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1. Full Text Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
by Voight, Benjamin F, PhD and Peloso, Gina M, PhD and Orho-Melander, Marju, PhD and Frikke-Schmidt, Ruth, DMSc and Barbalic, Maja, PhD and Jensen, Majken K, PhD and Hindy, George, MD and Hólm, Hilma, MD and Ding, Eric L, ScD and Johnson, Toby, PhD and Schunkert, Heribert, Prof and Samani, Nilesh J, Prof and Clarke, Robert, MD and Hopewell, Jemma C, PhD and Thompson, John F, Prof and Li, Mingyao, PhD and Thorleifsson, Gudmar, PhD and Newton-Cheh, Christopher, MD and Musunuru, Kiran, MD and Pirruccello, James P, BS and Saleheen, Danish, MBBS and Chen, Li, MSc and Stewart, Alexandre FR, PhD and Schillert, Arne, PhD and Thorsteinsdottir, Unnur, PhD and Thorgeirsson, Gudmundur, MD and Anand, Sonia, Prof and Engert, James C, PhD and Morgan, Thomas, MD and Spertus, John, Prof and Stoll, Monika, Prof and Berger, Klaus, Prof and Martinelli, Nicola, MD and Girelli, Domenico, Prof and McKeown, Pascal P, Prof and Patterson, Christopher C, PhD and Epstein, Stephen E, MD and Devaney, Joseph, PhD and Burnett, Mary-Susan, PhD and Mooser, Vincent, MD and Ripatti, Samuli, PhD and Surakka, Ida, BSci and Nieminen, Markku S, Prof and Sinisalo, Juha, MD and Lokki, Marja-Liisa, PhD and Perola, Markus, Prof and Havulinna, Aki, PhD and de Faire, Ulf, Prof and Gigante, Bruna, MD and Ingelsson, Erik, PhD and Zeller, Tanja, PhD and Wild, Philipp, MD and de Bakker, Paul I W, Prof and Klungel, Olaf H, PhD and Maitland-van der Zee, Anke-Hilse, PhD and Peters, Bas J M, PhD and de Boer, Anthonius, Prof and Grobbee, Diederick E, Prof and Kamphuisen, Pieter W, PhD and Deneer, Vera H M, PhD and Elbers, Clara C, PhD and Onland-Moret, N Charlotte, PhD and Hofker, Marten H, Prof and Wijmenga, Cisca, Prof and Verschuren, WM Monique, PhD and Boer, Jolanda MA, PhD and van der Schouw, Yvonne T, Prof and Rasheed, Asif and Frossard, Philippe and Demissie, Serkalem, PhD and Willer, Cristen, PhD and Do, Ron, PhD and Ordovas, Jose M, Prof and Abecasis, Gonçalo R, Prof and Boehnke, Michael, Prof and Mohlke, Karen L, PhD and Daly, Mark J, PhD and Guiducci, Candace, BS and Burtt, Noël P, BS and Surti, Aarti, BS and Gonzalez, Elena, BS and Purcell, Shaun, PhD and Gabriel, Stacey, PhD and Marrugat, Jaume, PhD and Peden, John, PhD and Erdmann, Jeanette, PhD and Diemert, Patrick, MD and Willenborg, Christina, MSc and König, Inke R, PhD and Fischer, Marcus, MD and Hengstenberg, Christian, MD and Ziegler, Andreas, PhD and Buysschaert, Ian, MD and Lambrechts, Diether, PhD and Van de Werf, Frans, Prof and Fox, Keith A, Prof and El Mokhtari, Nour Eddine, MD and Rubin, Diana, MD and Schrezenmeir, Jürgen, PhD and Schreiber, Stefan, Prof and ...
Lancet, The, ISSN 0140-6736, 08/2012, Volume 380, Issue 9841, pp. 572 - 580
Summary Background High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear.... 
