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1. Full Text Development of immune checkpoint therapy for cancer
by Fritz, Jill M and Lenardo, Michael J
The Journal of experimental medicine, ISSN 0022-1007, 06/2019, Volume 216, Issue 6, pp. 1244 - 1254
Since the early 20th century, immunologists have investigated mechanisms that protect vertebrates from damaging immune responses against self-antigens by... 
317 | 314 | Reviews
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2. Full Text A Defect in the Bone Marrow Microenvironment of ERdj4GT/GT Mice Impacts B Cell Development
by Fritz, Jill M and Weaver, Timothy E
Blood, ISSN 0006-4971, 11/2012, Volume 120, Issue 21, pp. 3463 - 3463
Abstract Abstract 3463 ERdj4 is a critical component of the unfolded protein response (UPR) that facilitates the removal of unfolded/misfolded substrates from... 
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3. Full Text Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy
by Lo, Bernice and Zhang, Kejian and Lu, Wei and Zheng, Lixin and Zhang, Qian and Kanellopoulou, Chrysi and Zhang, Yu and Liu, Zhiduo and Fritz, Jill M and Marsh, Rebecca and Husami, Ammar and Kissell, Diane and Nortman, Shannon and Chaturvedi, Vijaya and Haines, Hilary and Young, Lisa R and Mo, Jun and Filipovich, Alexandra H and Bleesing, Jack J and Mustillo, Peter and Stephens, Michael and Rueda, Cesar M and Chougnet, Claire A and Hoebe, Kasper and McElwee, Joshua and Hughes, Jason D and Karakoc-Aydiner, Elif and Matthews, Helen F and Price, Susan and Su, Helen C and Rao, V. Koneti and Lenardo, Michael J and Jordan, Michael B
Science, ISSN 0036-8075, 07/2015, Volume 349, Issue 6246, pp. 436 - 440
Mutations in the LRBA gene (encoding the lipopolysaccharide-responsive and beige-like anchor protein) cause a syndrome of autoimmunity, lymphoproliferation,... 
RHEUMATOID-ARTHRITIS | ACTIVATION | LYMPHOPROLIFERATION | GENE | MULTIDISCIPLINARY SCIENCES | LONG-TERM SAFETY | DISEASE | REGULATORY T-CELLS | COMMON VARIABLE IMMUNODEFICIENCY | DISORDERS | MUTATIONS | Proteins | Autoimmune diseases | Drug therapy | Immune system | Degradation | Anchors | Drugs | Therapy | Receptors | Disorders | Patients
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4. Full Text Lipid transport and epithelial barrier integrity
by Fritz, Jill M and Yang, Li and Weaver, Timothy E
Oncotarget, 08/2015, Volume 6, Issue 25, p. 20744
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5. Full Text CHAI and LATAIE: New genetic diseases of CTLA-4 checkpoint insufficiency
by Lo, Bernice and Fritz, Jill M and Su, Helen C and Uzel, Gulbu and Jordan, Michael B and Lenardo, Michael J
Blood, ISSN 0006-4971, 08/2016, Volume 128, Issue 8, pp. 1037 - 1042
CTLA-4 is a critical inhibitory "checkpoint" molecule of immune activation. Several recent reports have described patients with immune dysregulation and... 
HYDROXYCHLOROQUINE | IMMUNE DYSREGULATION | LRBA | REGULATORY T-CELLS | PATIENT | MUTATIONS | IDENTIFICATION | ENDOCYTOSIS | HEMATOLOGY | FOLLICULAR HELPER | TRANSPLANTATION | Phenotype | Immune System Diseases - genetics | Humans | Immunotherapy | CTLA-4 Antigen - genetics | Cell Cycle Checkpoints - genetics | Immune System Diseases - therapy | Mutation - genetics | Spotlight | 100 | 101
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6. Full Text The BiP cochaperone ERdj4 is required for B cell development and function
by Fritz, Jill M and Weaver, Timothy E
PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, p. e107473
ERdj4 is a BiP cochaperone regulated by the unfolded protein response to facilitate degradation of unfolded and/or misfolded proteins in the endoplasmic... 
