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1. Full Text MED12 alterations in both human benign and malignant uterine soft tissue tumors
by Pérot, Gaëlle and Croce, Sabrina and Ribeiro, Agnès and Lagarde, Pauline and Velasco, Valérie and Neuville, Agnès and Coindre, Jean-Michel and Stoeckle, Eberhard and Floquet, Anne and MacGrogan, Gaëtan and Chibon, Frédéric
PLoS ONE, ISSN 1932-6203, 06/2012, Volume 7, Issue 6, p. e40015
The relationship between benign uterine leiomyomas and their malignant counterparts, i.e. leiomyosarcomas and smooth muscle tumors of uncertain malignant... 
NEOPLASMS | LEIOMYOSARCOMA | LEIOMYOMA | MEDIATOR | MULTIDISCIPLINARY SCIENCES | X-CHROMOSOME INACTIVATION | BROAD LIGAMENT | COMPARATIVE GENOMIC HYBRIDIZATION | ABERRATIONS | BETA-CATENIN EXPRESSION | CLONAL ORIGINS | Mediator Complex - metabolism | Uterine Neoplasms - pathology | Humans | DNA, Complementary - genetics | Gene Expression Regulation, Neoplastic | Molecular Sequence Data | Leiomyoma - pathology | Smooth Muscle Tumor - genetics | Cell Transformation, Neoplastic - genetics | DNA Mutational Analysis | Base Sequence | Female | Soft Tissue Neoplasms - genetics | Uterine Neoplasms - genetics | Mediator Complex - genetics | Smooth Muscle Tumor - pathology | Mutation - genetics | beta Catenin - metabolism | Genome, Human - genetics | Protein Transport | Wnt Signaling Pathway - genetics | Alleles | Soft Tissue Neoplasms - pathology | Cell Transformation, Neoplastic - pathology | Leiomyoma - genetics | Immunohistochemistry | Development and progression | Gene mutations | Cancer | Wnt protein | Mesenchyme | Smooth muscle | Subgroups | β-catenin | Alterations | Uterus | Genetics | Tumorigenesis | Localization | Deoxyribonucleic acid--DNA | Sequences | Hot spots | Benign | Muscles | Fibroids | Breast cancer | RNA polymerase | Gene expression | Pathology | MicroRNAs | Pancreatic cancer | Mutation | Tumors | Deoxyribonucleic acid | DNA
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2. Full Text ETV4 is a useful marker for the diagnosis of CIC-rearranged undifferentiated round-cell sarcomas: A study of 127 cases including mimicking lesions
by Le Guellec, Sophie and Velasco, Valérie and Pérot, Gaëlle and Watson, Sarah and Tirode, Franck and Coindre, Jean-Michel
Modern Pathology, ISSN 0893-3952, 12/2016, Volume 29, Issue 12, pp. 1523 - 1531
Subsets of primitive round-cell sarcomas remain difficult to diagnose and classify. Among these is a rare round cell sarcoma that harbors a CIC gene... 
CIC-FOXO4 GENE FUSION | TUMOR | TRANSLOCATION | PATHOLOGY | EWING-LIKE-SARCOMA | Humans | Middle Aged | Male | Proto-Oncogene Proteins - biosynthesis | Sarcoma, Small Cell - diagnosis | Young Adult | Rhabdomyosarcoma, Alveolar - diagnosis | Proto-Oncogene Proteins - analysis | Sarcoma, Small Cell - genetics | Adenovirus E1A Proteins - biosynthesis | Aged, 80 and over | Adult | Female | Child | Sarcoma, Small Cell - pathology | Diagnosis, Differential | Biomarkers, Tumor - analysis | Repressor Proteins - genetics | Sarcoma, Ewing - diagnosis | Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis | Sarcoma, Synovial - diagnosis | Adenovirus E1A Proteins - analysis | Adolescent | Aged | Rhabdoid Tumor - diagnosis
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3. Full Text Chromosome Instability Accounts for Reverse Metastatic Outcomes of Pediatric and Adult Synovial Sarcomas
by Pauline Lagarde and Joanna Przybyl and Céline Brulard and Gaëlle Pérot and Gaelle Pierron and Olivier Delattre and Raf Sciot and Agnieszka Wozniak and Patrick Schöffski and Philippe Terrier and Agnès Neuville and Jean-Michel Coindre and Antoine Italiano and Daniel Orbach and Maria Debiec-Rychter and Frédéric Chibon
Journal of Clinical Oncology, ISSN 0732-183X, 02/2013, Volume 31, Issue 5, pp. 608 - 615
Purpose Synovial sarcoma (SS) occurs in both children and adults, although metastatic events are much more common in adults. Whereas the importance of the t(X;... 
