Clinical Infectious Diseases, ISSN 1058-4838, 12/2017, Volume 65, Issue 11, pp. 1884 - 1896
In a prospective study in allogeneic and autologous hematopoietic stem cell transplants the probability of pre-engraftment Gram-negative bacteremia was 17.3%...
epidemiology | multidrug resistance | stem cell transplant | Gram negative bacteremia | survival | MORTALITY | INFECTIOUS DISEASES | BACTERIAL-INFECTIONS | GUIDELINES | RESISTANT KLEBSIELLA-PNEUMONIAE | MICROBIOLOGY | NEUTROPENIC PATIENTS | IMMUNOLOGY | RECIPIENTS | ANTIMICROBIAL RESISTANCE | 4TH EUROPEAN CONFERENCE | BLOOD-STREAM INFECTIONS | Prospective Studies | Age Factors | Humans | Middle Aged | Child, Preschool | Bacteremia - mortality | Infant | Male | Transplantation, Autologous | Gram-Negative Bacteria - isolation & purification | Transplantation, Homologous | Incidence | Bacteremia - microbiology | Young Adult | Drug Resistance, Multiple, Bacterial | Hematopoietic Stem Cell Transplantation - adverse effects | Bacteremia - etiology | Adult | Female | Transplantation Conditioning - adverse effects | Child | Risk Factors | Gram-Negative Bacterial Infections - drug therapy | Escherichia coli - isolation & purification | Adolescent | Gram-Negative Bacterial Infections - epidemiology | Bacteremia - epidemiology | Italy - epidemiology | Aged | Complications and side effects | Usage | Transplantation | Research | Epidemiology | Bacteremia | Risk factors | Hematopoietic stem cells
epidemiology | multidrug resistance | stem cell transplant | Gram negative bacteremia | survival | MORTALITY | INFECTIOUS DISEASES | BACTERIAL-INFECTIONS | GUIDELINES | RESISTANT KLEBSIELLA-PNEUMONIAE | MICROBIOLOGY | NEUTROPENIC PATIENTS | IMMUNOLOGY | RECIPIENTS | ANTIMICROBIAL RESISTANCE | 4TH EUROPEAN CONFERENCE | BLOOD-STREAM INFECTIONS | Prospective Studies | Age Factors | Humans | Middle Aged | Child, Preschool | Bacteremia - mortality | Infant | Male | Transplantation, Autologous | Gram-Negative Bacteria - isolation & purification | Transplantation, Homologous | Incidence | Bacteremia - microbiology | Young Adult | Drug Resistance, Multiple, Bacterial | Hematopoietic Stem Cell Transplantation - adverse effects | Bacteremia - etiology | Adult | Female | Transplantation Conditioning - adverse effects | Child | Risk Factors | Gram-Negative Bacterial Infections - drug therapy | Escherichia coli - isolation & purification | Adolescent | Gram-Negative Bacterial Infections - epidemiology | Bacteremia - epidemiology | Italy - epidemiology | Aged | Complications and side effects | Usage | Transplantation | Research | Epidemiology | Bacteremia | Risk factors | Hematopoietic stem cells
Journal Article
British Journal of Haematology, ISSN 0007-1048, 10/2018, Volume 183, Issue 1, pp. 152 - 155
array CGH | loss of 22q11 | chronic lymphocytic leukaemia | PRAME GENE | CHRONIC LYMPHOCYTIC-LEUKEMIA | COMPARATIVE GENOMIC HYBRIDIZATION | ABERRATIONS | HEMATOLOGY | CYTOGENETICS | EXPRESSION | Chromosome Deletion | Humans | Middle Aged | In Situ Hybridization, Fluorescence | Male | Comparative Genomic Hybridization - methods | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - classification | Chromosome Aberrations | Aged, 80 and over | Female | Aged | Chromosomes, Human, Pair 22 | Karyotype | Cytogenetics | Genetic research | Chromosomes | Analysis | Leukemia | Deletion | Chromosome 22 | Chronic lymphatic leukemia | Chromosome deletion | Clonal deletion
Journal Article
American Journal of Hematology, ISSN 0361-8609, 06/2017, Volume 92, Issue 6, pp. 529 - 535
We hereby report the clinical and biologic features of 33 of 4680 (0.7%) patients with chronic lymphocytic leukemia (CLL), managed at 10 Italian centers, who...
