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by Rozman, Jan and Rathkolb, Birgit and Oestereicher, Manuela A and Schütt, Christine and Ravindranath, Aakash Chavan and Leuchtenberger, Stefanie and Sharma, Sapna and Kistler, Martin and Willershäuser, Monja and Brommage, Robert and Meehan, Terrence F and Mason, Jeremy and Haselimashhadi, Hamed and Aguilar-Pimentel, Antonio and Becker, Lore and Treise, Irina and Moreth, Kristin and Garrett, Lillian and Hölter, Sabine M and Zimprich, Annemarie and Marschall, Susan and Amarie, Oana V and Calzada-Wack, Julia and Neff, Frauke and Brachthäuser, Laura and Lengger, Christoph and Stoeger, Claudia and Zapf, Lilly and Cho, Yi-Li and Da Silva-Buttkus, Patricia and Kraiger, Markus J and Mayer-Kuckuk, Philipp and Gampe, Karen Kristine and Wu, Moya and Conte, Nathalie and Warren, Jonathan and Chen, Chao-Kung and Tudose, Ilinca and Relac, Mike and Matthews, Peter and Cater, Heather L and Natukunda, Helen P and Cleak, James and Teboul, Lydia M and Clementson-Mobbs, Sharon and Szoke-Kovacs, Zsombor and Walling, Alison P and Johnson, Sara J and Codner, Gemma F and Fiegel, Tanja and Ring, Natalie and Westerberg, Henrik and Greenaway, Simon and Sneddon, Duncan and Morgan, Hugh and Loeffler, Jorik and Stewart, Michelle E and Ramirez-Solis, Ramiro and Bradley, Allan and Skarnes, William C and Steel, Karen P and Maguire, Simon A and Dench, Joshua and Lafont, David and Vancollie, Valerie E and Pearson, Selina A and Gates, Amy S and Sanderson, Mark and Shannon, Carl and Anthony, Lauren F. E and Sumowski, Maksymilian T and McLaren, Robbie S. B and Doe, Brendan and Wardle-Jones, Hannah and Griffiths, Mark N. D and Galli, Antonella and Swiatkowska, Agnieszka and Isherwood, Christopher M and Speak, Anneliese O and Cambridge, Emma L and Wilson, Heather M and Caetano, Susana S and Maguire, Anna Karin B and Adams, David J and Bottomley, Joanna and Ryder, Ed and Gleeson, Diane and Pouilly, Laurent and Rousseau, Stephane and Auburtin, Aurélie and Reilly, Patrick and Ayadi, Abdel and Selloum, Mohammed and Wood, Joshua A and Clary, Dave and Havel, Peter and Tolentino, Todd and Tolentino, Heather and Schuchbauer, Mike and Pedroia, Sheryl and ... and IMPC Consortium
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 288 - 16
Journal Article
The EMBO Journal, ISSN 0261-4189, 09/2014, Volume 33, Issue 18, pp. 2020 - 2039
Journal Article
Genome Biology, ISSN 1474-7596, 2013, Volume 14, Issue 7, pp. R82 - R82
Journal Article
Nature Medicine, ISSN 1078-8956, 12/2016, Volume 22, Issue 12, pp. 1428 - 1438
Aging is associated with an increased risk of cardiovascular disease and death. Here we show that oral supplementation of the natural polyamine spermidine... 
