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1. Full Text Alanine-scanning mutagenesis of human signal transducer and activator of transcription 1 to estimate loss- or gain-of-function variants
by Kagawa, Reiko, MD and Fujiki, Ryoji, MS and Tsumura, Miyuki, PhD and Sakata, Sonoko, MD and Nishimura, Shiho, MD and Itan, Yuval, PhD and Kong, Xiao-Fei, MD, PhD and Kato, Zenichiro, MD, PhD and Ohnishi, Hidenori, MD, PhD and Hirata, Osamu, MD, PhD and Saito, Satoshi, MD and Ikeda, Maiko, MD and El Baghdadi, Jamila, PhD and Bousfiha, Aziz, MD and Fujiwara, Kaori, MD and Oleastro, Matias, MD and Yancoski, Judith, PhD and Perez, Laura, BSc and Danielian, Silvia, PhD and Ailal, Fatima, MD and Takada, Hidetoshi, MD, PhD and Hara, Toshiro, MD, PhD and Puel, Anne, PhD and Boisson-Dupuis, Stéphanie, PhD and Bustamante, Jacinta, MD, PhD and Casanova, Jean-Laurent, MD, PhD and Ohara, Osamu, PhD and Okada, Satoshi, MD, PhD and Kobayashi, Masao, MD, PhD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 140, Issue 1, pp. 232 - 241
Background Germline heterozygous mutations in human signal transducer and activator of transcription 1 (STAT1) can cause loss of function (LOF), as in patients... 
Allergy and Immunology | alanine scanning | Signal transduction and activator of transcription 1 | chronic mucocutaneous candidiasis | Mendelian susceptibility to mycobacterial disease | reference database | FUNCTION STAT1 MUTATIONS | MYCOBACTERIAL DISEASE | IMMUNOLOGY | MULTIFOCAL OSTEOMYELITIS | INBORN-ERRORS | IFN-GAMMA IMMUNITY | COMBINED IMMUNODEFICIENCY | ALLERGY | MENDELIAN SUSCEPTIBILITY | EX-VIVO | CLINICAL PHENOTYPE | Genetic Predisposition to Disease | Alanine - genetics | Mutagenesis | Humans | Mycobacterium Infections - genetics | Protein Domains | Biological Assay | Female | Male | Mutation | STAT1 Transcription Factor - genetics | Genetic research | Mycoses | Medical colleges | Disease susceptibility | Genetic transcription | Coils | Candidiasis | Scanning | Transcription | Genes | Amino acids | Genomes | Kinases | Assaying | Proteins | Fungi | Missense mutation | Fungal diseases | Stat1 protein | Deoxyribonucleic acid--DNA | Binding | Alanine | Chronic mucocutaneous candidiasis | Scanning mutagenesis | Patients | Mutants | Diseases | Human subjects | Infectious diseases | Computer applications | Viral infections
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2. Full Text A New Z Score Curve of the Coronary Arterial Internal Diameter Using the Lambda-Mu-Sigma Method in a Pediatric Population
by Kobayashi, Tohru, MD and Fuse, Shigeto, MD and Sakamoto, Naoko, PhD and Mikami, Masashi, MS and Ogawa, Shunichi, MD and Hamaoka, Kenji, MD and Arakaki, Yoshio, MD and Nakamura, Tsuneyuki, MD and Nagasawa, Hiroyuki, MD and Kato, Taichi, MD and Jibiki, Toshiaki, MD and Iwashima, Satoru, MD and Yamakawa, Masaru, MD and Ohkubo, Takashi, MD and Shimoyama, Shinya, MD and Aso, Kentaro, MD and Sato, Seiichi, MD and Saji, Tsutomu, MD and Z Score Project Investigators
Journal of the American Society of Echocardiography, ISSN 0894-7317, 2016, Volume 29, Issue 8, pp. 794 - 801.e29
Background Several coronary artery Z score models have been developed. However, a Z score model derived by the lambda-mu-sigma (LMS) method has not been... 
