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by Klionsky, Daniel J and Abdelmohsen, Kotb and Abe, Akihisa and Abedin, Md Joynal and Abeliovich, Hagai and Acevedo Arozena, Abraham and Adachi, Hiroaki and Adams, Christopher M and Adams, Peter D and Adeli, Khosrow and Adhihetty, Peter J and Adler, Sharon G and Agam, Galila and Agarwal, Rajesh and Aghi, Manish K and Agnello, Maria and Agostinis, Patrizia and Aguilar, Patricia V and Aguirre-Ghiso, Julio and Airoldi, Edoardo M and Ait-Si-Ali, Slimane and Akematsu, Takahiko and Akporiaye, Emmanuel T and Al-Rubeai, Mohamed and Albaiceta, Guillermo M and Albanese, Chris and Albani, Diego and Albert, Matthew L and Aldudo, Jesus and Algül, Hana and Alirezaei, Mehrdad and Alloza, Iraide and Almasan, Alexandru and Almonte-Beceril, Maylin and Alnemri, Emad S and Alonso, Covadonga and Altan-Bonnet, Nihal and Altieri, Dario C and Alvarez, Silvia and Alvarez-Erviti, Lydia and Alves, Sandro and Amadoro, Giuseppina and Amano, Atsuo and Amantini, Consuelo and Ambrosio, Santiago and Amelio, Ivano and Amer, Amal O and Amessou, Mohamed and Amon, Angelika and An, Zhenyi and Anania, Frank A and Andersen, Stig U and Andley, Usha P and Andreadi, Catherine K and Andrieu-Abadie, Nathalie and Anel, Alberto and Ann, David K and Anoopkumar-Dukie, Shailendra and Antonioli, Manuela and Aoki, Hiroshi and Apostolova, Nadezda and Aquila, Saveria and Aquilano, Katia and Araki, Koichi and Arama, Eli and Aranda, Agustin and Araya, Jun and Arcaro, Alexandre and Arias, Esperanza and Arimoto, Hirokazu and Ariosa, Aileen R and Armstrong, Jane L and Arnould, Thierry and Arsov, Ivica and Asanuma, Katsuhiko and Askanas, Valerie and Asselin, Eric and Atarashi, Ryuichiro and Atherton, Sally S and Atkin, Julie D and Attardi, Laura D and Auberger, Patrick and Auburger, Georg and Aurelian, Laure and Autelli, Riccardo and Avagliano, Laura and Avantaggiati, Maria Laura and Avrahami, Limor and Awale, Suresh and Azad, Neelam and Bachetti, Tiziana and Backer, Jonathan M and Bae, Dong-Hun and Bae, Jae-sung and Bae, Ok-Nam and Bae, Soo Han and Baehrecke, Eric H and Baek, Seung-Hoon and Baghdiguian, Stephen and Bagniewska-Zadworna, Agnieszka and ... and Medicinska fakulteten and Region Östergötland and Linköpings universitet and Institutionen för klinisk och experimentell medicin and Diagnostikcentrum and Klinisk patologi och klinisk genetik and Institutionen för medicin och hälsa and Avdelningen för läkemedelsforskning and Avdelningen för cellbiologi
Autophagy, ISSN 1554-8627, 01/2016, Volume 12, Issue 1, pp. 1 - 222
Journal Article
Nature, ISSN 0028-0836, 07/2018, Volume 559, Issue 7715, pp. 1 - 2
Writing in Nature, Kanarek et al.1 report that degradation of the amino acid histidine can increase the sensitivity of cancer cells to methotrexate, and the... 
Enzymes | Toxicity | Leukemia | Genes | Clinical trials | Amino acids | Cancer therapies | Proteins | Histidine | Diet | Vitamin B | Dihydrofolate reductase | Drug dosages | Cancer | Tumors
Journal Article
Nature, ISSN 0028-0836, 07/2018, Volume 559, Issue 7715, pp. 484 - 485
Clinical use of the anticancer drug methotrexate can be limited by its high toxicity. It emerges that a diet rich in the amino acid histidine increases the... 
Metabolism | Medical research | Cancer | Histidine | Mutation | Research | Methotrexate | Humans | Neoplasms | Complications and side effects | Usage | Care and treatment | Analysis | Innovations | Drug metabolism
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 05/2016, Volume 12, Issue 6, pp. 389 - 390
  Phosphoglycerate dehydrogenase (PHGDH) is an enzyme of serine biosynthesis overexpressed in various types of cancer. A new series of PHGDH inhibitors... 
Serine | Neoplasms | Enzymes | Cell growth | Biosynthesis | Metabolism | Cancer
Journal Article
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 03/2014, Volume 48, Issue 1, pp. 11 - 17
Mitochondria are intracellular organelles thought to have evolved from an alphaproteobacterium engulfed by the ancestor of the eukaryotic cell, an archeon, two... 
Signal transduction | Mitochondria | Biochemistry | Oncometabolite | Cancer | Neoplasms - metabolism | Mitochondria - metabolism | Signal Transduction | Cell Transformation, Neoplastic - metabolism | Humans | Electric power-plants | Mitochondrial DNA | Power plants | Cellular | Tumours | Cascades | Physiology | Organelles | Diseases
Journal Article
BBA - Bioenergetics, ISSN 0005-2728, 09/2018, Volume 1859, pp. e4 - e5
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 06/2016, Volume 12, Issue 6, pp. 389 - 390
Journal Article
NATURE, ISSN 0028-0836, 07/2018, Volume 559, Issue 7715, pp. 484 - 485
Clinical use of the anticancer drug methotrexate can be limited by its high toxicity. It emerges that a diet rich in the amino acid histidine increases the... 
METHOTREXATE | MULTIDISCIPLINARY SCIENCES
Journal Article
ISSN 1552-4450, 2016
Cancer cells are biosynthetic factories that gear multiple metabolic pathways toward cell growth and proliferation. Serine is the metabolite consumed third... 
cancer therapy | metabolomics | metabolic pathways | small molecules
Journal Article
Nature Communications, ISSN 2041-1723, 10/2016, Volume 7, Issue 1, p. 13041
Cancer cells undergo a multifaceted rewiring of cellular metabolism to support their biosynthetic needs. Although the major determinants of this metabolic... 
GENE-EXPRESSION | CELLS | REDUCTIVE GLUTAMINE-METABOLISM | MULTIDISCIPLINARY SCIENCES
Journal Article