MEDICINE, RESEARCH & EXPERIMENTAL | PRESSURE-OVERLOAD | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIAL AUTOPHAGY | PRESERVED EJECTION FRACTION | TANDEM MASS-SPECTROMETRY | DIASTOLIC HEART-FAILURE | ROBUST QUANTIFICATION | ARGININE BIOAVAILABILITY | CELL BIOLOGY | SALT-SENSITIVE RATS | AMINO-ACIDS | MYOCARDIAL HYPERTROPHY | Mitochondria, Heart - metabolism | Prospective Studies | Diastole | Gene Expression - drug effects | Longevity - drug effects | Humans | Middle Aged | Aging - drug effects | Immunoblotting | Male | Autophagy-Related Protein 5 - genetics | Chromatography, High Pressure Liquid | Mitochondria, Heart - drug effects | Autophagy - drug effects | Aging - immunology | Mass Spectrometry | Cardiovascular Diseases - epidemiology | Heart Failure | Adult | Female | Surveys and Questionnaires | Blood Pressure - drug effects | Rats, Inbred Dahl | Phosphorylation - drug effects | Cytokines - immunology | Glucose Tolerance Test | Echocardiography | Diet - statistics & numerical data | Connectin - drug effects | Cardiomegaly - diagnostic imaging | Rats | Inflammation | Cardiotonic Agents - pharmacology | Heart - diagnostic imaging | Animals | Myocytes, Cardiac - drug effects | Connectin - metabolism | Cytokines - drug effects | Mitochondrial Degradation - drug effects | Spermidine - pharmacology | Heart - drug effects | Aged | Mice | Aging - metabolism | Cardiovascular diseases | Polyamines | Research | Aging | Cardiomyocytes | Mitochondria | Kardiologi | Biological Sciences | Clinical Medicine | Cardiac and Cardiovascular Systems | Naturvetenskap | Medical and Health Sciences | Medicin och hälsovetenskap | Biologiska vetenskaper | Natural Sciences | Klinisk medicin
Journal Article
by Dickinson, Mary E and Flenniken, Ann M and Ji, Xiao and Teboul, Lydia and Wong, Michael D and White, Jacqueline K and Meehan, Terrence F and Weninger, Wolfgang J and Westerberg, Henrik and Adissu, Hibret and Baker, Candice N and Bower, Lynette and Brown, James M and Brianna Caddle, L and Chiani, Francesco and Clary, Dave and Cleak, James and Daly, Mark J and Denegre, James M and Doe, Brendan and Dolan, Mary E and Edie, Sarah M and Fuchs, Helmut and Gailus-Durner, Valerie and Galli, Antonella and Gambadoro, Alessia and Gallegos, Juan and Guo, Shiying and Horner, Neil R and Hsu, Chih-wei and Johnson, Sara J and Kalaga, Sowmya and Keith, Lance C and Lanoue, Louise and Lawson, Thomas N and Lek, Monkol and Mark, Manuel and Marschall, Susan and Mason, Jeremy and McElwee, Melissa L and Newbigging, Susan and Nutter, Lauryl M.J and Peterson, Kevin A and Ramirez-Solis, Ramiro and Rowland, Douglas J and Ryder, Edward and Samocha, Kaitlin E and Seavitt, John R and Selloum, Mohammed and Szoke-Kovacs, Zsombor and Tamura, Masaru and Trainor, Amanda G and Tudose, Ilinca and Wakana, Shigeharu and Warren, Jonathan and Wendling, Olivia and West, David B and Wong, Leeyean and Yoshiki, Atsushi and MacArthur, Daniel G and Tocchini-Valentini, Glauco P and Gao, Xiang and Flicek, Paul and Bradley, Allan and Skarnes, William C and Justice, Monica J and Parkinson, Helen E and Moore, Mark and Wells, Sara and Braun, Robert E and Svenson, Karen L and Hrabe de Angelis, Martin and Herault, Yann and Mohun, Tim and Mallon, Ann-Marie and Mark Henkelman, R and Brown, Steve D.M and Adams, David J and Kent Lloyd, K.C and McKerlie, Colin and Beaudet, Arthur L and Bucan, Maja and Murray, Stephen A and McKay, Matthew and Urban, Barbara and Lund, Caroline and Froeter, Erin and LaCasse, Taylor and Mehalow, Adrienne and Gordon, Emily and Donahue, Leah Rae and Taft, Robert and Kutney, Peter and Dion, Stephanie and Goodwin, Leslie and Kales, Susan and Urban, Rachel and Palmer, Kristina and Pertuy, Fabien and Bitz, Deborah and ... and Int Mouse Phenotyping Consortium and The International Mouse Phenotyping Consortium
Nature, ISSN 0028-0836, 09/2016, Volume 537, Issue 7621, pp. 508 - 514
Approximately one-third of all mammalian genes are essential for life. Phenotypes resulting from knockouts of these genes in mice have provided tremendous... 
