Nature Genetics, ISSN 1061-4036, 2013, Volume 45, Issue 11, pp. 1353 - 1362
Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants...
AUTOIMMUNE | ALLELES | METAANALYSIS | GENOTYPE IMPUTATION | GENETIC RISK | INFORMATION | ANNOTATION | PRIMARY BILIARY-CIRRHOSIS | DISEASE | GENETICS & HEREDITY | GENOME-WIDE ASSOCIATION | Genetic Variation | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Gene Frequency | Humans | Multiple Sclerosis - immunology | Genotype | Multiple Sclerosis - genetics | Chromosome Mapping | Polymorphism, Single Nucleotide | Genetic Loci | Multiple sclerosis | Chromosome mapping | Genetic susceptibility | Genetic variation | Genetic aspects | Identification and classification | Methods | Testing | Confidence intervals | Disease | Quality control | Genomes | Stratigraphy | Autoimmune diseases | Gene expression | Meta-analysis | Teknik och teknologier | TEKNIKVETENSKAP | Engineering and Technology | TECHNOLOGY
AUTOIMMUNE | ALLELES | METAANALYSIS | GENOTYPE IMPUTATION | GENETIC RISK | INFORMATION | ANNOTATION | PRIMARY BILIARY-CIRRHOSIS | DISEASE | GENETICS & HEREDITY | GENOME-WIDE ASSOCIATION | Genetic Variation | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Gene Frequency | Humans | Multiple Sclerosis - immunology | Genotype | Multiple Sclerosis - genetics | Chromosome Mapping | Polymorphism, Single Nucleotide | Genetic Loci | Multiple sclerosis | Chromosome mapping | Genetic susceptibility | Genetic variation | Genetic aspects | Identification and classification | Methods | Testing | Confidence intervals | Disease | Quality control | Genomes | Stratigraphy | Autoimmune diseases | Gene expression | Meta-analysis | Teknik och teknologier | TEKNIKVETENSKAP | Engineering and Technology | TECHNOLOGY
Journal Article
Science, ISSN 0036-8075, 2014, Volume 343, Issue 6175, pp. 1119 - 1119
Little is known about how human genetic variation affects the responses to environmental stimuli in the context of complex diseases. Experimental and...
MULTIDISCIPLINARY SCIENCES | MYCOBACTERIUM-TUBERCULOSIS INFECTION | TOLL-LIKE RECEPTORS | ARCHITECTURE | RESISTANCE | INFLUENZA | LOCI | PATTERN-RECOGNITION RECEPTORS | EXPRESSION | GENOME-WIDE ASSOCIATION | INNATE IMMUNITY | Genome-Wide Association Study | Dendritic Cells - immunology | Escherichia coli | Humans | Middle Aged | Transcriptome | Communicable Diseases - genetics | Male | Genetic Loci | Interferon Regulatory Factor-7 - genetics | Gene-Environment Interaction | Lipopolysaccharides - immunology | Autoimmune Diseases - genetics | Young Adult | STAT Transcription Factors - genetics | Host-Pathogen Interactions - genetics | Influenza A virus | Interferon-beta - pharmacology | HEK293 Cells | Adult | Dendritic Cells - drug effects | Female | Polymorphism, Single Nucleotide | Quantitative Trait Loci | Immune response | Dendritic cells | Genetic variation | Physiological aspects | Genetic research | Genetic aspects | Research
MULTIDISCIPLINARY SCIENCES | MYCOBACTERIUM-TUBERCULOSIS INFECTION | TOLL-LIKE RECEPTORS | ARCHITECTURE | RESISTANCE | INFLUENZA | LOCI | PATTERN-RECOGNITION RECEPTORS | EXPRESSION | GENOME-WIDE ASSOCIATION | INNATE IMMUNITY | Genome-Wide Association Study | Dendritic Cells - immunology | Escherichia coli | Humans | Middle Aged | Transcriptome | Communicable Diseases - genetics | Male | Genetic Loci | Interferon Regulatory Factor-7 - genetics | Gene-Environment Interaction | Lipopolysaccharides - immunology | Autoimmune Diseases - genetics | Young Adult | STAT Transcription Factors - genetics | Host-Pathogen Interactions - genetics | Influenza A virus | Interferon-beta - pharmacology | HEK293 Cells | Adult | Dendritic Cells - drug effects | Female | Polymorphism, Single Nucleotide | Quantitative Trait Loci | Immune response | Dendritic cells | Genetic variation | Physiological aspects | Genetic research | Genetic aspects | Research
Journal Article
Genome research, ISSN 1088-9051, 12/2018, Volume 28, Issue 12, pp. 1812 - 1825
While genetic variants are known to be associated with overall gene abundance in stimulated immune cells, less is known about their effects on alternative...
