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International Journal of Oncology, ISSN 1019-6439, 11/2018, Volume 53, Issue 5, pp. 2224 - 2240
Rho guanine nucleotide exchange factor 4 (ARHGEF4) is a guanine nucleotide exchange factor that is specific for Rac1 and Cdc42. The aim of the present study... 
Cell invasion | Actin cytoskeleton | Guanine nucleotide exchange factor | Cell protrusion | Pancreatic cancer | Immunoglobulins | Hospitals | Motility | Medical prognosis | Classification | Metastasis | Multivariate analysis | Kinases | Patients
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2006, Volume 103, Issue 42, pp. 15552 - 15557
Birt-Hogg-Dubé syndrome, a hamartoma disorder characterized by benign tumors of the hair follicle, lung cysts, and renal neoplasia, is caused by germ-line... 
Proteins | Cell culture techniques | Phosphorylation | HEK293 cells | Cell lines | Antibodies | Cultured cells | Amino acids | Western blotting | Hamartoma | Birt-Hogg-Dubé | Renal cancer | Tumor suppressor | Hamartoma syndrome | SPONTANEOUS PNEUMOTHORAX | Birt-Hogg-Dube | PEUTZ-JEGHERS-SYNDROME | MULTIDISCIPLINARY SCIENCES | KIDNEY NEOPLASIA | renal cancer | tumor suppressor | TSC2 | RENAL TUMORS | CELL-GROWTH | hamartoma syndrome | PATHWAY | HOGG-DUBE-SYNDROME | TUBEROUS SCLEROSIS | KINASE CASCADE | Protein Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Humans | Multiprotein Complexes | Molecular Sequence Data | Multienzyme Complexes - metabolism | Proto-Oncogene Proteins - genetics | AMP-Activated Protein Kinases | Syndrome | Proteins - genetics | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Tumor Suppressor Proteins - genetics | Cloning, Molecular | Protein Binding | Signal Transduction - physiology | TOR Serine-Threonine Kinases | Enzyme Activation | Protein-Serine-Threonine Kinases - metabolism | Causes of | Tumor suppressor genes | Genetic aspects | Research | Binding proteins | Health aspects | Mutation | Disease | Gene expression | Genes | Tumors | Index Medicus | Birt–Hogg–Dubé | Biological Sciences
Journal Article
Virology Journal, ISSN 1743-422X, 2012, Volume 9, Issue 1, pp. 154 - 154
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 1/2008, Volume 100, Issue 2, pp. 140 - 154
Background Patients with Birt-Hogg-Dubé (BHD) syndrome harbor germline mutations in the BHD tumor suppressor gene that are associated with an increased risk... 
COLLECTING DUCT | TUBEROUS SCLEROSIS COMPLEX | ONCOLOGY | GERMAN-SHEPHERD DOG | INTERCALATED CELLS | BHD GENE | CANCER | RENAL-CARCINOMA | GENITOURINARY TRACT | RAT MODEL | NODULAR DERMATOFIBROSIS | Immunohistochemistry | Polycystic Kidney Diseases - genetics | Protein Kinases - metabolism | Blotting, Southern | Kidney Neoplasms - genetics | Antibiotics, Antineoplastic - pharmacology | Kidney - pathology | Immunoblotting | Kidney Neoplasms - metabolism | Mitogen-Activated Protein Kinase 1 - drug effects | Polycystic Kidney Diseases - complications | Mitogen-Activated Protein Kinase 3 - drug effects | Kidney - metabolism | Polycystic Kidney Diseases - pathology | Tumor Suppressor Proteins - genetics | Germ-Line Mutation | Disease Models, Animal | Estrone - genetics | Polycystic Kidney Diseases - metabolism | Protein Kinases - drug effects | Kidney - drug effects | Gene Silencing | Kaplan-Meier Estimate | Genotype | Proto-Oncogene Proteins - genetics | Random Allocation | Reverse Transcriptase Polymerase Chain Reaction | Sirolimus - pharmacology | Syndrome | Mice, Knockout | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Fluorescent Antibody Technique | Kidney Neoplasms - pathology | Cell Proliferation - drug effects | Mice | TOR Serine-Threonine Kinases | Mitogen-Activated Protein Kinase 1 - metabolism | Cell proliferation | Gene silencing | Care and treatment | Kidney cancer | Physiological aspects | Genetic aspects | Research | Health aspects | Methods | Genetic disorders | Kidney diseases | Risk factors | Cancer | Tumors | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 08/2015, Volume 75, Issue 15 Supplement, pp. 2253 - 2253
Journal Article
INTERNATIONAL JOURNAL OF ONCOLOGY, ISSN 1019-6439, 11/2018, Volume 53, Issue 5, pp. 2224 - 2240
Rho guanine nucleotide exchange factor 4 (ARHGEF4) is a guanine nucleotide exchange factor that is specific for Rac1 and Cdc42. The aim of the present study... 