Internal Medicine | ENDOTHELIAL LIPASE | METAANALYSIS | BLOOD CHOLESTEROL | ATHEROSCLEROSIS | GENETIC-VARIANTS | LOCI | CORONARY-HEART-DISEASE | UMCG Approved | HIGH-DENSITY-LIPOPROTEIN | ISCHEMIC CARDIOVASCULAR-DISEASE | ARTERY-DISEASE | MEDICINE, GENERAL & INTERNAL | CONTRIBUTE | SUSCEPTIBILITY | CARDIOVASCULAR-DISEASE | ASSOCIATION | Mendelian Randomization Analysis - methods | Myocardial Infarction - blood | Myocardial Infarction - genetics | Genetic Predisposition to Disease | Myocardial Infarction - epidemiology | Prospective Studies | Gene Frequency | Humans | Risk Factors | Biomarkers - blood | Case-Control Studies | Cholesterol, HDL - blood | Cholesterol, LDL - blood | Polymorphism, Single Nucleotide | Myocardial Infarction - etiology | Lipase - genetics | Genetic aspects | High density lipoproteins | Health aspects | Heart attack | Risk factors | Studies | Plasma | Heart attacks | Diet | Cardiovascular disease | Lipids | Cholesterol | Medical and Health Sciences | Medicin och hälsovetenskap
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2. Full Text Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies
by The Emerging Risk Factors Collaboration and Emerging Risk Factors Collabor and Emerging Risk Factors Collaboration and Medicinska fakulteten and Geriatrik and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Institutionen för folkhälso- och vårdvetenskap
Lancet, The, ISSN 0140-6736, 2010, Volume 375, Issue 9733, pp. 2215 - 2222
Summary Background Uncertainties persist about the magnitude of associations of diabetes mellitus and fasting glucose concentration with risk of coronary heart... 
Internal Medicine | MORTALITY | WOMEN | ASIA-PACIFIC REGION | THERAPY | TASK-FORCE | ATHEROSCLEROSIS | CARDIOVASCULAR-DISEASES | CORONARY-HEART-DISEASE | UMCG Approved | PATHOPHYSIOLOGY | MEDICINE, GENERAL & INTERNAL | CARDIOVASCULAR-DISEASE | Diabetes Mellitus - blood | Fasting | Blood Glucose - analysis | Humans | Middle Aged | Risk Factors | Coronary Disease - etiology | Male | Diabetes Complications - blood | Stroke - etiology | Adult | Female | Aged | Stroke (Disease) | Complications and side effects | Research | Diabetes | Coronary heart disease | Risk factors | Heart failure | Heart attacks | Risk assessment | Data collection | Cardiovascular disease | Blood pressure | Estimates | Medical and Health Sciences | Medicin och hälsovetenskap
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3. Full Text Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease
by Zanoni, Paolo and Khetarpal, Sumeet A and Larach, Daniel B and Hancock-Cerutti, William F and Millar, John S and Cuchel, Marina and DerOhannessian, Stephanie and Kontush, Anatol and Surenan, Praveen and Saleheen, Danish and Trompet, Stella and Jukema, J. Wouter and de Craen, Anton and Deloukas, Panos and Sattar, Naveed and Ford, Ian and Packard, Chris and Majumder, Abdullah al Shafi and Alam, Dewan S and Di Angelantonio, Emanuele and Abecasis, Goncalo and Chowdhury, Rajiv and Erdmann, Jeanette and Nordestgaard, Børge G and Nielsen, Sune F and Tybjærg-Hansen, Anne and Schmidt, Ruth Frikke and Kuulasmaa, Kari and Liu, Dajiang J and Perola, Markus and Blankenberg, Stefan and Salomaa, Veikko and Männistö, Satu and Amouyel, Philippe and Arveiler, Dominique and Ferrieres, Jean and Müller-Nurasyid, Martina and Ferrario, Marco and Kee, Frank and Willer, Cristen J and Samani, Nilesh and Schunkert, Heribert and Butterworth, Adam S and Howson, Joanna M. M and Peloso, Gina M and Stitziel, Nathan O and Danesh, John and Kathiresan, Sekar and Kastelein, John J. P and Hovingh, G. Kees and Consortium, CE and Global Lipids Genetics Consortium and CARDIoGRAM Exome Consortium and CHD Exome+ Consortium
Science, ISSN 0036-8075, 2016, Volume 351, Issue 6278, pp. 1166 - 1171
Scavenger receptor BI (SR-BI) is the major receptor for high-density lipoprotein (HDL) cholesterol (HDL-C). In humans, high amounts of HDL-C in plasma are... 