B-CELL LYMPHOMA | WORKING-GROUP | CLL | RISK-FACTORS | PROGNOSTIC-FACTORS | MODERN-ERA | DISEASE | RETROSPECTIVE ANALYSIS | HEMATOLOGY | EPSTEIN-BARR-VIRUS | STERNBERG CELLS | Doxorubicin - therapeutic use | Prognosis | Dacarbazine - therapeutic use | Humans | Middle Aged | Male | Neoplasms, Second Primary - mortality | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Vinblastine - therapeutic use | Hodgkin Disease - etiology | Bleomycin - therapeutic use | Aged, 80 and over | Hodgkin Disease - drug therapy | Hodgkin Disease - mortality | Adult | Female | Retrospective Studies | Risk Factors | Hodgkin Disease - diagnosis | Treatment Outcome | Combined Modality Therapy - adverse effects | Remission Induction | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Neoplasms, Second Primary - diagnosis | Neoplasms, Second Primary - etiology | Leukemia, Lymphocytic, Chronic, B-Cell - therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Combined Modality Therapy - methods | Leukemia, Lymphocytic, Chronic, B-Cell - mortality | Mutation | Neoplasms, Second Primary - drug therapy | Immunoglobulin Heavy Chains - genetics | Medicine, Experimental | Medical research | Chronic lymphocytic leukemia | Lymphomas | Patient outcomes
B-CELL LYMPHOMA | WORKING-GROUP | CLL | RISK-FACTORS | PROGNOSTIC-FACTORS | MODERN-ERA | DISEASE | RETROSPECTIVE ANALYSIS | HEMATOLOGY | EPSTEIN-BARR-VIRUS | STERNBERG CELLS | Doxorubicin - therapeutic use | Prognosis | Dacarbazine - therapeutic use | Humans | Middle Aged | Male | Neoplasms, Second Primary - mortality | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Vinblastine - therapeutic use | Hodgkin Disease - etiology | Bleomycin - therapeutic use | Aged, 80 and over | Hodgkin Disease - drug therapy | Hodgkin Disease - mortality | Adult | Female | Retrospective Studies | Risk Factors | Hodgkin Disease - diagnosis | Treatment Outcome | Combined Modality Therapy - adverse effects | Remission Induction | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Neoplasms, Second Primary - diagnosis | Neoplasms, Second Primary - etiology | Leukemia, Lymphocytic, Chronic, B-Cell - therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Combined Modality Therapy - methods | Leukemia, Lymphocytic, Chronic, B-Cell - mortality | Mutation | Neoplasms, Second Primary - drug therapy | Immunoglobulin Heavy Chains - genetics | Medicine, Experimental | Medical research | Chronic lymphocytic leukemia | Lymphomas | Patient outcomes
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 1990 - 1990
Abstract INTRODUCTION: Twice weekly carfilzomib is approved at two different doses, 27 mg/m2 in combination with lenalidomide and dexamethasone, and 56 mg/m2...
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 3240 - 3240
Abstract INTRODUCTION: High-risk cytogenetic abnormalities, such as del(17p), t(4;14), and/or t(14;16), are associated to an unfavorable prognosis. Several...
Journal Article
Annals of Hematology, ISSN 0939-5555, 06/2010, Volume 89, Issue 6, pp. 591 - 596
Therapeutic plasma exchange (PE) is the accepted therapy for thrombotic thrombocytopenic purpura (TTP). Because not all patients achieve remission, other...
