp and Donald N Forthal and Friedrich Altmann and Herta Steinkellner and Lukas Mach
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2015, Volume 112, Issue 41, p. 12675
  Broadly neutralizing anti-HIV-1 monoclonal antibodies, such as PG9, and its derivative RSH hold great promise in AIDS therapy and prevention. An important... 
Proteins | Antigens | Monoclonal antibodies | Cytotoxicity | Cells | Binding sites
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7. Full Text Fc-glycosylation influences Fcγ receptor binding and cell-mediated anti-hivactivity of monoclonal antibody 2G12
by Forthal, Donald N and Gach, Johannes S and Landucci, Gary and Jez, Jakub and Strasser, Richard and Kunert, Renate and Steinkellner, Herta
Journal of Immunology, ISSN 0022-1767, 12/2010, Volume 185, Issue 11, pp. 6876 - 6882
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8. Full Text Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers
by Hessell, Ann J and Rakasz, Eva G and Poignard, Pascal and Hangartner, Lars and Landucci, Gary and Forthal, Donald N and Koff, Wayne C and Watkins, David I and Burton, Dennis R
PLoS Pathogens, ISSN 1553-7366, 05/2009, Volume 5, Issue 5, pp. e1000433 - e1000433
Developing an immunogen that elicits broadly neutralizing antibodies (bNAbs) is an elusive but important goal of HIV vaccine research, especially after the... 
PBL-SCID MICE | VAGINAL TRANSMISSION | DENDRITIC CELL | MACAQUE MONKEYS | HUMAN MONOCLONAL-ANTIBODY | MICROBIOLOGY | PASSIVE-IMMUNIZATION | SIMIAN IMMUNODEFICIENCY | HIV-1/SIV CHIMERIC VIRUS | VIROLOGY | DC-SIGN | IMMUNODEFICIENCY-VIRUS TYPE-1 | PARASITOLOGY | HIV Antibodies - blood | HIV Infections - prevention & control | Humans | AIDS Vaccines - immunology | Administration, Intravaginal | Neutralization Tests | HIV - immunology | Macaca mulatta | Viral Load | HIV Infections - immunology | Simian Acquired Immunodeficiency Syndrome - virology | HIV Antibodies - immunology | Vaginal Discharge - immunology | Leukocytes, Mononuclear - immunology | Female | Antibodies, Monoclonal - immunology | Simian Immunodeficiency Virus - immunology | Data Interpretation, Statistical | Simian Immunodeficiency Virus - pathogenicity | Enzyme-Linked Immunosorbent Assay | HIV Infections - virology | Cells, Cultured | RNA, Viral - analysis | HIV - pathogenicity | Animals | Simian Acquired Immunodeficiency Syndrome - immunology | Antibodies, Monoclonal - administration & dosage | Immunization, Passive | Genes, MHC Class I | AIDS vaccines | Research | HIV (Viruses) | T cells | Health aspects | Studies | AIDS | Acquired immune deficiency syndrome | Experiments
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9. Full Text Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques
by Santra, Sampa and Tomaras, Georgia D and Warrier, Ranjit and Nicely, Nathan I and Liao, Hua-Xin and Pollara, Justin and Liu, Pinghuang and Alam, S. Munir and Zhang, Ruijun and Cocklin, Sarah L and Shen, Xiaoying and Duffy, Ryan and Xia, Shi-Mao and Schutte, Robert J and Pemble IV, Charles W and Dennison, S. Moses and Li, Hui and Chao, Andrew and Vidnovic, Kora and Evans, Abbey and Klein, Katja and Kumar, Amit and Robinson, James and Landucci, Gary and Forthal, Donald N and Montefiori, David C and Kaewkungwal, Jaranit and Nitayaphan, Sorachai and Pitisuttithum, Punnee and Rerks-Ngarm, Supachai and Robb, Merlin L and Michael, Nelson L and Kim, Jerome H and Soderberg, Kelly A and Giorgi, Elena E and Blair, Lily and Korber, Bette T and Moog, Christiane and Shattock, Robin J and Letvin, Norman L and Schmitz, Joern E and Moody, M.A and Gao, Feng and Ferrari, Guido and Shaw, George M and Haynes, Barton F and Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
PLoS Pathogens, ISSN 1553-7366, 08/2015, Volume 11, Issue 8, p. e1005042
HIV-1 mucosal transmission begins with virus or virus-infected cells moving through mucus across mucosal epithelium to infect CD4(+) T cells. Although broadly... 
