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Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 07/2017, Volume 171, pp. 201 - 208
Glucocorticoids (GCs) induce Toll-like receptor (TLR) 2 expression and synergistically upregulate TLR2 with pro-inflammatory cytokines or bacteria. These... 
Toll-like receptors | Skin | Inflammation | Dexamethasone | Glucocorticoids | CORTICOTROPIN-RELEASING HORMONE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FACTOR-KAPPA-B | HACAT CELLS | HUMAN KERATINOCYTES | CROSS-TALK | TOLL-LIKE RECEPTOR-2 | IN-VITRO | EPITHELIAL-CELLS | ENDOCRINOLOGY & METABOLISM | PROPIONIBACTERIUM-ACNES | UP-REGULATION | Skin - cytology | Toll-Like Receptor 2 - agonists | Toll-Like Receptor 2 - genetics | Skin - metabolism | Humans | Dexamethasone - adverse effects | Male | Interleukin-8 - agonists | Dermis - drug effects | Macrophages - secretion | Anti-Inflammatory Agents - adverse effects | Toll-Like Receptor 6 - genetics | Interleukin-8 - secretion | Interleukin-8 - metabolism | TNF Receptor-Associated Factor 6 - genetics | Dermis - cytology | Child | Glucocorticoids - adverse effects | Macrophages - immunology | Skin - immunology | Propionibacterium acnes - immunology | Toll-Like Receptor 6 - metabolism | Cell Line | Epidermis - metabolism | Dermis - metabolism | Epidermis - drug effects | Toll-Like Receptor 1 - metabolism | Cells, Cultured | Keratinocytes - cytology | Interleukin-8 - antagonists & inhibitors | Toll-Like Receptor 2 - metabolism | Dermis - immunology | Keratinocytes - immunology | Gene Expression Regulation - drug effects | Toll-Like Receptor 1 - genetics | Macrophages - metabolism | MAP Kinase Signaling System - drug effects | Toll-Like Receptor 1 - antagonists & inhibitors | Epidermis - immunology | Keratinocytes - drug effects | Keratinocytes - metabolism | TNF Receptor-Associated Factor 6 - metabolism | Macrophages - drug effects | TNF Receptor-Associated Factor 6 - agonists | Toll-Like Receptor 6 - antagonists & inhibitors | Myeloid Differentiation Factor 88 - metabolism | Skin - drug effects | Epidermis - cytology | Corticosteroids | Steroids | Skin diseases | Skin care products | TRAF6 protein | Cytokines | Calcium | Keratinocytes | MAP kinase | JNK protein | T cell receptors | Gene expression | Studies | TLR1 protein | Molecular modelling | TLR2 protein | MyD88 protein | Fibroblasts | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2007, Volume 117, Issue 12, pp. 3664 - 3672
Mammalian TLRs are central mediators of the innate immune system that instruct cells of the innate and adaptive response to clear microbial infections. Here,... 
NEUTROPHIL NADPH OXIDASE | MEDICINE, RESEARCH & EXPERIMENTAL | CANDIDA-ALBICANS | RECOGNITION | IMMUNE-RESPONSES | ORAL CANDIDOSIS | ENDOTHELIAL-CELLS | TOLL-LIKE RECEPTORS | HOST-DEFENSE | MODEL | EXPRESSION | Tumor Necrosis Factor-alpha - metabolism | Epithelial Cells - metabolism | Toll-Like Receptor 4 - biosynthesis | Coculture Techniques | Humans | Immunity, Mucosal - drug effects | Signal Transduction - immunology | RNA, Small Interfering - immunology | Immunity, Innate - physiology | Tumor Necrosis Factor-alpha - immunology | Antibodies - immunology | Immunity, Mucosal - physiology | Neutrophils - microbiology | Toll-Like Receptor 4 - antagonists & inhibitors | Candidiasis - immunology | Candidiasis - pathology | Mouth Mucosa - pathology | Neutrophils - metabolism | Neutrophils - pathology | Mouth Mucosa - microbiology | Immunity, Innate - drug effects | RNA, Small Interfering - pharmacology | Cells, Cultured | Mouth Mucosa - immunology | Neutrophils - immunology | Epithelial Cells - pathology | Toll-Like Receptor 4 - immunology | Candida albicans - immunology | Antibodies - pharmacology | Up-Regulation - drug effects | Candidiasis - metabolism | Mouth Mucosa - metabolism | Signal Transduction - drug effects | Up-Regulation - immunology | Models, Biological | Epithelial Cells - immunology | Epithelial Cells - microbiology | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Mycoses | Control | Properties | Epithelial cells | Health aspects | Index Medicus | Abridged Index Medicus
Journal Article
Nature Protocols, ISSN 1754-2189, 01/2007, Volume 1, Issue 6, pp. 2767 - 2773
Journal Article
Immunology, ISSN 0019-2805, 02/2015, Volume 144, Issue 2, pp. 218 - 230
The specific function of human skin‐resident dendritic cell (DC) subsets in the regulation of immunity or tolerance is still a matter of debate. Langerhans... 
