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1. Full Text Aberrant methylation of tRNAs links cellular stress to neuro‐developmental disorders
by Blanco, Sandra and Dietmann, Sabine and Flores, Joana V and Hussain, Shobbir and Kutter, Claudia and Humphreys, Peter and Lukk, Margus and Lombard, Patrick and Treps, Lucas and Popis, Martyna and Kellner, Stefanie and Hölter, Sabine M and Garrett, Lillian and Wurst, Wolfgang and Becker, Lore and Klopstock, Thomas and Fuchs, Helmut and Gailus‐Durner, Valerie and Hrabĕ de Angelis, Martin and Káradóttir, Ragnhildur T and Helm, Mark and Ule, Jernej and Gleeson, Joseph G and Odom, Duncan T and Frye, Michaela
The EMBO journal, ISSN 0261-4189, 09/2014, Volume 33, Issue 18, pp. 2020 - 2039
RNA modification | Misu | NSun2 | 5‐methylcytidine | 5-methylcytidine | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Oxidative Stress | RNA, Transfer - metabolism | Humans | Methyltransferases - metabolism | Gene Expression Regulation | Methyltransferases - genetics | Gene Expression Profiling | Nervous System Diseases - congenital | Animals | Ribonuclease, Pancreatic - metabolism | Brain - pathology | Mice | Methylation | Nervous System Diseases - pathology | Medical research | Cellular biology | Disease | Gene expression | Ribonucleic acid--RNA | Neurological disorders | Index Medicus
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2. Full Text A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains
by Simon, Michelle M and Greenaway, Simon and White, Jacqueline K and Fuchs, Helmut and Gailus-Durner, Valérie and Wells, Sara and Sorg, Tania and Wong, Kim and Bedu, Elodie and Cartwright, Elizabeth J and Dacquin, Romain and Djebali, Sophia and Estabel, Jeanne and Graw, Jochen and Ingham, Neil J and Jackson, Ian J and Lengeling, Andreas and Mandillo, Silvia and Marve, Jacqueline and Meziane, Hamid and Preitner, Frédéric and Puk, Oliver and Roux, Michel and Adams, David J and Atkins, Sarah and Ayadi, Abdel and Becker, Lore and Blake, Andrew and Brooker, Debra and Cater, Heather and Champy, Marie-France and Combe, Roy and Danecek, Petr and Di Fenza, Armida and Gates, Hilary and Gerdin, Anna-Karin and Golini, Elisabetta and Hancock, John M and Hans, Wolfgang and Hölter, Sabine M and Hough, Tertius and Jurdic, Pierre and Keane, Thomas M and Morgan, Hugh and Müller, Werner and Neff, Frauke and Nicholson, George and Pasche, Bastian and Roberson, Laura-Anne and Rozman, Jan and Sanderson, Mark and Santos, Luis and Selloum, Mohammed and Shannon, Carl and Southwel, Anne and Tocchini-Valentini, Glauco P and Vancollie, Valerie E and Westerberg, Henrik and Wurst, Wolfgang and Zi, Min and Yalcin, Binnaz and Ramirez-Solis, Ramiro and Steel, Karen P and Mallon, Ann-Marie and De Angelis, Martin Hrabe and Herault, Yann and Brown, Steve D.M
Genome Biology, ISSN 1474-7596, 2013, Volume 14, Issue 7, pp. R82 - R82
Mouse phenotyping | Sequence variation | Gene knockout | C57BL/6 | Mouse inbred lines | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Eye - pathology | Spleen - immunology | Mice, Inbred C57BL | Genome - genetics | Hypersensitivity - immunology | INDEL Mutation - genetics | Male | Disease Resistance - immunology | Femur - diagnostic imaging | X-Ray Microtomography | Behavior, Animal | Phenotype | Animals | Maze Learning | Listeriosis - immunology | Killer Cells, Natural - immunology | Polymorphism, Single Nucleotide - genetics | Female | Listeriosis - microbiology | Index Medicus | Life Sciences | Genetics | Biochemistry, Molecular Biology | Genomics | mouse phenotyping | gene knockout | C57BL | 6 | sequence variation | Research
