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1. Full Text Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial
by James, Nicholas D, Prof and Sydes, Matthew R, MSc and Clarke, Noel W, Prof and Mason, Malcolm D, Prof and Dearnaley, David P, Prof and Spears, Melissa R, MSc and Ritchie, Alastair W S, MD and Parker, Christopher C, MD and Russell, J Martin, FRCR and Attard, Gerhardt, MD PhD and de Bono, Johann, Prof and Cross, William, PhD and Jones, Rob J, Prof and Thalmann, George, Prof and Amos, Claire, PhD and Matheson, David, PhD and Millman, Robin and Alzouebi, Mymoona, FRCR and Beesley, Sharon, FRCR and Birtle, Alison J, MD and Brock, Susannah, FRCR and Cathomas, Richard, MD and Chakraborti, Prabir, FRCR and Chowdhury, Simon, MD and Cook, Audrey, FRCR and Elliott, Tony, PhD and Gale, Joanna, DM and Gibbs, Stephanie, FRCR and Graham, John D, FRCP and Hetherington, John, FRCS[Eng] and Hughes, Robert, FRCR and Laing, Robert, FRCR and McKinna, Fiona, FRCR and McLaren, Duncan B, FRCR, FRCP[Ed] and O'Sullivan, Joe M, Prof and Parikh, Omi, FRCR and Peedell, Clive, FRCR and Protheroe, Andrew, PhD and Robinson, Angus J, FRCR and Srihari, Narayanan, MD and Srinivasan, Rajaguru, FRCR and Staffurth, John, MD and Sundar, Santhanam, FRCR and Tolan, Shaun, MD and Tsang, David, MCRP and Wagstaff, John, Prof and Parmar, Mahesh K B, Prof and STAMPEDE Investigators and STAMPEDE investigators
Lancet, The, ISSN 0140-6736, 2016, Volume 387, Issue 10024, pp. 1163 - 1177
Summary Background Long-term hormone therapy has been the standard of care for advanced prostate cancer since the 1940s. STAMPEDE is a randomised controlled... 
Internal Medicine | ANDROGEN-DEPRIVATION THERAPY | MEDICINE, GENERAL & INTERNAL | PREDNISONE | DESIGN | MITOXANTRONE | CABAZITAXEL | CLINICAL-TRIALS | OPEN-LABEL | CHEMOTHERAPY | ENZALUTAMIDE | ESTRAMUSTINE | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Imidazoles - administration & dosage | Male | Antineoplastic Agents, Hormonal - adverse effects | Neoplasm Metastasis | Aged, 80 and over | Adult | Diphosphonates - adverse effects | Prostatic Neoplasms - drug therapy | Taxoids - adverse effects | Drug Administration Schedule | Antineoplastic Agents, Hormonal - administration & dosage | Imidazoles - adverse effects | Docetaxel | Kaplan-Meier Estimate | Treatment Outcome | Diphosphonates - administration & dosage | Zoledronic Acid | Disease Progression | Taxoids - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Androgen Antagonists - administration & dosage | Androgen Antagonists - adverse effects | Survival analysis | Medical prognosis | Clinical trials | Hormone replacement therapy | Metastasis | Prostate cancer | Cancer therapies
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2. Full Text Radiotherapy to the primary tumour for newly diagnosed, metastatic prostate cancer (STAMPEDE): a randomised controlled phase 3 trial
by Parker, Christopher C and James, Nicholas D and Brawley, Christopher D and Clarke, Noel W and Hoyle, Alex P and Ali, Adnan and Ritchie, Alastair W S and Attard, Gerhardt and Chowdhury, Simon and Cross, William and Dearnaley, David P and Gillessen, Silke and Gilson, Clare and Jones, Robert J and Langley, Ruth E and Malik, Zafar I and Mason, Malcolm D and Matheson, David and Millman, Robin and Russell, J Martin and Thalmann, George N and Amos, Claire L and Alonzi, Roberto and Bahl, Amit and Birtle, Alison and Din, Omar and Douis, Hassan and Eswar, Chinnamani and Gale, Joanna and Gannon, Melissa R and Jonnada, Sai and Khaksar, Sara and Lester, Jason F and O'Sullivan, Joe M and Parikh, Omi A and Pedley, Ian D and Pudney, Delia M and Sheehan, Denise J and Srihari, Narayanan Nair and Tran, Anna T H and Parmar, Mahesh K B and Sydes, Matthew R and Systemic Therapy Adv Metastatic and Systemic Therapy for Advanced or Metastatic Prostate cancer: Evaluation of Drug Efficacy (STAMPEDE) investigators
The Lancet, ISSN 0140-6736, 12/2018, Volume 392, Issue 10162, pp. 2353 - 2366
Based on previous findings, we hypothesised that radiotherapy to the prostate would improve overall survival in men with metastatic prostate cancer, and that... 
