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1. Full Text Antiphospholipid Syndrome: It’s Far More Than You Think
by Annem, Chandrahasa and Furie, Richard A
JCR: Journal of Clinical Rheumatology, ISSN 1076-1608, 08/2017, Volume 23, Issue 5, pp. 278 - 284
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2. Full Text β2-glycoprotein-1 autoantibodies from patients with antiphospholipid syndrome are sufficient to potentiate arterial thrombus formation in a mouse model
by Arad, Ariela and Proulle, Valerie and Furie, Richard A and Furie, Barbara C and Furie, Bruce
Blood, ISSN 0006-4971, 03/2011, Volume 117, Issue 12, pp. 3453 - 3459
Antiphospholipid syndrome is characterized by thrombosis, recurrent fetal loss, and the presence of the lupus anticoagulant, anticardiolipin antibodies, or... 
Humans | Mice, Inbred C57BL | Middle Aged | Male | Arteries - pathology | Antiphospholipid Syndrome - immunology | Thrombosis - pathology | Thrombosis - metabolism | beta 2-Glycoprotein I - metabolism | Animals | Thrombosis - etiology | Autoantibodies - isolation & purification | Adult | Female | Mice | Antiphospholipid Syndrome - blood | Autoantibodies - adverse effects | beta 2-Glycoprotein I - immunology | Disease Models, Animal | Thrombosis and Hemostasis
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3. Full Text Baricitinib for systemic lupus erythematosus – Authors' reply
by Wallace, Daniel J and Furie, Richard A and Tanaka, Yoshiya and de Bono, Stephanie and Hoffman, Robert W
The Lancet, ISSN 0140-6736, 02/2019, Volume 393, Issue 10170, pp. 402 - 403
[...]we are carrying out a more extensive benefit–risk assessment in the ongoing baricitinib phase 3 global systemic lupus erythematosus programme... 
Lupus | Creatine kinase | Neutrophils | Health risks | Lipids | Arthritis | Creatine | Thrombosis | Chronic conditions | Systemic lupus erythematosus | Rheumatoid arthritis | Risk assessment | Janus kinase
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4. Full Text Platelets are required for enhanced activation of the endothelium and fibrinogen in a mouse thrombosis model of APS
by Proulle, Valerie and Furie, Richard A and Merrill-Skoloff, Glenn and Furie, Barbara C and Furie, Bruce
Blood, ISSN 0006-4971, 07/2014, Volume 124, Issue 4, pp. 611 - 622
Antiphospholipid syndrome (APS) is defined by thrombosis, fetal loss, and the presence of antiphospholipid antibodies, including anti-beta 2-glycoprotein-1... 
CELL-ADHESION MOLECULE-1 | HUMAN ANTIPHOSPHOLIPID ANTIBODIES | ANTI-BETA-GLYCOPROTEIN I ANTIBODIES | DIMERIC BETA-GLYCOPROTEIN-I | BETA-GLYCOPROTEIN I | PROTEIN DISULFIDE-ISOMERASE | ANTICARDIOLIPIN ANTIBODIES | TOLL-LIKE RECEPTOR | APOLIPOPROTEIN-E RECEPTOR-2 | HEMATOLOGY | TISSUE FACTOR | Antibodies, Antiphospholipid - blood | Blood Platelets - immunology | Autoantibodies - blood | Humans | beta 2-Glycoprotein I - metabolism | Blood Platelets - cytology | Cell Membrane - metabolism | Antiphospholipid Syndrome - metabolism | Disease Models, Animal | Mice, Inbred C57BL | Cells, Cultured | Thrombosis - immunology | Endothelium - immunology | Blotting, Western | Endothelium - cytology | Antiphospholipid Syndrome - immunology | Thrombosis - pathology | Autoantibodies - immunology | Intercellular Adhesion Molecule-1 - metabolism | Thrombosis - metabolism | Animals | Antiphospholipid Syndrome - pathology | Endothelium - metabolism | Blood Platelets - metabolism | Platelet Activation | Fibrinogen - metabolism | Mice | Fibrin - metabolism | beta 2-Glycoprotein I - immunology | Thrombosis and Hemostasis
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5. Full Text Baricitinib for systemic lupus erythematosus: a double-blind, randomised, placebo-controlled, phase 2 trial
by Wallace, Daniel J and Furie, Richard A and Tanaka, Yoshiya and Kalunian, Kenneth C and Mosca, Marta and Petri, Michelle A and Dörner, Thomas and Cardiel, Mario H and Bruce, Ian N and Gomez, Elisa and Carmack, Tara and DeLozier, Amy M and Janes, Jonathan M and Linnik, Matthew D and de Bono, Stephanie and Silk, Maria E and Hoffman, Robert W
The Lancet, ISSN 0140-6736, 07/2018, Volume 392, Issue 10143, pp. 222 - 231
Patients with systemic lupus erythematosus have substantial unmet medical need. Baricitinib is an oral selective Janus kinase (JAK)1 and JAK2 inhibitor that we... 
