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02/2013
Tuberculosis is a global burden with one –third of the world’s population infected with the pathogen Mycobacterium tuberculosis and an annual 2 million deaths... 
Mycobacterium tuberculosis | Uvaria afzelli | Tetracera alnifolia | crude extracts
Web Resource
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2010, Volume 107, Issue 10, pp. 4573 - 4578
Protein tyrosine phosphatases are often exploited and subverted by pathogenic bacteria to cause human diseases. The tyrosine phosphatase mPTPB from... 
Cell culture techniques | Phosphatases | Mycobacterium tuberculosis | Epithelial cells | Cell lines | Libraries | Click chemistry | Macrophages | Bacterial load | Apoptosis | Combinatorial chemistry | Phosphatase inhibitor | Pathogen-host interaction | Signaling mechanism | SPECIFICITY | CLICK CHEMISTRY | TUBERCULOSIS | MULTIDISCIPLINARY SCIENCES | LIBRARY | IDENTIFICATION | DISCOVERY | signaling mechanism | phosphatase inhibitor | INTERFERON-GAMMA | SUBSTRATE | combinatorial chemistry | INHIBITORS | IN-SITU | pathogen-host interaction | Antitubercular Agents - chemical synthesis | Antitubercular Agents - chemistry | Models, Chemical | Apoptosis - drug effects | Triazoles - chemistry | Humans | Benzofurans - pharmacology | Protein Tyrosine Phosphatases - metabolism | Tuberculosis - microbiology | Interferon-gamma - metabolism | Enzyme Inhibitors - chemical synthesis | Benzofurans - chemistry | Microbial Sensitivity Tests | Protein Tyrosine Phosphatases - antagonists & inhibitors | Protein Tyrosine Phosphatases - genetics | Enzyme Inhibitors - chemistry | Mycobacterium tuberculosis - physiology | Triazoles - chemical synthesis | Molecular Structure | Macrophages - microbiology | Bacterial Proteins - antagonists & inhibitors | Cell Line | Cell Survival - drug effects | Antitubercular Agents - pharmacology | Bacterial Proteins - genetics | Enzyme Inhibitors - pharmacology | Benzofurans - chemical synthesis | Host-Pathogen Interactions | Triazoles - pharmacology | Macrophages - metabolism | Animals | Mycobacterium tuberculosis - enzymology | Tuberculosis - prevention & control | Bacterial Proteins - metabolism | Macrophages - drug effects | Mice | Kinetics | Mitogen-Activated Protein Kinases - metabolism | Tyrosine | Mycobacterium | Bacterial proteins | Mycobacteria | Physiological aspects | Antitubercular agents | Research | Chemical properties | Health aspects | Proteins | Cell growth | Tuberculosis | Inhibitor drugs | Gram-positive bacteria | Biochemistry | Drug therapy | Cytoplasm | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 07/2013, Volume 110, Issue 27, pp. E2510 - E2517
A cell-based phenotypic screen for inhibitors of biofilm formation in mycobacteria identified the small molecule TCA1, which has bactericidal activity against... 
Drug resistance | Dual mechanism | MYCOBACTERIUM-TUBERCULOSIS | dual mechanism | BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | GROWTH | TOLERANT | drug resistance | INHIBITORS | MODEL | Oxidoreductases - antagonists & inhibitors | Tuberculosis, Pulmonary - microbiology | Antitubercular Agents - chemistry | Bacterial Proteins - chemistry | Biofilms - growth & development | Drug Resistance, Bacterial | Molecular Sequence Data | Carbohydrate Epimerases - antagonists & inhibitors | Tuberculosis, Pulmonary - drug therapy | Thiophenes - administration & dosage | Mycobacterium tuberculosis - drug effects | Oxidoreductases - chemistry | Microbial Sensitivity Tests | Female | Rifampin - administration & dosage | Alcohol Oxidoreductases | Biofilms - drug effects | Amino Acid Sequence | Bacterial Proteins - antagonists & inhibitors | Genes, Bacterial | Benzothiazoles - pharmacology | Oxidoreductases - genetics | Antitubercular Agents - pharmacology | Bacterial Proteins - genetics | Thiophenes - pharmacology | Carbohydrate Epimerases - chemistry | Isoniazid - administration & dosage | Animals | High-Throughput Screening Assays | Mycobacterium tuberculosis - enzymology | Antitubercular Agents - administration & dosage | Benzothiazoles - chemistry | Mice | Mice, Inbred BALB C | Thiophenes - chemistry | Carbohydrate Epimerases - genetics | Benzothiazoles - administration & dosage | Mycobacterium tuberculosis - genetics | Genotype & phenotype | Tuberculosis | Rodents | Genetics | Antimicrobial agents | Biosynthesis | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, pp. e0138436 - e0138436
Several enzymes involved in central carbon metabolism and gluconeogenesisplay a critical role in survival and pathogenesis of Mycobacterium tuberculosis (Mtb).... 
