Biophysical Journal, ISSN 0006-3495, 02/2018, Volume 114, Issue 3, pp. 165a - 165a
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Biophysical Journal, ISSN 0006-3495, 02/2018, Volume 114, Issue 3, pp. 202a - 202a
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Biophysical Journal, ISSN 0006-3495, 02/2018, Volume 114, Issue 3, pp. 547a - 547a
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Cell Biochemistry and Biophysics, ISSN 1085-9195, 06/2018, Volume 76, Issue 1-2, pp. 29 - 37
Whether class-A G-protein coupled receptors (GPCRs) exist and work as monomers or dimers has drawn extensive attention. A class-A GPCR dopamine D2 receptor...
G protein-coupled receptor (GPCR) | Cultured cell | Dopamine receptor | Dimerization | Plasma membrane | Single-molecule biophysics | METABOTROPIC GLUTAMATE-RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESONANCE ENERGY-TRANSFER | CELL-SURFACE | LIVE CELLS | LIGAND-INDUCED REARRANGEMENT | CELL BIOLOGY | BIOPHYSICS | INTERFACE | PROTEIN-COUPLED RECEPTOR | CONSTITUTIVE DIMERIZATION | OLIGOMERIZATION | LIVING CELLS | Schizophrenia | Phenols | Development and progression | Dopamine | G proteins | Membrane proteins | Psychosis | Receptors | G protein-coupled receptors | Amphetamine | Tracking | Mental disorders | Physiology | Dimers | Dopamine D2 receptors | Monomers | Original Paper
G protein-coupled receptor (GPCR) | Cultured cell | Dopamine receptor | Dimerization | Plasma membrane | Single-molecule biophysics | METABOTROPIC GLUTAMATE-RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESONANCE ENERGY-TRANSFER | CELL-SURFACE | LIVE CELLS | LIGAND-INDUCED REARRANGEMENT | CELL BIOLOGY | BIOPHYSICS | INTERFACE | PROTEIN-COUPLED RECEPTOR | CONSTITUTIVE DIMERIZATION | OLIGOMERIZATION | LIVING CELLS | Schizophrenia | Phenols | Development and progression | Dopamine | G proteins | Membrane proteins | Psychosis | Receptors | G protein-coupled receptors | Amphetamine | Tracking | Mental disorders | Physiology | Dimers | Dopamine D2 receptors | Monomers | Original Paper
Journal Article
Traffic, ISSN 1398-9219, 11/2019
Journal Article
Biophysical Journal, ISSN 0006-3495, 02/2019, Volume 116, Issue 3, pp. 307a - 307a
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Biophysical Journal, ISSN 0006-3495, 02/2019, Volume 116, Issue 3, p. 305
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Nature Chemical Biology, ISSN 1552-4450, 2014, Volume 10, Issue 7, pp. 524 - 532
Methods for imaging and tracking single molecules conjugated with fluorescent probes, called single-molecule tracking (SMT), are now providing researchers with...
LOCALIZATION MICROSCOPY | RECEPTOR CLUSTERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PARTICLE TRACKING | SIGNALING MOLECULES | SUBUNIT COMPOSITION | RESOLUTION LIMIT | FLUORESCENCE CORRELATION SPECTROSCOPY | PLASMA-MEMBRANE | T-CELLS | FLUID-MOSAIC MODEL | Fluorescent Dyes - chemistry | Receptors, G-Protein-Coupled - metabolism | Signal Transduction | Membrane Proteins - genetics | Humans | Gene Expression Regulation | Eukaryotic Cells - metabolism | Photons | GPI-Linked Proteins - metabolism | Cell Tracking | Animals | Biological Transport | Stochastic Processes | Adaptor Proteins, Signal Transducing - genetics | Eukaryotic Cells - cytology | Membrane Proteins - metabolism | Receptors, G-Protein-Coupled - genetics | Adaptor Proteins, Signal Transducing - metabolism | Microscopy, Fluorescence | GPI-Linked Proteins - genetics | Fluorescence | Molecules | Cells
LOCALIZATION MICROSCOPY | RECEPTOR CLUSTERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PARTICLE TRACKING | SIGNALING MOLECULES | SUBUNIT COMPOSITION | RESOLUTION LIMIT | FLUORESCENCE CORRELATION SPECTROSCOPY | PLASMA-MEMBRANE | T-CELLS | FLUID-MOSAIC MODEL | Fluorescent Dyes - chemistry | Receptors, G-Protein-Coupled - metabolism | Signal Transduction | Membrane Proteins - genetics | Humans | Gene Expression Regulation | Eukaryotic Cells - metabolism | Photons | GPI-Linked Proteins - metabolism | Cell Tracking | Animals | Biological Transport | Stochastic Processes | Adaptor Proteins, Signal Transducing - genetics | Eukaryotic Cells - cytology | Membrane Proteins - metabolism | Receptors, G-Protein-Coupled - genetics | Adaptor Proteins, Signal Transducing - metabolism | Microscopy, Fluorescence | GPI-Linked Proteins - genetics | Fluorescence | Molecules | Cells
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 2012, Volume 8, Issue 9, pp. 774 - 783
Advanced single-molecule fluorescent imaging was applied to study the dynamic organization of raft-associated glycosylphosphatidylinositol- anchored proteins...