Cardiovascular | Lambda-mu-sigma method | Z score | Kawasaki disease | Coronary artery abnormality | Pediatric | CENTILE CURVES | CARDIAC & CARDIOVASCULAR SYSTEMS | COUNCIL | SURFACE-AREA | FORMULA | CHILDREN | DIMENSIONS | KAWASAKI-DISEASE | INFANTS | ECHOCARDIOGRAPHY | WEIGHT | Coronary Vessels - diagnostic imaging | Japan - epidemiology | Humans | Echocardiography - methods | Imaging, Three-Dimensional - methods | Child, Preschool | Infant | Male | Reference Values | Imaging, Three-Dimensional - standards | Computer Simulation | Sensitivity and Specificity | Echocardiography - standards | Female | Child | Infant, Newborn | Coronary Vessels - anatomy & histology | Reproducibility of Results | Models, Cardiovascular | Models, Statistical | Sex Characteristics | Aging - pathology | Algorithms | Aging - physiology | Adolescent | Pediatrics - standards | Pediatrics | Analysis | Methods
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3. Full Text Evaluation of peripapillary choroidal thickness in patients with normal-tension glaucoma
by Hirooka, Kazuyuki and Tenkumo, Kaori and Fujiwara, Atsushi and Baba, Tetsuya and Sato, Shino and Shiraga, Fumio
BMC Ophthalmology, ISSN 1471-2415, 2012, Volume 12, Issue 1, pp. 29 - 29
Background: To compare peripapillary choroidal thickness measurements between normal and normal-tension glaucoma eyes. Methods: Cross-sectional comparative... 
Normal-tension glaucoma | Peripapillary choroidal thickness | Enhanced depth imaging optical coherence tomography | OPEN-ANGLE GLAUCOMA | EYES | REDUCTION | OPTICAL COHERENCE TOMOGRAPHY | OPHTHALMOLOGY | JAPANESE | NERVE HEAD | INTRAOCULAR-PRESSURE | Cross-Sectional Studies | Follow-Up Studies | Intraocular Pressure | Tomography, Optical Coherence | Humans | Middle Aged | Male | Low Tension Glaucoma - diagnosis | Visual Fields | Aged | Retrospective Studies | Choroid - pathology | Low Tension Glaucoma - physiopathology | Optic Disk - pathology | Glaucoma | Choroid | Care and treatment | Comparative analysis | Diabetic retinopathy | Medical imaging | Pathogenesis | Blood pressure | Manuscripts | Defects
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4. Full Text Lupus anticoagulant-hypoprothrombinemia syndrome and immunoglobulin-A vasculitis: a report of Japanese sibling cases and review of the literature
by Fujiwara, Kaori and Shimizu, Junya and Tsukahara, Hirokazu and Shimada, Akira
Rheumatology International, ISSN 0172-8172, 10/2019, Volume 39, Issue 10, pp. 1811 - 1819
Lupus anticoagulant-hypoprothrombinemia syndrome (LAHPS) is a rare bleeding disorder caused by antiprothrombin antibodies. LAHPS is associated with systemic... 
Lupus anticoagulant-hypoprothrombinemia syndrome | Medicine & Public Health | Immunoglobulin-A vasculitis | Rheumatology | Japanese | Pediatric | Henoch–Schönlein purpura | Hypoprothrombinemia | CRITERIA | DIAGNOSIS | HEMORRHAGE | Henoch-Schonlein purpura | RHEUMATOLOGY | ANTIPHOSPHOLIPID SYNDROME | ERYTHEMATOSUS | CHILDREN | PROTHROMBIN | ANTIBODY-LEVELS
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5. Full Text Establishment of a model of sentinel lymph node metastasis using immunodeficient swine
by Kurihara, Toshiaki and Matsuda, Sachiko and Nakamura, Yuki and Suzuki, Shunichi and Fuchimoto, Daiichiro and Onishi, Akira and Saeki, Kohei and Nakagawa, Takayuki and Fujiwara, Reina and Kamata, Masatoshi and Kuramoto, Junko and Kameyama, Kaori and Sekino, Masaki and Kusakabe, Moriaki and Hayashida, Tetsu and Jinno, Hiromitsu and Kitagawa, Yuko
Scientific reports, ISSN 2045-2322, 05/2019, Volume 9, Issue 1, pp. 7923 - 9
Lymph node metastasis occurs via the migration of cancer cells through the lymphatic system. Sentinel lymph node (SLN) biopsy is a common diagnostic strategy.... 
Immunohistochemistry | Nests | Auricle | Lymphatic system | Leukocyte migration | Invasiveness | Immunodeficiency | Transplantation | Metastasis | Follicles | Lymph nodes | Metastases | RAG2 protein | Biopsy | Lymphocytes | Green fluorescent protein | Indigo | Cell migration | Tumors
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6. Full Text Demonstration and Characterization of the Heterodimerization of ZnT5 and ZnT6 in the Early Secretory Pathway
by Ayako Fukunaka and Tomoyuki Suzuki and Yayoi Kurokawa and Tomohiro Yamazaki and Naoko Fujiwara and Kaori Ishihara and Hitoshi Migaki and Katsuzumi Okumura and Seiji Masuda and Yuko Yamaguchi-Iwai and Masaya Nagao and Taiho Kambe
Journal of Biological Chemistry, ISSN 0021-9258, 11/2009, Volume 284, Issue 45, pp. 30798 - 30806
The majority of CDF/ZnT zinc transporters form homo-oligomers. However, ZnT5, ZnT6, and their orthologues form hetero-oligomers in the early secretory pathway... 