MASTER CHAPERONE | STEM-CELLS | UNFOLDED PROTEIN RESPONSE | ER STRESS | MULTIDISCIPLINARY SCIENCES | BONE-MARROW | GP96 | TRANSCRIPTION FACTOR XBP-1 | TOLL-LIKE RECEPTORS | IMMUNOGLOBULIN | DIFFERENTIATION | Spleen - immunology | Endoplasmic Reticulum - genetics | Unfolded Protein Response - genetics | Lipopolysaccharides - administration & dosage | Precursor Cells, B-Lymphoid - metabolism | Molecular Chaperones - genetics | Hematopoiesis - genetics | Precursor Cells, B-Lymphoid - immunology | Lipopolysaccharides - immunology | Membrane Glycoproteins - genetics | Hematopoiesis - immunology | Lymphocyte Activation - immunology | Animals | Bone Marrow Cells - immunology | Endoplasmic Reticulum - immunology | Antibodies - immunology | Cell Proliferation - drug effects | Mice | Membrane Glycoproteins - immunology | Molecular Chaperones - immunology | Cell Lineage - genetics | Cell Lineage - immunology | Proteins | T cells | B cells | Cell proliferation | Flow cytometry | Lymphopoiesis | Genes | Homeostasis | Lymphocytes T | Homozygosity | Antibody response | Defects | Lipopolysaccharides | Protein folding | Lymphocytes | Bone marrow | Spleen | Antigens | Lymphoid cells | Myeloid cells | Immunoglobulins | Cell survival | Survival | Hemopoiesis | Class switching | Lymphocytes B | Hypergammaglobulinemia | Stem cells | Bone | Endoplasmic reticulum | Apoptosis
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7. The BiP Cochaperone ERdj4 Is Required for B Cell Development and Function: e107473
by Fritz, Jill M and Weaver, Timothy E
PLoS ONE, 09/2014, Volume 9, Issue 9
ERdj4 is a BiP cochaperone regulated by the unfolded protein response to facilitate degradation of unfolded and/or misfolded proteins in the endoplasmic... 
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8. Full Text Lipid transport and epithelial barrier integrity
by Fritz, Jill M and Yang, Li and Weaver, Timothy E
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 25, pp. 20744 - 20745
START domain | Mitochondria | Stard7 | Asthma | Phospholipid transport protein
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9. Full Text Haploinsufficiency for Stard7 is Associated With Enhanced Allergic Responses in Lung and Skin1
by Yang, Li and Lewkowich, Ian and Apsley, Karen and Fritz, Jill M and Wills-Karp, Marsha and Weaver, Timothy E
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 6/2015, Volume 194, Issue 12, pp. 5635 - 5643
Allergic asthma is a chronic inflammatory disorder that affects approximately 20% of the population worldwide. Microarray analyses of nasal epithelial cells... 
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10. Full Text STAT5B: A differential regulator of the life and death of CD4+ effector memory T cells
by Majri, Sonia S and Fritz, Jill M and Villarino, Alejandro V and Zheng, Lixin and Kanellopoulou, Chrysi and Chaigne-Delalande, Benjamin and Grönholm, Juha and Niemela, Julie E and Afzali, Behdad and Biancalana, Matthew and Pittaluga, Stefania and Sun, Ashleigh and Cohen, José L and Holland, Steven M and O'Shea, John J and Uzel, Gulbu and Lenardo, Michael J
Journal of Immunology, ISSN 0022-1767, 01/2018, Volume 200, Issue 1, pp. 110 - 118
Understanding the control of Ag restimulation-induced T cell death (RICD), especially in cancer immunotherapy, where highly proliferating T cells will... 