ESTER | SELECTIVE LIPID UPTAKE | METABOLISM | MULTIDISCIPLINARY SCIENCES | I SR-BI | TARGETED MUTATION | ATHEROSCLEROSIS | DEFICIENT MICE | EXPRESSION | HIGH-DENSITY-LIPOPROTEIN | TRANSGENIC MICE | Coronary Disease - blood | Humans | Middle Aged | Male | Risk | Scavenger Receptors, Class B - genetics | Genetic Variation | Proline - genetics | Homozygote | Animals | Coronary Disease - genetics | DNA Mutational Analysis | Cholesterol, HDL - blood | Female | Heterozygote | Aged | Mice | Protein Processing, Post-Translational | Scavenger Receptors, Class B - metabolism | Leucine - genetics | Amino Acid Substitution | Physiological aspects | Blood cholesterol | Coronary heart disease | Risk factors | Cholesterol, HDL | Health aspects | Genotype & phenotype | Cardiovascular disease | Lipoproteins | Cholesterol
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4. Full Text C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis
by Kaptoge, Stephen and Di Angelantonio, Emanuele and Lowe, Gordon and Pepys, Mark B and Thompson, Simon G and Collins, Rory and Danesh, John and Tipping, Robert W and Ford, C. E and Pressel, S. L and Walldius, G and Jungner, I and Folsom, Aaron R and Chambless, L.E and Ballantyne, C. M and Panagiotakos, Demosthenes B and Pitsavos, C and Chrysohoou, C and Stefanadis, Christodoulos and Knuiman, Matthew W and Goldbourt, Uri and Benderly, M and Tanne, David and Whincup, P.H and Wannamethee, S.G and Morris, Richard W and Kiechl, S and Willeit, J and Mayr, A and Schett, G and Wald, N and Ebrahim, S and Lawlor, D.A and Yarnell, J.W and Gallacher, J and Casiglia, Edoardo and Tikhonoff, Valerie and Nietert, Paul J and Sutherland, Susan E and Bachman, D. L and Keil, J. E and Cushman, M and Psaty, Bruce M and Tracy, R and Tybjaerg-Hansen, A and Nordestgaard, B. G and Zacho, J and Frikke-Schmidt, R and Giampaoli, S and Palmieri, L and Panico, S and Vanuzzo, D and Pilotto, L and de la Camara, A. Gomez and Gerique, J. A. Gomez and Simons, Laura and McCallum, J and Friedlander, Yechiel and Fowkes, F. Gerry R and Lee, A and Taylor, Clare J and Guralnik, Jack M and Phillips, Caroline L and Wallace, Robert B and Blazer, Dan G and Khaw, Kay-Tee and Brenner, H and Raum, E and Mueller, Heiko and Rothenbacher, Dietrich and Jansson, J-H and Wennberg, Patrik and Nissinen, A and Donfrancesco, C and Salomaa, Veikko and Harald, K and Jousilahti, P and Vartiainen, E and Woodward, M and D'Agostino, Ralph B., Sr and Wolf, P. A and Vasan, Ramachanan S and Benjamin, Emelia J and Bladbjerg, E.M and Jorgensen, T and Moller, L and Jespersen, J and Dankner, Rachel and Chetrit, A and Lubin, F and Rosengren, Annika and Wilhelmsen, Lars and Lappas, G and Eriksson, HG and Bjorkelund, Cecilia and Lissner, L and Bengtsson, C and Cremer, Peter and Nagel, Dorothea and Tilvis, Reijo S and ... and Emerging Risk Factors Collaboration
Lancet, The, ISSN 0140-6736, 2010, Volume 375, Issue 9709, pp. 132 - 140
Summary Background Associations of C-reactive protein (CRP) concentration with risk of major diseases can best be assessed by long-term prospective follow-up... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | INDEPENDENT PREDICTOR | PLASMA-FIBRINOGEN | REGRESSION DILUTION | INFLAMMATION | CARDIOVASCULAR-DISEASE | PROSPECTIVE COHORTS | LOW-DENSITY LIPOPROTEIN | NONVASCULAR MORTALITY | MENDELIAN RANDOMIZATION | VASCULAR-DISEASE | Blood Pressure | Diabetes Mellitus - blood | Cholesterol - blood | Humans | Middle Aged | Lung Diseases - mortality | Male | Motor Activity | Coronary Disease - mortality | Neoplasms - blood | Lung Diseases - blood | Interleukin-6 - blood | Female | Leukocyte Count | Stroke - mortality | C-Reactive