SURVIVAL | MEDICINE, GENERAL & INTERNAL | MEN | RADICAL PROSTATECTOMY | TIME | BONE | ANDROGEN DEPRIVATION THERAPY | RADIATION-THERAPY | Prostatic Neoplasms - pathology | Prostatic Neoplasms - radiotherapy | Lymph Nodes - pathology | Prostatic Neoplasms - surgery | Standard of Care | Humans | Middle Aged | Male | Treatment Outcome | Antineoplastic Agents - therapeutic use | Gonadotropin-Releasing Hormone - antagonists & inhibitors | Radiotherapy - adverse effects | Orchiectomy | Disease-Free Survival | Neoplasm Metastasis | Survival Analysis | Docetaxel - therapeutic use | Aged | Gonadotropin-Releasing Hormone - agonists | Prostatic Neoplasms - drug therapy | Metastasis | Radiotherapy | Prostate cancer | Analysis | Drug abuse | Substance abuse treatment | Prostate-specific antigen | Radiation | Bladder | Subgroups | Metastases | Randomization | Motivation | Nonsteroidal anti-inflammatory drugs | Urogenital system | Medical research | Aspirin | Deprivation | Hazards | Inflammation | Radiation therapy | Patients | Survival | Androgens | Hypotheses | Medical prognosis | Men | Prostate | Cancer | Tumors
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3. Full Text Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial
by Hausenloy, DJ and Kharbanda, RK and Moller, UK and Ramlall, M and Aaroe, J and Butler, R and Bulluck, H and Clayton, T and Dana, A and Dodd, M and Engstrom, T and Evans, R and Lassen, JF and Christensen, EF and Garcia-Ruiz, JM and Gorog, DA and Hjort, J and Houghton, RF and Ibanez, B and Knight, R and Lippert, FK and Lonborg, JT and Maeng, M and Milasinovic, D and More, R and Nicholas, JM and Jensen, LO and Perkins, A and Radovanovic, N and Rakhit, RD and Ravkilde, J and Ryding, AD and Schmidt, MR and Riddervold, IS and Sorensen, HT and Stankovic, G and Varma, M and Webb, I and Terkelsen, CJ and Greenwood, JP and Yellon, DM and Botker, HE and CONDI-2 ERIC-PPCI Investigators and CONDI-2/ERIC-PPCI Investigators
LANCET, ISSN 0140-6736, 10/2019, Volume 394, Issue 10207, pp. 1415 - 1424
Background Remote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown to reduce myocardial infarct size in... 
LIMB | MEDICINE, GENERAL & INTERNAL | PERCUTANEOUS CORONARY INTERVENTION | ISCHEMIA/REPERFUSION INJURY | TASK-FORCE | SIZE | ADJUNCT | ST-SEGMENT ELEVATION | CARDIOPROTECTION | Heart failure | Myocardial infarction | Heart | Stroke | Heart attacks | Cardiac conditioning | Mortality | Medical services | Patients | Clinical outcomes | Studies | Side effects | Randomization | Reperfusion | Motivation | Ischemia | Coronary vessels | Electrocardiography | Data collection | Death | Conditioning | Heart diseases | Veins & arteries
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4. Full Text Associations between vascular risk factors and brain MRI indices in UK Biobank
by Cox, Simon R and Lyall, Donald M and Ritchie, Stuart J and Bastin, Mark E and Harris, Mathew A and Buchanan, Colin R and Fawns-Ritchie, Chloe and Barbu, Miruna C and de Nooij, Laura and Reus, Lianne M and Alloza, Clara and Shen, Xueyi and Neilson, Emma and Alderson, Helen L and Hunter, Stuart and Liewald, David C and Whalley, Heather C and McIntosh, Anew M and Lawrie, Stephen J and Pell, Jill P and Tucker-b, Elliot M and Wardlaw, Joanna M and Gale, Catharine R and Deary, Ian J
European Heart Journal, ISSN 0195-668X, 03/2019, Volume 40, Issue 28, pp. 2290 - 2300
AIMS: Several factors are known to increase risk for cerebrovascular disease and dementia, but there is limited evidence on associations between multiple... 