DUCTAL ADENOCARCINOMA | PHOSPHORYLATION | PROTRUSIONS | TUMOR-CELLS | SUPPRESSION | ASEF | actin cytoskeleton | INVASIVENESS | pancreatic cancer | ADENOMATOUS POLYPOSIS-COLI | guanine nucleotide exchange factor | APC | ONCOLOGY | cell protrusion | cell invasion | BINDING
Journal Article
International Journal of Cancer, ISSN 0020-7136, 05/2013, Volume 132, Issue 9, pp. 2006 - 2019
To identify molecular targets in leukemia stem cells (LSCs), this study compared the protein expression profile of freshly isolated CD34 + /CD38 − cells with... 
AML | leukemia stem cells | CD82 | MMP9 | bone marrow microenvironment | ABILITY IN-VITRO | PROGENITOR CELLS | REPOPULATING CELLS | SCID MICE | BONE-MARROW | KINASE | ACUTE MYELOID-LEUKEMIA | ONCOLOGY | MOUSE MODEL | C-MET | STEM/PROGENITOR CELLS | RNA, Small Interfering - genetics | Antigens, CD34 - metabolism | Cell Proliferation | Humans | Leukemia, Myeloid, Acute - metabolism | Gene Expression Regulation, Neoplastic | Immunoenzyme Techniques | Matrix Metalloproteinase 9 - metabolism | Flow Cytometry | Kangai-1 Protein - metabolism | Neoplastic Stem Cells - metabolism | Matrix Metalloproteinase 9 - genetics | Bone Marrow Transplantation | Kangai-1 Protein - genetics | Neoplastic Stem Cells - pathology | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | ADP-ribosyl Cyclase 1 - genetics | Leukemia, Myeloid, Acute - pathology | Matrix Metalloproteinase 2 - metabolism | RNA, Messenger - genetics | Mesenchymal Stromal Cells - metabolism | Kangai-1 Protein - antagonists & inhibitors | Reverse Transcriptase Polymerase Chain Reaction | Cell Adhesion | Blotting, Western | Peptide Fragments - analysis | Matrix Metalloproteinase 2 - genetics | Animals | ADP-ribosyl Cyclase 1 - metabolism | Mice, Inbred NOD | Mice | Mesenchymal Stromal Cells - pathology | Homeodomain Proteins - physiology | Antigens, CD34 - genetics | Cell Movement | Leukemia, Myeloid, Acute - genetics | Fibronectins | Medical colleges | RNA | Drug resistance | Analysis | Stem cells | Bone marrow | Glycoproteins | Leukemia | Cell adhesion & migration | Index Medicus
Journal Article
Cancer Medicine, ISSN 2045-7634, 11/2018, Volume 7, Issue 11, pp. 5733 - 5751
WAVE2 is a member of the WASP/WAVE family of actin cytoskeletal regulatory proteins; unfortunately, little is known about its function in pancreatic cancers.... 
actin cytoskeleton | WAVE2 | pancreatic cancer | ACTN4 | cell invasion | p27 | PROTEIN | WISKOTT-ALDRICH-SYNDROME | DOWN-REGULATION | ARP2/3 COMPLEX | ACTIN-FILAMENTS | P27(KIP1) | LAMELLIPODIA FORMATION | HEPATOCELLULAR-CARCINOMA | ONCOLOGY | MEMBRANE-TRANSPORT | UP-REGULATION | Muscle proteins | Pancreatic cancer | Prognosis | Phosphorylation | Motility | Medical prognosis
Journal Article
Nature Genetics, ISSN 1061-4036, 04/2012, Volume 44, Issue 4, pp. 426 - 429
Journal Article