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phosphorylation (97) 97
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protein-serine-threonine kinases - metabolism (82) 82
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immunology (23) 23
mitogen-activated protein kinases - metabolism (23) 23
molecular sequence data (23) 23
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amino acid sequence (22) 22
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mk2 (21) 21
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protein-serine-threonine kinases - deficiency (17) 17
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heat-shock proteins - metabolism (16) 16
in-vivo (16) 16
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beer (15) 15
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intracellular signaling peptides and proteins - deficiency (14) 14
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hela cells (13) 13
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1. Full Text Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity
by Frederik Köpper and Cathrin Bierwirth and Margarete Schön and Meike Kunze and Ingegerd Elvers and Dominique Kranz and Priyanka Saini and Manoj B. Menon and David Walter and Claus Storgaard Sørensen and Matthias Gaestel and Thomas Helleday and Michael P. Schön and Matthias Dobbelstein and Stockholms universitet and Naturvetenskapliga fakulteten and Institutionen för genetik, mikrobiologi och toxikologi
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2013, Volume 110, Issue 42, pp. 16856 - 16861
DNA damage can obstruct replication forks, resulting in replicative stress. By siRNA screening, we identified kinases involved in the accumulation of... 
DNA replication | Phosphorylation | Interphase | DNA damage | DNA | Cell cycle | Small interfering RNA | Irradiation | Nucleosides | Cells | CYCLE CHECKPOINT KINASE | ORIGINS | CHK1 | POLYMERASE-ETA | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | RNA STABILIZATION | VERTEBRATE S-PHASE | STRESS | FORK PROGRESSION | H2AX PHOSPHORYLATION | Protein Kinases - metabolism | Protein Kinases - genetics | Humans | Deoxycytidine - pharmacology | Intracellular Signaling Peptides and Proteins - metabolism | Gene Knockdown Techniques | MAP Kinase Signaling System | DNA, Single-Stranded - genetics | Ultraviolet Rays | Antimetabolites, Antineoplastic - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | DNA, Single-Stranded - metabolism | Protein-Serine-Threonine Kinases - genetics | p38 Mitogen-Activated Protein Kinases - genetics | DNA Replication | G2 Phase Cell Cycle Checkpoints | Mice, Knockout | Animals | Histones - genetics | Cell Line, Tumor | Checkpoint Kinase 1 | Mice | DNA Damage | Histones - metabolism | Deoxycytidine - analogs & derivatives | Physiological aspects | Research | Health aspects | Mitogen-activated protein kinases | Ultraviolet radiation | DNA polymerase | Kinases | Apoptosis | Index Medicus | Biological Sciences | Teknik och teknologier | Engineering and Technology | Naturvetenskap | Natural Sciences
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2. Molecular Chaperones in Health and Disease
by Gaestel, Matthias
01/2006, ISBN 1280413042
Annotation Molecular chaperones are involved in a wide variety of essential cellular processes in living cells. A subset of molecular chaperones have been... 
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3. Molecular Chaperones in Health and Disease
by Gaestel, Matthias
01/2006, ISBN 1280413042
Annotation Molecular chaperones are involved in a wide variety of essential cellular processes in living cells. A subset of molecular chaperones have been... 
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4. Molecular chaperones in health and disease
by Gaestel, Matthias
2006, Handbook of experimental pharmacology, ISBN 9783540297178, Volume 172
Heat-Shock Response | Molecular chaperones | Heat-Shock Proteins | Physiological effect
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5. Molecular chaperones in health and disease
by Gaestel, Matthias and MyiLibrary
2006, Handbook of experimental pharmacology, ISBN 3540258752, Volume 172
Molecular chaperones | Physiological effect
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6. Molecular Chaperones in Health and Disease
by Gaestel,Matthias Volume Editor
02/2010, Handbook of Experimental Pharmacology Ser., ISBN 3642065244, Volume 172
Annotation Molecular chaperones are involved in a wide variety of essential cellular processes in living cells. A subset of molecular chaperones have been... 
Proteins | Science
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7. Molecular Chaperones in Health and Disease
by Gaestel,Matthias Volume Editor
02/2010, Handbook of Experimental Pharmacology Ser., ISBN 3642065244, Volume 172
Annotation Molecular chaperones are involved in a wide variety of essential cellular processes in living cells. A subset of molecular chaperones have been... 
