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1. Full Text Cytochrome P450 2C19 681G>A Polymorphism and High On-Clopidogrel Platelet Reactivity Associated With Adverse 1-Year Clinical Outcome of Elective Percutaneous Coronary Intervention With Drug-Eluting or Bare-Metal Stents
by Trenk, Dietmar, PhD and Hochholzer, Willibald, MD and Fromm, Martin F., MD and Chialda, Ligia-Emilia, MD and Pahl, Andreas, PhD and Valina, Christian M., MD and Stratz, Christian, MD and Schmiebusch, Peter, MD and Bestehorn, Hans-Peter, MD and Büttner, Heinz Joachim, MD and Neumann, Franz-Josef, MD
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2008, Volume 51, Issue 20, pp. 1925 - 1934
Cytochrome P450 2C19 681G>A Polymorphism and High On-Clopidogrel Platelet Reactivity Associated With Adverse 1-Year Clinical Outcome of Elective Percutaneous... 
Cardiovascular | Internal Medicine | 600-MG | CARDIAC & CARDIOVASCULAR SYSTEMS | INHIBITION | INCREASED RISK | LOW-RESPONDERS | THROMBOSIS | RESISTANCE | IDENTIFICATION | ANTIPLATELET THERAPY | ACTIVE METABOLITE | ADP RECEPTOR | Myocardial Infarction - mortality | Ticlopidine - pharmacology | Ticlopidine - therapeutic use | Humans | Middle Aged | Aryl Hydrocarbon Hydroxylases - genetics | Male | Treatment Outcome | Ticlopidine - analogs & derivatives | Drug-Eluting Stents - adverse effects | Polymorphism, Genetic | Angioplasty, Balloon, Coronary - adverse effects | Angioplasty, Balloon, Coronary - mortality | Cytochrome P-450 CYP2C19 | Platelet Aggregation Inhibitors - pharmacology | Female | Aged | Platelet Aggregation - drug effects | Mixed Function Oxygenases - genetics | Platelet Aggregation Inhibitors - therapeutic use | Myocardial Infarction - etiology | Transluminal angioplasty | Stent (Surgery) | Adenosine triphosphatase | Cytochrome P-450 | Enzymes | Heart attacks | Cardiovascular disease | Thrombosis | Confidence intervals | Hospitals | Blood platelets | Intubation | Drug therapy | Stents | Drug dosages | Deoxyribonucleic acid--DNA | Polymorphism
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2. Full Text Impact of Cytochrome P450 2C19 Loss-of-Function Polymorphism and of Major Demographic Characteristics on Residual Platelet Function After Loading and Maintenance Treatment With Clopidogrel in Patients Undergoing Elective Coronary Stent Placement
by Hochholzer, Willibald, MD and Trenk, Dietmar, PhD and Fromm, Martin F., MD and Valina, Christian M., MD and Stratz, Christian, MD and Bestehorn, Hans-Peter, MD and Büttner, Heinz Joachim, MD and Neumann, Franz-Josef, MD
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2010, Volume 55, Issue 22, pp. 2427 - 2434
Objectives The aim of this study was to evaluate the relative impact of demographic and clinical variables versus the cytochrome P450 2C19 ( CYP2C19 )... 