Protein - analysis | Databases, Factual | Body Mass Index | Coronary Disease - blood | Stroke - prevention & control | Risk Assessment | Smoking - blood | Risk Factors | Neoplasms - mortality | Biomarkers - blood | Stroke - blood | Regression Analysis | Coronary Disease - prevention & control | Serum Albumin | Alcohol Drinking - blood | Alcohol Drinking - epidemiology | Smoking - epidemiology | Diabetes Mellitus - epidemiology | Fibrinogen - analysis | Sex Factors | Triglycerides - blood | Proteins | Mortality | Cardiovascular disease | Statistical methods | Blood pressure | Risk factors | Statins | Inflammatory diseases | Meta-analysis | Clinical Medicine | Kirurgisk forskning | Medical and Health Sciences | Medicin och hälsovetenskap | MEDICIN | Surgery | Surgical research | Klinisk medicin | MEDICINE | Kirurgi | Ortopedi | Orthopaedics
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5. Full Text Rare and low-frequency coding variants alter human adult height
by Marouli, Eirini and Graff, Mariaelisa and Medina-Gomez, Carolina and Lo, Ken Sin and Wood, Anew R and Kjaer, Troels R and Fine, Rebecca S and Lu, Yingchang and Schurmann, Claudia and Highland, Heather M and Rüeger, Sina and Thorleifsson, Gudmar and Justice, Anne E and Lamparter, David and Stirrups, Kathleen E and Turcot, Valérie and Young, Kristin L and Winkler, Thomas W and Esko, Tõnu and Karaderi, Tugce and Locke, Adam E and Masca, Nicholas G. D and Ng, Maggie C. Y and Mudgal, Poorva and Rivas, Manuel A and Vedantam, Sailaja and Mahajan, Anubha and Guo, Xiuqing and Abecasis, Goncalo and Aben, Katja K and Adair, Linda S and Alam, Dewan S and Albrecht, Eva and Allin, Kristine H and Allison, Matthew and Amouyel, Philippe and Appel, Emil V and Arveiler, Dominique and Asselbergs, Folkert W and Auer, Paul L and Balkau, Beverley and Banas, Bernhard and Bang, Lia E and Benn, Marianne and Bergmann, Sven and Bielak, Lawrence F and Blüher, Matthias and Boeing, Heiner and Boerwinkle, Eric and Böger, Carsten A and Bonnycastle, Lori L and Bork-Jensen, Jette and Bots, Michiel L and Bottinger, Erwin P and Bowden, Donald W and Brandslund, Ivan and Breen, Gerome and Brilliant, Murray H and Broer, Linda and Burt, Amber A and Butterworth, Adam S and Carey, David J and Caulfield, Mark J and Chambers, John C and Chasman, Daniel I and Chen, Yii-Der Ida and Chowdhury, Rajiv and Christensen, Cramer and Chu, Auey Y and Cocca, Massimiliano and Collins, Francis S and Cook, James P and Corley, Janie and Galbany, Jordi Corominas and Cox, Amanda J and Cuellar-Partida, Gabriel and Danesh, John and Davies, Gail and de Bakker, Paul I. W and de Borst, Gert J and de Denus, Simon and de Groot, Mark C. H and de Mutsert, Renée and Deary, Ian J and Dedoussis, George and Demerath, Ellen W and den Hollander, Anneke I and Dennis, Joe G and Di Angelantonio, Emanuele and nos, Fotios and Du, Mengmeng and Dunning, Alison M and Easton, Douglas F and Ebeling, Tapani and Edwards, Todd L and Ellinor, Patrick T and Elliott, Paul and Evangelou, Evangelos and Farmaki, Aliki-Eleni and Faul, Jessica D and ... and EPIC-CVD Consortium and GoT2D Genes Consortium and MAGIC Investigators and Global Lipids Genetics Consortium and EPIC-InterAct Consortium and ReproGen Consortium and ExomeBP Consortium and CHD Exome Consortium and T2D-Genes Consortium and The EPIC-InterAct Consortium and CHD Exome+ Consortium and Medicinska fakulteten and Institutionen för folkhälsa och klinisk medicin and Enheten för biobanksforskning and Allmänmedicin and Umeå universitet and Medicin
Nature, ISSN 0028-0836, 2017, Volume 542, Issue 7640, pp. 186 - 190
Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so... 