SIGNAL-TRANSDUCTION | INTERLEUKIN-2 | HOMEOSTASIS | EXPRESSION ANALYSIS | GENE | GENERATION | IL-2 | MUTATIONS | IMMUNOLOGY | DNA-SEQUENCING DATA | ANTIBODY-RESPONSES | Signal Transduction | Cell Survival | Lymphocyte Activation | Humans | Mice, Inbred C57BL | Antibodies, Neutralizing - metabolism | Cells, Cultured | Male | Mutation, Missense - genetics | Mice, Knockout | CD4-Positive T-Lymphocytes - immunology | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Animals | Interleukin-2 - immunology | Autoimmune Lymphoproliferative Syndrome - genetics | Autoimmune Lymphoproliferative Syndrome - immunology | Female | Immunologic Memory | Transcription, Genetic | Mice | Apoptosis | Transcription factors | Effector cells | Lymphocytes T | Proteins | T-cell receptor | Immunology | Missense mutation | Interleukin 2 | Lymphocytes | Immunotherapy | Peripheral blood | Immunological memory | Memory cells | Cell survival | Cytokines | Mortality | Stat5 protein | Gene expression | CD4 antigen | Signaling | Cell death | Stat5b protein | Cancer
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11. Full Text Haploinsufficiency for Stard7 is associated with enhanced allergic responses in lung and skin
by Yang, Li and Lewkowich, Ian and Apsley, Karen and Fritz, Jill M and Wills-Karp, Marsha and Weaver, Timothy E
Journal of Immunology, ISSN 0022-1767, 06/2015, Volume 194, Issue 12, pp. 5635 - 5643
Allergic asthma is a chronic inflammatory disorder that affects similar to 20% of the population worldwide. Microarray analyses of nasal epithelial cells from... 
MURINE MODEL | PHOSPHATIDYLCHOLINE TRANSFER PROTEIN | ASTHMA PATHOGENESIS | MITOCHONDRIA | ACTIVATED-RECEPTOR-GAMMA | AIRWAY INFLAMMATION | PPAR-GAMMA | ALPHA | IMMUNOLOGY | NF-KAPPA-B | EXPRESSION | Ovalbumin - immunology | Dermatitis - immunology | Skin - metabolism | Dendritic Cells - immunology | Hypersensitivity - immunology | Male | Th2 Cells - immunology | Adoptive Transfer | Respiratory Mucosa - pathology | Gene Deletion | Ovalbumin - adverse effects | Respiratory Mucosa - immunology | Female | Hypersensitivity - genetics | Lung - metabolism | Dendritic Cells - metabolism | Disease Models, Animal | Skin - immunology | Lung - pathology | Cytokines - metabolism | Dermatitis - genetics | Permeability | Th2 Cells - metabolism | Disease Progression | Haploinsufficiency | Mice, Knockout | Carrier Proteins - genetics | Animals | Models, Biological | Mice | Respiratory Mucosa - metabolism | Lung - immunology | Dermatitis - metabolism
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12. Full Text Deficiency of the BiP cochaperone ERdj4 causes constitutive endoplasmic reticulum stress and metabolic defects
by Fritz, Jill M and Dong, Mei and Apsley, Karen S and Martin, Emily P and Na, Cheng-Lun and Sitaraman, Sneha and Weaver, Timothy E
Molecular Biology of the Cell, ISSN 1059-1524, 02/2014, Volume 25, Issue 4, pp. 431 - 440
Endoplasmic reticulum-localized DnaJ 4 (ERdj4) is an immunoglobulin-binding protein (BiP) cochaperone and component of the endoplasmic reticulum-associated... 
