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surgery (36) 36
humans (33) 33
pediatrics (31) 31
index medicus (30) 30
female (28) 28
male (20) 20
child (17) 17
child, preschool (15) 15
infant (15) 15
retrospective studies (14) 14
adolescent (11) 11
infant, newborn (11) 11
medicine & public health (11) 11
children (9) 9
choledochal cyst (8) 8
pancreatic ducts - abnormalities (8) 8
treatment outcome (8) 8
bile ducts - abnormalities (7) 7
cancer (7) 7
follow-up studies (7) 7
neuroblastoma (7) 7
pediatric surgery (7) 7
risk factors (7) 7
carcinoma (6) 6
care and treatment (6) 6
tumors (6) 6
anomalous arrangement (5) 5
anomalous arrangement of the pancreaticobiliary duct (5) 5
pancreaticobiliary maljunction (5) 5
prognosis (5) 5
animals (4) 4
bile-duct (4) 4
biliary atresia (4) 4
dilatation (4) 4
gallbladder (4) 4
immunohistochemistry (4) 4
infants (4) 4
adult (3) 3
bile ducts - pathology (3) 3
bile ducts - surgery (3) 3
biopsy (3) 3
cholangiography (3) 3
choledochal cyst - complications (3) 3
choledochal cyst - diagnosis (3) 3
choledochal cyst - surgery (3) 3
complications (3) 3
complications and side effects (3) 3
congenital biliary dilatation (3) 3
diagnosis (3) 3
ductal plate malformation (3) 3
genetic disorders (3) 3
health aspects (3) 3
liver transplantation (3) 3
magnetic resonance imaging (3) 3
management (3) 3
medical colleges (3) 3
mice (3) 3
neuroblastoma - pathology (3) 3
neuroblastoma - surgery (3) 3
pancreatic ducts - surgery (3) 3
postoperative complications (3) 3
research (3) 3
stem cells (3) 3
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analysis (2) 2
anus, imperforate - surgery (2) 2
biliary (2) 2
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biliary atresia - surgery (2) 2
biliopancreatic reflux (2) 2
bronchopulmonary sequestration - surgery (2) 2
case report (2) 2
cell line, tumor (2) 2
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cholangiopancreatography, magnetic resonance (2) 2
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cloaca (2) 2
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common bile duct - abnormalities (2) 2
congenital diaphragmatic hernia (2) 2
ct imaging (2) 2
cysts - etiology (2) 2
diaphragm (2) 2
digestive system abnormalities - diagnosis (2) 2
digestive system surgical procedures - methods (2) 2
disease models, animal (2) 2
disease progression (2) 2
disease-free survival (2) 2
expression (2) 2
fetal therapy (2) 2
follow-up (2) 2
gallbladder - pathology (2) 2
hernia (2) 2
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1. Full Text An intra-amniotic injection of mesenchymal stem cells promotes lung maturity in a rat congenital diaphragmatic hernia model
by Takayama, Shohei and Sakai, Kohei and Fumino, Shigehisa and Furukawa, Taizo and Kishida, Tsunao and Mazda, Osam and Tajiri, Tatsuro
Pediatric Surgery International, ISSN 0179-0358, 12/2019, Volume 35, Issue 12, pp. 1353 - 1361
We aimed to evaluate the effect of human mesenchymal stem cells (hMSCs) on congenital diaphragmatic hernia (CDH) by intra-amniotic injection in a rat CDH... 
Mesenchymal stem cell | Pediatrics | Congenital diaphragmatic hernia | Medicine & Public Health | Lung hypoplasia | Surgery | Fetal therapy | Pediatric Surgery | Intra-amniotic injection | Nitrofen
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2. Full Text Mesenchymal hamartoma of the chest wall in a 10-year-old girl mimicking malignancy: a case report
by Tanaka, Tomoko and Tanaka, Tomoko and Fumino, Shigehisa and Fumino, Shigehisa and Shirai, Toshiharu and Shirai, Toshiharu and Konishi, Eiichi and Konishi, Eiichi and Tajiri, Tatsuro and Tajiri, Tatsuro
Skeletal Radiology, ISSN 0364-2348, 4/2019, Volume 48, Issue 4, pp. 643 - 647
We herein report a rare case of mesenchymal hamartoma of the chest wall in a 10-year-old girl. She complained of chest pain and was diagnosed with a large... 