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3. Full Text High-throughput discovery of novel developmental phenotypes
by Dickinson, Mary E and Ji, Xiao and Teboul, Lydia and Wong, Michael D and White, Jacqueline K and Meehan, Terrence F and Westerberg, Henrik and Adissu, Hibret and Baker, Candice N and Brianna Caddle, L and Chiani, Francesco and Clary, Dave and Cleak, James and Daly, Mark J and Denegre, James M and Edie, Sarah M and Gailus-Durner, Valerie and Galli, Antonella and Gambadoro, Alessia and Gallegos, Juan and Johnson, Sara J and Lawson, Thomas N and Lek, Monkol and Mason, Jeremy and McElwee, Melissa L and Nutter, Lauryl M.J and Rowland, Douglas J and Samocha, Kaitlin E and Seavitt, John R and Szoke-Kovacs, Zsombor and Trainor, Amanda G and Wakana, Shigeharu and Warren, Jonathan and West, David B and Tocchini-Valentini, Glauco P and Flicek, Paul and Bradley, Allan and Skarnes, William C and Justice, Monica J and Parkinson, Helen E and Moore, Mark and Wells, Sara and Svenson, Karen L and Herault, Yann and Mallon, Ann-Marie and Mark Henkelman, R and Brown, Steve D.M and Adams, David J and Kent Lloyd, K.C and McKerlie, Colin and Urban, Barbara and Lund, Caroline and LaCasse, Taylor and Mehalow, Adrienne and Taft, Robert and Kutney, Peter and Goodwin, Leslie and Kales, Susan and Urban, Rachel and Palmer, Kristina and Pertuy, Fabien and Bitz, Deborah and Weber, Bruno and Jacobs, Hughes and Ennah, Hamid and Ali-Hadji, Dalila and Wattenhofer-Donze, Marie and André, Philippe and Birling, Marie-Christine and Pavlovic, Guillaume and Sorg, Tania and Morse, Iva and Benso, Frank and Harrison, Jackie and Guo, Ruolin and Qu, Dawei and Spring, Shoshana and Ellegood, Jacob and Shang, Xueyuan and Feugas, Pat and Creighton, Amie and Penton, Patricia Castellanos and Danisment, Ozge and Griggs, Nicola and Tudor, Catherine L and Green, Angela L and Icoresi Mazzeo, Cecilia and Siragher, Emma and Lillistone, Charlotte and Gleeson, Diane and Sethi, Debarati and Bayzetinova, Tanya and Burvill, Jonathan and Habib, Bishoy and Maswood, Ryea and Woods, Michael and Grau, Evelyn and Sinclair, Caroline and Brown, Ellen and Ayabe, Shinya and Int Mouse Phenotyping Consortium and The International Mouse Phenotyping Consortium
Nature (London), ISSN 0028-0836, 09/2016, Volume 537, Issue 7621, pp. 508 - 514
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Genetic research | Phenotype | Research | High-throughput screening (Biochemical assaying) | Methods | Genotype & phenotype | Disease | Developmental biology | Genes | Genomes | Mutation | Embryos | Index Medicus | knockout | embryonic lethal | mouse | KOMP | IMPC | EUCOMM
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4. Full Text RNA editing of Filamin A pre‐mRNA regulates vascular contraction and diastolic blood pressure
by Jain, Mamta and Mann, Tomer D and Stulić, Maja and Rao, Shailaja P and Kirsch, Andrijana and Pullirsch, Dieter and Strobl, Xué and Rath, Claus and Reissig, Lukas and Moreth, Kristin and Klein‐Rodewald, Tanja and Bekeredjian, Raffi and Gailus‐Durner, Valerie and Fuchs, Helmut and Hrabě de Angelis, Martin and Pablik, Eleonore and Cimatti, Laura and Martin, David and Zinnanti, Jelena and Graier, Wolfgang F and Sibilia, Maria and Frank, Saša and Levanon, Erez Y and Jantsch, Michael F
The EMBO journal, ISSN 0261-4189, 10/2018, Volume 37, Issue 19, p. n/a
