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British Journal of Cancer, ISSN 0007-0920, 05/2014, Volume 110, Issue 10, pp. 2441 - 2449
textabstractBackground:Plasma exposure of sunitinib shows large inter-individual variation. Therefore, a pharmacokinetic (PK) study was performed to determine... 
sunitinib | kinase and phosphatase inhibitors | TOXICITY | ANTITUMOR-ACTIVITY | INDIVIDUALIZATION | RENAL-CELL CARCINOMA | SU11248 | BREAST-CANCER | LUNG-CANCER | PHASE-II TRIAL | ONCOLOGY | personalised medicine | TYROSINE KINASE INHIBITOR | biodistribution/toxicology | therapeutic drug monitoring | pharmacokinetics and pharmacodynamics | ENDOTHELIAL GROWTH-FACTOR | Pyrroles - pharmacokinetics | Humans | Middle Aged | Salvage Therapy | Male | Fatigue - chemically induced | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Indoles - administration & dosage | Feasibility Studies | Dose-Response Relationship, Drug | Antineoplastic Agents - adverse effects | Pyrroles - administration & dosage | Pyrroles - adverse effects | Adult | Female | Antineoplastic Agents - pharmacokinetics | Protein Kinase Inhibitors - pharmacokinetics | Hematologic Diseases - chemically induced | Drug Administration Schedule | Indoles - blood | Neoplasms - enzymology | Pyrroles - blood | Protein Kinase Inhibitors - blood | Neoplasms - drug therapy | Protein Kinase Inhibitors - administration & dosage | Pilot Projects | Indoles - adverse effects | Antineoplastic Agents - blood | Indoles - pharmacokinetics | Nervous System Diseases - chemically induced | Aged | Drug Monitoring | Gastrointestinal Diseases - chemically induced | Index Medicus | toxicology | biodistribution | Clinical Study
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2016, Volume 11, Issue 2, pp. e0149405 - e0149405
Journal Article
Journal Article
British Journal of Cancer, ISSN 0007-0920, 2014, Volume 110, Issue 10, p. 2441
BACKGROUND: Plasma exposure of sunitinib shows large inter-individual variation. Therefore, a pharmacokinetic (PK) study was performed to determine safety and... 
Journal Article
Journal Article
Future Oncology, ISSN 1479-6694, 02/2014, Volume 10, Issue 3, pp. 417 - 428
Tumor heterogeneity is regarded as a major obstacle to successful personalized cancer medicine. The lack of reliable response assays reflective of in vivo... 
Heterogeneity | Innovation | Selection | Evolution | Tumor | Personalized cancer medicine | Metastases | innovation | CELLS | GENOMIC REARRANGEMENTS | COLORECTAL CANCERS | INTRATUMOR HETEROGENEITY | ACQUIRED-RESISTANCE | evolution | personalized cancer medicine | heterogeneity | metastases | INHIBITION | THERAPY | selection | ONCOLOGY | COPY-NUMBER | tumor | MUTATIONS
Journal Article
Journal Article
Annals of Oncology, ISSN 0923-7534, 09/2014, Volume 25, Issue suppl_4, pp. iv162 - iv162
Abstract Aim: Retrospective analyses of clinical studies of pazopanib showed an increased median PFS in patients with plasma trough levels (TLs) ≥ 20.6 mg/L... 
Journal Article
EUROPEAN JOURNAL OF CANCER, ISSN 0959-8049, 09/2013, Volume 49, pp. S195 - S195
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