Thrombocytopenia | Plasma exchange | TTP | Steroids | HEMOLYTIC-UREMIC SYNDROME | ANTI-ADAMTS13 ANTIBODIES | CLEAVING PROTEASE | PROGNOSTIC VALUE | TRIAL | PLASMA-EXCHANGE | ADAMTS13 ACTIVITY | CRYOSUPERNATANT | HEMATOLOGY | CYCLOSPORINE | REMISSION | Humans | Middle Aged | Male | Treatment Outcome | Purpura, Thrombocytopenic, Idiopathic - mortality | Purpura, Thrombocytopenic, Idiopathic - drug therapy | Dose-Response Relationship, Drug | Acute-Phase Reaction - drug therapy | Purpura, Thrombocytopenic, Idiopathic - immunology | Survival Analysis | Adult | Anti-Inflammatory Agents - administration & dosage | Female | Acute-Phase Reaction - mortality | Methylprednisolone - administration & dosage | Thrombocytopenic purpura | Corticosteroids | Clinical trials | Respiratory tract diseases | Dosage and administration | Methylprednisolone | Standards
Thrombocytopenia | Plasma exchange | TTP | Steroids | HEMOLYTIC-UREMIC SYNDROME | ANTI-ADAMTS13 ANTIBODIES | CLEAVING PROTEASE | PROGNOSTIC VALUE | TRIAL | PLASMA-EXCHANGE | ADAMTS13 ACTIVITY | CRYOSUPERNATANT | HEMATOLOGY | CYCLOSPORINE | REMISSION | Humans | Middle Aged | Male | Treatment Outcome | Purpura, Thrombocytopenic, Idiopathic - mortality | Purpura, Thrombocytopenic, Idiopathic - drug therapy | Dose-Response Relationship, Drug | Acute-Phase Reaction - drug therapy | Purpura, Thrombocytopenic, Idiopathic - immunology | Survival Analysis | Adult | Anti-Inflammatory Agents - administration & dosage | Female | Acute-Phase Reaction - mortality | Methylprednisolone - administration & dosage | Thrombocytopenic purpura | Corticosteroids | Clinical trials | Respiratory tract diseases | Dosage and administration | Methylprednisolone | Standards
Journal Article
Blood, ISSN 0006-4971, 09/2011, Volume 118, Issue 12, pp. 3419 - 3425
We designed a phase 1-2 study to evaluate the safety and the efficacy of increasing doses of bendamustine (160 mg/m(2), 180 mg/m2, and 200 mg/m2 given on days...
EVERY 3 WEEKS | CONVENTIONAL CHEMOTHERAPY | B-CELL | SOLID TUMORS | BONE-MARROW-TRANSPLANTATION | REGIMEN-RELATED TOXICITY | NON-HODGKINS-LYMPHOMA | COMBINATION CHEMOTHERAPY | HIGH-DOSE CHEMOTHERAPY | PHASE-II MULTICENTER | HEMATOLOGY | Lymphoma, Non-Hodgkin - immunology | Recurrence | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Follow-Up Studies | Cytarabine - therapeutic use | Hodgkin Disease - pathology | Nitrogen Mustard Compounds - administration & dosage | Humans | Middle Aged | Drug Resistance, Neoplasm | Male | Transplantation, Autologous | Melphalan - therapeutic use | Lymphoma, Non-Hodgkin - pathology | Nitrogen Mustard Compounds - therapeutic use | Adult | Female | Transplantation Conditioning - methods | Hematopoietic Stem Cell Transplantation | Etoposide - administration & dosage | Etoposide - therapeutic use | Graft Survival | Remission Induction | Cytarabine - administration & dosage | Melphalan - administration & dosage | Bendamustine Hydrochloride | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Lymphoma, Non-Hodgkin - therapy | Hodgkin Disease - therapy | Hodgkin Disease - immunology | Aged | Salvage Therapy - methods
EVERY 3 WEEKS | CONVENTIONAL CHEMOTHERAPY | B-CELL | SOLID TUMORS | BONE-MARROW-TRANSPLANTATION | REGIMEN-RELATED TOXICITY | NON-HODGKINS-LYMPHOMA | COMBINATION CHEMOTHERAPY | HIGH-DOSE CHEMOTHERAPY | PHASE-II MULTICENTER | HEMATOLOGY | Lymphoma, Non-Hodgkin - immunology | Recurrence | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Follow-Up Studies | Cytarabine - therapeutic use | Hodgkin Disease - pathology | Nitrogen Mustard Compounds - administration & dosage | Humans | Middle Aged | Drug Resistance, Neoplasm | Male | Transplantation, Autologous | Melphalan - therapeutic use | Lymphoma, Non-Hodgkin - pathology | Nitrogen Mustard Compounds - therapeutic use | Adult | Female | Transplantation Conditioning - methods | Hematopoietic Stem Cell Transplantation | Etoposide - administration & dosage | Etoposide - therapeutic use | Graft Survival | Remission Induction | Cytarabine - administration & dosage | Melphalan - administration & dosage | Bendamustine Hydrochloride | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Lymphoma, Non-Hodgkin - therapy | Hodgkin Disease - therapy | Hodgkin Disease - immunology | Aged | Salvage Therapy - methods
Journal Article
Blood, ISSN 0006-4971, 03/2012, Volume 119, Issue 10, pp. 2310 - 2313
It is unclear whether karyotype aberrations that occur in regions uncovered by the standard fluorescence in situ hybridization (FISH) panel have prognostic...