cardiovascular disease | RNA editing | Filamin A (FLNA) | hypertension | adenosine deaminases acting on RNA (ADAR) | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Blood Pressure | Vascular Remodeling | RNA Editing | Humans | Myocardium - pathology | RNA Precursors - genetics | Hypertension - pathology | Hypertension - metabolism | Filamins - metabolism | Animals | Muscle Contraction | Sequence Analysis, RNA | Myocardium - metabolism | RNA Precursors - metabolism | Heart Ventricles - metabolism | Mice | Filamins - genetics | Hypertension - genetics | Heart Ventricles - pathology | Phosphorylation | Central nervous system | Editing | Smooth muscle | Cardiovascular disease | mRNA | Blood | Proteins | Actin | Myosin | Aorta | Blood pressure | Heart diseases | Thickening | Hypertension | Cardiovascular system | RNA modification | Adenosine | Muscles | Crosslinking | Ribonucleic acid--RNA | Disease control | Muscle contraction | Coronary artery disease | Substrates | Pressure dependence | Vertebrates | Ventricle | Cardiovascular diseases | Index Medicus | Vascular Biology & Angiogenesis | Development & Differentiation | RNA Biology
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5. Full Text Disease model discovery from 3,328 gene knockouts by the International Mouse Phenotyping Consortium
by Meehan, Terrence F and Conte, Nathalie and West, David B and Jacobsen, Julius O and Mason, Jeremy and Warren, Jonathan and Chen, Chao-Kung and Tudose, Ilinca and Relac, Mike and Matthews, Peter and Karp, Natasha and Santos, Luis and Fiegel, Tanja and Ring, Natalie and Westerberg, Henrik and Greenaway, Simon and Sneddon, Duncan and Morgan, Hugh and Codner, Gemma F and Stewart, Michelle E and Brown, James and Horner, Neil and Haendel, Melissa and Washington, Nicole and Mungall, Christopher J and Reynolds, Corey L and Gallegos, Juan and Gailus-Durner, Valerie and Sorg, Tania and Pavlovic, Guillaume and Bower, Lynette R and Moore, Mark and Morse, Iva and Gao, Xiang and Tocchini-Valentini, Glauco P and Obata, Yuichi and Cho, Soo Young and Seong, Je Kyung and Seavitt, John and Beaudet, Arthur L and Dickinson, Mary E and Herault, Yann and Wurst, Wolfgang and De Angelis, Martin Hrabe and Kent Lloyd, K.C and Flenniken, Ann M and Nutter, Lauryl M J and Newbigging, Susan and McKerlie, Colin and Justice, Monica J and Murray, Stephen A and Svenson, Karen L and Braun, Robert E and White, Jacqueline K and Bradley, Allan and Flicek, Paul and Wells, Sara and Skarnes, William C and Adams, David J and Parkinson, Helen and Mallon, Ann-Marie and Brown, Steve D.M and Smedley, Damian and Int Mouse Phenotyping Consortium and International Mouse Phenotyping Consortium and The International Mouse Phenotyping Consortium
Nature genetics, ISSN 1061-4036, 08/2017, Volume 49, Issue 8, pp. 1231 - 1238
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Genetic Predisposition to Disease | Phenotype | Animals | Humans | Female | Genetic Diseases, Inborn | Male | Mice | Gene Knockout Techniques | Disease Models, Animal | Mice, Knockout | Usage | Genetic aspects | Research | Animal models in research | Genomics | Heart | Animal models | Ontology | Disease | Genes | Disorders | Genomes | Statistical methods | Gene sequencing | Consortia | Signal transduction | Annotations | Databases | Rodents | Right ventricular dysplasia | Automation | Gene expression | Ventricular dysplasia | Diseases | Studies | Acids | Phenotyping | Diagnostic systems | Mutation | Ventricle | Index Medicus
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6. Full Text Alternative oxidase‐mediated respiration prevents lethal mitochondrial cardiomyopathy