Chest wall tumor | Pathology | Medicine & Public Health | Orthopedics | Nuclear Medicine | Mesenchymal hamartoma of the chest wall | Imaging / Radiology | Thoracoscopic surgery | ORTHOPEDICS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Medical colleges | Health aspects | Stem cells | Cancer | Hamartoma | Reconstruction | Chest | Chondrosarcoma | Deformation | Mesenchyme | Rib | Thorax | Malignancy | Mimicry | Biomedical materials | Pain | Osteosarcoma | Biopsy | Biocompatibility | Neoplasia | Tumors
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3. Full Text Derivation of neural stem cells from human teratomas
by Kim, Kiyokazu and Higashi, Mayumi and Fumino, Shigehisa and Tajiri, Tatsuro
Stem Cell Research, ISSN 1873-5061, 12/2019, Volume 41, p. 101633
Human teratoma is a germ cell tumor that contains normal tissues (e.g., hair, skin or cartilage) differentiated from embryonal germ layers. Because of the... 
Teratoma | Neural stem cell
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4. Full Text Surgical treatment of anorectal malformations
by Iwai, Naomi and Iwai, Naomi and Fumino, Shigehisa and Fumino, Shigehisa
Surgery Today, ISSN 0941-1291, 9/2013, Volume 43, Issue 9, pp. 955 - 962
The goal of surgery for anorectal malformations (ARM) is to achieve good bowel, urinary, and sexual functions, as well as the ability for children to become... 
Imperforate anus | Anorectal malformations | Cloaca | Medicine & Public Health | Neonatal surgery | Surgery | Surgical Oncology | SURGERY | CURRARINO TRIAD | FECAL INCONTINENCE | HIGH IMPERFORATE ANUS | ANTEGRADE CONTINENCE ENEMA | ANOMALIES | BIOFEEDBACK THERAPY | POSTERIOR SAGITTAL ANORECTOPLASTY | FOLLOW-UP | STAGE CORRECTION | QUALITY-OF-LIFE | Sexual Dysfunction, Physiological - prevention & control | Prognosis | Humans | Postoperative Complications - prevention & control | Male | Treatment Outcome | Anorectal Malformations | Anus, Imperforate - surgery | Incidence | Anus, Imperforate - genetics | Fecal Incontinence - prevention & control | Adult | Female | Child | Urinary Incontinence - prevention & control | Anus, Imperforate - classification | Infant, Newborn | Anus, Imperforate - epidemiology | Digestive System Surgical Procedures - methods | Sexual disorders | Care and treatment
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5. Full Text Novel Mesenchymal Stem Cell Delivery System as Targeted Therapy Against Neuroblastoma Using the TH-MYCN Mouse Model
by Maniwa, Junnosuke and Fumino, Shigehisa and Kimura, Koseki and Tanaka, Tomoko and Higashi, Mayumi and Kishida, Tsunao and Mazda, Osam and Tajiri, Tatsuro
Journal of Pediatric Surgery, ISSN 0022-3468, 08/2019
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6. Full Text Enhanced metastatic growth after local tumor resection in the presence of synchronous metastasis in a mouse allograft model of neuroblastoma
by Inoue, Maho and Tsuchiya, Yoshiki and Koike, Nobuya and Umemura, Yasuhiro and Inokawa, Hitoshi and Togashi, Yuichi and Maniwa, Junnosuke and Higashi, Mayumi and Fumino, Shigehisa and Tajiri, Tatsuro and Yagita, Kazuhiro
Pediatric Surgery International, ISSN 0179-0358, 12/2019, Volume 35, Issue 12, pp. 1403 - 1411
We investigated how local tumor resection affects metastatic lesions in neuroblastoma.MYCN Tg tumor-derived cells were injected subcutaneously into 129+Ter... 