Proteins | Science
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8. Full Text Guidelines for the use and interpretation of assays for monitoring autophagy
by Klionsky, Daniel J and Abdalla, Fabio C and Abeliovich, Hagai and Abraham, Robert T and Acevedo-Arozena, Abraham and Adeli, Khosrow and Agholme, Lotta and Agnello, Maria and Agostinis, Patrizia and Aguirre-Ghiso, Julio A and Ahn, Hyung Jun and Ait-Mohamed, Ouardia and Ait-Si-Ali, Slimane and Akematsu, Takahiko and Akira, Shizuo and Al-Younes, Hesham M and Al-Zeer, Munir A and Albert, Matthew L and Albin, Roger L and Alegre-Abarrategui, Javier and Aleo, Maria Francesca and Alirezaei, Mehrdad and Almasan, Alexandru and Almonte-Becerril, Maylin and Amano, Atsuo and Amaravadi, Ravi K and Amarnath, Shoba and Amer, Amal O and Andrieu-Abadie, Nathalie and Anantharam, Vellareddy and Ann, David K and Anoopkumar-Dukie, Shailendra and Aoki, Hiroshi and Apostolova, Nadezda and Arancia, Giuseppe and Aris, John P and Asanuma, Katsuhiko and Asare, Nana Y.O and Ashida, Hisashi and Askanas, Valerie and Askew, David S and Auberger, Patrick and Baba, Misuzu and Backues, Steven K and Baehrecke, Eric H and Bahr, Ben A and Bai, Xue-Yuan and Bailly, Yannick and Baiocchi, Robert and Baldini, Giulia and Balduini, Walter and Ballabio, Andrea and Bamber, Bruce A and Bampton, Edward T.W and Juhász, Gábor and Bartholomew, Clinton R and Bassham, Diane C and Bast, Robert C and Batoko, Henri and Bay, Boon-Huat and Beau, Isabelle and Béchet, Daniel M and Begley, Thomas J and Behl, Christian and Behrends, Christian and Bekri, Soumeya and Bellaire, Bryan and Bendall, Linda J and Benetti, Luca and Berliocchi, Laura and Bernardi, Henri and Bernassola, Francesca and Besteiro, Sébastien and Bhatia-Kissova, Ingrid and Bi, Xiaoning and Biard-Piechaczyk, Martine and Blum, Janice S and Boise, Lawrence H and Bonaldo, Paolo and Boone, David L and Bornhauser, Beat C and Bortoluci, Karina R and Bossis, Ioannis and Bost, Frédéric and Bourquin, Jean-Pierre and Boya, Patricia and Boyer-Guittaut, Michaël and Bozhkov, Peter V and Brady, Nathan R and Brancolini, Claudio and Brech, Andreas and Brenman, Jay E and Brennand, Ana and Bresnick, Emery H and Brest, Patrick and Bridges, Dave and Bristol, Molly L and Brookes, Paul S and Brown, Eric J and Brumell, John H and ... and Linköpings universitet and Institutionen för klinisk och experimentell medicin and Geriatrik and Institutionen för medicin och hälsa and Farmakologi and Experimentell patologi and Hälsouniversitetet and Cellbiologi
Autophagy, ISSN 1554-8627, 04/2012, Volume 8, Issue 4, pp. 445 - 544
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and... 
stress | vacuole | autolysosome | flux | LC3 | autophagosome | lysosome | phagophore | Proteins | Binding | Landes | Calcium | Biology | Bioscience | Cell | Cycle | Organogenesis | Cancer | Phagophore | Lysosome | Autolysosome | Flux | Autophagosome | Vacuole | Stress | ACTIVATED PROTEIN-KINASE | CHAPERONE-MEDIATED AUTOPHAGY | VACUOLE TARGETING PATHWAY | ENDOPLASMIC-RETICULUM STRESS | ISOLATED RAT HEPATOCYTES | STARVATION-INDUCED AUTOPHAGY | GLUCAGON-INDUCED AUTOPHAGY | CELL BIOLOGY | PROGRAMMED CELL-DEATH | BREAST-CANCER CELLS | BETAINE HOMOCYSTEINE METHYLTRANSFERASE | Biological Assay - methods | Animals | Autophagy - genetics | Models, Biological | Humans | Index Medicus | Life Sciences | Cellular Biology | Review | Medical and Health Sciences | Medicin och hälsovetenskap
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9. Molecular chaperones in health and disease
by Gaestel, Matthias
2006, Handbook of experimental pharmacology, ISBN 9783540258759, Volume 172, viii, 442
Molecular chaperones are involved in a wide variety of essential cellular processes in living cells. A subset of molecular chaperones have been initially... 