Cardiovascular | Internal Medicine | polymorphism | predictor | antiplatelet therapy | CYP2C19 | platelet function | RESPONSIVENESS | CARDIAC & CARDIOVASCULAR SYSTEMS | THROMBOSIS | REACTIVITY | DETERMINANT | ANTIPLATELET | THERAPY | INHIBITION | TYPE-2 DIABETES-MELLITUS | INTERVENTION | AGGREGATION | Multivariate Analysis | Predictive Value of Tests | Confidence Intervals | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Aryl Hydrocarbon Hydroxylases - genetics | Male | Dose-Response Relationship, Drug | Prosthesis Failure | Angioplasty, Balloon, Coronary - mortality | Platelet Aggregation Inhibitors - administration & dosage | Ticlopidine - administration & dosage | Adult | Female | Platelet Aggregation - drug effects | Odds Ratio | Platelet Aggregation - genetics | Stents | Drug-Eluting Stents | Coronary Stenosis - therapy | Drug Administration Schedule | Risk Assessment | Angioplasty, Balloon, Coronary - methods | Probability | Coronary Stenosis - drug therapy | Logistic Models | Polymorphism, Genetic - drug effects | Ticlopidine - analogs & derivatives | Coronary Stenosis - genetics | Cytochrome P-450 CYP2C19 | Survival Analysis | Aged | Coronary Stenosis - mortality | Elective Surgical Procedures | Medical colleges | Genetic aspects | Stent (Surgery) | Cytochrome P-450 | Hypertension | Plasma | Aspirin | Heart attacks | Statistical methods | Thrombosis | Polymerase chain reaction | Confidence intervals | Variables | Body mass index | Blood platelets | Intubation | Clinical medicine | Diabetes | Drug therapy | Drug dosages | Deoxyribonucleic acid--DNA | Polymorphism
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3. Full Text First M87 Event Horizon Telescope Results. I. the Shadow of the Supermassive Black Hole
by Event Horizon Telescope Collaboration, The and Akiyama, Kazunori and Alberdi, Antxon and Alef, Walter and Asada, Keiichi and Azulay, Rebecca and Baczko, Anne-Kathrin and Ball, David and Baloković, Mislav and Barrett, John and Bintley, Dan and Blackburn, Lindy and Boland, Wilfred and Bouman, Katherine L and Bower, Geoffrey C and Bremer, Michael and Brinkerink, Christiaan D and Brissenden, Roger and Britzen, Silke and Broderick, Avery E and Broguiere, Dominique and Bronzwaer, Thomas and Byun, Do-Young and Carlstrom, John E and Chael, Andrew and Chan, Chi-Kwan and Chatterjee, Shami and Chatterjee, Koushik and Chen, Ming-Tang and Chen, Yongjun and Cho, Ilje and Christian, Pierre and Conway, John E and Cordes, James M and Crew, Geoffrey B and Cui, Yuzhu and Davelaar, Jordy and Laurentis, Mariafelicia De and Deane, Roger and Dempsey, Jessica and Desvignes, Gregory and Dexter, Jason and Doeleman, Sheperd S and Eatough, Ralph P and Falcke, Heino and Fish, Vincent L and Fomalont, Ed and Fraga-Encinas, Raquel and Freeman, William T and Friberg, Per and Fromm, Christian M and Gómez, José L and Galison, Peter and Gammie, Charles F and Garcia, Roberto and Gentaz, Olivier and Georgiev, Boris and Goddi, Ciriaco and Gold, Roman and Gu, Minfeng and Gurwell, Mark and Hada, Kazuhiro and Hecht, Michael H and Hesper, Ronald and Ho, Luis C and Ho, Paul and Honma, Mareki and Huang, Chih-Wei L and Huang, Lei and Hughes, David H and Ikeda, Shiro and Inoue, Makoto and Issaoun, Sara and James, David J and Jannuzi, Buell T and Janssen, Michael and Jeter, Britton and Jiang, Wu and Johnson, Michael D and Jorstad, Svetlana and Jung, Taehyun and Karami, Mansour and Karuppusamy, Ramesh and Kawashima, Tomohisa and Keating, Garrett K and Kettenis, Mark and Kim, Jae-Young and Kim, Junhan and Kim, Jongsoo and Kino, Motoki and Koay, Jun Yi and Koch, Patrick M and Koyama, Shoko and Kramer, Michael and Kramer, Carsten and Krichbaum, Thomas P and Kuo, Cheng-Yu and Lauer, Tod R and Lee, Sang-Sung and Li, Yan-Rong and ... and Event Horizon Telescope Collaborat and The Event Horizon Telescope Collaboration and Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States) and Los Alamos National Lab. (LANL), Los Alamos, NM (United States) and Argonne National Lab. (ANL), Argonne, IL (United States)
Astrophysical Journal Letters, ISSN 2041-8205, 04/2019, Volume 875, Issue 1, p. L1
When surrounded by a transparent emission region, black holes are expected to reveal a dark shadow caused by gravitational light bending and photon capture at... 