Pediatrics | Medicine & Public Health | MYCN transgenic mouse | Surgery | Concomitant tumor resistance | Neuroblastoma | Metastasis | Pediatric Surgery | Local tumor resection
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7. Full Text Thoracoscopic resection for mediastinal thymolipoma in a child
by Furukawa, Taizo and Sakai, Kohei and Higashi, Mayumi and Fumino, Shigehisa and Aoi, Shigeyoshi and Tajiri, Tatsuro
Asian Journal of Endoscopic Surgery, ISSN 1758-5902, 04/2019, Volume 12, Issue 2, pp. 218 - 221
Thymolipoma is a rare disease among benign tumors. We herein report the case of a child who underwent thoracoscopic resection of a large thymolipoma. A... 
thoracoscopic resection | thymolioma | Child
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8. Full Text Successful laparoscopic extirpation of a large omental lipoblastoma in a child
by Furukawa, Taizo and Aoi, Shigeyoshi and Sakai, Kohei and Higashi, Mayumi and Fumino, Shigehisa and Tajiri, Tatsuro
Asian Journal of Endoscopic Surgery, ISSN 1758-5902, 11/2015, Volume 8, Issue 4, pp. 473 - 476
Omental lipoblastoma is extremely rare among benign tumors. We herein report the case of a child who underwent laparoscopic extirpation of a large omental... 
laparoscopy | Child | omental lipoblastoma | Laparoscopy - methods | Humans | Peritoneal Neoplasms - surgery | Child, Preschool | Female | Omentum - surgery | Lipoblastoma - surgery
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9. Full Text Japanese clinical practice guidelines for sacrococcygeal teratoma, 2017
by Fumino, Shigehisa and Tajiri, Tatsuro and Usui, Noriaki and Tamura, Masanori and Sago, Haruhiko and Ono, Shigeru and Nosaka, Shunsuke and Yoneda, Akihiro and Souzaki, Ryota and Higashi, Mayumi and Sakai, Kohei and Takahashi, Ken and Sugiura, Takahiro and Taguchi, Tomoaki
Pediatrics International, ISSN 1328-8067, 07/2019, Volume 61, Issue 7, pp. 672 - 678
Background Sacrococcygeal teratoma (SCT) is the most common extragonadal germ cell tumor in neonates and infants. Although most cases of infantile SCT are... 
long‐term prognosis | sacrococcygeal teratoma | risk factor | guideline | MANAGEMENT | VASCULAR CONTROL | PROGNOSIS | RESECTION | EMBOLIZATION | FOLLOW-UP | GIANT | long-term prognosis | PEDIATRICS | FUNCTIONAL SEQUELAE | MEDIAN SACRAL ARTERY | PRENATAL-DIAGNOSIS | Medicine, Experimental | Medical research | Teratoma | Infants | Heart | Neonates | Transformation | Physicians | Coagulation | Bladder | Disseminated intravascular coagulation | Risk factors | Bleeding | Guidelines | Information systems | Intestine | Paralysis | Lesions | Heart diseases | Cesarean section | Medical personnel | Complications | Case reports | Blood vessels | Risk analysis | Patients | Quality of life | Radiology | Clinical medicine | Tumors
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10. Full Text Long-term outcomes after hepaticojejunostomy for choledochal cyst: a 10- to 27-year follow-up
by Ono, Shigeru and Fumino, Shigehisa and Shimadera, Shinichi and Iwai, Naomi
Journal of Pediatric Surgery, ISSN 0022-3468, 2010, Volume 45, Issue 2, pp. 376 - 378
Abstract Introduction Choledochal cyst (CC) is closely associated with anomalous arrangement of the pancreaticobiliary duct, which is considered a high-risk... 