α | β | angerhans cells | oll‐like receptors | dendritic cells | T | interleukin‐1 | tumour necrosis factor | L | Langerhans cells | Toll-like receptors | Tumour necrosis factor-α | Dendritic cells | Interleukin-1β | MIGRATION | IMMUNE-RESPONSE | ACTIVATION | interleukin-1 | LYMPH-NODES | RECEPTOR EXPRESSION | IMMUNOLOGY | CUTTING EDGE | SEMI-MATURE | STEADY-STATE | SKIN | DIFFERENTIATION | Receptors, CCR7 - immunology | Up-Regulation | Interleukin-1beta - pharmacology | Antigens, CD - biosynthesis | Humans | Membrane Glycoproteins - biosynthesis | Th1 Cells - immunology | Lipopolysaccharides | RNA, Messenger - biosynthesis | Lymphocyte Activation - immunology | Bacterial Infections - immunology | Langerhans Cells - immunology | Immunoglobulins - biosynthesis | Interleukin-12 - biosynthesis | Poly I-C - pharmacology | Toll-Like Receptors - immunology | Cells, Cultured | Inflammation - immunology | Tumor Necrosis Factor-alpha - pharmacology | B7-2 Antigen - biosynthesis | Interferon Type I - genetics | Interleukin-23 - biosynthesis | Interleukin-6 - biosynthesis | Th17 Cells - immunology | Cell Movement | Interferon Inducers - pharmacology | Antiviral agents | Skin | Biological response modifiers | T cells | Cytokines | Rodents | Immune system | Index Medicus | tumour necrosis factor-α | Original | interleukin-1β
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 09/2017, Volume 140, pp. 64 - 72
Toll-like receptor (TLR) 4-independent recognition of lipopolysaccharide (LPS) in the cytosol by inflammatory caspases leads to non-canonical inflammasome... 
Inflammatory caspases | Interleukin-1beta (IL-1β) | Synthetic anti-endotoxin peptides | Pyroptosis | Cytoplasmic lipopolysaccharide (LPS) | DEFENSE | RECEPTOR | NLRP3 INFLAMMASOME | RELEASE | NONCANONICAL INFLAMMASOME ACTIVATION | IMMUNE-RESPONSES | CASPASES | TARGETS | PHARMACOLOGY & PHARMACY | IL-1-BETA | Interleukin-1beta (IL-1 beta) | Inflammasomes - metabolism | Pyroptosis - drug effects | Monocytes - cytology | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Cytoplasm - metabolism | Monocytes - metabolism | Monocytes - immunology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Macrophages - secretion | Inflammasomes - drug effects | Interleukin-1beta - metabolism | Myeloid Cells - immunology | Myeloid Cells - drug effects | Toll-Like Receptor 4 - antagonists & inhibitors | Macrophages - immunology | Interleukin-1beta - secretion | Cell Survival - drug effects | Lipopolysaccharides - toxicity | Peptides - chemistry | Cells, Cultured | Keratinocytes - secretion | Sulfonamides - pharmacology | Toll-Like Receptor 4 - metabolism | Keratinocytes - immunology | Peptides - pharmacology | Monocytes - drug effects | Endotoxins - antagonists & inhibitors | Macrophages - metabolism | Myeloid Cells - secretion | Keratinocytes - drug effects | Keratinocytes - metabolism | Inflammasomes - immunology | Cell Line, Tumor | Myeloid Cells - metabolism | Macrophages - drug effects | Macrophage Activation - drug effects | Cytoplasm - drug effects | Cell Line, Transformed | Endotoxins - toxicity | Chromosomal proteins | Peptides | Interleukins | Cell death | Pharmacy | Septic shock | Skin | Macrophages | Mitogens | Index Medicus
Journal Article
European Journal of Pharmaceutics and Biopharmaceutics, ISSN 0939-6411, 11/2014, Volume 88, Issue 3, pp. 625 - 634
Polyglycerol scaffolds and nanoparticles emerged as prominent material for various biomedical applications including topical drug delivery. The impact of... 