FARADAY-ROTATION | ADVECTION-DOMINATED ACCRETION | galaxies: individual (M87) | galaxies: jets | GRMHD SIMULATIONS | accretion, accretion disks | SAGITTARIUS-A-ASTERISK | GHZ VLBI OBSERVATIONS | black hole physics | gravitation | galaxies: active | ENERGY-DISTRIBUTIONS | ASTRONOMY & ASTROPHYSICS | HIGH-RESOLUTION | IONIZED-GAS | GALACTIC-CENTER | RADIO-SOURCES | ASTRONOMY AND ASTROPHYSICS
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4. Full Text First M87 Event Horizon Telescope Results. V. Physical Origin of the Asymmetric Ring
by Event Horizon Telescope Collaboration, The and Akiyama, Kazunori and Alberdi, Antxon and Alef, Walter and Asada, Keiichi and Azulay, Rebecca and Baczko, Anne-Kathrin and Ball, David and Baloković, Mislav and Barrett, John and Bintley, Dan and Blackburn, Lindy and Boland, Wilfred and Bouman, Katherine L and Bower, Geoffrey C and Bremer, Michael and Brinkerink, Christiaan D and Brissenden, Roger and Britzen, Silke and Broderick, Avery E and Broguiere, Dominique and Bronzwaer, Thomas and Byun, Do-Young and Carlstrom, John E and Chael, Andrew and Chan, Chi-Kwan and Chatterjee, Shami and Chatterjee, Koushik and Chen, Ming-Tang and Chen, Yongjun and Cho, Ilje and Christian, Pierre and Conway, John E and Cordes, James M and Crew, Geoffrey B and Cui, Yuzhu and Davelaar, Jordy and De Laurentis, Mariafelicia and Deane, Roger and Dempsey, Jessica and Desvignes, Gregory and Dexter, Jason and Doeleman, Sheperd S and Eatough, Ralph P and Falcke, Heino and Fish, Vincent L and Fomalont, Ed and Fraga-Encinas, Raquel and Friberg, Per and Fromm, Christian M and Gómez, José L and Galison, Peter and Gammie, Charles F and Garcia, Roberto and Gentaz, Olivier and Georgiev, Boris and Goddi, Ciriaco and Gold, Roman and Gu, Minfeng and Gurwell, Mark and Hada, Kazuhiro and Hecht, Michael H and Hesper, Ronald and Ho, Luis C and Ho, Paul and Honma, Mareki and Huang, Chih-Wei L and Huang, Lei and Hughes, David H and Ikeda, Shiro and Inoue, Makoto and Issaoun, Sara and James, David J and Jannuzi, Buell T and Janssen, Michael and Jeter, Britton and Jiang, Wu and Johnson, Michael D and Jorstad, Svetlana and Jung, Taehyun and Karami, Mansour and Karuppusamy, Ramesh and Kawashima, Tomohisa and Keating, Garrett K and Kettenis, Mark and Kim, Jae-Young and Kim, Junhan and Kim, Jongsoo and Kino, Motoki and Koay, Jun Yi and Koch, Patrick M and Koyama, Shoko and Kramer, Michael and Kramer, Carsten and Krichbaum, Thomas P and Kuo, Cheng-Yu and Lauer, Tod R and Lee, Sang-Sung and Li, Yan-Rong and Li, Zhiyuan and ... and Event Horizon Telescope Collaborat and The Event Horizon Telescope Collaboration
Astrophysical Journal Letters, ISSN 2041-8205, 04/2019, Volume 875, Issue 1, p. L5
The Event Horizon Telescope (EHT) has mapped the central compact radio source of the elliptical galaxy M87 at 1.3 mm with unprecedented angular resolution.... 
techniques: high angular resolution | galaxies: individual (M87) | black hole physics | galaxies: jets | accretion, accretion disks | magnetohydrodynamics (MHD) | EDDINGTON ACCRETION | ADVECTION-DOMINATED ACCRETION | GRMHD SIMULATIONS | JET FORMATION | MAGNETICALLY DRIVEN ACCRETION | SUPERMASSIVE BLACK-HOLE | SAGITTARIUS A-ASTERISK | DISKS | ASTRONOMY & ASTROPHYSICS | galaxies: jets magnetohydrodynamics (MHD) | FLOWS | RELATIVISTIC MAGNETOHYDRODYNAMIC SIMULATIONS
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5. Full Text First M87 Event Horizon Telescope Results. VI. the Shadow and Mass of the Central Black Hole
by Akiyama, Kazunori and Alberdi, Antxon and Alef, Walter and Asada, Keiichi and Azulay, Rebecca and Baczko, Anne-Kathrin and Ball, David and Baloković, Mislav and Barrett, John and Bintley, Dan and Blackburn, Lindy and Boland, Wilfred and Bouman, Katherine L and Bower, Geoffrey C and Bremer, Michael and Brinkerink, Christiaan D and Brissenden, Roger and Britzen, Silke and Broderick, Avery E and Broguiere, Dominique and Bronzwaer, Thomas and Byun, Do-Young and Carlstrom, John E and Chael, Andrew and Chan, Chi-Kwan and Chatterjee, Shami and Chatterjee, Koushik and Chen, Ming-Tang and Chen, Yongjun and Cho, Ilje and Christian, Pierre and Conway, John E and Cordes, James M and Crew, Geoffrey B and Cui, Yuzhu and Davelaar, Jordy and De Laurentis, Mariafelicia and Deane, Roger and Dempsey, Jessica and