QUALITY | VARIANTS | RECONSTRUCTION | QUANTIFICATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTERFERON | TRANSFER-RNA SYNTHETASE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | IMMUNE-RESPONSES | GENETICS & HEREDITY | ARCHITECTURE | EXPRESSION | GENOME-WIDE ASSOCIATION | Research
QUALITY | VARIANTS | RECONSTRUCTION | QUANTIFICATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTERFERON | TRANSFER-RNA SYNTHETASE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | IMMUNE-RESPONSES | GENETICS & HEREDITY | ARCHITECTURE | EXPRESSION | GENOME-WIDE ASSOCIATION | Research
Journal Article
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Full Text
Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus
Neurology, ISSN 0028-3878, 11/2013, Volume 81, Issue 22, pp. 1891 - 1899
OBJECTIVE:We set out to characterize the clinical impact and functional consequences of rs1800693, the multiple sclerosis (MS) susceptibility allele found in...
AA 5 Amino Acids | MSSS 5 Multiple Sclerosis Severity Scale | MS 5 Multiple Sclerosis | NF 5 Nuclear Factor | BWH 5 Brigham and Women's Hospital | TRAPS 5 TNF receptor-associated periodic syndrome | CI 5 Confidence Interval | STNFRSF1A 5 soluble TNFRSF1A | IFN-b 5 Interferon-B | TNF 5 tumor necrosis factor | GA 5 Glatiramer Acetate | MAPK 5 Mitogen-Activated Protein Kinase | PBMC 5 Peripheral Blood Mononuclear Cell | METAANALYSIS | SYNDROME TRAPS | GENETIC RISK | CHEMOKINES | TNF-RECEPTOR | SUSCEPTIBILITY | TRANSCRIPTION | ASSOCIATION | EXPRESSION | CLINICAL NEUROLOGY | I INTERFERON | Multiple Sclerosis - blood | Humans | Tumor Necrosis Factor-alpha - blood | Male | Monocytes - metabolism | Arginine - genetics | HEK293 Cells | Monocytes - pathology | Phorbol Esters - pharmacology | Female | Genetic Predisposition to Disease - genetics | RNA Isoforms - genetics | Receptors, Tumor Necrosis Factor, Type I - blood | Gene Expression Regulation - genetics | Genotype | Multiple Sclerosis - genetics | Signal Transduction - genetics | Mutation - genetics | Receptors, Tumor Necrosis Factor, Type I - genetics | Gene Expression Regulation - drug effects | Monocytes - drug effects | Tumor Necrosis Factor-alpha - pharmacology | Animals | Signal Transduction - drug effects | Chemokine CXCL10 - genetics | Glutamine - genetics | Longitudinal Studies | Immunologic Factors - therapeutic use | Multiple Sclerosis - drug therapy | 132 | 120
AA 5 Amino Acids | MSSS 5 Multiple Sclerosis Severity Scale | MS 5 Multiple Sclerosis | NF 5 Nuclear Factor | BWH 5 Brigham and Women's Hospital | TRAPS 5 TNF receptor-associated periodic syndrome | CI 5 Confidence Interval | STNFRSF1A 5 soluble TNFRSF1A | IFN-b 5 Interferon-B | TNF 5 tumor necrosis factor | GA 5 Glatiramer Acetate | MAPK 5 Mitogen-Activated Protein Kinase | PBMC 5 Peripheral Blood Mononuclear Cell | METAANALYSIS | SYNDROME TRAPS | GENETIC RISK | CHEMOKINES | TNF-RECEPTOR | SUSCEPTIBILITY | TRANSCRIPTION | ASSOCIATION | EXPRESSION | CLINICAL NEUROLOGY | I INTERFERON | Multiple Sclerosis - blood | Humans | Tumor Necrosis Factor-alpha - blood | Male | Monocytes - metabolism | Arginine - genetics | HEK293 Cells | Monocytes - pathology | Phorbol Esters - pharmacology | Female | Genetic Predisposition