MICRO-CT | MULTIDISCIPLINARY SCIENCES | DISEASE | GENOME-WIDE | MAMMALIAN GENE-FUNCTION | SCREENS | GLYCOGENIN-1 DEFICIENCY | IDENTIFICATION | EXPRESSION | MOUSE EMBRYO | RESOURCE | Genetic research | Phenotype | Research | High-throughput screening (Biochemical assaying) | Methods | Genotype & phenotype | Disease | Developmental biology | Genes | Genomes | Mutation | Embryos | knockout | embryonic lethal | mouse | KOMP | IMPC | EUCOMM
Journal Article
The EMBO Journal, ISSN 0261-4189, 10/2018, Volume 37, Issue 19, p. n/a
Journal Article
by Bowl, Michael R and Simon, Michelle M and Ingham, Neil J and Greenaway, Simon and Santos, Luis and Cater, Heather and Taylor, Sarah and Mason, Jeremy and Kurbatova, Natalja and Pearson, Selina and Bower, Lynette R and Clary, Dave A and Meziane, Hamid and Reilly, Patrick and Minowa, Osamu and Kelsey, Lois and Allen, Sue and Clementson-Mobbs, Sharon and Codner, Gemma and Fray, Martin and Gardiner, Wendy and Joynson, Russell and Kenyon, Janet and Loeffler, Jorik and Nell, Barbara and Parker, Andrew and Quwailid, Deen and Stewart, Michelle and Walling, Alison and Zaman, Rumana and Chen, Chao-Kung and Conte, Nathalie and Matthews, Peter and Relac, Mike and Tudose, Ilinca and Warren, Jonathan and Le Marchand, Elise and El Amri, Amal and El Fertak, Leila and Ennah, Hamid and Ali-Hadji, Dalila and Ayadi, Abdel and Wattenhofer-Donze, Marie and Moulaert, David and Jacquot, Sylvie and André, Philippe and Birling, Marie-Christine and Pavlovic, Guillaume and Lalanne, Valérie and Lux, Aline and Riet, Fabrice and Mittelhaeuser, Christophe and Bour, Raphael and Guimond, Alain and Bam'Hamed, Chaouki and Leblanc, Sophie and Vasseur, Laurent and Selloum, Mohammed and Sorg, Tania and Ayabe, Shinya and Furuse, Tamio and Kaneda, Hideki and Kobayashi, Kimio and Masuya, Hiroshi and Miura, Ikuo and Obata, Yuichi and Suzuki, Tomohiro and Tamura, Masaru and Tanaka, Nobuhiko and Yamada, Ikuko and Yoshiki, Atsushi and Berberovic, Zorana and Bubshait, Mohammed and Cabezas, Jorge and Carroll, Tracy and Clark, Greg and Clarke, Shannon and Creighton, Amie and Danisment, Ozge and Eskandarian, Mohammad and Feugas, Patricia and Gertsenstein, Marina and Guo, Ruolin and Hunter, Jane and Jacob, Elsa and Lan, Qing and Laurin, Valerie and Law, Napoleon and MacMaster, Sue and Miller, David and Morikawa, Lily and Newbigging, Susan and Owen, Celeste and Penton, Patricia and Pereira, Monica and Qu, Dawei and Shang, Xueyuan and Sleep, Gillian and Sohel, Khondoker and Tondat, Sandra and ... and Int Mouse Phenotyping Consortium and International Mouse Phenotyping Consortium and The International Mouse Phenotyping Consortium
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 886 - 11
The developmental and physiological complexity of the auditory system is likely reflected in the underlying set of genes involved in auditory function. In... 
HAIR-CELLS | MUTAGENESIS | PROJECT | OTITIS-MEDIA | MULTIDISCIPLINARY SCIENCES | MOUSE | MUTATION | DISEASE | GENOME-WIDE | IMPAIRMENT | RESOURCE | Consortia | Genes | Phenotyping | Auditory system | Hearing protection | Hearing impairment | Hearing loss
Journal Article
Nature Genetics, ISSN 1061-4036, 08/2017, Volume 49, Issue 8, pp. 1231 - 1238
Although next-generation sequencing has revolutionized the ability to associate variants with human diseases, diagnostic rates and development of new therapies... 
RESOURCES | DATABASE | GENETICS & HEREDITY | GENOME-WIDE | ONTOLOGY | MICE | GENERATION |