ALKALINE-PHOSPHATASES | HOMEOSTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAMMALIAN ZINC TRANSPORTER | VERTEBRATE CELLS | TRAFFICKING | FUNCTIONAL-CHARACTERIZATION | ENDOPLASMIC-RETICULUM | PROTEINS | DIFFUSION FACILITATOR FAMILY | SACCHAROMYCES-CEREVISIAE | Amino Acid Sequence | Cell Line | Humans | Secretory Pathway | Molecular Sequence Data | Amino Acid Motifs | Sequence Alignment | Animals | Cation Transport Proteins - metabolism | Chickens | Protein Binding | Cation Transport Proteins - genetics | Cation Transport Proteins - chemistry | Dimerization | Index Medicus | Membrane Transport, Structure, Function, and Biogenesis
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7. Full Text Effect of egualen sodium hydrate on small-intestinal mucosal damage induced by low-dose aspirin: a prospective randomized clinical trial
by Iguchi, Munetaka and Kakimoto, Kazuki and Kuramoto, Takanori and Nakazawa, Kei and Kubota, Minori and Hirata, Yuki and Fujiwara, Kaori and Harada, Satoshi and Sakanaka, Taisuke and Ota, Kazuhiro and Edogawa, Shoko and Kojima, Yuichi and Nouda, Sadaharu and Okada, Toshihiko and Kawakami, Ken and Takeuchi, Toshihisa and Inoue, Takuya and Higuchi, Kazuhide
Journal of Clinical Biochemistry and Nutrition, ISSN 0912-0009, 2018, Volume 62, Issue 2, pp. 174 - 178
Low-dose aspirin, which is widely used to reduce the risk of cardio- and cerebrovascular thrombosis, often induces gastroenteropathy by increasing the... 
video capsule endoscopy | small intestinal injury | aspirin | NSAIDs | egualen sodium hydrate | Egualen sodium hydrate | Aspirin | Small intestinal injury | Video capsule endoscopy | INDUCED ENTEROPATHY | DOUBLE-BALLOON METHOD | HEALTHY-SUBJECTS | RATS | ANTIULCER AGENT | ANTIPLATELET THERAPY | NUTRITION & DIETETICS | SMALL-BOWEL INJURY | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | PROTON PUMP INHIBITOR | CAPSULE ENDOSCOPY | Transferrin | Dysbacteriosis | Mucosa | Blood tests | Risk reduction | Clinical trials | Permeability | Thrombosis | Patients | Blood | Injury prevention | Endoscopes | Sodium | Intestine | Indomethacin | Endoscopy | Nonsteroidal anti-inflammatory drugs | Thromboembolism | Damage | Health risk assessment | Original
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8. Full Text High-Pressure Carbon Monoxide and Oxygen Mixture is Effective for Lung Preservation
by Fujiwara, Atsushi and Hatayama, Naoyuki and Matsuura, Natsumi and Yokota, Naoya and Fukushige, Kaori and Yakura, Tomiko and Tarumi, Shintaro and Go, Tetsuhiko and Hirai, Shuichi and Naito, Munekazu and Yokomise, Hiroyasu
International journal of molecular sciences, ISSN 1422-0067, 06/2019, Volume 20, Issue 11, p. 2719
(1) Background: Heme oxygenase-1 (HO-1) degrades heme and generates carbon monoxide (CO), producing various anti-inflammatory, anti-oxidative, and... 