Biocompatibility | Topical drug delivery | Hyperbranched polyglycerol | Nanotoxicology | Structural modifications | PEG nanoparticles | ASSAY | HUMAN SKIN | VIVO | DNA-DAMAGE | PENETRATION | DENDRIMERS | IN-VITRO | PHARMACOLOGY & PHARMACY | ABSORPTION | CYTOTOXICITY | DISEASED SKIN | Human Umbilical Vein Endothelial Cells | Skin Irritancy Tests | Nanoparticles - chemistry | Skin - metabolism | Biocompatible Materials - chemistry | Humans | BALB 3T3 Cells | Drug Carriers - toxicity | Polyethylene Glycols - chemistry | Biocompatible Materials - toxicity | Drug Carriers - chemistry | Biocompatible Materials - chemical synthesis | Swine | Skin Absorption - drug effects | Molecular Structure | Oxazines - administration & dosage | Glycerol - analogs & derivatives | Glycerol - chemistry | Pharmaceutical Preparations - administration & dosage | Cell Survival - drug effects | Drug Carriers - chemical synthesis | Glycerol - toxicity | Polyethylene Glycols - toxicity | Fibroblasts - pathology | Comet Assay | Particle Size | Keratinocytes - pathology | Animals | Glycerol - chemical synthesis | Keratinocytes - drug effects | Fibroblasts - drug effects | Cell Line, Tumor | Drug Liberation | Mice | Polyethylene Glycols - chemical synthesis | DNA Damage | Skin - drug effects | Drugs | Drug delivery systems | Polyethylene glycol | Vehicles | Index Medicus
Journal Article
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 04/2014, Volume 1841, Issue 4, pp. 484 - 494
Dermal fibroblasts are important regulators of inflammatory and immune responses in the skin. The aim of the present study was to elucidate the interaction... 
Dermal fibroblast | Myofibroblast | Toll-like receptor | Sphingosine-1-phosphate | Cytokine | DENDRITIC CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SYSTEMIC-SCLEROSIS | CELL BIOLOGY | GINGIVAL EPITHELIAL-CELLS | BIOPHYSICS | ENDOTHELIAL-CELLS | TOLL-LIKE RECEPTORS | GENE-EXPRESSION | DERMAL FIBROBLASTS | TNF-ALPHA | NF-KAPPA-B | RECONSTRUCTED HUMAN SKIN | Inflammation - pathology | Interleukin-8 - genetics | Lysophospholipids - metabolism | Toll-Like Receptor 2 - genetics | Lipopeptides - pharmacology | Skin - metabolism | Humans | Myofibroblasts - metabolism | Inflammation - metabolism | Collagen - genetics | Sphingosine - metabolism | Interleukin-8 - metabolism | Myocytes, Smooth Muscle - drug effects | Interleukin-6 - metabolism | Myocytes, Smooth Muscle - metabolism | Skin - pathology | Fibroblasts - metabolism | Interleukin-6 - genetics | Signal Transduction | Toll-Like Receptor 1 - metabolism | Gene Expression Regulation | Toll-Like Receptor 2 - metabolism | Myofibroblasts - drug effects | Myofibroblasts - cytology | Toll-Like Receptor 1 - genetics | Cell Movement - drug effects | Collagen - metabolism | Sphingosine - analogs & derivatives | Cell Differentiation - drug effects | Inflammation - genetics | Fibroblasts - cytology | Phosphates | Collagen | Sphingosine | Bone morphogenetic proteins | Sphingolipids | Inflammation | Transforming growth factors | Index Medicus
Journal Article