Pediatrics | Surgery | Long-term outcome | Choledochal cyst | Late complications | ANOMALOUS ARRANGEMENT | SURGERY | BILE-DUCT | GALLBLADDER | PEDIATRICS | PATIENT | PANCREATICOBILIARY DUCT | CARCINOMA | CANCER | Bile Duct Neoplasms - surgery | Prognosis | Follow-Up Studies | Humans | Male | Treatment Outcome | Choledochal Cyst - surgery | Disease-Free Survival | Cholangiocarcinoma - surgery | Biliary Tract Surgical Procedures - methods | Adolescent | Adult | Common Bile Duct - surgery | Dilatation, Pathologic - surgery | Female | Retrospective Studies | Bile Ducts, Intrahepatic - surgery | Longitudinal Studies
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11. Full Text Noninvasive estimation of central venous pressure after Fontan procedure using biochemical markers and abdominal echography
by Oka, Tatsujiro, MD, PhD and Kato, Ryuichi, MD and Fumino, Shigehisa, MD, PhD and Toiyama, Kentaro, MD and Yamagishi, Masaaki, MD, PhD and Itoi, Toshiyuki, MD, PhD and Hamaoka, Kenji, MD, PhD
Journal of Thoracic and Cardiovascular Surgery, The, ISSN 0022-5223, 2013, Volume 146, Issue 1, pp. 153 - 157
Objectives Patients may develop liver dysfunction, including liver fibrosis, over the long term following Fontan procedure. Therefore, early detection of liver... 
Cardiothoracic Surgery | CARDIAC-FUNCTION | SURGERY | CARDIAC & CARDIOVASCULAR SYSTEMS | CIRCULATION | CHRONIC HEPATITIS-C | LIVER HISTOLOGY | HEPATOCELLULAR-CARCINOMA | OPERATION | PREDICT | RESPIRATORY SYSTEM | SIGNIFICANT FIBROSIS | CIRRHOSIS | INDEX | Fontan Procedure | Humans | Adolescent | Central Venous Pressure | Ultrasonography | Child, Preschool | Abdomen - diagnostic imaging | Female | Male | Biomarkers - blood | Child | Blood Pressure Determination - methods | Biological markers | Venous pressure
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12. Full Text Diagnosis and treatment of pancreaticobiliary maljunction in children
by Ono, Shigeru and Fumino, Shigehisa and Iwai, Naomi
Surgery Today, ISSN 0941-1291, 5/2011, Volume 41, Issue 5, pp. 601 - 605
Pancreaticobiliary maljunction (PBM), which may be called by synonymous terms such as “anomalous arrangement of the pancreaticobiliary duct” or “anomalous... 
Pancreaticobiliary maljunction | Medicine & Public Health | Cardiac Surgery | Surgery | Abdominal Surgery | Choledochal cyst | Vascular Surgery | Thoracic Surgery | Children | Biliary tract malignancy | Surgical Oncology | ANOMALOUS ARRANGEMENT | SURGERY | BILE-DUCT DILATATION | GALLBLADDER | BILIARY | PATIENT | PROPHYLACTIC EXCISION | CARCINOMA | Amylases - blood | Cholangiography | Humans | Risk Factors | Biliary Tract Neoplasms - etiology | Cholangiopancreatography, Endoscopic Retrograde | Tomography, X-Ray Computed | Pancreatic Ducts - abnormalities | Choledochal Cyst - diagnosis | Common Bile Duct - abnormalities | Choledochal Cyst - complications | Cholangiopancreatography, Magnetic Resonance | Child | Digestive System Surgical Procedures - methods
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13. Full Text Immunologic Effects of Sirolimus in Patients With Vascular Anomalies
by Nozawa, Akifumi and Ozeki, Michio and Yasue, Shiho and Endo, Saori and Kawamoto, Norio and Ohnishi, Hidenori and Fumino, Shigehisa and Furukawa, Taizo and Tajiri, Tatsuro and Maekawa, Takanobu and Fujino, Akihiro and Souzaki, Ryota and Fukao, Toshiyuki
Journal of Pediatric Hematology/Oncology, ISSN 1077-4114, 11/2019, p. 1
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14. Full Text The roles played by the MYCN, Trk, and ALK genes in neuroblastoma and neural development
by Higashi, Mayumi and Sakai, Kohei and Fumino, Shigehisa and Aoi, Shigeyoshi and Furukawa, Taizo and Tajiri, Tatsuro
Surgery Today, ISSN 0941-1291, 9/2019, Volume 49, Issue 9, pp. 721 - 727
Neuroblastoma is one of the most frequent, yet distinctive and challenging childhood tumors. The uniqueness of this tumor depends on its biological markers,... 
