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The New England journal of medicine, ISSN 1533-4406, 2014, Volume 370, Issue 4, pp. 322 - 333
In two phase 3 trials in patients with Alzheimer's disease, bapineuzumab, a humanized anti–amyloid-beta monoclonal antibody, did not improve clinical outcomes.... 
ANTIBODIES | MEDICINE, GENERAL & INTERNAL | EPITOPE | IMAGING ABNORMALITIES | PEPTIDE | MOUSE MODEL | Phosphorylation | Humans | Middle Aged | Male | Positron-Emission Tomography | Treatment Failure | Aged, 80 and over | Amyloid beta-Peptides - cerebrospinal fluid | Female | Severity of Illness Index | Antibodies, Monoclonal, Humanized - adverse effects | Antibodies, Monoclonal, Humanized - therapeutic use | Double-Blind Method | Biomarkers - analysis | Alzheimer Disease - drug therapy | tau Proteins - cerebrospinal fluid | Alzheimer Disease - cerebrospinal fluid | Cognition - drug effects | Neuropsychological Tests | Amyloid beta-Peptides - antagonists & inhibitors | Apolipoproteins E - genetics | Intention to Treat Analysis | Amyloid beta-Peptides - analysis | Brain - pathology | Aged | Biomarkers - cerebrospinal fluid | Edema - chemically induced | Alzheimer Disease - genetics | Monoclonal antibodies | Product development | Research | Drug therapy | Alzheimer's disease | Health aspects | Edema | Nuclear magnetic resonance--NMR | Intravenous administration | Neurodegenerative diseases | Cognitive ability | Clinical trials | Cerebrospinal fluid | Patients | Studies | Tau protein | Apolipoprotein E | Immunotherapy | Alleles | Dementia disorders | Alzheimers disease | Brain | Neurosciences | pathology | Biological Markers | Antibodies | Cognition | tau Proteins | 80 and over | genetics | Amyloid beta-Peptides | Apolipoproteins E | Monoclonal | Neurovetenskaper | drug therapy | chemically induced | Humanized | drug effects | Alzheimer Disease | analysis | antagonists & inhibitors | cerebrospinal fluid | adverse effects | therapeutic use
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2011, Volume 365, Issue 10, pp. 883 - 891
In this trial, 14,264 patients with atrial fibrillation were randomly assigned to receive either rivaroxaban or warfarin. In a per-protocol, as-treated... 
NON-INFERIORITY | ENOXAPARIN | MEDICINE, GENERAL & INTERNAL | DABIGATRAN | STROKE PREVENTION | PHARMACOKINETICS | EFFICACY | ANTITHROMBOTIC THERAPY | PHARMACODYNAMICS | THROMBOPROPHYLAXIS | ANTICOAGULATION | Thiophenes - therapeutic use | Thiophenes - adverse effects | Humans | Middle Aged | Warfarin - adverse effects | Male | Thiophenes - administration & dosage | Warfarin - administration & dosage | Warfarin - therapeutic use | Rivaroxaban | Aged, 80 and over | Female | Stroke - epidemiology | Embolism - epidemiology | Morpholines - adverse effects | Morpholines - therapeutic use | Stroke - prevention & control | Embolism - prevention & control | Double-Blind Method | Administration, Oral | Atrial Fibrillation - drug therapy | Morpholines - administration & dosage | Atrial Fibrillation - complications | Anticoagulants - therapeutic use | Treatment Outcome | Anticoagulants - adverse effects | Intention to Treat Analysis | Aged | Hemorrhage - chemically induced | Stroke (Disease) | Warfarin | Atrial fibrillation | Patient outcomes | Dosage and administration | Drug therapy | Comparative analysis | Risk factors | Fees & charges | Cardiac arrhythmia | Stroke | Heart attacks | Research & development--R&D | Embolisms | Equity | Equity stake | Hemorrhage | Bleeding | Embolism | Studies | Prevention | Fibrillation | Motivation | Ischemia | Thromboembolism | Drug dosages | Pharmaceuticals | Anticoagulants | Morpholines | Life Sciences | Thiophenes | Atrial Fibrillation
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2012, Volume 366, Issue 15, pp. 1404 - 1413
Patients with atherosclerotic vascular disease were randomly assigned to receive the thrombin antagonist vorapaxar or placebo. Vorapaxar reduced the rate of... 
