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Nature Communications, ISSN 2041-1723, 2015, Volume 6, Issue 1, p. 6377
Tyrosine kinase inhibitors are effective treatments for non-small-cell lung cancers (NSCLCs) with epidermal growth factor receptor (EGFR) mutations. However,... 
GROWTH-FACTOR RECEPTOR | DRUG-SENSITIVITY | GEFITINIB | AMPLIFICATION | MODELS | GENE | MULTIDISCIPLINARY SCIENCES | MUTATION | ACQUIRED-RESISTANCE | KINASE INHIBITORS | CHEMOTHERAPY | Lung Neoplasms - drug therapy | Recurrence | Adenocarcinoma - pathology | Adenocarcinoma of Lung | Humans | Lung Neoplasms - metabolism | ErbB Receptors - genetics | Gene Expression Regulation, Neoplastic | bcl-X Protein - genetics | Lung Neoplasms - pathology | Small Cell Lung Carcinoma - drug therapy | Small Cell Lung Carcinoma - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Adenocarcinoma - metabolism | Adenocarcinoma - genetics | Antineoplastic Agents - pharmacology | Lung - metabolism | Gefitinib | ErbB Receptors - deficiency | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Lung - pathology | Aniline Compounds - pharmacology | ErbB Receptors - antagonists & inhibitors | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Retinoblastoma Protein - deficiency | Small Cell Lung Carcinoma - genetics | Sulfonamides - pharmacology | Adenocarcinoma - drug therapy | Disease Progression | Drug Resistance, Neoplasm - genetics | Small Cell Lung Carcinoma - pathology | Afatinib | Retinoblastoma Protein - genetics | Erlotinib Hydrochloride - pharmacology | Lung - drug effects | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Quinazolines - pharmacology | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Drug Resistance, Neoplasm - drug effects
Journal Article
by Warren, Wesley C and Clayton, David F and Ellegren, Hans and Arnold, Arthur P and Hillier, Ladeana W and Künstner, Axel and Searle, Steve and White, Simon and Vilella, Albert J and Fairley, Susan and Heger, Andreas and Kong, Lesheng and Ponting, Chris P and Jarvis, Erich D and Mello, Claudio V and Minx, Pat and Lovell, Peter and Velho, Tarciso A. F and Ferris, Margaret and Balakrishnan, Christopher N and Sinha, Saurabh and Blatti, Charles and London, Sarah E and Li, Yun and Lin, Ya-Chi and George, Julia and Sweedler, Jonathan and Southey, Bruce and Gunaratne, Preethi and Watson, Michael and Nam, Kiwoong and Backström, Niclas and Smeds, Linnea and Nabholz, Benoit and Itoh, Yuichiro and Whitney, Osceola and Pfenning, Andreas R and Howard, Jason and Völker, Martin and Skinner, Bejamin M and Griffin, Darren K and Ye, Liang and McLaren, William M and Flicek, Paul and Quesada, Victor and Velasco, Gloria and Lopez-Otin, Carlos and Puente, Xose S and Olender, Tsviya and Lancet, Doron and Smit, Arian F. A and Hubley, Robert and Konkel, Miriam K and Walker, Jerilyn A and Batzer, Mark A and Gu, Wanjun and Pollock, David D and Chen, Lin and Cheng, Ze and Eichler, Evan E and Stapley, Jessica and Slate, Jon and Ekblom, Robert and Birkhead, Tim and Burke, Terry and Burt, David and Scharff, Constance and Adam, Iris and Richard, Hugues and Sultan, Marc and Soldatov, Alexey and Lehrach, Hans and Edwards, Scott V and Yang, Shiaw-Pyng and Li, Xiaoching and Graves, Tina and Fulton, Lucinda and Nelson, Joanne and Chinwalla, Asif and Hou, Shunfeng and Mardis, Elaine R and Wilson, Richard K and Teknisk-naturvetenskapliga vetenskapsområdet and Evolutionsbiologi and Biologiska sektionen and Uppsala universitet and Institutionen för ekologi och genetik
Nature, ISSN 0028-0836, 04/2010, Volume 464, Issue 7289, pp. 757 - 762
Journal Article
Cancer Discovery, ISSN 2159-8274, 07/2015, Volume 5, Issue 7, pp. 713 - 723
Rociletinib is a third-generation EGFR inhibitor active in lung cancers with T790M, the gatekeeper mutation underlying most first-generation EGFR drug... 
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 09/2016, Volume 22, Issue 18, pp. 4585 - 4593
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2015, Volume 33, Issue 15_suppl, pp. 8015 - 8015
Journal Article
Academic Radiology, ISSN 1076-6332, 2015, Volume 23, Issue 3, pp. 329 - 336
Rationale and Objectives The aims of this study were to investigate the association between 8-week tumor volume decrease and survival in an independent cohort... 
Radiology | tyrosine kinase inhibitors | EGFR mutations | tumor volume | Lung cancer | non-small cell | Tumor volume | Tyrosine kinase inhibitors | Non-small cell | SURVIVAL | CRITERIA | 1ST-LINE TREATMENT | MULTICENTER | OPEN-LABEL | CHEMOTHERAPY | CELL LUNG-CANCER | VARIABILITY | GROWTH-FACTOR RECEPTOR | MUTATIONS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Follow-Up Studies | Humans | Middle Aged | Tomography, X-Ray Computed - methods | Lung Neoplasms - pathology | Male | Antineoplastic Agents - therapeutic use | Young Adult | Aged, 80 and over | Adult | Female | Retrospective Studies | Carcinoma, Non-Small-Cell Lung - pathology | Survival Rate | Mutation - genetics | Remission Induction | Disease Progression | Tumor Burden - drug effects | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Lung Neoplasms - diagnostic imaging | Aged | Carcinoma, Non-Small-Cell Lung - diagnostic imaging | Erlotinib Hydrochloride - therapeutic use | Carcinoma, Non-Small-Cell Lung - drug therapy | Cohort Studies | Protein-Tyrosine Kinases - antagonists & inhibitors | Development and progression | Care and treatment | Erlotinib | Lung cancer, Non-small cell | Gefitinib | Tumors | lung cancer | non-small-cell
Journal Article
Journal Article
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