Desvignes, Gregory and Dexter, Jason and Doeleman, Sheperd S and Eatough, Ralph P and Falcke, Heino and Fish, Vincent L and Fomalont, Ed and Fraga-Encinas, Raquel and Friberg, Per and Fromm, Christian M and Gómez, José L and Galison, Peter and Gammie, Charles F and Garcia, Roberto and Gentaz, Olivier and Georgiev, Boris and Goddi, Ciriaco and Gold, Roman and Gu, Minfeng and Gurwell, Mark and Hada, Kazuhiro and Hecht, Michael H and Hesper, Ronald and Ho, Luis C and Ho, Paul and Honma, Mareki and Huang, Chih-Wei L and Huang, Lei and Hughes, David H and Ikeda, Shiro and Inoue, Makoto and Issaoun, Sara and James, David J and Jannuzi, Buell T and Janssen, Michael and Jeter, Britton and Jiang, Wu and Johnson, Michael D and Jorstad, Svetlana and Jung, Taehyun and Karami, Mansour and Karuppusamy, Ramesh and Kawashima, Tomohisa and Keating, Garrett K and Kettenis, Mark and Kim, Jae-Young and Kim, Junhan and Kim, Jongsoo and Kino, Motoki and Koay, Jun Yi and Koch, Patrick M and Koyama, Shoko and Kramer, Michael and Kramer, Carsten and Krichbaum, Thomas P and Kuo, Cheng-Yu and Lauer, Tod R and Lee, Sang-Sung and Li, Yan-Rong and Li, Zhiyuan and Lindqvist, Michael and ... and Event Horizon Telescope Collaborat and The Event Horizon Telescope Collaboration
Astrophysical Journal Letters, ISSN 2041-8205, 04/2019, Volume 875, Issue 1, p. L6
We present measurements of the properties of the central radio source in M87 using Event Horizon Telescope data obtained during the 2017 campaign. We develop... 
techniques: high angular resolution | galaxies: individual (M87) | black hole physics | gravitation | techniques: interferometric | DISTANCE | DIFFERENTIAL EVOLUTION | ACCRETION DISKS | RADIO JET | GENETIC ALGORITHM | GALAXY | DISTRIBUTIONS | NUCLEUS | ASTRONOMY & ASTROPHYSICS | INNER JET | EMISSION
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6. Full Text First M87 Event Horizon Telescope Results. IV. Imaging the Central Supermassive Black Hole
by Event Horizon Telescope Collaboration, The and Akiyama, Kazunori and Alberdi, Antxon and Alef, Walter and Asada, Keiichi and Azulay, Rebecca and Baczko, Anne-Kathrin and Ball, David and Baloković, Mislav and Barrett, John and Bintley, Dan and Blackburn, Lindy and Boland, Wilfred and Bouman, Katherine L and Bower, Geoffrey C and Bremer, Michael and Brinkerink, Christiaan D and Brissenden, Roger and Britzen, Silke and Broderick, Avery E and Broguiere, Dominique and Bronzwaer, Thomas and Byun, Do-Young and Carlstrom, John E and Chael, Andrew and Chan, Chi-Kwan and Chatterjee, Shami and Chatterjee, Koushik and Chen, Ming-Tang and Chen, Yongjun and Cho, Ilje and Christian, Pierre and Conway, John E and Cordes, James M and Crew, Geoffrey B and Cui, Yuzhu and Davelaar, Jordy and De Laurentis, Mariafelicia and Deane, Roger and Dempsey, Jessica and Desvignes, Gregory and Dexter, Jason and Doeleman, Sheperd S and Eatough, Ralph P and Falcke, Heino and Fish, Vincent L and Fomalont, Ed and Fraga-Encinas, Raquel and Freeman, William T and Friberg, Per and Fromm, Christian M and Gómez, José L and Galison, Peter and Gammie, Charles F and Garcia, Roberto and Gentaz, Olivier and Georgiev, Boris and Goddi, Ciriaco and Gold, Roman and Gu, Minfeng and Gurwell, Mark and Hada, Kazuhiro and Hecht, Michael H and Hesper, Ronald and Ho, Luis C and Ho, Paul and Honma, Mareki and Huang, Chih-Wei L and Huang, Lei and Hughes, David H and Ikeda, Shiro and Inoue, Makoto and Issaoun, Sara and James, David J and Jannuzi, Buell T and Janssen, Michael and Jeter, Britton and Jiang, Wu and Johnson, Michael D and Jorstad, Svetlana and Jung, Taehyun and Karami, Mansour and Karuppusamy, Ramesh and Kawashima, Tomohisa and Keating, Garrett K and Kettenis, Mark and Kim, Jae-Young and Kim, Junhan and Kim, Jongsoo and Kino, Motoki and Koay, Jun Yi and Koch, Patrick M and Koyama, Shoko and Kramer, Michael and Kramer, Carsten and Krichbaum, Thomas P and Kuo, Cheng-Yu and Lauer, Tod R and Lee, Sang-Sung and Li, Yan-Rong and ... and Event Horizon Telescope Collaborat and The Event Horizon Telescope Collaboration
Astrophysical Journal Letters, ISSN 2041-8205, 04/2019, Volume 875, Issue 1, p. L4
We present the first Event Horizon Telescope (EHT) images of M87, using observations from April 2017 at 1.3 mm wavelength. These images show a prominent ring... 