Molecular chaperones | Physiological effect | Proteins | Medical Biochemistry | Biomedicine | Pharmacology/Toxicology | Cell Biology
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10. MK2–TNF–Signaling Comes Full Circle
by Manoj B Menon and Matthias Gaestel
Trends in Biochemical Sciences, ISSN 0968-0004, 03/2018, Volume 43, Issue 3, p. 170
MK2 (p38MAPK-activated protein kinase 2) is essential for tumor necrosis factor (TNF) biosynthesis, mainly operating by post-transcriptional regulation.... 
Tumor necrosis factor receptors | Shock | Post-transcription | Gene regulation | DNA damage | Biosynthesis | Kinases | Gene deletion | Gene expression | Autophagy | Substrates | Proteins | Signaling | Clonal deletion | Protein kinase | Tumor necrosis factor | Cell death | Deletion | Tumor necrosis factor-TNF | Endotoxemia | Phagocytosis | Deoxyribonucleic acid--DNA | Apoptosis
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11. Full Text TNF and Increased Intracellular Iron Alter Macrophage Polarization to a Detrimental M1 Phenotype in the Injured Spinal Cord
by Kroner, Antje and Greenhalgh, Andrew D and Zarruk, Juan G and Passos dos Santos, Rosmarini and Gaestel, Matthias and David, Samuel
Neuron, ISSN 0896-6273, 09/2014, Volume 83, Issue 5, pp. 1098 - 1116
Macrophages and microglia can be polarized along a continuum toward a detrimental (M1) or a beneficial (M2) state in the injured CNS. Although phagocytosis of... 
PROINFLAMMATORY CYTOKINE | IMMUNE-SYSTEM | COLONY-STIMULATING FACTOR | MIGRATION INHIBITORY FACTOR | CONTUSION INJURY | IN-VIVO | MONOCYTE-DERIVED MACROPHAGES | GENE-EXPRESSION | NECROSIS-FACTOR-ALPHA | NEUROSCIENCES | ALTERNATIVE ACTIVATION | Tumor Necrosis Factor-alpha - metabolism | Macrophages - transplantation | Microglia - metabolism | Protein-Serine-Threonine Kinases - deficiency | Tumor Necrosis Factor-alpha - genetics | Green Fluorescent Proteins - genetics | Cytoprotection - physiology | Myelin Sheath - metabolism | Spinal Cord Injuries - pathology | Intracellular Signaling Peptides and Proteins - deficiency | Time Factors | Cytoprotection - drug effects | Iron - pharmacology | Cytokines - genetics | Intracellular Signaling Peptides and Proteins - genetics | Intracellular Fluid - metabolism | Disease Models, Animal | Macrophages - physiology | Green Fluorescent Proteins - metabolism | Cytokines - metabolism | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Spinal Cord Injuries - surgery | Mice, Transgenic | Iron - metabolism | Phenotype | Animals | Cytoprotection - genetics | Spinal Cord Injuries - immunology | Mice | Apoptosis | Spinal cord injuries | Genetic aspects | Macrophages | Tumor necrosis factor | Genotype & phenotype | Cytokines | Rodents | Cytotoxicity | Kinases | Chemokines | Immune system | Index Medicus
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12. Full Text Emerging Functions of Septins
by Matthias Gaestel and Manoj B. Menon
2017, ISBN 9782889452873
Together with the microfilament, microtubule and intermediate-filament networks, septins constitute an integral part of the eukaryotic cytoskeleton.... 