FRUCTOSE 1,6-BISPHOSPHATASE | ENZYME | INOSITOL MONOPHOSPHATASE | MALATE SYNTHASE | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | FRUCTOSE-1,6-BISPHOSPHATASE | BIOCHEMICAL-CHARACTERIZATION | ISOCITRATE LYASE | MICE | VIRULENCE | Genes, Bacterial | Nitroimidazoles - pharmacology | Microbial Viability - drug effects | Gluconeogenesis - drug effects | Bacterial Proteins - genetics | Tuberculosis - microbiology | Mycobacterium tuberculosis - drug effects | Microbial Sensitivity Tests | Fructose-Bisphosphatase - metabolism | Animals | Gene Deletion | Mycobacterium tuberculosis - enzymology | Bacterial Proteins - metabolism | Anti-Bacterial Agents - pharmacology | Fructose-Bisphosphatase - genetics | Mice, Inbred BALB C | Stress, Physiological - drug effects | Tuberculosis - metabolism | Carbon - pharmacology | Fatty Acids - pharmacology | Mycobacterium tuberculosis - genetics | Mycobacterium tuberculosis - growth & development | Tuberculosis | Mycobacterium tuberculosis | Physiological aspects | Development and progression | Genetic aspects | Research | Gluconeogenesis | Media (enrichment) | Pathogenesis | Genes | Homologous recombination | Leprosy | Amino acids | Homology | Genomes | Phosphatase | E coli | Oleic acid | Pharmaceutical sciences | Deoxyribonucleic acid--DNA | Enzymes | Cloning | Glycerol | Metabolism | Survival | Fatty acids | Fructose | Substrates | Studies | Mutagenesis | Lungs | Pharmacy | Drug discovery | Acetic acid | Index Medicus | Lung | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, pp. e56980 - e56980
1,5-Diphenyl pyrroles were previously identified as a class of compounds endowed with high in vitro efficacy against M. tuberculosis. To improve the physical... 
MYCOBACTERIUM-TUBERCULOSIS | ANTIMYCOBACTERIAL | ASSAY | MEMBRANE | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | ANTIFUNGAL ACTIVITIES | PYRROLE DERIVATIVE BM212 | IDENTIFICATION | STREPTOMYCIN | Bacterial Proteins - antagonists & inhibitors | Cell Line | Microsomes - metabolism | Humans | Bacterial Proteins - genetics | Piperazines - toxicity | Piperazines - chemistry | Antibiotics, Antitubercular - pharmacology | Antibiotics, Antitubercular - toxicity | Mycobacterium tuberculosis - drug effects | Piperazines - pharmacology | Microbial Sensitivity Tests | Pyrroles - pharmacology | Animals | Antibiotics, Antitubercular - chemistry | Pyrroles - toxicity | Tuberculosis - drug therapy | Pyrroles - chemistry | Bacterial Proteins - metabolism | Female | Mice | Mycobacterium tuberculosis - metabolism | Tuberculosis - metabolism | Mycobacterium tuberculosis - genetics | Tuberculosis | Drug discovery | Chemical properties | Gene mutations | Health aspects | Drugs | Animal models | Research & development--R&D | Pyrroles | Event-related potentials | Thiomorpholine | Infections | Mutants | Gene sequencing | Morpholine | Discovery tools | Mutation | Sulfur | Lipophilicity | Index Medicus | Piperazines | Microsomes | Bacterial Proteins | Life Sciences | Mycobacterium tuberculosis | Antibiotics, Antitubercular | Pharmaceutical sciences | Research & development | R&D
Journal Article
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2015, Volume 1285, pp. 281 - 292
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 04/2007, Volume 51, Issue 4, pp. 1380 - 1385
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, pp. e64242 - e64242
Rifampicin, discovered more than 50 years ago, represents the last novel class of antibiotics introduced for the first-line treatment of tuberculosis. Drugs in... 