techniques: high angular resolution | galaxies: individual (M87) | black hole physics | galaxies: jets | techniques: image processing | techniques: interferometric | RECONSTRUCTION | IMPLEMENTATION | PRINCIPLES | DECONVOLUTION | MOTION | SELF-CALIBRATION | ASTRONOMY & ASTROPHYSICS | HIGH-RESOLUTION | JET | INTERFEROMETRY
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7. Full Text Spectral evolution of flaring blazars from numerical simulations
by Fromm, C.M and Perucho, M and Mimica, P and Ros, E
Astronomy and Astrophysics, ISSN 0004-6361, 04/2016, Volume 588, p. A101
High-resolution Very Long Baseline Interferometry (VLBI) observations of active galactic nuclei revealed traveling and stationary or quasi-stationary radio... 
Radiation mechanisms: non-thermal | Galaxies: active | Hydrodynamics | Galaxies: jets | Shock waves | Computer simulation | Perturbation methods | Jet nozzles | Evolution | Blazars | Radio | Spectra
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8. Full Text First M87 Event Horizon Telescope Results. III. Data Processing and Calibration
by Event Horizon Telescope Collaboration, The and Akiyama, Kazunori and Alberdi, Antxon and Alef, Walter and Asada, Keiichi and Azulay, Rebecca and Baczko, Anne-Kathrin and Ball, David and Baloković, Mislav and Barrett, John and Bintley, Dan and Blackburn, Lindy and Boland, Wilfred and Bouman, Katherine L and Bower, Geoffrey C and Bremer, Michael and Brinkerink, Christiaan D and Brissenden, Roger and Britzen, Silke and Broderick, Avery E and Broguiere, Dominique and Bronzwaer, Thomas and Byun, Do-Young and Carlstrom, John E and Chael, Andrew and Chan, Chi-Kwan and Chatterjee, Shami and Chatterjee, Koushik and Chen, Ming-Tang and Chen, Yongjun and Cho, Ilje and Christian, Pierre and Conway, John E and Cordes, James M and Crew, Geoffrey B and Cui, Yuzhu and Davelaar, Jordy and De Laurentis, Mariafelicia and Deane, Roger and Dempsey, Jessica and Desvignes, Gregory and Dexter, Jason and Doeleman, Sheperd S and Eatough, Ralph P and Falcke, Heino and Fish, Vincent L and Fomalont, Ed and Fraga-Encinas, Raquel and Friberg, Per and Fromm, Christian M and Gómez, José L and Galison, Peter and Gammie, Charles F and Garcia, Roberto and Gentaz, Olivier and Georgiev, Boris and Goddi, Ciriaco and Gold, Roman and Gu, Minfeng and Gurwell, Mark and Hada, Kazuhiro and Hecht, Michael H and Hesper, Ronald and Ho, Luis C and Ho, Paul and Honma, Mareki and Huang, Chih-Wei L and Huang, Lei and Hughes, David H and Ikeda, Shiro and Inoue, Makoto and Issaoun, Sara and James, David J and Jannuzi, Buell T and Janssen, Michael and Jeter, Britton and Jiang, Wu and Johnson, Michael D and Jorstad, Svetlana and Jung, Taehyun and Karami, Mansour and Karuppusamy, Ramesh and Kawashima, Tomohisa and Keating, Garrett K and Kettenis, Mark and Kim, Jae-Young and Kim, Junhan and Kim, Jongsoo and Kino, Motoki and Koay, Jun Yi and Koch, Patrick M and Koyama, Shoko and Kramer, Michael and Kramer, Carsten and Krichbaum, Thomas P and Kuo, Cheng-Yu and Lauer, Tod R and