NEUTRALIZING ANTIBODIES | FAB FRAGMENT | CRYSTAL-STRUCTURE | EFFECTOR FUNCTION | MICROBIOLOGY | MEDIATING ANTIBODIES | VIRION CAPTURE | DEPENDENT CELLULAR CYTOTOXICITY | VIROLOGY | MEMBRANE PROXIMAL REGION | VACCINE EFFICACY | IMMUNODOMINANT DOMAIN | PARASITOLOGY | Surface Plasmon Resonance | Humans | Intestinal Mucosa - virology | Macaca mulatta | Reverse Transcriptase Polymerase Chain Reaction | CD4-Positive T-Lymphocytes - immunology | Simian Acquired Immunodeficiency Syndrome - prevention & control | HIV-1 - immunology | Animals | Viral Envelope Proteins - chemistry | Fluorescent Antibody Technique | Rectum | Antibodies, Viral - immunology | Protein Conformation | Viral Envelope Proteins - immunology | Antibodies, Monoclonal - immunology | Simian Immunodeficiency Virus - immunology | Monoclonal antibodies | Rhesus monkey | Host-virus relationships | Observations | HIV (Viruses) | Health aspects | HIV-1 | macaque | macrophages | rhesus monkeys | BASIC BIOLOGICAL SCIENCES | enzyme-linked immunoassays | antibodies | T cells | virions | Immunoglobulins | AIDS | Viruses | Infections | Vaccines | Crystallography | Immunology | HIV | Acquired immune deficiency syndrome | Human immunodeficiency virus | Mutation | Viral infections | Crystal structure
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10. Full Text Broadly Neutralizing Monoclonal Antibodies 2F5 and 4E10 Directed against the Human Immunodeficiency Virus Type 1 gp41 Membrane-Proximal External Region Protect against Mucosal Challenge by Simian-Human Immunodeficiency Virus SHIVBa-L
by Ann J. Hessell and Eva G. Rakasz and David M. Tehrani and Michael Huber and Kimberly L. Weisgrau and Gary Landucci and Donald N. Forthal and Wayne C. Koff and Pascal Poignard and David I. Watkins and Dennis R. Burton
Journal of Virology, ISSN 0022-538X, 02/2010, Volume 84, Issue 3, pp. 1302 - 1313
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
LONG-TERM | HIV-1/SIV CHIMERIC VIRUS | T-CELL RESPONSES | EPITOPE | REPLICATION | VIROLOGY | CLASS-I ALLELES | PASSIVE TRANSFER | ENVELOPE GLYCOPROTEIN | INFECTION | RHESUS MACAQUES | Antibodies, Neutralizing - immunology | HIV-1 - immunology | Enzyme-Linked Immunosorbent Assay | HIV Envelope Protein gp41 - immunology | HIV-1 - isolation & purification | Humans | Immunity, Mucosal | HeLa Cells | Antibodies, Monoclonal - immunology | Viral Load | Simian Immunodeficiency Virus - immunology | Vaccines and Antiviral Agents
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11. Full Text Fc receptor but not complement binding is important in antibody protection against HIV
by Hessell, Ann J and Hangartner, Lars and Hunter, Meredith and Havenith, Carin E. G and Beurskens, Frank J and Bakker, Joost M and Lanigan, Caroline M. S and Landucci, Gary and Forthal, Donald N and Parren, Paul W. H. I and Marx, Preston A and Burton, Dennis R
Nature, ISSN 0028-0836, 09/2007, Volume 449, Issue 7158, pp. 101 - 104
Most successful vaccines elicit neutralizing antibodies and this property is a high priority when developing an HIV vaccine(1,2). Indeed, passively... 