to Disease - genetics | RNA Isoforms - genetics | Receptors, Tumor Necrosis Factor, Type I - blood | Gene Expression Regulation - genetics | Genotype | Multiple Sclerosis - genetics | Signal Transduction - genetics | Mutation - genetics | Receptors, Tumor Necrosis Factor, Type I - genetics | Gene Expression Regulation - drug effects | Monocytes - drug effects | Tumor Necrosis Factor-alpha - pharmacology | Animals | Signal Transduction - drug effects | Chemokine CXCL10 - genetics | Glutamine - genetics | Longitudinal Studies | Immunologic Factors - therapeutic use | Multiple Sclerosis - drug therapy | 132 | 120
Journal Article
SCIENCE, ISSN 0036-8075, 09/2019, Volume 365, Issue 6460, pp. 1417 - 1417
We analyzed genetic data of 47,429 multiple sclerosis (MS) and 68,374 control subjects and established a reference map of the genetic architecture of MS that...
RISK ALLELES | AUTOIMMUNE | METAANALYSIS | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | ARCHITECTURE | MECHANISMS | DIAGNOSTIC-CRITERIA | COMPLEX TRAITS | ASSOCIATION | HERITABILITY | Enrichment | Brain | Multiple sclerosis | Adaptive systems | Genes | Central nervous system | Risk | Nervous system | Lymphocytes T | Genomes | Consortia | Proteins | Prevention | Annotations | Maps | Lymphocytes | Genetics | Natural killer cells | Chromosomes | Genotypes | Immune system | Atlases | Evaluation | Data analysis | Myeloid cells | Young adults | Architecture | Neurons | Astrocytes | Perturbation | Gene expression | Statistics | Loci | Microglia | Major histocompatibility complex | Lymphocytes B | Stem cells | Replication | Heritability | Gene mapping | Protein interaction | Histocompatibility | Pluripotency | Basic Medicine | Medical Genetics | Medicinsk genetik | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
RISK ALLELES | AUTOIMMUNE | METAANALYSIS | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | ARCHITECTURE | MECHANISMS | DIAGNOSTIC-CRITERIA | COMPLEX TRAITS | ASSOCIATION | HERITABILITY | Enrichment | Brain | Multiple sclerosis | Adaptive systems | Genes | Central nervous system | Risk | Nervous system | Lymphocytes T | Genomes | Consortia | Proteins | Prevention | Annotations | Maps | Lymphocytes | Genetics | Natural killer cells | Chromosomes | Genotypes | Immune system | Atlases | Evaluation | Data analysis | Myeloid cells | Young adults | Architecture | Neurons | Astrocytes | Perturbation | Gene expression | Statistics | Loci | Microglia | Major histocompatibility complex | Lymphocytes B | Stem cells | Replication | Heritability | Gene mapping | Protein interaction | Histocompatibility | Pluripotency | Basic Medicine | Medical Genetics | Medicinsk genetik | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
Journal Article
Nature Genetics, ISSN 1546-1718, 2013, Volume 45, Issue 11, p. 1353
Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants...
Neurologi | Clinical Medicine | Neurology | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin
Neurologi | Clinical Medicine | Neurology | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin
Journal Article
Nature genetics, ISSN 1546-1718, 2013, Volume 45, Issue 11, p. 1353
Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants...