by Rajendran, Jayasimman and Purhonen, Janne and Tegelberg, Saara and Smolander, Olli‐Pekka and Mörgelin, Matthias and Rozman, Jan and Gailus‐Durner, Valerie and Fuchs, Helmut and Hrabe de Angelis, Martin and Auvinen, Petri and Mervaala, Eero and Jacobs, Howard T and Szibor, Marten and Fellman, Vineta and Kallijärvi, Jukka
EMBO molecular medicine, ISSN 1757-4676, 01/2019, Volume 11, Issue 1, p. n/a
BCS1L | complex III | GRACILE syndrome | respiratory chain | mitochondrial disorder | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Recombinant Proteins - metabolism | Oxidoreductases - metabolism | Oxidoreductases - genetics | Mice, Inbred C57BL | Cardiomyopathies - prevention & control | Mitochondrial Proteins - genetics | Recombinant Proteins - genetics | Ciona intestinalis - genetics | Ciona intestinalis - enzymology | Gene Knock-In Techniques | Plant Proteins - genetics | Animals | Cell Respiration | Mitochondrial Proteins - metabolism | Survival Analysis | Plant Proteins - metabolism | Electron Transport Complex III - deficiency | Heart | Enzymes | Reactive oxygen species | Liver diseases | Transcription | Cardiomyopathy | Alternative oxidase | Gene expression | Survival | Homozygotes | Atrophy | Mitochondria | Gliosis | Ultrastructure | Lipodystrophy | Oxidation | Electron transport | Respiration | Quinol | Shunts | s | Genetics, Gene Therapy & Genetic Disease | Cardiovascular System
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7. Full Text Rapamycin extends murine lifespan but has limited effects on aging
by Neff, Frauke and Flores-Dominguez, Diana and Ryan, Devon P and Horsch, Marion and Schröder, Susanne and Adler, Thure and Afonso, Luciana Caminha and Aguilar-Pimentel, Juan Antonio and Becker, Lore and Garrett, Lillian and Hans, Wolfgang and Hettich, Moritz M and Holtmeier, Richard and Hölter, Sabine M and Moreth, Kristin and Prehn, Cornelia and Puk, Oliver and Rácz, Ildikó and Rathkolb, Birgit and Rozman, Jan and Naton, Beatrix and Ordemann, Rainer and Adamski, Jerzy and Beckers, Johannes and Bekeredjian, Raffi and Busch, Dirk H and Ehninger, Gerhard and Graw, Jochen and Höfler, Heinz and Klingenspor, Martin and Klopstock, Thomas and Ollert, Markus and Stypmann, Jörg and Wolf, Eckhard and Wurst, Wolfgang and Zimmer, Andreas and Fuchs, Helmut and Gailus-Durner, Valérie and De Angelis, Martin Hrabe and Ehninger, Dan
The Journal of clinical investigation, ISSN 0021-9738, 08/2013, Volume 123, Issue 8, pp. 3272 - 3291
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Liver - pathology | Granuloma - prevention & control | Longevity - drug effects | Aging - drug effects | Male | TOR Serine-Threonine Kinases - antagonists & inhibitors | Liver - drug effects | T-Lymphocytes - drug effects | Immunoglobulins - blood | Leukocyte Count | Drug Evaluation, Preclinical | Thyroid Gland - drug effects | Liver Cirrhosis - prevention & control | Mice, Inbred C57BL | Psychomotor Performance - drug effects | Maze Learning - drug effects | Sirolimus - pharmacology | Phenotype | Animals | Platelet Count | Oxygen Consumption - drug effects | Thyroid Gland - pathology | Survival Analysis | T-Lymphocytes - immunology | Mice | Muscle Strength - drug effects | Cell Transformation, Neoplastic - drug effects | Life spans (Biology) | Aging | Physiological aspects | Rapamycin | Dosage and administration | Research | Proteins | Confidence intervals | Survival analysis | Rodents | Behavior | Alliances | Diabetes | Mammals | Age | Index Medicus | Abridged Index Medicus
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