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1. Full Text Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy
by Chow, Melvyn T and Ozga, Aleksandra J and Servis, Rachel L and Frederick, Dennie T and Lo, Jennifer A and Fisher, David E and Freeman, Gordon J and Boland, Genevieve M and Luster, Andrew D
Immunity, ISSN 1074-7613, 06/2019, Volume 50, Issue 6, pp. 1498 - 1512.e5
Despite compelling rates of durable clinical responses to programmed cell death-1 (PD-1) blockade, advances are needed to extend these benefits to resistant... 
CXCL10 | CD8+ T cells | CXCL9 | chemokine | dendritic cells | CXCR3 | immune checkpoint | immunotherapy | PD-1 | CD8 | T cells | MIGRATION | RESPONSES | T-CELL TRAFFICKING | PD-1 BLOCKADE | CD4(+) | RECEPTOR | CANCER-IMMUNOTHERAPY | IMMUNOLOGY | IP-10 | EXPRESSION | LYMPHOCYTES | PD-1 protein | CD8 antigen | Lymphocytes T | Cell interactions | Cancer therapies | Bearing | Metastases | Cell adhesion & migration | CD103 antigen | Scholarships & fellowships | Lymphocytes | Bone marrow | Tumor necrosis factor-TNF | Bioindicators | Medical research | Antigens | Statistical analysis | Cytokines | Dendritic cells | Melanoma | CXCR3 protein | Cell death | Biomarkers | Ligands | Mice | Infiltration | Chemokines | Tumors | Apoptosis
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2. Full Text Costimulatory Genes: Hotspots of Conflict between Host Defense and Autoimmunity
by Jones, Jennifer C and Freeman, Gordon J
Immunity, ISSN 1074-7613, 06/2013, Volume 38, Issue 6, pp. 1083 - 1085
To understand the adaptations of costimulatory molecules through mammalian evolution, Forni et al. ( ) studied evolutionary selection in key costimulatory... 
IMMUNOLOGY | Animals | Programmed Cell Death 1 Receptor - genetics | Humans | Autoimmune Diseases - immunology | T-Lymphocytes, Regulatory - immunology | Autoimmunity | Genetic research | Genes | Proteins | Disease | Lymphocytes | Amino acids | Ligands | Genomes | Genetic diversity | Mutation | Gene expression | Hominids | Index Medicus
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3. Full Text The science of checkpoint inhibition in kidney cancer
by Freeman, Gordon J
Clinical Advances in Hematology and Oncology, ISSN 1543-0790, 2016, Volume 14, Issue 4, pp. 214 - 217
Immunomodulation - drug effects | Antibodies, Monoclonal - pharmacology | Humans | Kidney Neoplasms - immunology | Programmed Cell Death 1 Receptor - metabolism | Antibodies, Monoclonal - therapeutic use | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Kidney Neoplasms - metabolism | Immune System - cytology | Molecular Targeted Therapy | B7-H1 Antigen - metabolism | Animals | B7-H1 Antigen - antagonists & inhibitors | Signal Transduction - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Immune System - metabolism | Immune System - drug effects | Immune System - immunology | Antineoplastic Agents - pharmacology | Kidney Neoplasms - drug therapy | Index Medicus
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4. Full Text Therapeutic PD-1 pathway blockade augments with other modalities of immunotherapy T-cell function to prevent immune decline in ovarian cancer
by Duraiswamy, Jaikumar and Freeman, Gordon J and Coukos, George
Cancer Research, ISSN 0008-5472, 12/2013, Volume 73, Issue 23, pp. 6900 - 6912
The tumor microenvironment mediates induction of the immunosuppressive programmed cell death-1 (PD-1) pathway, and targeted interventions against this pathway... 
