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Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2017, Volume 40, Issue 8, pp. 1153 - 1160
It has become widely acknowledged that astrocytes play essential roles in maintaining physiological central nervous system (CNS) activities. Astrocytes fulfill... 
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2017, Volume 40, Issue 12, pp. 2110 - 2116
While it is well known that L-carnitine [3-hydroxy-4-(trimethylazaniumyl)-butanoate] is an essential molecule for β-oxidation, it provides anti-oxidative... 
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2018, Volume 41, Issue 3, pp. 440 - 444
Liver sinusoidal endothelial cells (LSECs), which are specialized endothelial cells that line liver sinusoids, have been reported to participate in a variety... 
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2018, Volume 41, Issue 3, pp. 440 - 444
Journal Article
Current Drug Metabolism, ISSN 1389-2002, 06/2015, Volume 16, Issue 6, pp. 474 - 485
Human organic anion transporting polypeptide 1B3 (OATP1B3) is a hepatocyte drug transporter that facilitates uptake of various therapeutic drugs from the... 
Cancer biomarker | Splice variant | SLCO1B3 | OATP1B3 | Transporter | Cancer | Cancer-specific molecule | METHYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PANCREATIC-CANCER | COLON | HEPATIC-UPTAKE | cancer biomarker | MESSENGER-RNA | PROGNOSTIC BIOMARKER | COLORECTAL-CANCER | DNA | transporter | RESISTANCE | PHARMACOLOGY & PHARMACY | cancer-specific molecule | splice variant
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 12/2007, Volume 24, Issue 12, pp. 2327 - 2332
Purpose. The aim of the present study was to clarify the factors responsible for interindividual variability of organic anion transporting polypeptide (OATP,... 
Organic anion transporting polypeptide 1B1 | Hepatocyte nuclear factor 1α | Transcriptional regulation | Interindividual variability | Liver | BILE-ACID | GENE-EXPRESSION MEASUREMENTS | liver | TRANSPORTERS | interindividual variability | transcriptional regulation | organic anion transporting polypeptide 1B1 | TRANSCRIPTION | MOUSE | C SLC21A6 | CHEMISTRY, MULTIDISCIPLINARY | ACYLCARNITINE HYDROLASE | YOUNG | PHARMACOKINETICS | PHARMACOLOGY & PHARMACY | HUMAN HEPATOCELLULAR-CARCINOMA | hepatocyte nuclear factor 1 alpha | Hepatocyte Nuclear Factor 1-alpha - genetics | Humans | Middle Aged | Asian Continental Ancestry Group - genetics | Male | Hepatocyte Nuclear Factor 1-alpha - metabolism | RNA, Messenger - metabolism | Organic Anion Transporters - metabolism | Luciferases - genetics | Organic Anion Transporters - genetics | Transfection | Chromatin Immunoprecipitation | Adult | Female | Electrophoretic Mobility Shift Assay | Genes, Reporter | Promoter Regions, Genetic | Japan | Liver - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Cell Line, Tumor | Protein Binding | Aged | Polymorphism, Single Nucleotide | Solute Carrier Organic Anion Transporter Family Member 1b1 | Genetic research | Messenger RNA | Biomedical research | Peptides | Ribonucleic acid | Pharmacology | Real time | Ribonucleic acid--RNA | Asians
Journal Article
Journal of Pharmacological Sciences, ISSN 1347-8613, 08/2018, Volume 137, Issue 4, pp. 350 - 358
Astrocytes have shown longstanding promise as therapeutic targets for various central nervous system diseases. To facilitate drug development targeting... 
In vitro model | Drug development | Astrocytes | Immortalized cells | Central nervous system | In vitro model | MOUSE | ESTABLISHMENT | ROLES | CA2 | DOCOSAHEXAENOIC ACID | LINE | ENRICHMENT | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | RECEPTORS | Central nervous system diseases | Usage | Models | Forecasts and trends | Drug discovery
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 10/2019, Volume 168, pp. 26 - 37
Constitutive androstane receptor (CAR), a member of the nuclear receptor superfamily, is retained as an inactive form phosphorylated at threonine in the... 
Phenobarbital | Cytoplasmic retention | Nuclear translocation | Constitutive androstane receptor | Three-dimensional culture | Cytochrome P450 3A4 | Epidermal growth factor | Genetic transcription | Cytochrome P-450
Journal Article
Current Drug Metabolism, ISSN 1389-2002, 07/2015, Volume 16, Issue 6, pp. 474 - 485
Human organic anion transporting polypeptide 1B3 (OATP1B3) is a hepatocyte drug transporter that facilitates uptake of various therapeutic drugs from the... 
Journal Article
Anticancer research, ISSN 0250-7005, 01/2019, Volume 39, Issue 1, pp. 159 - 165
Background/Aim: L-type amino acid transporter 1 (LAT1) is a promising molecular target for cancer therapy. The present study aimed to characterize the... 
anti-cancer drug | L-type amino acid transporter 1 | gastric cancer | JPH203 | colon cancer | 1 LAT1 | ONCOLOGY | MECHANISMS | EXPRESSION | Colorectal cancer | Cytotoxicity | Amino acids | mRNA | Tumor cell lines | Resistance factors | Esophagus | Anticancer properties | Inhibitors | Colon cancer | Acids | Cell lines | Colon | Viability | Transporter | Cancer
Journal Article
Journal Article
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