ATOPAXAR | MEDICINE, GENERAL & INTERNAL | CLOPIDOGREL | EFFICACY | SAFETY | TOLERABILITY | DOUBLE-BLIND | PRASUGREL | LESSONS | ANTAGONISTS | ASPIRIN | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Male | Risk | Secondary Prevention | Pyridines - adverse effects | Cardiovascular Diseases - mortality | Female | Platelet Aggregation Inhibitors - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Pyridines - therapeutic use | Double-Blind Method | Hemorrhage - epidemiology | Receptor, PAR-1 - antagonists & inhibitors | Kaplan-Meier Estimate | Peripheral Arterial Disease - drug therapy | Stroke - drug therapy | Lactones - adverse effects | Lactones - therapeutic use | Retreatment | Myocardial Infarction - drug therapy | Brain Ischemia - drug therapy | Intracranial Hemorrhages - chemically induced | Intracranial Hemorrhages - epidemiology | Aged | Hemorrhage - chemically induced | Prevention | Drugs | Aggregation | Dose-response relationship (Biochemistry) | Atheroembolism | Blood platelets | Atherosclerosis | Product/Service Evaluations | Dosage and administration | Drug therapy | Myocardial infarction | Cerebral infarction | Stroke | Aspirin | Heart attacks | Proteinase-activated receptor 1 | Thrombin | Hemorrhage | Patients | Bleeding | Disease prevention | Ischemia | Arteriosclerosis | Death | Cardiovascular diseases | Health risk assessment | Computer Science | Medical Imaging
Journal Article
by Voight, Benjamin F and Peloso, Gina M and Orho-Melander, Marju and Frikke-Schmidt, Ruth and Barbalic, Maja and Jensen, Majken K and Hindy, George and Hólm, Hilma and Ding, Eric L and Johnson, Toby and Schunkert, Heribert and Samani, Nilesh J and Clarke, Robert and Hopewell, Jemma C and Thompson, John F and Li, Mingyao and Thorleifsson, Gudmar and Newton-Cheh, Christopher and Musunuru, Kiran and Pirruccello, James P and Saleheen, Danish and Chen, Li and Stewart, Alexandre FR and Schillert, Arne and Thorsteinsdottir, Unnur and Thorgeirsson, Gudmundur and Anand, Sonia and Engert, James C and Morgan, Thomas and Spertus, John and Stoll, Monika and Berger, Klaus and Martinelli, Nicola and Girelli, Domenico and McKeown, Pascal P and Patterson, Christopher C and Epstein, Stephen E and Devaney, Joseph and Burnett, Mary-Susan and Mooser, Vincent and Ripatti, Samuli and Surakka, Ida and Nieminen, Markku S and Sinisalo, Juha and Lokki, Marja-Liisa and Perola, Markus and Havulinna, Aki and de Faire, Ulf and Gigante, Bruna and Ingelsson, Erik and Zeller, Tanja and Wild, Philipp and de Bakker, Paul I W and Klungel, Olaf H and Maitland-van der Zee, Anke-Hilse and Peters, Bas J M and de Boer, Anthonius and Grobbee, Diederick E and Kamphuisen, Pieter W and Deneer, Vera H M and Elbers, Clara C and Onland-Moret, N Charlotte and Hofker, Marten H and Wijmenga, Cisca and Verschuren, WM Monique and Boer, Jolanda MA and van der Schouw, Yvonne T and Rasheed, Asif and Frossard, Philippe and Demissie, Serkalem and Willer, Cristen and Do, Ron and Ordovas, Jose M and Abecasis, Gonçalo R and Boehnke, Michael and Mohlke, Karen L and Daly, Mark J and Guiducci, Candace and Burtt, Noël P and Surti, Aarti and Gonzalez, Elena and Purcell, Shaun and Gabriel, Stacey and Marrugat, Jaume and Peden, John and Erdmann, Jeanette and Diemert, Patrick and Willenborg, Christina and König, Inke R and Fischer, Marcus and Hengstenberg, Christian and Ziegler, Andreas and Buysschaert, Ian and Lambrechts, Diether and Van de Werf, Frans and Fox, Keith A and El Mokhtari, Nour Eddine and Rubin, Diana and Schrezenmeir, Jürgen and Schreiber, Stefan and ...
The Lancet (British edition), ISSN 0140-6736, 2012, Volume 380, Issue 9841, pp. 572 - 580
Journal Article
Lancet neurology, ISSN 1474-4422, 2012, Volume 11, Issue 4, pp. 315 - 322
Journal Article