RHEUMATOID-ARTHRITIS | MEDICINE, GENERAL & INTERNAL | 2-PHASE III TRIALS | INHIBITION | REVISED CRITERIA | MULTICENTER COHORT | RESPONDER INDEX | CLASSIFICATION | QUALITY-OF-LIFE | DISEASE-ACTIVITY | Lupus | Medical research | Systemic lupus erythematosus | Analysis | Clinical trials | Medicine, Experimental | Arthritis | Therapy | Signs and symptoms | Cytokines | Laboratories | Pathogenesis | Exanthema | Joint diseases | Patients | Chronic conditions | Randomization | Pain | Janus kinase 2 | Janus kinase | Skin diseases | Safety | Autoimmune diseases | Drug dosages
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6. Full Text Long‐Term Safety and Efficacy of Belimumab in Patients With Systemic Lupus Erythematosus
: A Continuation of a Seventy‐Six–Week Phase
by Furie, Richard A and Wallace, Daniel J and Aranow, Cynthia and Fettiplace, James and Wilson, Barbara and Mistry, Prafull and Roth, David A and Gordon, David
Arthritis & Rheumatology (Hoboken, N.j.), ISSN 2326-5191, 6/2018, Volume 70, Issue 6, pp. 868 - 877
Systemic Lupus Erythematosus | Original
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7. Cryptogenic Stroke
by Yaghi Shadi and Bernstein Richard A and Passman Rod and Okin Peter M and Furie Karen L
Circulation Research, ISSN 0009-7330, 02/2017, Volume 120, Issue 3, pp. 527 - 540
Background:Cryptogenic stroke accounts for 30% to 40% of ischemic stroke. It is essential to determine the possible culprit because this will improve secondary... 
Literature reviews | Prevention | Stroke | Fibrillation | Ischemia | Arteriosclerosis | Aortic arch | Atherosclerosis | Clinical trials | Aorta
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8. Full Text Cryptogenic Stroke: Research and Practice
by Yaghi, Shadi and Bernstein, Richard A and Passman, Rod and Okin, Peter M and Furie, Karen L
Circulation Research, ISSN 0009-7330, 02/2017, Volume 120, Issue 3, pp. 527 - 540
BACKGROUND:Cryptogenic stroke accounts for 30% to 40% of ischemic stroke. It is essential to determine the possible culprit because this will improve secondary... 