GLUCOSE-HOMEOSTASIS | UNFOLDED-PROTEIN RESPONSE | ER STRESS | MOLECULAR CHAPERONES | BETA-CELL APOPTOSIS | INSULIN-SECRETION | WOLCOTT-RALLISON-SYNDROME | DNAJ HOMOLOG | TRANSLATIONAL CONTROL | TRANSGENIC MICE | CELL BIOLOGY | Liver - pathology | Fetal Growth Retardation - genetics | Male | Hypoglycemia - pathology | Genetic Loci | Endoplasmic Reticulum Stress - genetics | Glucose Intolerance | Heat-Shock Proteins - genetics | Insulin-Secreting Cells - metabolism | Fetal Death | Gene Expression Regulation, Developmental | Female | Fetus | Hypoglycemia - genetics | Glycogen - deficiency | Signal Transduction | Heat-Shock Proteins - metabolism | Liver - metabolism | Mice, Inbred C57BL | Mice, Transgenic | Fetal Growth Retardation - metabolism | Hypoglycemia - metabolism | Genes, Essential | Fetal Growth Retardation - pathology | Membrane Glycoproteins - genetics | Homozygote | Animals | Mutagenesis | Insulin - deficiency | Mice | Insulin-Secreting Cells - pathology | Blood Glucose - metabolism | Membrane Glycoproteins - deficiency | Crosses, Genetic
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13. Full Text Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy
by Lo, Bernice and Zhang, Kejian and Lu, Wei and Zheng, Lixin and Zhang, Qian and Kanellopoulou, Chrysi and Zhang, Yu and Liu, Zhiduo and Fritz, Jill M and Marsh, Rebecca and Husami, Amraar and Kissell, Diane and Nortman, Shannon and Chaturvedi, Vijaya and Haines, Hilary and Young, Lisa R and Mo, Jun and Filipovich, Alexandra H and Bleesing, Jack J and Mustillo, Peter and Stephens, Michael and Rueda, Cesar M and Chougnet, Claire A and Hoebe, Kasper and McElwee, Joshua and Hughes, Jason D and Karakoc-Aydiner, Elif and Matthews, Helen F and Price, Susan and Su, Helen C and Rao, V. Koneti and Lenardo, Michael J and Jordan, Michael B
Science, ISSN 0036-8075, 07/2015, Volume 349, Issue 6246, p. 436
Mutations in the LRBA gene (encoding the lipopolysaccharide-responsive and beige-like anchor protein) cause a syndrome of autoimmunity, lymphoproliferation,... 
Immune response | Gene mutations | Genetic aspects | Binding proteins | T cells | Identification and classification | Health aspects
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14. Full Text AUTOIMMUNE DISEASE. Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy
by Lo, Bernice and Zhang, Kejian and Lu, Wei and Zheng, Lixin and Zhang, Qian and Kanellopoulou, Chrysi and Zhang, Yu and Liu, Zhiduo and Fritz, Jill M and Marsh, Rebecca and Husami, Ammar and Kissell, Diane and Nortman, Shannon and Chaturvedi, Vijaya and Haines, Hilary and Young, Lisa R and Mo, Jun and Filipovich, Alexandra H and Bleesing, Jack J and Mustillo, Peter and Stephens, Michael and Rueda, Cesar M and Chougnet, Claire A and Hoebe, Kasper and McElwee, Joshua and Hughes, Jason D and Karakoc-Aydiner, Elif and Matthews, Helen F and Price, Susan and Su, Helen C and Rao, V Koneti and Lenardo, Michael J and Jordan, Michael B
Science (New York, N.Y.), 07/2015, Volume 349, Issue 6246, p. 436
Mutations in the LRBA gene (encoding the lipopolysaccharide-responsive and beige-like anchor protein) cause a syndrome of autoimmunity, lymphoproliferation,... 
Lung Diseases, Interstitial - metabolism | Common Variable Immunodeficiency - drug therapy | Humans | Male | Endosomes - metabolism | Gene Knockdown Techniques | Young Adult | Chloroquine - pharmacology | Lysosomes - metabolism | Abatacept | Proteolysis | T-Lymphocytes - drug effects | HEK293 Cells | Immunoconjugates - therapeutic use | Female | Autoimmune Diseases - metabolism | Child | Autoimmune Diseases - drug therapy | Lymphocyte Activation | CTLA-4 Antigen - genetics | Lung Diseases, Interstitial - drug therapy | CTLA-4 Antigen - deficiency | Common Variable Immunodeficiency - metabolism | Adaptor Proteins, Signal Transducing - genetics | Adolescent | Forkhead Transcription Factors - analysis | T-Lymphocytes - immunology | Adaptor Proteins, Signal Transducing - metabolism
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15. Full Text The Neurological Exercise Training (NExT) program: A pilot study of a community exercise program for survivors of stroke
by Regan, Elizabeth W and Handlery, Reed and Liuzzo, Derek M and Stewart, Jill C and Burke, Andrew R and Hainline, Garrett M and Horn, Curtis and Keown, Jonathan T and McManus, Abby E and Lawless, Brianna S and Purcell, Morgan and Fritz, Stacy
Disability and Health Journal, ISSN 1936-6574, 07/2019, Volume 12, Issue 3, pp. 528 - 532
Many survivors of stroke face chronic disability and increased risk for recurrent stroke. Regular physical activity can reduce these risk factors and improve... 