ACTIVATION | DENDRITIC CELLS | ONCOLOGY | GM-CSF | TOLERANCE | IN-VIVO | REGULATORY T | SUPPRESSOR-CELLS | CHRONIC VIRAL-INFECTION | MYELOID CELLS | TUMOR-IMMUNITY | Immunotherapy - methods | Ovarian Neoplasms - pathology | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antineoplastic Agents - administration & dosage | Ovarian Neoplasms - mortality | Neoplasms, Glandular and Epithelial - immunology | Lymphocytes, Tumor-Infiltrating - physiology | Signal Transduction - immunology | Neoplasms, Glandular and Epithelial - mortality | Female | Drug Evaluation, Preclinical | Neoplasms, Glandular and Epithelial - pathology | Mice, Inbred C57BL | Cells, Cultured | Neoplasms, Glandular and Epithelial - therapy | Lymphocytes, Tumor-Infiltrating - drug effects | B7-H1 Antigen - immunology | CD8-Positive T-Lymphocytes - physiology | Drug Synergism | Antibodies - administration & dosage | Animals | B7-H1 Antigen - antagonists & inhibitors | Lymphocytes, Tumor-Infiltrating - pathology | CD8-Positive T-Lymphocytes - drug effects | Carcinoma, Ovarian Epithelial | Lymphocyte Count | Ovarian Neoplasms - therapy | Mice | Programmed Cell Death 1 Receptor - immunology | Ovarian Neoplasms - immunology | Index Medicus
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5. Full Text Anti-PD-1/PD-L1 therapy augments lenvatinib's efficacy by favorably altering the immune microenvironment of murine anaplastic thyroid cancer
: Combining lenvatinib and anti-PD-1/PD-L1 therapy in orthotopic murine anaplastic thyroid cancer
by Gunda, Viswanath and Gigliotti, Benjamin and Ashry, Tameem and Ndishabandi, Dorothy and McCarthy, Michael and Zhou, Zhiheng and Amin, Salma and Lee, Kyu Eun and Stork, Tabea and Wirth, Lori and Freeman, Gordon J and Alessandrini, Alessandro and Parangi, Sareh
International Journal of Cancer, ISSN 0020-7136, 05/2019, Volume 144, Issue 9, pp. 2266 - 2278
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6. Full Text Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors
by Duraiswamy, Jaikumar and Kaluza, Karen M and Freeman, Gordon J and Coukos, George
Cancer Research, ISSN 0008-5472, 06/2013, Volume 73, Issue 12, pp. 3591 - 3603
Tumor progression is facilitated by regulatory T cells (Treg) and restricted by effector T cells. In this study, we document parallel regulation of CD8(+) T... 
DISTINCT MECHANISMS | ONCOLOGY | PROGRAMMED DEATH-1 | IMMUNE ESCAPE | MYELOID-LEUKEMIA | SYNGENEIC MOUSE MODEL | REGULATORY T | GROWTH-FACTOR | CHRONIC VIRAL-INFECTION | ANTITUMOR-ACTIVITY | HUMAN OVARIAN-CANCER | T-Lymphocytes, Regulatory - metabolism | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antibodies, Blocking - pharmacology | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Neoplasms, Experimental - pathology | Flow Cytometry | T-Lymphocytes - metabolism | Neoplasms, Experimental - immunology | CD8-Positive T-Lymphocytes - metabolism | Female | Lymphocytes, Tumor-Infiltrating - metabolism | Cytokines - immunology | Cytokines - metabolism | Cancer Vaccines - administration & dosage | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Neoplasms, Experimental - therapy | CTLA-4 Antigen - metabolism | Lymphocytes, Tumor-Infiltrating - transplantation | Programmed Cell Death 1 Receptor - metabolism | Combined Modality Therapy | CTLA-4 Antigen - immunology | B7-H1 Antigen - immunology | Cancer Vaccines - immunology | B7-H1 Antigen - metabolism | Animals | Antibodies, Blocking - immunology | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | CTLA-4 Antigen - antagonists & inhibitors | Lymphocytes, Tumor-Infiltrating - immunology | Tumor Burden - immunology | Index Medicus
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7. Full Text The microsatellite instable subset of colorectal cancer is a particularly good candidate for checkpoint blockade immunotherapy
by Xiao, Yanping and Freeman, Gordon J
Cancer Discovery, ISSN 2159-8274, 2015, Volume 5, Issue 1, pp. 16 - 18
The microsatellite instable (MSI) subset of colorectal cancer exhibits an active Th1/CTL immune microenvironment, probably due to recognition of a high number... 
FUSOBACTERIUM | INSTABILITY | ONCOLOGY | BRAF MUTATION | CARCINOMA | Tumor Microenvironment - immunology | Cell Cycle Checkpoints | Colonic Neoplasms - genetics | Microsatellite Instability | Tumor Microenvironment - genetics | Colonic Neoplasms - immunology | Humans | Index Medicus
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8. Full Text IMMU-15. PD-1 BLOCKADE ACTIVATES CD4 T CELLS AND THE INNATE IMMUNE RESPONSE FOR GLIOBLASTOMA ERADICATION
by Klein, Sarah R and Speranza, Maria Carmela and Gokhale, Prafulla C and Wilkens, Margaret K and Jones, Kristen L and Kirschmeier, Paul T and Chaudhri, Apoorvi and Reardon, David and Freeman, Gordon J
Neuro-Oncology, ISSN 1522-8517, 11/2017, Volume 19, Issue suppl_6, pp. vi115 - vi116
Blockade of immune cell co-inhibitory receptor PD-1 using monoclonal antibodies (mAbs) allows the development of anti-tumor immunity in various solid tumors... 
