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Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 05/2014, Volume 24, Issue 9, pp. 2118 - 2122
This Letter describes our attempts to elaborate dually acting compounds possessing serotonin re-uptake transporter inhibitor and serotonin 5-HT sub(2C)... 
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 02/2016, Volume 26, Issue 3, pp. 914 - 920
As a result of our exploratory programme aimed at elaborating dually acting compounds towards the serotonin (5-HT) transporter (SERT) and the 5-HT sub(2C)... 
Journal Article
Neurochemistry International, ISSN 0197-0186, 12/2009, Volume 55, Issue 7, pp. 467 - 475
Adrenergic alpha sub(1), alpha sub(2) and beta receptors are members of the G-protein-coupled receptor families (GPCRs) mediating physiological responses to... 
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2005, Volume 15, Issue 12, pp. 3012 - 3015
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2006, Volume 16, Issue 17, pp. 4638 - 4640
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 05/2012, Volume 22, Issue 10, pp. 3437 - 3440
Medicinal chemistry optimization of an impurity isolated during the scale-up synthesis of a pyridylsulfonamide type dopamine D /D compound (1) led to a series... 
and D | ligands | Cariprazine | RGH-188 | Chloro-scan | Antipsychotic | Dopamine D | CHEMISTRY, MEDICINAL | EFFICACY | Dopamine D-3 and D-2 ligands | IN-VIVO | RG-15 | CHEMISTRY, ORGANIC
Journal Article
Journal of Chemical Information and Modeling, ISSN 1549-9596, 01/2012, Volume 52, Issue 1, p. 233
Ligand-based approaches are particularly important in the hit identification process of drug discovery when no structural information on the target is... 
Histamine | Serotonin | Research & development--R&D | Ligands | Pharmacology | Graph representations
Journal Article
Neurochemistry International, ISSN 0197-0186, 12/2009, Volume 55, Issue 7, pp. 467 - 475
Adrenergic α , α and β receptors are members of the G-protein-coupled receptor families (GPCRs) mediating physiological responses to adrenaline (epinephrine)... 
AR | Fluorometric Ca | assay | Promiscuosus Gα | protein | High-throughput screening | Chimeric Gα
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2008, Volume 51, Issue 3, pp. 479 - 486
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2007, Volume 50, Issue 5, pp. 901 - 914
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2008, Volume 16, Issue 9, pp. 5322 - 5330
The inhibition of cyclooxygenase enzymes plays an important role in the treatment of inflammatory diseases.... 
Cyclooxygenase-2 inhibitor | Active metabolite | COX-2 | Valdecoxib analogues | Non-steroidal anti-inflammatory drugs | CHEMISTRY, MEDICINAL | ANALOGS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | non-steroidal anti-inflammatory drugs | CELECOXIB | REPLACEMENT | SYNTHASE CYCLOOXYGENASE | valdecoxib analogues | active metabolite | MESSENGER-RNA | cyclooxygenase-2 inhibitor | DRUGS | PROSTAGLANDIN SYNTHASE | INHIBITOR | EXPRESSION | Hyperalgesia - chemically induced | Rats, Wistar | Stereoisomerism | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Crystallography, X-Ray | Male | Cyclooxygenase 2 Inhibitors - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Dose-Response Relationship, Drug | Time Factors | Cattle | Inflammation - drug therapy | Pain - drug therapy | Cyclooxygenase 1 - chemistry | Cyclooxygenase 2 Inhibitors - metabolism | Molecular Structure | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Disease Models, Animal | Rabbits | Cyclooxygenase 2 Inhibitors - pharmacology | Sulfonamides - chemistry | Cyclooxygenase 2 - chemistry | Isoxazoles - metabolism | Models, Molecular | Rats | Cyclooxygenase 2 - drug effects | Edema - drug therapy | Isoxazoles - chemistry | Sulfonamides - pharmacology | Isoxazoles - pharmacology | Pain Measurement - methods | Animals | Hyperalgesia - drug therapy | Recombinant Proteins - drug effects | Sulfonamides - metabolism | Carrageenan | Edema - chemically induced | Index Medicus
Journal Article
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