ALK | MYCN | Medicine & Public Health | Surgery | Neuroblastoma | Trk | Surgical Oncology | SURGERY | SOLID TUMORS | TARGETING MYCN | CELL FATE | IN-VITRO | AMPLIFICATION | N-MYC | LYMPHOMA | RECEPTORS | UP-REGULATION | EXPRESSION
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15. Full Text Surgical intervention and perioperative risk factors of retroperitoneal teratomas in children: a single institution experience
by Fumino, Shigehisa and Maniwa, Junnosuke and Takeuchi, Yuki and Sakai, Kohei and Higashi, Mayumi and Aoi, Shigeyoshi and Furukawa, Taizo and Kimura, Osamu and Tajiri, Tatsuro
Pediatric Surgery International, ISSN 0179-0358, 9/2016, Volume 32, Issue 9, pp. 909 - 914
Retroperitoneal teratomas (RTs) are rare among germ cell tumors and predominantly occur in infants. RTs are often difficult to manage by perioperative... 
Pediatrics | Medicine & Public Health | Surgical complication | Surgery | Mesenteric ischemia | Perioperative management | Retroperitoneal teratoma | Down syndrome | Pediatric Surgery | SURGERY | PEDIATRICS | Intraoperative Complications | Humans | Risk Factors | Child, Preschool | Female | Infant | Male | Retrospective Studies | Teratoma - surgery | Retroperitoneal Neoplasms - surgery | Postoperative Complications | Infant, Newborn | Complications and side effects | Care and treatment | Complications | Infants | Research | Health aspects | Risk factors | Index Medicus
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16. Full Text In vivo effects of short- and long-term MAPK pathway inhibition against neuroblastoma
by Takeuchi, Yuki and Tanaka, Tomoko and Higashi, Mayumi and Fumino, Shigehisa and Iehara, Tomoko and Hosoi, Hajime and Sakai, Toshiyuki and Tajiri, Tatsuro
Journal of Pediatric Surgery, ISSN 0022-3468, 12/2018, Volume 53, Issue 12, pp. 2454 - 2459
It was reported that almost 80% of relapsed neuroblastomas showed MAPK pathway mutations. In our previous study, both trametinib (MEK inhibitor) and CH5126766... 
MAPK pathway inhibition | MEK inhibitor | Neuroblastoma | Partial differentiation | pERK IHC | Acquired drug resistance | RO5126766 | VITRO | SURGERY | PEDIATRICS | PERK IHC | PHASE-I | Immunohistochemistry | eIF-2 Kinase - metabolism | Humans | Neoplasm Recurrence, Local - drug therapy | Ki-67 Antigen - metabolism | Coumarins - pharmacology | Xenograft Model Antitumor Assays | Animals | Neuroblastoma - drug therapy | Cell Line, Tumor | Female | Pyrimidinones - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Mitogen-Activated Protein Kinases - drug effects | Neuroblastoma - pathology | Pyridones - pharmacology | Medical colleges | Drug resistance | Analysis
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17. Full Text MEK inhibitors as a novel therapy for neuroblastoma: Their in vitro effects and predicting their efficacy
by Tanaka, Tomoko and Higashi, Mayumi and Kimura, Koseki and Wakao, Junko and Fumino, Shigehisa and Iehara, Tomoko and Hosoi, Hajime and Sakai, Toshiyuki and Tajiri, Tatsuro
Journal of Pediatric Surgery, ISSN 0022-3468, 2016, Volume 51, Issue 12, pp. 2074 - 2079
Abstract Background A recent study reported that relapsed neuroblastomas had frequent RAS–ERK pathway mutations. We herein investigated the effects and... 
