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Diabetes, Obesity and Metabolism, ISSN 1462-8902, 08/2017, Volume 19, Issue 8, pp. 1078 - 1087
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 08/2017, Volume 19, Issue 8, pp. 1078 - 1087
Aim: Small molecule activators of glucokinase (GKAs) have been explored extensively as potential anti-hyperglycaemic drugs for type 2 diabetes (T2D). Several... 
antidiabetic drug | GLUCOSE-6-PHOSPHATASE | GLYCOGEN | INHIBITION | GLUCONEOGENESIS | METABOLISM | PHOSPHORYLATION | PROTEIN-KINASE | LIVER GLUCOKINASE | ENDOCRINOLOGY & METABOLISM | RATS | CARBOHYDRATE | Enzyme Activators - pharmacology | Gene Expression Regulation, Enzymologic - drug effects | Glucose-6-Phosphatase - genetics | Rats, Wistar | Pyruvate Kinase - chemistry | Hepatocytes - pathology | Male | Hepatocytes - metabolism | Promoter Regions, Genetic - drug effects | Fructosediphosphates - metabolism | Overweight - metabolism | Hepatocytes - cytology | Glucokinase - chemistry | Hepatocytes - drug effects | Glucose-6-Phosphatase - chemistry | Overweight - pathology | Fructose - adverse effects | Pyruvate Kinase - metabolism | Metformin - pharmacology | Overweight - enzymology | Cells, Cultured | Glucokinase - genetics | Glucokinase - metabolism | Diet, Western - adverse effects | Mice, Inbred C3H | Glucose-6-Phosphatase - metabolism | Hypoglycemic Agents - pharmacology | Pyruvate Kinase - antagonists & inhibitors | Animals | Glucokinase - antagonists & inhibitors | Active Transport, Cell Nucleus - drug effects | Glucose-6-Phosphatase - antagonists & inhibitors | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Thiazoles - pharmacology | Glucose-6-Phosphate - metabolism | Pyruvate Kinase - genetics | Fructose - administration & dosage | Type 2 diabetes | Phosphates | Drugs | Phosphatases | Isoenzymes | Blood sugar | Genes | Gene expression | Fructose | Prescribing | Pyrimidines | Metabolites | Analysis | Hypoglycemic agents | Kinases
Journal Article
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