Prognosis | Mitogens - pharmacology | Humans | Middle Aged | Male | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Metaphase - drug effects | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Karyotyping - methods | Metaphase - genetics | Oligonucleotides - pharmacology | Chromosome Aberrations | Survival Analysis | Aged, 80 and over | Interleukin-2 - pharmacology | Adult | Female | Aged | In Situ Hybridization, Fluorescence - methods | Karyotype | Cohort Studies
Prognosis | Mitogens - pharmacology | Humans | Middle Aged | Male | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Metaphase - drug effects | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Karyotyping - methods | Metaphase - genetics | Oligonucleotides - pharmacology | Chromosome Aberrations | Survival Analysis | Aged, 80 and over | Interleukin-2 - pharmacology | Adult | Female | Aged | In Situ Hybridization, Fluorescence - methods | Karyotype | Cohort Studies
Journal Article
HAEMATOLOGICA, ISSN 0390-6078, 07/2019, Volume 104, Issue 8, pp. 1640 - 1647
Twice-weekly carfilzomib is approved at 27 and 56 mg/m(2) to treat relapsed multiple myeloma patients. In the phase III study ARROW, once-weekly 70 mg/m(2)...
SURVIVAL | MULTICENTER | PHASE 1/2 | CYCLOPHOSPHAMIDE | LENALIDOMIDE | RISK | OPEN-LABEL | BORTEZOMIB | HEMATOLOGY | LOW-DOSE DEXAMETHASONE | Index Medicus
SURVIVAL | MULTICENTER | PHASE 1/2 | CYCLOPHOSPHAMIDE | LENALIDOMIDE | RISK | OPEN-LABEL | BORTEZOMIB | HEMATOLOGY | LOW-DOSE DEXAMETHASONE | Index Medicus
Journal Article
Therapeutic Advances in Medical Oncology, ISSN 1758-8340, 1/2017, Volume 9, Issue 1, pp. 22 - 32
Background: Many patients with solid tumours or nonmyeloid haematopoietic tumours develop symptomatic anaemia, which has a major impact on quality of life...
epoetin alfa | erythropoiesis-stimulating agents | biosimilar | chemotherapy-induced anaemia | erythropoietin | HEMOGLOBIN | CHEMOTHERAPY-INDUCED ANEMIA | SAFETY | GUIDELINES | PATTERNS | CANCER-TREATMENT ACT | EUROPE | ONCOLOGY | OUTCOMES | Original Research
epoetin alfa | erythropoiesis-stimulating agents | biosimilar | chemotherapy-induced anaemia | erythropoietin | HEMOGLOBIN | CHEMOTHERAPY-INDUCED ANEMIA | SAFETY | GUIDELINES | PATTERNS | CANCER-TREATMENT ACT | EUROPE | ONCOLOGY | OUTCOMES | Original Research
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 121 - 121
Abstract Background: Proteasome inhibitor (PI)-based induction and consolidation proved to be effective in newly diagnosed multiple myeloma (NDMM) patients...
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 3235 - 3235
Abstract Introduction Multiple myeloma (MM) can be associated with paraskeletal (PP) or extramedullary (EMP) plasmocytomas (PL). Although PLs are relatively...
Journal Article
Blood, ISSN 0006-4971, 11/2014, Volume 124, Issue 19, pp. 3029 - 3031
HODGKINS-LYMPHOMA | THERAPY | HEMATOLOGY | RITUXIMAB | TRANSPLANTATION | Cytarabine - therapeutic use | Humans | Drug Resistance, Neoplasm | Transplantation, Autologous | Combined Modality Therapy | Melphalan - therapeutic use | Antineoplastic Agents, Alkylating - therapeutic use | Antimetabolites, Antineoplastic - therapeutic use | Bendamustine Hydrochloride | Nitrogen Mustard Compounds - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Hematopoietic Stem Cell Transplantation - methods | Lymphoma, Non-Hodgkin - drug therapy
Journal Article
14.
Nongastrointestinal low-grade mucosa-associated lymphoid tissue lymphoma: Analysis of 75 patients
Journal of Clinical Oncology, ISSN 0732-183X, 04/1999, Volume 17, Issue 4, pp. 1254 - 1258
Purpose: Nongastrointestinal locations represent about 30% to 40% of all low-grade mucosa-associated lymphoid tissue (MALT) lymphomas. We report a...