NONREPLICATING PERSISTENCE | ASSAY | MULTIDISCIPLINARY SCIENCES | AGENTS | DRUG-RESISTANCE | LIGAND | MODEL | Antitubercular Agents - chemical synthesis | Antitubercular Agents - adverse effects | Antitubercular Agents - chemistry | Phosphines - pharmacology | Humans | Toxicity Tests, Acute | Mycobacterium tuberculosis - drug effects | Ruthenium - chemistry | Mutagenesis - drug effects | Microbial Sensitivity Tests | Phosphines - chemistry | Mutagenicity Tests | Imines - chemistry | Coordination Complexes - pharmacology | Picolinic Acids - chemical synthesis | Picolinic Acids - chemistry | Female | Drug Resistance, Bacterial - drug effects | Imines - chemical synthesis | Picolinic Acids - pharmacology | Mice, Inbred C57BL | Antitubercular Agents - pharmacology | Imines - pharmacology | Coordination Complexes - chemistry | Mycobacterium tuberculosis - isolation & purification | Ruthenium - pharmacology | Phosphines - chemical synthesis | Animals | Coordination Complexes - chemical synthesis | Mice | Mycobacterium tuberculosis - growth & development | Highly active antiretroviral therapy | Independent regulatory commissions | Ruthenium | Tuberculosis | Drug approval | Drugs | Salmonella | Regulatory agencies | Disease | Toxicity | Handbooks | Cytotoxicity | Selectivity | Infections | Drug development | Drug resistance | Biological effects | Antiretroviral agents | Human immunodeficiency virus--HIV | Biocompatibility | Research & development--R&D | Phosphine | Antimicrobial agents | Biological activity | Ruthenium compounds | Chemistry | Chemotherapy | Antibiotics | Mutagenesis | Ames test | Pharmacy | In vivo methods and tests | Mutagenicity | Mutation | Rifampin | Acute toxicity | Index Medicus | Research & development | R&D | HIV | Human immunodeficiency virus
Journal Article
African Journal of Biomedical Research, ISSN 1119-5096, 2011, Volume 14, Issue 1, pp. 17 - 21
Journal Article
Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, 02/2012, Volume 67, Issue 2, pp. 415 - 421
Objectives: New classes of drugs are needed to treat tuberculosis (TB) in order to combat the emergence of resistance to existing agents and shorten the... 
Non-replicating bacteria | Benzimidazole | Non-tuberculous mycobacteria | Topoisomerase | Novobiocin | Ciprofloxacin | Drug resistance | INFECTIOUS DISEASES | ASSAY | MICROBIOLOGY | novobiocin | DNA GYRASE | topoisomerase | benzimidazole | non-tuberculous mycobacteria | PHARMACOLOGY & PHARMACY | drug resistance | INHIBITORS | MOXIFLOXACIN | non-replicating bacteria | ciprofloxacin | Lung - microbiology | Tuberculosis, Pulmonary - microbiology | Novobiocin - adverse effects | Antitubercular Agents - pharmacology | Enzyme Inhibitors - pharmacology | Tuberculosis, Pulmonary - drug therapy | Novobiocin - administration & dosage | Mycobacterium tuberculosis - drug effects | Enzyme Inhibitors - administration & dosage | Microbial Sensitivity Tests | DNA Gyrase - metabolism | Animals | Drug Interactions | Novobiocin - pharmacology | Benzimidazoles - administration & dosage | Mycobacterium tuberculosis - enzymology | Topoisomerase II Inhibitors | Antitubercular Agents - administration & dosage | Benzimidazoles - pharmacology | Female | Mice | Mice, Inbred BALB C | Benzimidazoles - adverse effects | Disease Models, Animal | Bacteria | Cytotoxicity | Antibiotics | Deoxyribonucleic acid--DNA | Index Medicus | Fluoroquinolones | Animal models | Oxygen | Cross-resistance | Lung | DNA topoisomerase | Colony-forming cells | Bactericidal activity | Tuberculosis | Minimum inhibitory concentration | Models | Isoniazid | Rifampin | Original Research
Journal Article
Journal Article