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Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2018, Volume 26, Issue 20, p. 5462
(5aR)-5a-C-pentyl-4-epi-isofagomine 1 is a powerful inhibitor of lysosomal [beta]-galactosidase and a remarkable chaperone for mutations associated with... 
Crystals | Derivatives (Financial instruments) | Sulfates | Structure | Investigations
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2009, Volume 284, Issue 35, pp. 23187 - 23196
Mycobacterium tuberculosis modulates host immune responses through proteins and complex glycolipids. Here, we report that the glycosylphosphatidylinositol... 
ACYLATION STATE | MYO-INOSITOL MANNOSIDES | BACILLUS-CALMETTE-GUERIN | HUMAN DENDRITIC CELLS | BOVIS BCG | DC-SIGN | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRAP MASS-SPECTROMETRY | STRUCTURAL-CHARACTERIZATION | TUBERCULOSIS INFECTION | ELECTROSPRAY-IONIZATION | Inflammation Mediators - immunology | Gene Expression | Down-Regulation | Humans | Mice, Inbred C57BL | Adaptor Proteins, Vesicular Transport - genetics | Cells, Cultured | Mycobacterium tuberculosis - immunology | Myeloid Differentiation Factor 88 - genetics | Toll-Like Receptor 4 - genetics | Tuberculosis - microbiology | Phosphatidylinositols - immunology | Toll-Like Receptor 4 - immunology | Adaptor Proteins, Vesicular Transport - immunology | Mice, Knockout | Tuberculosis - immunology | Animals | Tuberculosis - genetics | Inflammation Mediators - metabolism | Myeloid Differentiation Factor 88 - immunology | Mice | Cytokines - genetics | Macrophages - immunology | Cytokines - immunology | b-Interferon | Macrophages | adaptor proteins | Immunity | Lipopolysaccharides | Interleukin 6 | Lead | Toll-like receptors | Respiratory tract diseases | Translocation | Antiinflammatory agents | Immune response | Cytokines | Interleukin 12 | Inflammation | Leukocytes (neutrophilic) | TLR4 protein | Glycolipids | phosphatidylinositol | Tumor necrosis factor | Nitric oxide | TLR2 protein | Interleukin 10 | Glycosylphosphatidylinositol | Differentiation | Chemokines | Mechanisms of Signal Transduction
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2017, Volume 126, p. 160
This report is about the identification, synthesis and initial biological characterization of derivatives of 4-epi-isofagomine as pharmacological chaperones... 
Genetic research | Genetic aspects | Gangliosides | Cells | Physiological aspects
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2011, Volume 6, Issue 9, p. e24631
Mycobacteria develop strategies to evade the host immune system. Among them, mycobacterial LAM or PIMs inhibit the expression of pro-inflammatory cytokines by... 
TUBERCULOSIS LIPOARABINOMANNAN | HUMAN DENDRITIC CELLS | BACILLUS-CALMETTE-GUERIN | DC-SIGN | IMMUNE-RESPONSES | MURINE MACROPHAGES | BIOLOGY | TOLL-LIKE RECEPTORS | MANNOSE-RECEPTOR | ALLERGIC AIRWAY DISEASE | PHOSPHATIDYLINOSITOL MANNOSIDE | Solubility - drug effects | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Acylation - drug effects | Paclitaxel - pharmacology | Humans | Host-Pathogen Interactions - drug effects | Host-Pathogen Interactions - immunology | Paclitaxel - chemistry | Signal Transduction - immunology | HEK293 Cells | Toll-Like Receptors - metabolism | Interleukin-12 - secretion | Inflammation - microbiology | Mycobacterium - immunology | Mice, Inbred C57BL | Lipopolysaccharide Receptors - immunology | Inflammation - immunology | Toll-Like Receptors - agonists | Surface-Active Agents - pharmacology | Mycobacterium - drug effects | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Mannosides - metabolism | Mice | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Macrophages | Tumor necrosis factor | Analysis | Biochemistry | CD14 antigen | Lipopolysaccharides | Proteins | Signal transduction | Embryology | Immunology | Rodents | Toll-like receptors | Inhibition | Immune system | Binding | Antigens | Cytokines | Dendritic cells | Interleukin 12 | Inflammation | Pattern recognition | TLR4 protein | Gene expression | TLR9 protein | Mode of action | Signaling | Tuberculosis | TLR2 protein | Powder injection molding | Surface-Active Agents | Mycobacterium | Mannosides | Signal Transduction | Antigens, CD14 | Interleukin-12 | Solubility | Tumor Necrosis Factor-alpha | Host-Pathogen Interactions | Life Sciences | Toll-Like Receptors | Paclitaxel | Acylation
Journal Article
Journal Article
Bioconjugate Chemistry, ISSN 1043-1802, 01/2013, Volume 24, Issue 1, p. 72
  Phosphatidyl inositol mannosides (PIMs) are constituents of the mycobacterial cell wall; these glycolipids are known to exhibit potent inhibitory activity... 
Membranes | Cytokines | Bacteria | Lipids | Kinetics
Journal Article
Information and Software Technology, ISSN 0950-5849, 05/2013, Volume 55, Issue 5, p. 795
  Designers and developers are increasingly expected to deliver high quality systems, i.e. systems that are usable, robust, consistent as well as evolutionary,... 
Studies | Systems design | Decision making models | Software quality | Vocabularies & taxonomies | Software engineering
Journal Article
Information and Software Technology, ISSN 0950-5849, 05/2013, Volume 55, Issue 5, pp. 795 - 821
Context: Designers and developers are increasingly expected to deliver high quality systems, i.e. systems that are usable, robust, consistent as well as... 
Learning | Design engineering | Developers | Websites | Taxonomy | Adhesion tests | Classification | Flexibility
Journal Article
Information and Software Technology, ISSN 0950-5849, 05/2013, Volume 55, Issue 5, pp. 795 - 821
Designers and developers are increasingly expected to deliver high quality systems, i.e. systems that are usable, robust, consistent as well as evolutionary,... 
Characterization | Process models | Design methods | Taxonomy | CENTERED DESIGN | LIFE-CYCLE | COMPUTER SCIENCE, SOFTWARE ENGINEERING | REQUIREMENTS | SYSTEMS-DEVELOPMENT METHODOLOGIES | FRAMEWORK | COMPUTER SCIENCE, INFORMATION SYSTEMS | SOFTWARE-DEVELOPMENT | Models | Classification | Software engineering | Human-Computer Interaction | Computer Science
Journal Article
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), ISSN 0302-9743, 2007, Volume 4849, pp. 84 - 97
Conference Proceeding
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), ISSN 0302-9743, 2013, Volume 8186, pp. 343 - 352
Conference Proceeding
ChemMedChem, ISSN 1860-7179, 11/2011, Volume 6, Issue 11, pp. 2081 - 2093
Journal Article