SSX FUSION TYPE | SOFT-TISSUE SARCOMAS | ONCOLOGY | MESSENGER-RNA EXPRESSION | GENE-EXPRESSION | KIF14 | IMBALANCES | COMPARATIVE GENOMIC HYBRIDIZATION | EPITHELIAL DIFFERENTIATION | CANCER | SYT | Oncogene Proteins - genetics | Prognosis | Sarcoma, Synovial - therapy | Humans | Gene Expression Regulation, Neoplastic | Kaplan-Meier Estimate | Male | Gene Expression Profiling | Reverse Transcriptase Polymerase Chain Reaction | DNA Copy Number Variations | Young Adult | Carrier Proteins - genetics | Sarcoma, Synovial - genetics | Adolescent | Cell Cycle Proteins - genetics | Kinesin - genetics | Adult | Female | Biomarkers, Tumor - genetics | Nuclear Proteins - genetics | Sarcoma, Synovial - pathology | Child | Chromosomal Instability | Real-Time Polymerase Chain Reaction
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4. Full Text Nuclear-Receptor-Mediated Telomere Insertion Leads to Genome Instability in ALT Cancers
by Marzec, Paulina and Armenise, Claudia and Pérot, Gaëlle and Roumelioti, Fani-Marlen and Basyuk, Eugenia and Gagos, Sarantis and Chibon, Frédéric and Déjardin, Jérôme
Cell, ISSN 0092-8674, 02/2015, Volume 160, Issue 5, pp. 913 - 927
The breakage-fusion-bridge cycle is a classical mechanism of telomere-driven genome instability in which dysfunctional telomeres are fused to other chromosomal... 
ORGANIZATION | CELLS | LOCALIZATION | CHROMOSOME INSTABILITY | PROTEIN | SEQUENCES | DNA | SARCOMAS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | BINDING | CELL BIOLOGY | Genomic Instability | Translocation, Genetic | Neoplasms - genetics | Humans | Receptors, N-Methyl-D-Aspartate - metabolism | Telomeric Repeat Binding Protein 2 - metabolism | Telomere - metabolism | Chromosomes, Human - metabolism | DNA Breaks, Double-Stranded | Proteins | Genetic research | Genetic aspects | Chromosomes | Genomics | Cancer | Medical research | Telomeres | Chromatin | Medicine, Experimental | Genomes | DNA binding proteins | Genetic transcription | Life Sciences | Genetics
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5. Full Text Recurrent TRIO fusion in nontranslocation-related sarcomas
by Delespaul, Lucile and Lesluyes, Tom and Pérot, Gaëelle and Brulard, Céline and Lartigue, Lydia and Baud, Jessica and Lagarde, Pauline and Guellec, Sophie Le and Neuville, Agnés and Terrier, Philippe and Vince-Ranchére, Dominique and Schmidt, Susanne and Debant, Anne and Coindre, Jean-Michel and Chibon, Frédéric
Clinical Cancer Research, ISSN 1078-0432, 02/2017, Volume 23, Issue 3, pp. 857 - 867
Purpose: Despite various differences, nontranslocation-related sarcomas (e.g., comprising undifferentiated pleomorphic sarcoma, leiomyosarcoma,... 
LARGE SERIES | GENE FUSIONS | SOFT-TISSUE SARCOMAS | MALIGNANT FIBROUS HISTIOCYTOMAS | ONCOLOGY | TRANSCRIPTION | RHO GTPASES | COMPARATIVE GENOMIC HYBRIDIZATION | IDENTIFICATION | EXPRESSION | TOOL | Sarcoma - classification | RNA, Small Interfering - genetics | Translocation, Genetic | Guanine Nucleotide Exchange Factors - physiology | Humans | Middle Aged | Neoplasm Proteins - physiology | Male | Telomerase - genetics | RNA Interference | Female | Telomerase - metabolism | Sarcoma - genetics | Neoplasm Proteins - genetics | Guanine Nucleotide Exchange Factors - genetics | Protein-Serine-Threonine Kinases - physiology | RNA, Messenger - genetics | Protein-Serine-Threonine Kinases - genetics | In Situ Hybridization, Fluorescence | RNA, Long Noncoding - genetics | DNA-Binding Proteins - genetics | Sarcoma - pathology | Sarcoma - metabolism | Sequence Analysis, RNA | Oncogene Proteins, Fusion - genetics | Cell Line, Tumor | RNA, Neoplasm - genetics | Aged | Protein Isoforms - genetics | Trio protein | Alternative splicing | Sarcoma | Splicing | Genes | Genomes | Gene expression | Ribonucleic acid--RNA | Immunity | Computer programs | Gene sequencing | Polymerase chain reaction | Chromosome translocations | Experimental design | Predictions | Genetics | Protein transport | Bioinformatics
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6. Full Text Identification of a recurrent STRN/ALK fusion in thyroid carcinomas
by Pérot, Gaëlle and Soubeyran, Isabelle and Ribeiro, Agnès and Bonhomme, Benjamin and Savagner, Frédérique and Boutet-Bouzamondo, Nathalie and Hostein, Isabelle and Bonichon, Françoise and Godbert, Yann and Chibon, Frédéric
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, p. e87170
Thyroid carcinoma is the most common endocrine malignant tumor and accounts for 1% of all new malignant diseases. Among all types and subtypes of thyroid... 