Community program | Stroke | Exercise | MANAGEMENT | GAIT | MOTIVATORS | PERFORMANCE | BARRIERS | RELIABILITY | INDIVIDUALS | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | HEALTH CARE SCIENCES & SERVICES | REHABILITATION | HEALTH POLICY & SERVICES | PHYSICAL-ACTIVITY | BERG BALANCE SCALE | POSTSTROKE | Physical therapy | Therapeutics, Physiological
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16. Full Text Status of breeding and wintering Snowy Plovers in San Diego County, California, 1994–1999
by Abby N. Powell and Christine L. Fritz and Bonnie L. Peterson and Jill M. Terp
Journal of Field Ornithology, ISSN 0273-8570, 2002, Volume 73, Issue 2, pp. 156 - 165
Abstract We conducted intensive surveys of breeding and wintering Snowy Plovers (Charadrius alexandrinus nivosus) in San Diego County from 1994 through the... 
nest success | Charadrius alexandrinus nivosus | southern California | populations | Threatened and Endangered Species | Animal nesting | Bird nesting | Breeding | Breeding sites | Male animals | Lagoons | Chicks | Breeding seasons | Beaches | Nesting sites | Southern California | Populations | Nest success | threatened and endangered species | AREAS | ORNITHOLOGY | REPRODUCTIVE SUCCESS
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17. Full Text Instrument-assisted soft tissue mobilization and proprioceptive neuromuscular facilitation techniques improve hamstring flexibility better than static stretching alone: a randomized clinical trial
by Gunn, Leanna J and Stewart, Jill Campbell and Morgan, Brittany and Metts, Steven T and Magnuson, Justin M and Iglowski, Nicholas J and Fritz, Stacy L and Arnot, Catherine
Journal of Manual & Manipulative Therapy, ISSN 1066-9817, 01/2019, Volume 27, Issue 1, pp. 15 - 23
Objectives: Tight hamstrings contribute to inefficiency of movement and increased risk for injury. Static stretching is the most common intervention for this... 
hip flexion | active straight leg raise | range of motion | knee flexors | digital inclinometer | passive straight leg raise | Flexibility | lower extremity
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18. Full Text Merocyanine 540-sensitized photoinactivation of enveloped viruses in blood products: Site and mechanism of phototoxicity
by O'Brien, J.M and O'Brien, Jill M and Gaffney, David K and Gaffney, D.K and Wang, Tian P and Wang, T.P and Sieber, Fritz and Sieber, F
Blood, ISSN 0006-4971, 1992, Volume 80, Issue 1, pp. 277 - 285
The amphipathic dye, merocyanine 540 (MC540), which preferentially photosensitizes enveloped viruses and virus-infected cells, is currently being evaluated in... 
HEMATOPOIETIC-CELLS | LEUKEMIC-CELLS | MEROCYANINE 540-SENSITIZED PHOTOINACTIVATION | BONE-MARROW TRANSPLANTATION | SINGLET OXYGEN PRODUCTION | DYE-MEDIATED PHOTOLYSIS | 540-MEDIATED PHOTOSENSITIZATION | MEMBRANES | HEMATOLOGY | FLUORESCENT-PROBE | NEURO-BLASTOMA CELLS | Simplexvirus - drug effects | Oxidation-Reduction | Photochemotherapy - methods | Receptors, Virus - metabolism | Cysteamine - chemistry | Humans | Cells, Cultured | Simplexvirus - ultrastructure | Pyrimidinones - chemistry | Cell Membrane - chemistry | Animals | Virus Diseases - drug therapy | Cell Membrane - metabolism | Glutathione - chemistry | Dithiothreitol - chemistry | Pyrimidinones - toxicity | In Vitro Techniques | Simplexvirus - metabolism | Vero Cells
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