ACTIVATION | MICRODOMAINS | H-RAS | SINGLE-MOLECULE TRACKING | K-RAS | CHOLESTEROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | PLASMA-MEMBRANE | LIVE CELLS | LIVING CELLS | Membrane Microdomains | Fluorescence Resonance Energy Transfer | CD59 Antigens - metabolism | Glycosylphosphatidylinositols - metabolism | Dimerization | Proteins | Signal transduction | Membranes | Cellular biology | Gene expression
ACTIVATION | MICRODOMAINS | H-RAS | SINGLE-MOLECULE TRACKING | K-RAS | CHOLESTEROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | PLASMA-MEMBRANE | LIVE CELLS | LIVING CELLS | Membrane Microdomains | Fluorescence Resonance Energy Transfer | CD59 Antigens - metabolism | Glycosylphosphatidylinositols - metabolism | Dimerization | Proteins | Signal transduction | Membranes | Cellular biology | Gene expression
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Biophysical Journal, ISSN 0006-3495, 01/2013, Volume 104, Issue 2, pp. 191a - 191a
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Biophysical Journal, ISSN 0006-3495, 01/2012, Volume 102, Issue 3, pp. 239a - 239a
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Trends in Biochemical Sciences, ISSN 0968-0004, 2011, Volume 36, Issue 11, pp. 604 - 615
Based on recent single-molecule imaging results in the living cell plasma membrane, we propose a hierarchical architecture of three-tiered mesoscale (2–300 nm)...
PHASE-SEPARATION | RECEPTOR TYROSINE KINASES | SINGLE-MOLECULE TRACKING | PROTEIN-COUPLED RECEPTOR | CHOLESTEROL DEPLETION | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESONANCE ENERGY-TRANSFER | TRANSLATIONAL DIFFUSION | CELL-MEMBRANES | HYDRODYNAMIC INTERACTIONS | GPI-ANCHORED PROTEINS | Membrane Microdomains - chemistry | Animals | Signal Transduction | Membrane Microdomains - metabolism | Models, Biological | Humans | Proteins | Oligomers | Cell membranes
PHASE-SEPARATION | RECEPTOR TYROSINE KINASES | SINGLE-MOLECULE TRACKING | PROTEIN-COUPLED RECEPTOR | CHOLESTEROL DEPLETION | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESONANCE ENERGY-TRANSFER | TRANSLATIONAL DIFFUSION | CELL-MEMBRANES | HYDRODYNAMIC INTERACTIONS | GPI-ANCHORED PROTEINS | Membrane Microdomains - chemistry | Animals | Signal Transduction | Membrane Microdomains - metabolism | Models, Biological | Humans | Proteins | Oligomers | Cell membranes
Journal Article
Autophagy, ISSN 1554-8627, 10/2013, Volume 9, Issue 10, pp. 1491 - 1499
Autophagosome formation is governed by sequential functions of autophagy-related (ATG) proteins. Although their genetic hierarchy in terms of localization to...
VMP1 | ULK1 | autophagosome | live-cell imaging | ATG5 | Live-cell imaging | Autophagosome | CELLS | MEMBRANE | MITOCHONDRIA | CELL BIOLOGY | YEAST | ATG16L1 | FIP200 | STARVATION | LC3 | Animals | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Phagosomes - metabolism | Cells, Cultured | Endoplasmic Reticulum - metabolism | Autophagy - physiology | Membrane Proteins - metabolism | Mice | Autophagy - genetics
VMP1 | ULK1 | autophagosome | live-cell imaging | ATG5 | Live-cell imaging | Autophagosome | CELLS | MEMBRANE | MITOCHONDRIA | CELL BIOLOGY | YEAST | ATG16L1 | FIP200 | STARVATION | LC3 | Animals | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Phagosomes - metabolism | Cells, Cultured | Endoplasmic Reticulum - metabolism | Autophagy - physiology | Membrane Proteins - metabolism | Mice | Autophagy - genetics
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2012, Volume 7, Issue 3, p. e32948
Confinement of molecules in specific small volumes and areas within a cell is likely to be a general strategy that is developed during evolution for regulating...