ALK | LUNG-CANCER | PROTEIN | MULTIDISCIPLINARY SCIENCES | GENES | PATIENT | NPM | PAPILLARY | Calmodulin-Binding Proteins - genetics | Immunohistochemistry | Pyrazoles - therapeutic use | Membrane Proteins - genetics | Humans | Thyroid Carcinoma, Anaplastic | Molecular Sequence Data | In Situ Hybridization, Fluorescence | Reverse Transcriptase Polymerase Chain Reaction | Nerve Tissue Proteins - genetics | Sequence Analysis, DNA | Gene Fusion - genetics | Thyroid Neoplasms - genetics | Comparative Genomic Hybridization | Lung Neoplasms - secondary | Receptor Protein-Tyrosine Kinases - genetics | Thyroid Neoplasms - drug therapy | Base Sequence | Gene Rearrangement - genetics | Pyridines - therapeutic use | Care and treatment | Chemotherapy | Thyroid cancer | Analysis | Genes | Cytogenetics | Lymphomas | Metastasis | Cancer | Nuclear medicine | Transcription | Lung cancer | Fluorescence | Cancer therapies | Metastases | Proteins | Surgery | Fluorescence in situ hybridization | Lesions | Protein-tyrosine kinase | Deoxyribonucleic acid--DNA | Thyroid | Iodine 131 | Lung carcinoma | Radiation therapy | Patients | Lymphoma | Polymerase chain reaction | Medical prognosis | Gene rearrangement | Hybridization analysis | Papillary thyroid carcinoma | Tumors | Deoxyribonucleic acid | DNA
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7. Full Text RCBTB1 deletion is associated with metastatic outcome and contributes to docetaxel resistance in nontranslocation-related pleomorphic sarcomas
by Mauduit, Olivier and Brulard, Céline and Lesluyes, Tom and Delcroix, Vanessa and Pérot, Gaëlle and Choublier, Nina and Michaud, Mickael and Baud, Jessica and Lagarde, Pauline and Aurias, Alain and Coindre, Jean-Michel and Lartigue, Lydia and Blay, Jean-Yves and Chibon, Frédéric
Cancers, ISSN 2072-6694, 01/2019, Volume 11, Issue 1, p. 81
Half of soft-tissue sarcomas are tumors with complex genomics, which display no specific genetic alterations and respond poorly to treatment. It is therefore... 
Pleomorphic sarcoma | Sarcoma with complex genomics | RCBTB1 | Docetaxel | Cancer | TARGET | LIPOSARCOMA | SAFETY | sarcoma with complex genomics | PHASE-II | RANDOMIZED MULTICENTER | pleomorphic sarcoma | CHEMOTHERAPY | CHROMOSOME 13Q14 | GENE | ONCOLOGY | docetaxel | cancer | SOFT-TISSUE SARCOMA
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8. Full Text Developmental and cancer-associated plasticity of DNA replication preferentially targets GC-poor, lowly expressed and late-replicating regions
by Wu, Xia and Kabalane, Hadi and Kahli, Malik and Petryk, Nataliya and Laperrousaz, Bastien and Jaszczyszyn, Yan and Drillon, Guenola and Nicolini, Frank-Emmanuel and Perot, Gaëlle and Robert, Aude and Fund, Cédric and Chibon, Frédéric and Xia, Ruohong and Wiels, Joëlle and Argoul, Françoise and Maguer-Satta, Véronique and Arneodo, Alain and Audit, Benjamin and Hyrien, Olivier
Nucleic Acids Research, ISSN 0305-1048, 11/2018, Volume 46, Issue 19, pp. 10157 - 10172
Abstract The spatiotemporal program of metazoan DNA replication is regulated during development and altered in cancers. We have generated novel OK-seq,... 