Brain | CARDIAC & CARDIOVASCULAR SYSTEMS | DEMENTIA | WHITE-MATTER INTEGRITY | MRI | ATROPHY | Cortex | COGNITIVE IMPAIRMENT | White matter | DECLINE | PRESSURE | Vascular risk | DISEASE | Diffusion | AGE | LIFE | Editor's Choice | Fast Track Clinical Research
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5. Full Text Abstracts of the HIV Research for Prevention Meeting, HIVR4P, 21-25 October, 2018, Madrid
AIDS Research and Human Retroviruses, ISSN 0889-2229, 10/2018, Volume 34, Issue S1, pp. 1 - 407
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6. Full Text Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis
by Rhodes, Christopher J and Batai, Ken and Bleda, Marta and Haimel, Matthias and Southgate, Laura and Germain, Marine and Pauciulo, Michael W and Hadinnapola, Charaka and Aman, Jurjan and Girerd, Barbara and Arora, Amit and Knight, Jo and Hanscombe, Ken B and Karnes, Jason H and Kaakinen, Marika and Gall, Henning and Ulrich, Anna and Harbaum, Lars and Cebola, Inês and Ferrer, Jorge and Lutz, Katie and Swietlik, Emilia M and Ahmad, Ferhaan and Amouyel, Philippe and Archer, Stephen L and Argula, Rahul and Austin, Eric D and Badesch, David and Bakshi, Sahil and Barnett, Christopher and Benza, Raymond and Bhatt, Nitin and Bogaard, Harm J and Burger, Charles D and Chakinala, Murali and Church, Colin and Coghlan, John G and Condliffe, Robin and Corris, Paul A and Danesino, Cesare and Debette, Stéphanie and Elliott, C Gregory and Elwing, Jean and Eyries, Melanie and Fortin, Terry and Franke, Andre and Frantz, Robert P and Frost, Adaani and Garcia, Joe G N and Ghio, Stefano and Ghofrani, Hossein-Ardeschir and Gibbs, J Simon R and Harley, John and He, Hua and Hill, Nicholas S and Hirsch, Russel and Houweling, Arjan C and Howard, Luke S and Ivy, Dunbar and Kiely, David G and Klinger, James and Kovacs, Gabor and Lahm, Tim and Laudes, Matthias and Machado, Rajiv D and MacKenzie Ross, Robert V and Marsolo, Keith and Martin, Lisa J and Moledina, Shahin and Montani, David and Nathan, Steven D and Newnham, Michael and Olschewski, Horst and Olschewski, Andrea and Oudiz, Ronald J and Ouwehand, Willem H and Peacock, Andrew J and Pepke-Zaba, Joanna and Rehman, Zia and Robbins, Ivan and Roden, Dan M and Rosenzweig, Erika B and Saydain, Ghulam and Scelsi, Laura and Schilz, Robert and Seeger, Werner and Shaffer, Christian M and Simms, Robert W and Simon, Marc and Sitbon, Olivier and Suntharalingam, Jay and Tang, Haiyang and Tchourbanov, Alexander Y and Thenappan, Thenappan and Torres, Fernando and Toshner, Mark R and Treacy, Carmen M and Vonk Noordegraaf, Anton and Waisfisz, Quinten and Walsworth, Anna K and ... and US PAH Biobank Consortium and UK PAH Cohort Study Consortium and UK NIHR Bioresource Rare Dis Conso and UK NIHR BioResource Rare Diseases Consortium
The Lancet Respiratory Medicine, ISSN 2213-2600, 03/2019, Volume 7, Issue 3, pp. 227 - 238
Rare genetic variants cause pulmonary arterial hypertension, but the contribution of common genetic variation to disease risk and natural history is poorly... 