SIGNAL-TRANSDUCTION | ORGANIZATION | CELLS | PROTEIN | SINGLE-MOLECULE TRACKING | MULTIDISCIPLINARY SCIENCES | INTRACELLULAR ENVIRONMENTS | RATE LAWS | DIFFUSION | COMPARTMENTS | PHOSPHATASES | Cell Membrane - chemistry | Algorithms | Time Factors | Membrane Microdomains - metabolism | Models, Biological | Computer Simulation | Membrane Lipids - metabolism | Membrane Microdomains - chemistry | Cell Membrane - metabolism | Membrane Proteins - metabolism | Kinetics | Diffusion | Models | Cell membranes | Chemical reaction, Rate of | Analysis | Membranes | Phosphorylation | Confinement | Medical imaging | Computer simulation | Biology | Kinases | Phosphatase | Equilibrium | Physics | Proteins | Studies | Signal transduction | Bursting strength | Bursts | Compartments | Reaction kinetics | Cytoskeleton | Biomolecules | Mesoscale phenomena | Confining | Enzyme kinetics | Localization
SIGNAL-TRANSDUCTION | ORGANIZATION | CELLS | PROTEIN | SINGLE-MOLECULE TRACKING | MULTIDISCIPLINARY SCIENCES | INTRACELLULAR ENVIRONMENTS | RATE LAWS | DIFFUSION | COMPARTMENTS | PHOSPHATASES | Cell Membrane - chemistry | Algorithms | Time Factors | Membrane Microdomains - metabolism | Models, Biological | Computer Simulation | Membrane Lipids - metabolism | Membrane Microdomains - chemistry | Cell Membrane - metabolism | Membrane Proteins - metabolism | Kinetics | Diffusion | Models | Cell membranes | Chemical reaction, Rate of | Analysis | Membranes | Phosphorylation | Confinement | Medical imaging | Computer simulation | Biology | Kinases | Phosphatase | Equilibrium | Physics | Proteins | Studies | Signal transduction | Bursting strength | Bursts | Compartments | Reaction kinetics | Cytoskeleton | Biomolecules | Mesoscale phenomena | Confining | Enzyme kinetics | Localization
Journal Article
Trends in Biochemical Sciences, ISSN 0968-0004, 11/2011, Volume 36, Issue 11, p. 604
Based on recent single-molecule imaging results in the living cell plasma membrane, we propose a hierarchical architecture of three-tiered mesoscale (2-300 nm)...
Proteins | Plasma | Molecules | Signal transduction | Cells
Proteins | Plasma | Molecules | Signal transduction | Cells
Journal Article
Traffic, ISSN 1398-9219, 06/2014, Volume 15, Issue 6, pp. 583 - 612
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Annual Review of Cell and Developmental Biology, ISSN 1081-0706, 11/2012, Volume 28, Issue 1, pp. 215 - 250
The recent rapid accumulation of knowledge on the dynamics and structure of the plasma membrane has prompted major modifications of the textbook fluid-mosaic...
mesoscale-domain architecture | molecular diffusion and collision | picket-fence model | actin-based membrane skeleton | single-molecule imaging | actin-based membrane skeleton, picket-fence model | FC-EPSILON-RI | UNDERGO HOP DIFFUSION | RESONANCE ENERGY-TRANSFER | DEVELOPMENTAL BIOLOGY | FLUORESCENCE CORRELATION SPECTROSCOPY | CELL BIOLOGY | IMMUNE-SYNAPSE FORMATION | ATOMIC-FORCE MICROSCOPY | LIVING CELL-MEMBRANES | SEPTIN DIFFUSION BARRIER | COATED PIT LOCALIZATION | GPI-ANCHORED PROTEINS | Signal Transduction | Membrane Microdomains - metabolism | Humans | Cell Membrane Permeability | Cell Membrane - ultrastructure | Cytoskeleton - ultrastructure | Cell Membrane - physiology | Animals | Membrane Proteins - physiology | Models, Biological | Protein Structure, Quaternary | Cytoskeleton - metabolism | Cell Membrane - metabolism | Membrane Microdomains - physiology | Membrane Proteins - metabolism | Cell proliferation | Physiological aspects | Cell membranes | Polarity (Biology) | Research | Health aspects
mesoscale-domain architecture | molecular diffusion and collision | picket-fence model | actin-based membrane skeleton | single-molecule imaging | actin-based membrane skeleton, picket-fence model | FC-EPSILON-RI | UNDERGO HOP DIFFUSION | RESONANCE ENERGY-TRANSFER | DEVELOPMENTAL BIOLOGY | FLUORESCENCE CORRELATION SPECTROSCOPY | CELL BIOLOGY | IMMUNE-SYNAPSE FORMATION | ATOMIC-FORCE MICROSCOPY | LIVING CELL-MEMBRANES | SEPTIN DIFFUSION BARRIER | COATED PIT LOCALIZATION | GPI-ANCHORED PROTEINS | Signal Transduction | Membrane Microdomains - metabolism | Humans | Cell Membrane Permeability | Cell Membrane - ultrastructure | Cytoskeleton - ultrastructure | Cell Membrane - physiology | Animals | Membrane Proteins - physiology | Models, Biological | Protein Structure, Quaternary | Cytoskeleton - metabolism | Cell Membrane - metabolism | Membrane Microdomains - physiology | Membrane Proteins - metabolism | Cell proliferation | Physiological aspects | Cell membranes | Polarity (Biology) | Research | Health aspects
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