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Drug Discovery Today, ISSN 1359-6446, 2008, Volume 13, Issue 19, pp. 869 - 874
A drug molecule should bind to its target with high affinity and selectivity. Because the binding affinity is a combined function of the binding enthalpy and... 
ISOTHERMAL TITRATION CALORIMETRY | THERMODYNAMICS | PERMEABILITY | COMPENSATION | DRUG DESIGN | BINDING ENERGETICS | PHARMACOLOGY & PHARMACY | HIV-1 PROTEASE | OPTIMIZATION | INHIBITORS | SOLUBILITY | Receptors, Drug - chemistry | Thermodynamics | Animals | Hydrogen Bonding | Humans | Drug Design | Pharmaceutical Preparations - chemistry | Ligands | Entropy
Journal Article
Journal Article
Nature Reviews Drug Discovery, ISSN 1474-1776, 01/2010, Volume 9, Issue 1, pp. 23 - 27
Journal Article
Nature Protocols, ISSN 1754-2189, 06/2006, Volume 1, Issue 1, pp. 186 - 191
...Author(s): Adrian Velazquez-Campoy [1]; Ernesto Freire (corresponding author) [2] Introduction One aim of drug development is to optimize the binding... 
DESIGN | HIV-1 PROTEASE | DRUG-RESISTANCE | BINDING | BIOCHEMICAL RESEARCH METHODS | Thermodynamics | Proteins - metabolism | Titrimetry - methods | Drug Design | Ligands | Proteins - chemistry | Calorimetry - methods
Journal Article
PLOS ONE, ISSN 1932-6203, 04/2019, Volume 14, Issue 4, p. e0215508
Journal Article
Enzyme and Microbial Technology, ISSN 0141-0229, 10/2018, Volume 117, pp. 45 - 55
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/1999, Volume 96, Issue 18, pp. 10118 - 10122
... of the binding of the monoclonal antibody D1.3 to lysozyme ERNESTO FREIRE* Department of Biology and Biocalorimetry Center, Johns Hopkins University, Baltimore, MD 21218... 
Molecules | Solvents | Gibbs free energy | Structural stability | Hydrogen | Cooperation | Antibodies | Ligands | Biochemistry | Binding sites | COOPERATIVE INTERACTIONS | GLOBAL STABILITY | MOLTEN GLOBULE | FOLDING PATHWAY | MULTIDISCIPLINARY SCIENCES | EQUILIBRIUM | HIV-1 PROTEASE | STAPHYLOCOCCAL NUCLEASE | HYDROGEN-EXCHANGE RATES | ANTIGEN | MOLECULES | Ligand binding (Biochemistry) | Research | Monoclonal antibody probes | Lysozyme | Protein binding
Journal Article
Drug Discovery Today, ISSN 1359-6446, 2011, Volume 16, Issue 21, pp. 985 - 990
Extremely high affinity and selectivity are two of the most sought-after properties of drug molecules. Selectivity has been difficult to achieve, especially... 
THROMBIN INHIBITORS | BINDING THERMODYNAMICS | PHARMACOLOGY & PHARMACY | KINASE INHIBITORS | OPTIMIZATION | AFFINITY | Structure-Activity Relationship | Molecular Targeted Therapy | Humans | Drug Design | Pharmaceutical Preparations - chemistry | Proteases | Analysis
Journal Article
Journal Article
Journal Article