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Organic Letters, ISSN 1523-7060, 01/2016, Volume 18, Issue 1, pp. 16 - 19
Regioselective N-alkylation of 1,3-azoles is a valuable transformation. Organomagnesium reagents were discovered to be competent bases to affect regioselective... 
NUCLEOSIDE | METHYLATION | PURINES | ANALOGS | BIOLOGICAL EVALUATION | CHEMISTRY, ORGANIC | INHIBITORS | IMIDAZOLES | DERIVATIVES | 9-SUBSTITUTED TETRAHYDRODIAZEPINOPURINES | Azoles - chemistry | Magnesium - chemistry | Stereoisomerism | Organometallic Compounds - chemistry | Molecular Structure | Catalysis | Alkylation
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 06/2015, Volume 372, Issue 25, pp. 2387 - 2397
In this trial, patients with an acute coronary syndrome within the previous 10 days were randomly assigned to simvastatin plus either ezetimibe or placebo. At... 
CHOLESTEROL ABSORPTION | CARDIAC OUTCOMES | MEDICINE, GENERAL & INTERNAL | MYOCARDIAL-INFARCTION | EFFICACY | CARDIOVASCULAR OUTCOMES | CLINICAL-TRIALS | SIMVASTATIN | PRIMARY PREVENTION | IMPROVE-IT | ATORVASTATIN | Simvastatin - therapeutic use | Double-Blind Method | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Azetidines - adverse effects | Ezetimibe | Kaplan-Meier Estimate | Male | Anticholesteremic Agents - adverse effects | Acute Coronary Syndrome - drug therapy | Anticholesteremic Agents - therapeutic use | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Azetidines - therapeutic use | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Triglycerides - blood | Cardiovascular Diseases - epidemiology | Cardiovascular Diseases - mortality | Cholesterol, LDL - blood | Female | Aged | Drug Therapy, Combination | Usage | Simvastatin | Analysis | Practice guidelines (Medicine) | Dosage and administration | Drug therapy, Combination | Acute coronary syndrome | Drug therapy | Myocardial infarction | Cerebral infarction | Lipoproteins (low density) | Stroke | Angina | Cholesterol | Intestine | Gallbladder | Acute coronary syndromes | Cardiovascular diseases | Statins | Pharmaceuticals | Cancer | Life Sciences | Human health and pathology | Cardiology and cardiovascular system
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2017, Volume 60, Issue 14, pp. 5969 - 5989
Several reports have recently emerged regarding the identification of heteroarylsulfonamides as NaV1.7 inhibitors that demonstrate high levels of selectivity... 
Journal Article
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2018, Volume 28, Issue 11, pp. 2103 - 2108
Recently, the identification of several classes of aryl sulfonamides and acyl sulfonamides that potently inhibit Na 1.7 and demonstrate high levels of... 
Sodium channel | Pain | Bioisostere | 3-(Sulfonyl)-1,2,4-triazole | Triazolesulfone | pKa | NaV1.5 | Acylsulfonamide | NaV1.7 | 1.5 | 1.7
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2018, Volume 28, Issue 11, p. 2103
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1016/j.bmcl.2018.04.035... 
Triazoles | Sulfonamides
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2012, Volume 55, Issue 21, pp. 9009 - 9024
Journal Article