Pediatrics | Surgery | MEK inhibitor | Neuroblastoma | RAF/MEK inhibitor | CH5126766 | Trametinib | RAS–ERK pathway | SURGERY | RAS-ERK pathway | SOLID TUMORS | RO5126766 | PATHWAY | PEDIATRICS | GSK1120212 | MUTATIONS | PHASE-I | MAP Kinase Signaling System - physiology | Humans | Pyrimidinones - therapeutic use | Neoplasm Recurrence, Local | Neuroblastoma - diagnosis | Coumarins - therapeutic use | Signal Transduction - drug effects | Protein Kinase Inhibitors - therapeutic use | Neuroblastoma - drug therapy | Cell Line, Tumor | Pyridones - therapeutic use | Phosphorylation - drug effects | Molecular Targeted Therapy - methods
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18. Full Text Surgical intervention strategies for pediatric congenital cystic lesions of the lungs: A 20-year single-institution experience
by Furukawa, Taizo and Kimura, Osamu and Sakai, Kouhei and Higashi, Mayumi and Fumino, Shigehisa and Aoi, Shigeyoshi and Tajiri, Tatsuro
Journal of Pediatric Surgery, ISSN 0022-3468, 2015, Volume 50, Issue 12, pp. 2025 - 2027
Abstract Background The aim of this study was to assess surgical intervention strategies for congenital cystic lesions of the lungs (CCL), focusing on the... 
Pediatrics | Surgery | Minimally invasive surgery | CCAM | Neonatal surgery | Operative indication | Key words CCAM | SURGERY | ADENOMATOID MALFORMATION | MANAGEMENT | DISEASE | PEDIATRICS | PULMONARY-FUNCTION | CHILDREN | Bronchogenic Cyst - congenital | Follow-Up Studies | Humans | Child, Preschool | Infant | Male | Pulmonary Emphysema - surgery | Treatment Outcome | Pneumonectomy | Bronchopulmonary Sequestration - surgery | Operative Time | Cystic Adenomatoid Malformation of Lung, Congenital - surgery | Bronchogenic Cyst - surgery | Female | Pulmonary Emphysema - congenital | Genetic disorders
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19. Full Text Clinical analysis of liver fibrosis in choledochal cyst
by Fumino, Shigehisa and Higuchi, Koji and Aoi, Shigeyoshi and Furukawa, Taizo and Kimura, Osamu and Tajiri, Tatsuro
Pediatric Surgery International, ISSN 0179-0358, 11/2013, Volume 29, Issue 11, pp. 1097 - 1102
Although most patients with choledochal cyst (CC) have a favorable prognosis with prompt treatment, some of them are complicated with liver fibrosis, resulting... 
Pediatrics | Medicine & Public Health | Surgery | Risk factor | Choledochal cyst | Liver fibrosis | Liver cirrhosis | Pediatric Surgery | Liver transplantation | ANOMALOUS ARRANGEMENT | SURGERY | DIAGNOSIS | BILE-DUCT | CLASSIFICATION | CHILDREN | IMPACT | CIRRHOSIS | PEDIATRICS | CONGENITAL BILIARY DILATATION | PANCREATICOBILIARY DUCT | AGE | Liver Cirrhosis - etiology | Liver - pathology | Liver Cirrhosis - diagnosis | Liver Transplantation | Prognosis | Follow-Up Studies | Humans | Risk Factors | Child, Preschool | Infant | Male | Tomography, X-Ray Computed | Choledochal Cyst - surgery | Disease Progression | Hepatectomy | Choledochal Cyst - diagnosis | Magnetic Resonance Imaging | Biopsy | Choledochal Cyst - complications | Female | Liver Cirrhosis - surgery | Retrospective Studies | Infant, Newborn | Complications and side effects | Care and treatment | Liver diseases | Cysts | Fibrosis | Gallbladder diseases | Diagnosis
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20. Full Text Advanced surgical strategy for giant mediastinal germ cell tumor in children
by Fumino, Shigehisa and Sakai, Kohei and Higashi, Mayumi and Aoi, Shigeyoshi and Furukawa, Taizo and Yamagishi, Masaaki and Inoue, Masayoshi and Iehara, Tomoko and Hosoi, Hajime and Tajiri, Tatsuro
Journal of Pediatric Surgery Case Reports, ISSN 2213-5766, 2017, Volume 27, Issue C, pp. 51 - 55
Abstract Purpose Giant mediastinal germ cell tumor (MGCT) requires a well-planned advanced surgical approach. We retrospectively reviewed our surgical strategy... 
Surgery
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