carbon monoxide | ischemia–reperfusion injury | lung preservation | high-pressure gas | ischemia-reperfusion injury | RAT HEARTS | APOPTOSIS | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRIVEN | MOLECULES CO-RMS | CHEMISTRY, MULTIDISCIPLINARY | Transplants & implants | Transplantation | Kinases | Hemorrhage | Reperfusion | Ischemia | Rodents | Heme | Hemoglobin | Carbon monoxide | Alveoli | Enzymes | Oxygen | Level (quantity) | Kidneys | Preservation | Heme oxygenase (decyclizing) | Inflammation | Gene expression | Pressure | Oxygenase | Gases | Otology | Lungs | Lactic acid | Oxygenation | Methods | Apoptosis
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9. Full Text Panel-based next-generation sequencing identifies prognostic and actionable genes in childhood acute lymphoblastic leukemia and is suitable for clinical sequencing
by Ishida, Hisashi and Iguchi, Akihiro and Aoe, Michinori and Takahashi, Takahide and Tamefusa, Kosuke and Kanamitsu, Kiichiro and Fujiwara, Kaori and Washio, Kana and Matsubara, Takehiro and Tsukahara, Hirokazu and Sanada, Masashi and Shimada, Akira
Annals of Hematology, ISSN 0939-5555, 03/2019, Volume 98, Issue 3, pp. 657 - 668
Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. Although the cure rate of ALL has greatly improved, a considerable number of... 
ALL | Molecular genetics | Precision medicine | Pediatric | Leukemia | JAPAN ASSOCIATION | AMERICAN-COLLEGE | RISK | MEDICAL GENETICS | CREBBP MUTATIONS | CHILDREN | GENOMIC LANDSCAPE | IKZF1 DELETION | 1ST RELAPSE | STEM-CELL TRANSPLANTATION | HEMATOLOGY | Recurrence | Prognosis | Genes, Neoplasm | Humans | Risk Factors | Child, Preschool | Infant | Male | DNA Mutational Analysis - methods | Molecular Targeted Therapy | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Karyotyping | Adolescent | Germ-Line Mutation | Female | Clone Cells | Polymorphism, Single Nucleotide | DNA, Neoplasm - genetics | Mutation | High-Throughput Nucleotide Sequencing - methods | Child | Infant, Newborn | Oncology, Experimental | Genes | Genetic research | Genetic aspects | Acute lymphocytic leukemia | Research | Tumor proteins | Cancer
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10. Full Text Long-Term Culture of Astrocytes Attenuates the Readily Releasable Pool of Synaptic Vesicles
by Kawano, Hiroyuki and Katsurabayashi, Shutaro and Kakazu, Yasuhiro and Yamashita, Yuta and Kubo, Natsuko and Kubo, Masafumi and Okuda, Hideto and Takasaki, Kotaro and Kubota, Kaori and Mishima, Kenichi and Fujiwara, Michihiro and Harata, N. Charles and Iwasaki, Katsunori
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e48034
The astrocyte is a major glial cell type of the brain, and plays key roles in the formation, maturation, stabilization and elimination of synapses. Thus,... 
ACTIVE ZONE | TRANSMITTER RELEASE | CAT VISUAL-CORTEX | NEUROTRANSMITTER RELEASE | FIBRILLARY ACIDIC PROTEIN | CNS SYNAPTOGENESIS | MULTIDISCIPLINARY SCIENCES | EXCITATORY SYNAPSES | CELL-CULTURE | SILENT SYNAPSES | HIPPOCAMPAL-NEURONS | Evaluation | Brain | Glutamate | Neurons | Intermediate filament proteins | Neurophysiology | Cell culture | Cerebral cortex | Senescence | Synaptogenesis | Glutamic acid receptors (ionotropic) | Galactosidase | Glutamic acid receptors | Kinases | Neuronal-glial interactions | Recruitment | Proteins | Receptors | Vesicles | Synaptic transmission | α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid | Aging | Physiology | Pharmaceutical sciences | Nerve endings | Maturation | Astrocytes | Glial fibrillary acidic protein | Cortex | Data processing | N-Methyl-D-aspartic acid receptors | Biophysics | Brain research | Collaboration | Information processing | Synaptic vesicles | Hippocampus | Synapses
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11. Full Text Novel CYP17A1 mutation in a Japanese patient with combined 17 α -hydroxylase/17,20-lyase deficiency
by Katsumata, Noriyuki and Ogawa, Eishin and Fujiwara, Ikuma and Fujikura, Kaori
Metabolism, ISSN 0026-0495, 2010, Volume 59, Issue 2, pp. 275 - 278
Abstract Combined 17 α -hydroxylase/17,20-lyase deficiency is caused by a defect of P450c17 that catalyzes both 17 α -hydroxylase and 17,20-lyase reactions in... 