cryptogenic stroke | embolism | therapeutic implications | diagnostic testing | prevention | CARDIAC & CARDIOVASCULAR SYSTEMS | LEFT ATRIAL APPENDAGE | RISK-FACTORS | PATENT FORAMEN OVALE | TRANSIENT ISCHEMIC ATTACK | TRANSESOPHAGEAL ECHOCARDIOGRAPHY | COMPUTED-TOMOGRAPHY | CANCER-PATIENTS | CEREBROVASCULAR COMPLICATIONS | PROTRUDING AORTIC ATHEROMAS | MAGNETIC-RESONANCE | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Foramen Ovale, Patent - therapy | Anticoagulants - administration & dosage | Stroke - diagnostic imaging | Randomized Controlled Trials as Topic - methods | Atrial Fibrillation - therapy | Humans | Risk Factors | Foramen Ovale, Patent - epidemiology | Secondary Prevention - methods | Atherosclerosis - epidemiology | Atherosclerosis - diagnostic imaging | Atherosclerosis - therapy | Atrial Fibrillation - diagnostic imaging | Atrial Fibrillation - epidemiology | Heart Diseases - epidemiology | Heart Diseases - therapy | Foramen Ovale, Patent - diagnostic imaging | Stroke - epidemiology | Heart Diseases - diagnostic imaging | Stroke - therapy
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9. Full Text Efficacy and safety of subcutaneous tabalumab, a monoclonal antibody to B-cell activating factor, in patients with systemic lupus erythematosus: results from ILLUMINATE-2, a 52-week, phase III, multicentre, randomised, double-blind, placebo-controlled study
by Merrill, J T and van Vollenhoven, R F and Buyon, J P and Furie, R A and Stohl, W and Morgan-Cox, M and Dickson, C and Anderson, P W and Lee, C and Berclaz, P-Y and Dörner, T
Annals of the Rheumatic Diseases, ISSN 0003-4967, 02/2016, Volume 75, Issue 2, pp. 332 - 40
ObjectivesTo evaluate the efficacy and safety of tabalumab, a human IgG4 monoclonal antibody that neutralises membrane and soluble B-cell activating factor... 
Complement C3 | Humans | Middle Aged | Complement C4 | B-Lymphocytes | Male | Journal Article | Dose-Response Relationship, Drug | Young Adult | Clinical Trial, Phase III | Injections, Subcutaneous | Lupus Erythematosus, Systemic | Adult | Female | Severity of Illness Index | Autoantibodies | Double-Blind Method | Drug Administration Schedule | Antibodies, Antinuclear | Treatment Outcome | Antibodies, Monoclonal | Randomized Controlled Trial | B-Cell Activating Factor | Adolescent | Biomarkers | Multicenter Study | Aged | African Continental Ancestry Group | TRIALS | BELIMUMAB | FLARES | PREDICTORS | LYMPHOCYTE STIMULATOR | CLASSIFICATION | LIGAND | RHEUMATOLOGY | DISEASE-ACTIVITY | Autoantibodies - blood | B-Cell Activating Factor - antagonists & inhibitors | Lupus Erythematosus, Systemic - ethnology | Antibodies, Antinuclear - blood | Lupus Erythematosus, Systemic - drug therapy | B-Lymphocytes - metabolism | B-Cell Activating Factor - administration & dosage | Complement C4 - metabolism | Complement C3 - metabolism | Biomarkers - blood | Antibodies, Monoclonal - administration & dosage | Care and treatment | Usage | Systemic lupus erythematosus | Estrogen | Monoclonal antibodies | Clinical trials | Dosage and administration | Research | Lupus | Immunology | Laboratories | Suicides & suicide attempts | Response rates | Tumor necrosis factor-TNF | Mental depression | Drug dosages
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10. Full Text Novel paradigms in systemic lupus erythematosus
by Dörner, Thomas and Furie, Richard
The Lancet, ISSN 0140-6736, 06/2019, Volume 393, Issue 10188, pp. 2344 - 2358
The heterogeneity of systemic lupus erythematosus (SLE), long recognised by clinicians, is now challenging the entire lupus community, from geneticists to... 