MISSING HERITABILITY | GENETIC ARCHITECTURE | INTERLEUKIN-11 | MUTATIONS | MULTIDISCIPLINARY SCIENCES | GENOME-WIDE ASSOCIATION | Stature | Genetic aspects | Observations | Genetic variation | Studies | Datasets | Disease | Genes | Deoxyribonucleic acid--DNA | Hälsovetenskaper | Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi | Medical and Health Sciences | Medicin och hälsovetenskap | Public Health, Global Health, Social Medicine and Epidemiology | Health Sciences
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6. Full Text Exome-wide association study of plasma lipids in >300,000 individuals
by Liu, Dajiang J and Peloso, Gina M and Yu, Haojie and Butterworth, Adam S and Wang, Xiao and Mahajan, Anubha and Saleheen, Danish and Emdin, Connor and Alam, Dewan and Alves, Alexessander Couto and Amouyel, Philippe and Di Angelantonio, Emanuele and Arveiler, Dominique and Assimes, Themistocles L and Auer, Paul L and Baber, Usman and Ballantyne, Christie M and Bang, Lia E and Benn, Marianne and Bis, Joshua C and Boehnke, Michael and Boerwinkle, Eric and Bork-Jensen, Jette and Bottinger, Erwin P and Brandslund, Ivan and Brown, Morris and Busonero, Fabio and Caulfield, Mark J and Chambers, John C and Chasman, Daniel I and Chen, Y. Eugene and Chen, Yii-Der Ida and Chowdhury, Rajiv and Christensen, Cramer and Chu, Auey Y and Connell, John M and Cucca, Francesco and Cupples, L. Aienne and Damrauer, Scott M and Davies, Gail and Deary, Ian J and Dedoussis, George and Denny, Joshua C and Dominiczak, Anna and Dubé, Marie-Pierre and Ebeling, Tapani and Eiriksdottir, Gudny and Esko, Tõnu and Farmaki, Aliki-Eleni and Feitosa, Mary F and Ferrario, Marco and Ferrieres, Jean and Ford, Ian and Fornage, Myriam and Franks, Paul W and Frayling, Timothy M and Frikke-Schmidt, Ruth and Fritsche, Lars G and Frossard, Philippe and Fuster, Valentin and Ganesh, Santhi K and Gao, Wei and Garcia, Melissa E and Gieger, Christian and Giulianini, Franco and Goodarzi, Mark O and Grallert, Harald and Grarup, Niels and Groop, Leif and Grove, Megan L and Gudnason, Vilmundur and Hansen, Torben and Harris, Tamara B and Hayward, Caroline and Hirschhorn, Joel N and Holmen, Oddgeir L and Huffman, Jennifer and Huo, Yong and Hveem, Kristian and Jabeen, Sehrish and Jackson, Anne U and Jakobsdottir, Johanna and Jarvelin, Marjo-Riitta and Jensen, Gorm B and Jørgensen, Marit E and Jukema, J. Wouter and Justesen, Johanne M and Kamstrup, Pia R and Kanoni, Stavroula and Karpe, Freik and Kee, Frank and Khera, Amit V and Klarin, Derek and Koistinen, Heikki A and Kooner, Jaspal S and Kooperberg, Charles and Kuulasmaa, Kari and Kuusisto, Johanna and Laakso, Markku and Lakka, Timo and ... and VA Million Veteran Program and Charge Diabet Working Grp and EPIC-CVD Consortium and EPIC-InterAct Consortium and GOLD Consortium and Charge Diabetes Working Group and The EPIC-InterAct Consortium
Nature genetics, ISSN 1061-4036, 2017, Volume 49, Issue 12, pp. 1758 - 1766
We screened variants on an exome-focused genotyping array in >300,000 participants (replication in >280,000 participants) and identified 444 independent... 
APOBEC-1 COMPLEMENTATION FACTOR | MYELOPROLIFERATIVE DISORDERS | LOW-FREQUENCY | CLONAL HEMATOPOIESIS | B MESSENGER-RNA | GENETICS & HEREDITY | TYROSINE KINASE JAK2 | CARDIOVASCULAR-DISEASE | MACULAR DEGENERATION | GENETIC ARCHITECTURE | CODING-SEQUENCE VARIANTS | Genetic Predisposition to Disease - genetics | Diabetes Mellitus, Type 2 - genetics | Humans | Risk Factors | Genetic Association Studies - methods | Genotype | Coronary Artery Disease - blood | Macular Degeneration - blood | Genetic Variation | Diabetes Mellitus, Type 2 - blood | Exome - genetics | Phenotype | Macular Degeneration - genetics | Lipids - blood | Coronary Artery Disease - genetics | Genome-wide association studies | Genetic aspects | Blood lipids | Identification and classification | Methods | Plasma | Lipoproteins (low density) | Liver | Lipids | Risk | Cardiovascular disease | Genomes | Macular degeneration | Consortia | Janus kinase 2 | Heart diseases | Lipoproteins (high density) | Age | Diabetes mellitus | Coronary artery | Health risks | Thalassemia | Triglycerides | Coronary artery disease | Loci | Cholesterol | Lipolysis | Studies | Lipoproteins | Genotyping | Alleles | Quality control | Diabetes
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