CHRONIC MYELOGENOUS LEUKEMIA | GENE | LANDSCAPE | DAMAGE-RESPONSE | PART | BIOCHEMISTRY & MOLECULAR BIOLOGY | BARRIER | MODEL | STRESS | DOMAINS | REVEALS | Life Sciences | Biochemistry, Molecular Biology | Genomics | Genome Integrity, Repair and
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9. Full Text Fusion-mediated chromosomal instability promotes aneuploidy patterns that resemble human tumors
by Delespaul, L and Merle, C and Lesluyes, T and Lagarde, P and Le Guellecl, S and Perot, G and Baud, J and Carlotti, M and Danet, C and Fevre, M and Rousseau, B and Durrieu, S and Teichmannl, M and Coindre, JM and Lartigue, L and Chibon, F
ONCOGENE, ISSN 0950-9232, 08/2019, Volume 38, Issue 33, pp. 6083 - 6094
Oncogenesis is considered to result from chromosomal instability, in addition to oncogene and tumor-suppressor alterations. Intermediate to aneuploidy and... 
PURKINJE NEURONS | LARGE SERIES | SOFT-TISSUE SARCOMAS | METASTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUSCLE | CANCER | CELL BIOLOGY | ONCOLOGY | MARROW-DERIVED CELLS | DNA | GENETICS & HEREDITY | CONDENSATION | BONE | Aneuploidy | Development and progression | Care and treatment | Research | Carcinogenesis | Risk factors | Tetraploidy | Mesenchyme | Tumorigenesis | Genomes | Cell differentiation | Cell fusion | Tumors | Latency | Genomic instability
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10. Full Text Fluorescence in situ hybridization analysis is a helpful test for the diagnosis of dermatofibrosarcoma protuberans
by Karanian, Marie and Pérot, Gaëlle and Coindre, Jean-Michel and Chibon, Frédéric and Pedeutour, Florence and Neuville, Agnès
Modern Pathology, ISSN 0893-3952, 02/2015, Volume 28, Issue 2, pp. 230 - 237
Cytogenetically, most dermatofibrosarcoma protuberans are characterized by chromosomal rearrangements resulting in the collagen type-1 alpha 1... 
REARRANGEMENT | TRANSLOCATION | RING CHROMOSOMES | GROWTH-FACTOR-B | SEQUENCES | SARCOMA | PATHOLOGY | COL1A1-PDGFB FUSION | TUMORS | EXPRESSION | IMATINIB MESYLATE | Humans | Middle Aged | Dermatofibrosarcoma - diagnosis | Child, Preschool | Infant | Male | Dermatofibrosarcoma - genetics | Oncogene Proteins, Fusion - analysis | Skin Neoplasms - diagnosis | Skin Neoplasms - genetics | Adolescent | Aged, 80 and over | Adult | Female | Aged | Biomarkers, Tumor - genetics | Child | In Situ Hybridization, Fluorescence - methods
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11. Full Text New insights in sarcoma oncogenesis: a comprehensive analysis of a large series of 160 soft tissue sarcomas with complex genomics
by Gibault, Laure and Pérot, Gaëlle and Chibon, Frédéric and Bonnin, Sarah and Lagarde, Pauline and Terrier, Philippe and Coindre, Jean‐Michel and Aurias, Alain
The Journal of Pathology, ISSN 0022-3417, 01/2011, Volume 223, Issue 1, pp. 64 - 71
Adult soft tissue sarcomas (STS) are rare tumours of mesenchymal lineage. Based on cytogenetic and comparative genomic hybridization (CGH) data, they can be... 