Lupus | Medicine, Experimental | Medical colleges | Medical research | Systemic lupus erythematosus | Phenotypes | Nephritis | Immunoglobulins | Communities | Pathogenesis | Medical innovations | Mortality | Rheumatology | Arthritis | Lupus nephritis | Drug development | Damage prevention | Epidemiology | Patients | Heterogeneity | Chronic conditions | Classification | Rheumatism | Remission | Tumor necrosis factor-TNF | Autoimmune diseases
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11. Full Text Association of a Primary Stroke Center Protocol for Suspected Stroke by Large-Vessel Occlusion With Efficiency of Care and Patient Outcomes
by McTaggart, Ryan A and Yaghi, Shadi and Cutting, Shawna M and Hemendinger, Morgan and Baird, Grayson L and Haas, Richard A and Furie, Karen L and Jayaraman, Mahesh V
JAMA Neurology, ISSN 2168-6149, 07/2017, Volume 74, Issue 7, pp. 793 - 800
IMPORTANCE: While prehospital triage to the closest comprehensive stroke center (CSC) may improve the delivery of care for patients with suspected emergent... 
TRIAL | MANAGEMENT | THERAPY | ACUTE ISCHEMIC-STROKE | ENDOVASCULAR TREATMENT | THROMBECTOMY | VALIDATION | REPERFUSION | TIME | PREHOSPITAL SCALE | CLINICAL NEUROLOGY | Severity of Illness Index | Stroke - diagnostic imaging | Humans | Mechanical Thrombolysis - statistics & numerical data | Middle Aged | Arterial Occlusive Diseases - diagnostic imaging | Hospitalization - statistics & numerical data | Cerebral Arterial Diseases - therapy | Clinical Protocols - standards | Male | Emergency Service, Hospital - statistics & numerical data | Hospitals, Special - statistics & numerical data | Hospitals, Special - standards | Outcome and Process Assessment (Health Care) - statistics & numerical data | Time Factors | Aged, 80 and over | Female | Aged | Retrospective Studies | Cerebral Arterial Diseases - diagnostic imaging | Stroke - therapy | Arterial Occlusive Diseases - therapy | Emergency Service, Hospital - standards | Online First | Original Investigation | Research
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12. Full Text Long‐Term Safety and Efficacy of Belimumab in Patients With Systemic Lupus Erythematosus
by Furie, Richard A and Wallace, Daniel J and Aranow, Cynthia and Fettiplace, James and Wilson, Barbara and Mistry, Prafull and Roth, David A and Gordon, David
Arthritis & Rheumatology, ISSN 2326-5191, 06/2018, Volume 70, Issue 6, pp. 868 - 877
Objective We undertook this US multicenter continuation study (GlaxoSmithKline study BEL112233; ClinicalTrials.gov identifier: NCT00724867) to assess long‐term... 
Lupus | Damage assessment | Effectiveness | Identification methods | Estrogens | Prednisone | Patients | Chronic conditions | Systemic lupus erythematosus | Lymphocytes B | CD20 antigen | Safety | Autoimmune diseases
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13. Full Text Cardiac magnetic resonance imaging: a new tool to identify cardioaortic sources in ischaemic stroke
by Yaghi, Shadi and Liberman, Ava L and Atalay, Michael and Song, Christopher and Furie, Karen L and Kamel, Hooman and Bernstein, Richard A
Journal of Neurology, Neurosurgery & Psychiatry, ISSN 0022-3050, 01/2017, Volume 88, Issue 1, pp. 31 - 37
Stroke of undetermined aetiology or ‘cryptogenic’ stroke accounts for 30–40% of ischaemic strokes despite extensive diagnostic evaluation. The role and yield... 