Neurosciences | Genetic Predisposition to Disease | Genome-Wide Association Study | Gene Frequency | Humans | European Continental Ancestry Group | Genotype | Chromosome Mapping | Genetic Loci | Single Nucleotide | Genetic Variation | Multiple Sclerosis | genetics | immunology | Neurovetenskaper | Polymorphism
Neurosciences | Genetic Predisposition to Disease | Genome-Wide Association Study | Gene Frequency | Humans | European Continental Ancestry Group | Genotype | Chromosome Mapping | Genetic Loci | Single Nucleotide | Genetic Variation | Multiple Sclerosis | genetics | immunology | Neurovetenskaper | Polymorphism
Journal Article
Journal of High Energy Physics, ISSN 1029-8479, 10/2019, Volume 2019, Issue 10, pp. 1 - 61
Results are reported from a search for supersymmetric particles in the final state with multiple jets and large missing transverse momentum. The search uses a...
Supersymmetry | Hadron-Hadron scattering (experiments) | Quantum Physics | Quantum Field Theories, String Theory | Classical and Quantum Gravitation, Relativity Theory | Physics | Elementary Particles, Quantum Field Theory | INVARIANT | HIGGS | EXTENSION | MODEL | SQUARK | PAIR PRODUCTION | PHYSICS, PARTICLES & FIELDS | Protons | Standard model (particle physics) | Large Hadron Collider | Particle collisions | Particle production | Particle decay | Luminosity | Confidence intervals | Searching | Transverse momentum | Pair production | Jets | Physics - High Energy Physics - Experiment
Supersymmetry | Hadron-Hadron scattering (experiments) | Quantum Physics | Quantum Field Theories, String Theory | Classical and Quantum Gravitation, Relativity Theory | Physics | Elementary Particles, Quantum Field Theory | INVARIANT | HIGGS | EXTENSION | MODEL | SQUARK | PAIR PRODUCTION | PHYSICS, PARTICLES & FIELDS | Protons | Standard model (particle physics) | Large Hadron Collider | Particle collisions | Particle production | Particle decay | Luminosity | Confidence intervals | Searching | Transverse momentum | Pair production | Jets | Physics - High Energy Physics - Experiment
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Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes
Science, ISSN 0036-8075, 2014, Volume 344, Issue 6183, pp. 519 - 523
To extend our understanding of the genetic basis of human immune function and dysfunction, we performed an expression quantitative trait locus (eQTL) study of...
TRANSCRIPTOME | MULTIDISCIPLINARY SCIENCES | GENOME-WIDE ASSOCIATION | Autoimmune Diseases - ethnology | Humans | Immunity, Innate - genetics | Transcriptome | Autoimmunity - genetics | Monocytes - immunology | Rheumatic Fever - genetics | Adaptive Immunity - genetics | Autoimmune Diseases - genetics | CD4-Positive T-Lymphocytes - immunology | Ethnic Groups - genetics | Parkinson Disease - ethnology | Multiple Sclerosis - ethnology | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Multiple Sclerosis - genetics | Neurodegenerative Diseases - genetics | Parkinson Disease - genetics | Rheumatic Fever - ethnology | Alleles | Alzheimer Disease - ethnology | Genetic Predisposition to Disease - ethnology | Polymorphism, Single Nucleotide | Neurodegenerative Diseases - ethnology | Alzheimer Disease - genetics | Quantitative Trait Loci | Allelomorphism | Nervous system | Genetic aspects | Degeneration | Leukocytes | Autoimmune diseases | Health aspects | Risk factors | Leucocytes | Immunology | Genetics | Gene loci | Ribonucleic acid--RNA | Neurological disorders
TRANSCRIPTOME | MULTIDISCIPLINARY SCIENCES | GENOME-WIDE ASSOCIATION | Autoimmune Diseases - ethnology | Humans | Immunity, Innate - genetics | Transcriptome | Autoimmunity - genetics | Monocytes - immunology | Rheumatic Fever - genetics | Adaptive Immunity - genetics | Autoimmune Diseases - genetics | CD4-Positive T-Lymphocytes - immunology | Ethnic Groups - genetics | Parkinson Disease - ethnology | Multiple Sclerosis - ethnology | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Multiple Sclerosis - genetics | Neurodegenerative Diseases - genetics | Parkinson Disease - genetics | Rheumatic Fever - ethnology | Alleles | Alzheimer Disease - ethnology | Genetic Predisposition to Disease - ethnology | Polymorphism, Single Nucleotide | Neurodegenerative Diseases - ethnology | Alzheimer Disease - genetics | Quantitative Trait Loci | Allelomorphism | Nervous system | Genetic aspects | Degeneration | Leukocytes | Autoimmune diseases | Health aspects | Risk factors | Leucocytes | Immunology | Genetics | Gene loci | Ribonucleic acid--RNA | Neurological disorders
Journal Article
Zeitschrift für Naturforschung B, ISSN 0932-0776, 03/2010, Volume 65, Issue 3, pp. 311 - 316
Heterodinuclear helicate-type complexes are formed from acyl and tosyl hydrazone-substituted catechol ligands. Due to the different geometry of the carboxylate...