SOX17 | ENDODERM FORMATION | RESPIRATORY SYSTEM | SUSCEPTIBILITY | DISEASE | ALPHA | CRITICAL CARE MEDICINE | Life Sciences
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7. Full Text Cobalt Catalyst with a Proton‐Responsive Ligand for Water Oxidation
by Siewert, Inke and Gałęzowska, Joanna
Chemistry – A European Journal, ISSN 0947-6539, 02/2015, Volume 21, Issue 7, pp. 2780 - 2784
Herein, we report the synthesis, the thermochemical data, and the catalytic reactivity of a new mononuclear cobalt complex, which has four NH protons in the... 
N ligands | cobalt | electron transfer | water splitting | Electron transfer | Water splitting | Cobalt | DEPROTONATION | IMIDAZOLE COMPLEXES | DIOXYGEN | PYRIDINE | COPPER(II) | STATE | CHEMISTRY, MULTIDISCIPLINARY | HYDROGEN | O-2 | COUPLED ELECTRON-TRANSFER | METAL-COMPLEXES | Oxidation-reduction reaction | Ligands | Synthesis | Catalysts | Electrocatalysts | Joining | Oxidation | Catalysis
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8. Full Text Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy
by James, Nicholas D and de Bono, Johann S and Spears, Melissa R and Clarke, Noel W and Mason, Malcolm D and Dearnaley, David P and Ritchie, Alastair W.S and Amos, Claire L and Gilson, Clare and Jones, Rob J and Matheson, David and Millman, Robin and Attard, Gerhardt and Chowdhury, Simon and Cross, William R and Gillessen, Silke and Parker, Christopher C and Russell, J. Martin and Berthold, Dominik R and Brawley, Chris and Adab, Fawzi and Aung, San and Birtle, Alison J and Bowen, Jo and Brock, Susannah and Chakraborti, Prabir and Ferguson, Catherine and Gale, Joanna and Gray, Emma and Hingorani, Mohan and Hoskin, Peter J and Lester, Jason F and Malik, Zafar I and McKinna, Fiona and McPhail, Neil and Money-Kyrle, Julian and O’Sullivan, Joe and Parikh, Omi and Protheroe, Andrew and Robinson, Angus and Srihari, Narayanan N and Thomas, Carys and Wagstaff, John and Wylie, James and Zarkar, Anjali and Parmar, Mahesh K.B and Sydes, Matthew R and STAMPEDE Investigators
The New England Journal of Medicine, ISSN 0028-4793, 07/2017, Volume 377, Issue 4, pp. 338 - 351
The addition of abiraterone and prednisolone to standard androgen-deprivation therapy as the first treatment for patients with locally advanced or metastatic... 
ZOLEDRONIC ACID | SURVIVAL | MEDICINE, GENERAL & INTERNAL | PLUS PREDNISONE | CONTROL ARM | STAMPEDE TRIAL | OPEN-LABEL | MULTISTAGE | RANDOMIZED CONTROLLED-TRIAL | DOCETAXEL | MULTIARM | Prednisolone - adverse effects | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Prostatic Neoplasms - radiotherapy | Prednisolone - administration & dosage | Prostatic Neoplasms - surgery | Humans | Middle Aged | Abiraterone Acetate - adverse effects | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Neoplasm Recurrence, Local - drug therapy | Male | Prostate-Specific Antigen - blood | Prostatic Neoplasms - mortality | Abiraterone Acetate - administration & dosage | Neoplasm Metastasis - drug therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Survival Analysis | Aged, 80 and over | Adult | Aged | Androgen Antagonists - administration & dosage | Androgen Antagonists - adverse effects | Prostatic Neoplasms - drug therapy | Androgen suppression therapy | Usage | Care and treatment | Prostate cancer | Prednisolone | Medical research | Prostate-specific antigen | Clinical trials | Endocrine therapy | Oncology | Metastasis | Radiation therapy | Cancer therapies | Metastases | Mens health | Androgens | Medical prognosis | Death | Prostate
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