CEREBROVASCULAR | MRI | CEREBROVASCULAR DISEASE | FIBRILLATION | FIBROSIS | SURGERY | LEFT ATRIAL APPENDAGE | PSYCHIATRY | TRANSESOPHAGEAL ECHOCARDIOGRAPHY | RISK | NATRIURETIC PEPTIDE | CLINICAL NEUROLOGY | CRYPTOGENIC STROKE | CATHETER ABLATION | TRANSTHORACIC ECHOCARDIOGRAPHY | Brain Ischemia - complications | Magnetic Resonance Imaging | Stroke - etiology | Stroke - diagnostic imaging | Humans | Heart Diseases - complications | Heart Diseases - diagnostic imaging | Brain Ischemia - diagnostic imaging | Disease prevention | Studies | Anticoagulants | Cardiac arrhythmia | Stroke | Nuclear magnetic resonance--NMR | Embolisms | Morphology | Coronary vessels | Cardiovascular disease | Cardiology | Blood clots
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14. Full Text Antiphospholipid Syndrome: It's Far More Than You Think
by Annem, Chandrahasa and Furie, Richard A
Journal of Clinical Rheumatology, ISSN 1076-1608, 08/2017, Volume 23, Issue 5, pp. 278 - 284
RECURRENT THROMBOSIS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | INTERNATIONAL CONSENSUS STATEMENT | CLINICAL-TRIAL | ANTICARDIOLIPIN ANTIBODY | DOUBLE-BLIND | RENAL-TRANSPLANTATION | RHEUMATOLOGY | CLASSIFICATION CRITERIA | ANTIBODY-SYNDROME | AVASCULAR NECROSIS | Risk Assessment - methods | Antiphospholipid Syndrome - diagnosis | Antibodies, Antiphospholipid - blood | Drug Development - methods | Thrombocytopenia - etiology | Humans | Adrenal Insufficiency - diagnosis | Research | Secondary Prevention - methods | Antiphospholipid Syndrome - immunology | Heart Diseases - diagnosis | Adrenal Insufficiency - etiology | Heart Diseases - etiology | Livedo Reticularis - diagnosis | Abortion, Spontaneous - diagnosis | Thrombosis - etiology | Livedo Reticularis - etiology | Abortion, Spontaneous - etiology | Thrombocytopenia - diagnosis | Antiphospholipid Syndrome - therapy | Antiphospholipid Syndrome - physiopathology | Thrombosis - diagnosis
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15. Full Text Disease control and safety of belimumab plus standard therapy over 7 years in patients with systemic lupus erythematosus
by Ginzler, Ellen M and Wallace, Daniel J and Merrill, Joan T and Furie, Richard A and Stohl, William and Chatham, W. Winn and Weinstein, Arthur and McKay, James D and McCune, W. Joseph and Zhong, Z. John and Freimuth, William W and Petri, Michelle A and LBSL02 99 Study Grp and LBSL02/99 Study Group and The LBSL02/99 Study Group
Journal of Rheumatology, ISSN 0315-162X, 02/2014, Volume 41, Issue 2, pp. 300 - 309
To evaluate the efficacy/safety of belimumab plus standard therapy in patients (n = 449) with active systemic lupus erythematosus (SLE) treated up to 7 years... 
Selena-sledai | SLE responder index | Systemic lupus erythematosus | Belimumab | B-LYMPHOCYTE STIMULATOR | MORTALITY | BELIMUMAB | SELENA-SLEDAI SLE RESPONDER INDEX | FLARES | ORGAN DAMAGE | SJOGRENS-SYNDROME | MONOCLONAL-ANTIBODY | RHEUMATOLOGY | SYSTEMIC LUPUS ERYTHEMATOSUS | DOUBLE-BLIND | COHORT | ASSOCIATION | BILAG INDEX | Severity of Illness Index | Antibodies, Monoclonal, Humanized - adverse effects | Antibodies, Monoclonal, Humanized - therapeutic use | Autoantibodies | Double-Blind Method | Drug Administration Schedule | Humans | Immunosuppressive Agents - therapeutic use | Middle Aged | Male | Treatment Outcome | Antibodies, Monoclonal, Humanized - administration & dosage | Lupus Erythematosus, Systemic - drug therapy | Lupus Erythematosus, Systemic - immunology | Adult | Female | Immunosuppressive Agents - adverse effects | Drug Therapy, Combination | Longitudinal Studies | Immunosuppressive Agents - administration & dosage
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