B-CELL LYMPHOMA | HEPATITIS-C VIRUS | NEOPLASMS | ONCOLOGY | NON-HODGKINS-LYMPHOMAS | MYOEPITHELIAL SIALADENITIS | CONJUNCTIVA | SALIVARY-GLANDS | HELICOBACTER-PYLORI | GASTRIC LYMPHOMA | MALT LYMPHOMA | Prognosis | Humans | Middle Aged | Interferon-alpha - therapeutic use | Lymphoma, B-Cell, Marginal Zone - therapy | Male | Survival Rate | Antineoplastic Agents - therapeutic use | Combined Modality Therapy | Lymphoma, B-Cell, Marginal Zone - mortality | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged, 80 and over | Adult | Female | Aged | Retrospective Studies
B-CELL LYMPHOMA | HEPATITIS-C VIRUS | NEOPLASMS | ONCOLOGY | NON-HODGKINS-LYMPHOMAS | MYOEPITHELIAL SIALADENITIS | CONJUNCTIVA | SALIVARY-GLANDS | HELICOBACTER-PYLORI | GASTRIC LYMPHOMA | MALT LYMPHOMA | Prognosis | Humans | Middle Aged | Interferon-alpha - therapeutic use | Lymphoma, B-Cell, Marginal Zone - therapy | Male | Survival Rate | Antineoplastic Agents - therapeutic use | Combined Modality Therapy | Lymphoma, B-Cell, Marginal Zone - mortality | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged, 80 and over | Adult | Female | Aged | Retrospective Studies
Journal Article
British Journal of Haematology, ISSN 0007-1048, 08/2015, Volume 170, Issue 4, pp. 523 - 531
Summary Detection of circulating plasma cells (PCs) in multiple myeloma (MM) patients is a well‐known prognostic factor. We evaluated circulating PCs by flow...
multiple myeloma | flow cytometry | cytogenetic‐risk | prognostic factors | circulating plasma cells | Flow cytometry | Cytogenetic-risk | Circulating plasma cells | Prognostic factors | Multiple myeloma | SURVIVAL | PREDICTOR | QUANTIFICATION | BONE-MARROW | DISORDERS | PERIPHERAL-BLOOD | TRANSPLANTATION | cytogenetic-risk | FLOW-CYTOMETRY | HEMATOLOGY | MINIMAL RESIDUAL DISEASE | STRATIFICATION | Multiple Myeloma - diagnosis | Multiple Myeloma - mortality | Humans | Middle Aged | Male | Survival Rate | Plasma Cells - pathology | Biomarkers, Tumor - blood | Disease-Free Survival | Multiple Myeloma - pathology | Multiple Myeloma - therapy | Aged, 80 and over | Cytogenetics | Female | Plasma Cells - metabolism | Aged | Multiple Myeloma - blood | Care and treatment | Genetic aspects | Prognosis | Cancer
multiple myeloma | flow cytometry | cytogenetic‐risk | prognostic factors | circulating plasma cells | Flow cytometry | Cytogenetic-risk | Circulating plasma cells | Prognostic factors | Multiple myeloma | SURVIVAL | PREDICTOR | QUANTIFICATION | BONE-MARROW | DISORDERS | PERIPHERAL-BLOOD | TRANSPLANTATION | cytogenetic-risk | FLOW-CYTOMETRY | HEMATOLOGY | MINIMAL RESIDUAL DISEASE | STRATIFICATION | Multiple Myeloma - diagnosis | Multiple Myeloma - mortality | Humans | Middle Aged | Male | Survival Rate | Plasma Cells - pathology | Biomarkers, Tumor - blood | Disease-Free Survival | Multiple Myeloma - pathology | Multiple Myeloma - therapy | Aged, 80 and over | Cytogenetics | Female | Plasma Cells - metabolism | Aged | Multiple Myeloma - blood | Care and treatment | Genetic aspects | Prognosis | Cancer
Journal Article
Blood, ISSN 0006-4971, 12/2014, Volume 124, Issue 21, pp. 3353 - 3353
Abstract Multiple Myeloma (MM) is a clonal B-cell disorder characterized by accumulation of malignant plasma cells (PCs) in the bone marrow (BM). Circulating...
Journal Article
Blood, ISSN 0006-4971, 12/2015, Volume 126, Issue 23, pp. 1828 - 1828
Abstract Background Carfilzomib is a novel second generation proteasome-inhibitor with significant anti-MM activity and favorable toxicity profile. In a recent...
Journal Article
American Journal of Hematology, ISSN 0361-8609, 06/2017, Volume 92, Issue 6, pp. 529 - 535
Journal Article