CHALLENGE | MEDIATED PROTECTION | IN-VITRO | TRANSMISSION | REPLICATION | DENDRITIC CELLS | NEUTRALIZING ANTIBODY | MULTIDISCIPLINARY SCIENCES | IMMUNODEFICIENCY-VIRUS TYPE-1 | MONOCLONAL-ANTIBODY | RHESUS MACAQUES | HIV Infections - prevention & control | Immunity, Mucosal - immunology | Complement C1q - immunology | Humans | AIDS Vaccines - immunology | Macaca mulatta - immunology | Antibody-Dependent Cell Cytotoxicity - immunology | Complement System Proteins - immunology | Neutralization Tests | HIV - immunology | Viral Load | HIV Infections - immunology | Macaca mulatta - virology | Simian Acquired Immunodeficiency Syndrome - virology | HIV Antibodies - immunology | Time Factors | Female | Simian Immunodeficiency Virus - immunology | HIV Infections - blood | HIV Infections - virology | Simian Acquired Immunodeficiency Syndrome - blood | HIV Antibodies - chemistry | Complement C3 - immunology | Simian Acquired Immunodeficiency Syndrome - prevention & control | Animals | Receptors, Fc - immunology | HIV Antigens - immunology | Simian Acquired Immunodeficiency Syndrome - immunology | HIV Antibodies - genetics | Immunology | Vaccines | Human immunodeficiency virus | HIV | Monkeys & apes | Cells
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12. Full Text Initial B-Cell Responses to Transmitted Human Immunodeficiency Virus Type 1: Virion-Binding Immunoglobulin M (IgM) and IgG Antibodies Followed by Plasma Anti-gp41 Antibodies with Ineffective Control of Initial Viremia
by Georgia D. Tomaras and Nicole L. Yates and Pinghuang Liu and Li Qin and Genevieve G. Fouda and Leslie L. Chavez and Allan C. Decamp and Robert J. Parks and Vicki C. Ashley and Judith T. Lucas and Myron Cohen and Joseph Eron and Charles B. Hicks and Hua-Xin Liao and Steven G. Self and Gary Landucci and Donald N. Forthal and Kent J. Weinhold and Brandon F. Keele and Beatrice H. Hahn and Michael L. Greenberg and Lynn Morris and Salim S. Abdool Karim and William A. Blattner and David C. Montefiori and George M. Shaw and Alan S. Perelson and Barton F. Haynes
Journal of Virology, ISSN 0022-538X, 12/2008, Volume 82, Issue 24, pp. 12449 - 12463
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
PROXIMAL EXTERNAL REGION | NEUTRALIZING ANTIBODIES | SEROCONVERSION | VIROLOGY | DENDRITIC CELLS | PRIMARY HIV-1 INFECTION | VACCINE DESIGN | ENVELOPE | CD4(+) T-CELLS | SUBTYPE-C INFECTION | MONOCLONAL-ANTIBODIES | HIV Infections - blood | Virion - immunology | env Gene Products, Human Immunodeficiency Virus - immunology | HIV Envelope Protein gp41 - immunology | Humans | Immunoglobulin M - immunology | HIV Infections - immunology | HIV-1 - immunology | Lymphocyte Activation - immunology | B-Lymphocytes - immunology | Immunoglobulin G - immunology | Models, Biological | Viremia - immunology | Kinetics | Viremia - transmission | Pathogenesis and Immunity
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13. Full Text Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys
by Liu, Jinyan and O'Brien, Kara L and Lynch, Diana M and Simmons, Nathaniel L and La Porte, Annalena and Riggs, Ambryice M and Abbink, Peter and Coffey, Rory T and Grandpre, Lauren E and Seaman, Michael S and Landucci, Gary and Forthal, Donald N and Montefiori, David C and Carville, Angela and Mansfield, Keith G and Havenga, Menzo J and Pau, Maria G and Goudsmit, Jaap and Barouch, Dan H
Nature, ISSN 0028-0836, 2009, Volume 457, Issue 7225, pp. 87 - 91
A recombinant adenovirus serotype 5 (rAd5) vector-based vaccine for HIV-1 has recently failed in a phase 2b efficacy study in humans. Consistent with these... 
RESPONSES | IMMUNOGENICITY | ADENOVIRUS VECTORS | REPLICATION | MEMORY | HIV | MULTIDISCIPLINARY SCIENCES | INFECTION | MAMU-A-ASTERISK-01 | SIMIAN-IMMUNODEFICIENCY | IMMUNODEFICIENCY VIRUS SIVMAC239 | HIV Infections - prevention & control | Simian Acquired Immunodeficiency Syndrome - mortality | SAIDS Vaccines - administration & dosage | Humans | Vaccination | Macaca mulatta - immunology | Neutralization Tests | Viral Load | CD4-Positive T-Lymphocytes - immunology | Simian Acquired Immunodeficiency Syndrome - prevention & control | HIV Infections - immunology | Macaca mulatta - virology | Simian Acquired Immunodeficiency Syndrome - virology | Animals | SAIDS Vaccines - immunology | Simian Acquired Immunodeficiency Syndrome - immunology | Adenoviridae - genetics | Antibodies, Viral - immunology | Simian Immunodeficiency Virus - immunology | Prevention | Viral vaccines | Causes of | Dosage and administration | Research | Simian immunodeficiency virus | T cells | HIV infection | Health aspects | Immunization | Acquired immune deficiency syndrome--AIDS | Lymphocytes | Human immunodeficiency virus--HIV | Mortality | Monoclonal antibodies | Vaccines
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