mutation | cytoskeleton | cytokinesis | budding | SOCE | septin | cancer | GTPase | yeast | Cilia
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13. Full Text AATF/Che‐1 acts as a phosphorylation‐dependent molecular modulator to repress p53‐driven apoptosis
by Höpker, Katja and Hagmann, Henning and Khurshid, Safiya and Chen, Shuhua and Hasskamp, Pia and Seeger‐Nukpezah, Tamina and Schilberg, Katharina and Heukamp, Lukas and Lamkemeyer, Tobias and Sos, Martin L and Thomas, Roman K and Lowery, Drew and Roels, Frederik and Fischer, Matthias and Liebau, Max C and Resch, Ulrike and Kisner, Tülay and Röther, Fabian and Bartram, Malte P and Müller, Roman Ulrich and Fabretti, Francesca and Kurschat, Peter and Schumacher, Björn and Gaestel, Matthias and Medema, René H and Yaffe, Michael B and Schermer, Bernhard and Reinhardt, H Christian and Benzing, Thomas
The EMBO Journal, ISSN 0261-4189, 10/2012, Volume 31, Issue 20, pp. 3961 - 3975
Following genotoxic stress, cells activate a complex signalling network to arrest the cell cycle and initiate DNA repair or apoptosis. The tumour suppressor... 
checkpoint | MK2 | DNA damage | kinase signalling | apoptosis | AATF | p53 | GENOTOXIC STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | KINASE | P53 TRANSCRIPTION | CANCER | TRANSDUCTION PATHWAYS | CELL BIOLOGY | IN-VITRO | CHE-1 | EXPRESSION | Osmotic Pressure | Phosphorylation | Prognosis | Humans | Multiprotein Complexes | Molecular Sequence Data | Neuroblastoma - mortality | Repressor Proteins - physiology | Tumor Suppressor Protein p53 - physiology | DNA Damage - physiology | Endometrial Neoplasms - genetics | HEK293 Cells | Apoptosis Regulatory Proteins - genetics | DNA Damage - genetics | Female | Active Transport, Cell Nucleus | Amino Acid Sequence | Neuroblastoma - genetics | Repressor Proteins - genetics | Gene Dosage | Cell Cycle Checkpoints | Drug Resistance, Neoplasm - genetics | Animals | Gene Amplification | Apoptosis Regulatory Proteins - physiology | Mice | Myosin Light Chains - metabolism | Protein Processing, Post-Translational | Apoptosis - physiology | Doxorubicin - pharmacology | Molecular biology | Kinases | DNA repair | Cell cycle | Apoptosis | Index Medicus
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14. Full Text The p38/MK2-Driven Exchange between Tristetraprolin and HuR Regulates AU-Rich Element-Dependent Translation
by Tiedje, Christopher and Ronkina, Natalia and Tehrani, Mohammad and Dhamija, Sonam and Laass, Kathrin and Holtmann, Helmut and Kotlyarov, Alexey and Gaestel, Matthias
PLoS Genetics, ISSN 1553-7390, 09/2012, Volume 8, Issue 9, pp. e1002977 - e1002977
TNF expression of macrophages is under stringent translational control that depends on the p38 MAPK/MK2 pathway and the AU-rich element (ARE) in the TNF mRNA.... 
TUMOR-NECROSIS-FACTOR | ACTIVATED PROTEIN-KINASE | 3'-UNTRANSLATED REGION | ALPHA MESSENGER-RNA | MAPKAP KINASES | GENETICS & HEREDITY | BINDING-PROTEIN | ENDOPLASMIC-RETICULUM | BOUND RIBOSOMES | TNF-ALPHA | POSTTRANSLATIONAL MODIFICATION | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Protein Biosynthesis | Protein Precursors - genetics | Humans | RNA, Messenger - genetics | Tumor Necrosis Factor-alpha - genetics | ELAV Proteins - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | RNA, Messenger - metabolism | RNA Stability - genetics | Protein Precursors - metabolism | AU Rich Elements - genetics | Macrophages - metabolism | Tristetraprolin - genetics | Tristetraprolin - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Protein-Serine-Threonine Kinases - metabolism | Microbial genetics | Tumor necrosis factor | Physiological aspects | Genetic aspects | Research | Macrophages | Genetic translation | Health aspects | Proteins | Cytokines | Biosynthesis | Kinases | Gene expression | Experiments | Index Medicus
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15. Molecular chaperones in health and disease
by Alberti, S. (Simon) and Gaestel, Matthias
2006, Handbook of experimental pharmacology, ISBN 3540258752, Volume 172.
Heat-Shock Response | Molecular Chaperones | Heat-Shock Proteins
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16. Molecular chaperones in health and disease
by Alberti, S. (Simon) and Gaestel, Matthias
2006, Handbook of experimental pharmacology, ISBN 3540258752, Volume 172.
Heat-Shock Response | Molecular Chaperones | Heat-Shock Proteins
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