Self-assembly | Catechol | Heteronuclear | Hydrazone | Helicates | LIGANDS | COMPLEXES | CHEMISTRY, ORGANIC | CHEMISTRY, INORGANIC & NUCLEAR
Self-assembly | Catechol | Heteronuclear | Hydrazone | Helicates | LIGANDS | COMPLEXES | CHEMISTRY, ORGANIC | CHEMISTRY, INORGANIC & NUCLEAR
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 09/2011, Volume 50, Issue 38, pp. 8986 - 8989
Artificial oligo(ethylene amino) acids, together with selected natural amino acids and fatty acid modifications, have been used for the solid‐phase‐assisted...
siRNA | polymers | DNA | transfection | POLYPLEXES | GENE DELIVERY | VIVO | LINEAR POLYETHYLENIMINE | CARRIERS | CHEMISTRY, MULTIDISCIPLINARY | LOW TOXICITY | PEPTIDES | PEI | VECTORS | LIPID-LIKE MATERIALS | DNA - genetics | Solid-Phase Synthesis Techniques | RNA, Small Interfering - genetics | Animals | Transfection - methods | Polymers - chemical synthesis | Humans | Amino Acids - chemistry | Cell Line, Tumor | DNA - administration & dosage | RNA, Small Interfering - administration & dosage
siRNA | polymers | DNA | transfection | POLYPLEXES | GENE DELIVERY | VIVO | LINEAR POLYETHYLENIMINE | CARRIERS | CHEMISTRY, MULTIDISCIPLINARY | LOW TOXICITY | PEPTIDES | PEI | VECTORS | LIPID-LIKE MATERIALS | DNA - genetics | Solid-Phase Synthesis Techniques | RNA, Small Interfering - genetics | Animals | Transfection - methods | Polymers - chemical synthesis | Humans | Amino Acids - chemistry | Cell Line, Tumor | DNA - administration & dosage | RNA, Small Interfering - administration & dosage
Journal Article
Basic Research in Cardiology, ISSN 0300-8428, 2014, Volume 109, Issue 6, pp. 1 - 14
Increased levels of interleukin-6 (IL-6) have been observed in patients with acute myocarditis and are associated with poor prognosis. This study was designed...
Myocarditis | Medicine & Public Health | Titin | Cardiac inflammation | Cardiology | Remodeling | Interleukin-6 | MATRIX | CYTOKINES | CARDIAC & CARDIOVASCULAR SYSTEMS | HEART-FAILURE | NECROSIS-FACTOR-ALPHA | IL-6 | VIRAL MYOCARDITIS | CARDIAC FIBROBLASTS | INFLAMMATION | DISEASE | MICE | Virus diseases | Animal experimentation | Immunohistochemistry | Antiviral agents | Medical colleges | Immune response | Interleukins | Physiological aspects | Mice | Coxsackievirus infections | Health aspects
Myocarditis | Medicine & Public Health | Titin | Cardiac inflammation | Cardiology | Remodeling | Interleukin-6 | MATRIX | CYTOKINES | CARDIAC & CARDIOVASCULAR SYSTEMS | HEART-FAILURE | NECROSIS-FACTOR-ALPHA | IL-6 | VIRAL MYOCARDITIS | CARDIAC FIBROBLASTS | INFLAMMATION | DISEASE | MICE | Virus diseases | Animal experimentation | Immunohistochemistry | Antiviral agents | Medical colleges | Immune response | Interleukins | Physiological aspects | Mice | Coxsackievirus infections | Health aspects
Journal Article