leiomyosarcoma | RB1 | CGH | transcriptome | PTEN | undifferentiated sarcoma | DKK1 | CANCER-CENTERS-SARCOMA | MYOCARDIN | TRIO | CLASSIFICATION | PATHOLOGY | LEIOMYOSARCOMAS | TUMOR-NECROSIS-FACTOR | FRENCH-FEDERATION | MALIGNANT FIBROUS HISTIOCYTOMAS | ONCOLOGY | GENE-EXPRESSION | DIFFERENTIATION | PTEN Phosphohydrolase - genetics | Leiomyosarcoma - pathology | Genomics | Humans | Middle Aged | Intercellular Signaling Peptides and Proteins - genetics | Gene Expression Profiling - methods | Male | Comparative Genomic Hybridization - methods | Sarcoma - pathology | Cell Transformation, Neoplastic - genetics | Retinoblastoma Protein - genetics | Gene Deletion | Soft Tissue Neoplasms - pathology | Leiomyosarcoma - genetics | Adult | Female | Aged | Sarcoma - genetics | Soft Tissue Neoplasms - genetics | Cluster Analysis | Mesenchyme | Sarcoma | Wnt protein | Rhabdomyosarcoma | Data processing | Gene expression | Liposarcoma | genomics | Tumorigenesis | histiocytoma | Dkk1 protein | soft tissue sarcoma | PTEN protein | Tumors
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12. Full Text Recurrent \textitTRIO Fusion in Nontranslocation\textendashRelated Sarcomas
by Delespaul, Lucile and Lesluyes, Tom and Pérot, Gaëlle and Brulard, Céline and Lartigue, Lydia and Baud, Jessica and Lagarde, Pauline and Le Guellec, Sophie and Neuville, Agnès and Terrier, Philippe and Vince-Ranchère, Dominique and Schmidt, Susanne and Debant, Anne and Coindre, Jean-Michel and Chibon, Frédéric
Clinical Cancer Research, ISSN 1078-0432, 02/2017, Volume 23, Issue 3, pp. 857 - 867
Life Sciences | Cellular Biology
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13. Full Text Leiomyosarcomas: whole genome sequencing for a whole biology characterization
by Chibon, Frédéric and Darbo, Elodie and Pérot, Gaëlle
Current Opinion in Oncology, ISSN 1040-8746, 07/2019, Volume 31, Issue 4, pp. 317 - 321
PURPOSE OF REVIEWLeiomyosarcoma (LMS) is among the more aggressive sarcomas and still suffers from the lack of efficient systemic treatment after, or before,... 
LARGE SERIES | TARGET | PLACEBO | SOFT-TISSUE SARCOMAS | SUBTYPES | MTOR PATHWAY | smooth muscle | PATTERNS | leiomyosarcoma | IDENTIFIES 2 CLASSES | SMOOTH-MUSCLE DIFFERENTIATION | ONCOLOGY | chromosomal instability | genome sequencing | EXPRESSION | Usage | Gene mutations | Leiomyosarcoma | Genetic aspects | Nucleotide sequencing | Research | DNA sequencing
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14. Full Text Constant p53 Pathway Inactivation in a Large Series of Soft Tissue Sarcomas with Complex Genetics
by Pérot, Gaëlle and Chibon, Frédéric and Montero, Audrey and Lagarde, Pauline and de Thé, Hugues and Terrier, Philippe and Guillou, Louis and Ranchère, Dominique and Coindre, Jean-Michel and Aurias, Alain
American Journal of Pathology, The, ISSN 0002-9440, 2010, Volume 177, Issue 4, pp. 2080 - 2090
Alterations of the p53 pathway are among the most frequent aberrations observed in human cancers. We have performed an exhaustive analysis of TP53 , p14 , p15... 
Pathology | MALIGNANT FIBROUS HISTIOCYTOMAS | TUMOR SUPPRESSION | LEIOMYOSARCOMA | GENES | MDM2 | INK4A/ARF LOCUS | MUTATIONS | PATHOLOGY | COMPARATIVE GENOMIC HYBRIDIZATION | P16(INK4A) | CANCER | Oligonucleotide Array Sequence Analysis | Signal Transduction | Tumor Suppressor Protein p53 - antagonists & inhibitors | Humans | RNA, Messenger - genetics | Tumor Suppressor Protein p53 - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Gene Expression Profiling | Mutation - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Immunoenzyme Techniques | Tumor Suppressor Protein p53 - genetics | Sarcoma - metabolism | DNA Methylation | Comparative Genomic Hybridization | Cyclin-Dependent Kinase Inhibitor p15 - genetics | Gene Deletion | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Adult | Cyclin-Dependent Kinase Inhibitor p15 - metabolism | Sarcoma - genetics | Tumor Suppressor Protein p14ARF - genetics | Tumor Suppressor Protein p14ARF - metabolism | Regular
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15. Full Text Case report of an ewing’s sarcoma/primitive neuroectodermal tumor of the kidney
by Bontoux, Christophe and Khaddour, Sarah and Pérot, Gaëlle and Vaessen, Christophe and Boostandoost, Haidé and Augustin, Jérémy and Côté, Jean-François
International Urology and Nephrology, ISSN 0301-1623, 8/2018, Volume 50, Issue 8, pp. 1449 - 1451
Medicine & Public Health | Nephrology | Urology | Sarcoma | Nervous system diseases
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