Endocrinology & Metabolism
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12. Full Text Strict specificity for high-mannose type N-glycans and primary structure of a red alga Eucheuma serra lectin
by Hori, Kanji and Sato, Yuichiro and Ito, Kaori and Fujiwara, Yoshifumi and Iwamoto, Yasumasa and Makino, Hiroyuki and Kawakubo, Akihiro
Glycobiology, ISSN 0959-6658, 05/2007, Volume 17, Issue 5, pp. 479 - 491
We have elucidated the carbohydrate-binding profile of a non-monosaccharide-binding lectin named Eucheuma serra lectin (ESA)-2 from the red alga Eucheuma serra... 
Amino acid sequence | Eucheumal | Alagal lectin | High-mannose N-glycan specificity | Myxococcus xanthus hemagglutinin | MARINE-ALGAE | high-mannose N glycan specificity | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN-IMMUNODEFICIENCY-VIRUS | GLYCOSYLATION SITES | POTENT | amino acid sequence | CYANOVIRIN-N | Eucheuma | HIV-INACTIVATING PROTEIN | SURFACE-PLASMON RESONANCE | MYXOBACTERIAL HEMAGGLUTININ | PLANT-LECTINS | CARBOHYDRATE-BINDING | algal lectin | Carbohydrate Sequence | Amino Acid Sequence | Algal Proteins - chemistry | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Myxococcus xanthus - genetics | Rhodophyta - chemistry | Molecular Sequence Data | Substrate Specificity | Rhodophyta - genetics | Mannose-Binding Lectins - chemistry | Myxococcus xanthus - chemistry | Sequence Homology, Amino Acid | Mannose-Binding Lectins - genetics | Algal Proteins - genetics | Polysaccharides - chemistry | Protein Binding | Mannose - chemistry
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13. Full Text The effects of a TGR5 agonist and a dipeptidyl peptidase IV inhibitor on dextran sulfate sodium‐induced colitis in mice
by Sakanaka, Taisuke and Inoue, Takuya and Yorifuji, Naoki and Iguchi, Munetaka and Fujiwara, Kaori and Narabayashi, Ken and Kakimoto, Kazuki and Nouda, Sadaharu and Okada, Toshihiko and Kuramoto, Takanori and Ishida, Kumi and Abe, Yosuke and Takeuchi, Toshihisa and Umegaki, Eiji and Akiba, Yasutada and Kaunitz, Jonathan D and Higuchi, Kazuhide
Journal of Gastroenterology and Hepatology, ISSN 0815-9319, 03/2015, Volume 30, Issue 1, pp. 60 - 65
Background and Aim Luminal nutrients stimulate enteroendocrine L cells to release gut hormones, including intestinotrophic glucagon‐like peptide‐2 (GLP‐2).... 
TGR5 | DPPIV | sitagliptin | GLP‐2 | dextran sulfate sodium | Sitagliptin | GLP-2 | Dextran sulfate sodium | LOCALIZATION | ACID | RAT | L CELLS | SECRETION | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Sitagliptin Phosphate - administration & dosage | Dextran Sulfate | Sitagliptin Phosphate - pharmacology | Triterpenes - pharmacology | Cytokines - metabolism | Glucagon-Like Peptide 2 - metabolism | Mice, Inbred C57BL | Male | Peptide Fragments - pharmacology | Receptors, G-Protein-Coupled - agonists | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Dipeptidyl-Peptidase IV Inhibitors - administration & dosage | Dose-Response Relationship, Drug | Animals | Glucagon-Like Peptide 2 - pharmacology | Colitis - chemically induced | Colitis - metabolism | Inflammation Mediators - metabolism | Colitis - drug therapy | Triterpenes - administration & dosage | Dextran | Phosphates | Glucagon | RNA | Mice | Colitis | Sulfates | Deoxycholic acid
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14. Full Text Effect of egualen sodium hydrate on small-intestinal mucosal damage induced by low-dose aspirin: a prospective randomized clinical trial
by Iguchi, Munetaka and Kakimoto, Kazuki and Kuramoto, Takanori and Nakazawa, Kei and Kubota, Minori and Hirata, Yuki and Fujiwara, Kaori and Harada, Satoshi and Sakanaka, Taisuke and Ota, Kazuhiro and Edogawa, Shoko and Kojima, Yuichi and Nouda, Sadaharu and Okada, Toshihiko and Kawakami, Ken and Takeuchi, Toshihisa and Inoue, Takuya and Higuchi, Kazuhide
Journal of Clinical Biochemistry and Nutrition, ISSN 0912-0009, 2018
Low-dose aspirin, which is widely used to reduce the risk of cardio- and cerebrovascular thrombosis, often induces gastroenteropathy by increasing the... 
video capsule endoscopy | NSAIDs | egualen sodium hydrate | small intestinal injury | aspirin
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