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9. Full Text PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma
by Ansell, Stephen M and Lesokhin, Alexander M and Borrello, Ivan and Halwani, Ahmad and Scott, Emma C and Gutierrez, Martin and Schuster, Stephen J and Millenson, Michael M and Cattry, Deepika and Freeman, Gordon J and Rodig, Scott J and Chapuy, Bjoern and Ligon, Azra H and Zhu, Lili and Grosso, Joseph F and Kim, Su Young and Timmerman, John M and Shipp, Margaret A and Armand, Philippe
The New England Journal of Medicine, ISSN 0028-4793, 01/2015, Volume 372, Issue 4, pp. 311 - 319
In a small series of patients with refractory Hodgkin's lymphoma, a substantial rate of tumor regression (87%) was documented in response to blockade of the... 
THERAPEUTICS | MEDICINE, GENERAL & INTERNAL | ANTI-PD-1 ANTIBODY | RESPONSE CRITERIA | SAFETY | PHASE-II | PIDILIZUMAB | STEM-CELL TRANSPLANTATION | LYMPHOPROLIFERATIVE DISORDERS | CANCER | T-CELLS | Recurrence | Hodgkin Disease - metabolism | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | STAT Transcription Factors - metabolism | Programmed Cell Death 1 Ligand 2 Protein - metabolism | Programmed Cell Death 1 Receptor - metabolism | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Janus Kinases - metabolism | Antineoplastic Agents - administration & dosage | Stem Cell Transplantation | Antibodies, Monoclonal - administration & dosage | Antineoplastic Agents - adverse effects | Hodgkin Disease - therapy | Immunotherapy | Hodgkin Disease - drug therapy | Immunoconjugates - therapeutic use | Adult | Female | Reed-Sternberg Cells - drug effects | Medical research | Autografts | Transplants & implants | Transcription | PD-1 protein | Toxicity | Body weight | Blocking antibodies | Stat3 protein | Stem cell transplantation | Lymphoma | Chromosome 9 | PD-L1 protein | Tomography | PD-L2 protein | Janus kinase | Ligands | Lymphomas | Drug therapy | Hodgkin's disease | Cancer | Apoptosis | Tumors | Index Medicus | Abridged Index Medicus
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10. Full Text Comment on “Tim-3 Directly Enhances CD8 T Cell Responses to Acute Listeria monocytogenes Infection”
by Kuchroo, Vijay K and Anderson, Ana C and Freeman, Gordon J
The Journal of Immunology, ISSN 0022-1767, 07/2014, Volume 193, Issue 2, pp. 467 - 467
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11. Full Text Efficacy and Safety of Degludec versus Glargine in Type 2 Diabetes
by Marso, Steven P and McGuire, Darren K and Zinman, Bernard and Poulter, Neil R and Emerson, Scott S and Pieber, Thomas R and Pratley, Richard E and Haahr, Poul-Martin and Lange, Martin and Brown-Frandsen, Kirstine and Moses, Alan and Skibsted, Simon and Kvist, Kajsa and Buse, John B and DEVOTE Study Grp and DEVOTE Study Group
The New England Journal of Medicine, ISSN 0028-4793, 08/2017, Volume 377, Issue 8, pp. 723 - 732
In this randomized, double-blind trial involving patients with type 2 diabetes at high risk for cardiovascular events, basal insulin degludec was noninferior... 
VARIABILITY | MEDICINE, GENERAL & INTERNAL | METAANALYSIS | EVENTS | GLUCOSE CONTROL | BASAL INSULIN | HYPOGLYCEMIA | RISK | COMPLICATIONS | OUTCOMES | INSULIN GLARGINE | Hypoglycemic Agents - therapeutic use | Insulin Glargine - adverse effects | Blood Glucose - analysis | Double-Blind Method | Humans | Middle Aged | Insulin Glargine - therapeutic use | Kaplan-Meier Estimate | Male | Incidence | Insulin, Long-Acting - adverse effects | Diabetes Mellitus, Type 2 - blood | Insulin, Long-Acting - therapeutic use | Cardiovascular Diseases - epidemiology | Female | Aged | Cardiovascular Diseases - chemically induced | Diabetes Mellitus, Type 2 - drug therapy | Hypoglycemia - chemically induced | Hypoglycemic Agents - adverse effects | Diabetes Mellitus, Type 2 - complications | Type 2 diabetes | Care and treatment | Insulin glargine | Research | Drug testing | Adolescence | Fasting | Diabetes mellitus | Clinical trials | FDA approval | Glucose | Hypoglycemia | Patients | Insulin | Studies | Diabetes | Children | Health risk assessment | Drug dosages | Index Medicus | Abridged Index Medicus
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