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Journal Article
International Journal of Cancer, ISSN 0020-7136, 03/2012, Volume 130, Issue 6, pp. 1357 - 1366
The MET oncogene is amplified in a fraction of human gastric carcinoma cell lines, with consequent overexpression and constitutive activation of the... 
oncogene addiction | surrogate biomarkers | targeted therapies | Met receptor | CARCINOMA CELLS | NECROSIS-FACTOR-ALPHA | PLASMINOGEN-ACTIVATOR RECEPTOR | INTERLEUKIN-8 | IN-VITRO | ONCOLOGY | AUTOCRINE GROWTH-FACTOR | C-MET | PROSTATE-CANCER | UROKINASE RECEPTOR | CELL-LINE | Mannose-Binding Lectins - metabolism | Proto-Oncogene Proteins c-met - metabolism | Interleukin-8 - genetics | Membrane Glycoproteins - metabolism | Humans | Stomach Neoplasms - metabolism | Chemokine CXCL1 - genetics | Gene Expression Profiling | Sulfones - pharmacology | Interleukin-6 - blood | Biomarkers, Tumor - metabolism | Female | Indoles - pharmacology | Interleukin-8 - metabolism | Chemokine CXCL1 - metabolism | Interleukin-8 - blood | Interleukin-6 - metabolism | Stomach Neoplasms - genetics | Interleukin-6 - genetics | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Membrane Glycoproteins - blood | Receptors, Cell Surface - metabolism | Receptors, Cell Surface - blood | Chemokine CXCL1 - blood | Stomach Neoplasms - drug therapy | Membrane Glycoproteins - genetics | Proto-Oncogene Proteins c-met - genetics | Biomarkers, Tumor - blood | Xenograft Model Antitumor Assays | Animals | Mannose-Binding Lectins - genetics | Mannose-Binding Lectins - blood | Stomach Neoplasms - blood | Mice, Nude | Proteomics | Cell Line, Tumor | Biomarkers, Tumor - genetics | Mice | Receptors, Cell Surface - genetics | Biomarkers | Kinases | Gene expression | Tumors | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2006, Volume 103, Issue 44, pp. 16454 - 16459
JNKs are attractive targets for treatment of obesity and type-2 diabetes. A sustained increase in JNK activity was observed in dietary and genetic models of... 
Obesity | Phosphorylation | Hepatocytes | Liver | Genes | Nonesterified fatty acids | Insulin resistance | Diabetes | Insulin | Fatty acids | Insulin gene expression | Lipotoxicity | RAT-LIVER | ACTIVATION | insulin gene expression | IRS-1 | MULTIDISCIPLINARY SCIENCES | KINASE | GLUCOSE | lipotoxicity | RESISTANCE | PANCREATIC BETA-CELLS | C-JUN | diabetes | EXPRESSION | obesity | Palmitic Acid - pharmacology | Humans | Substrate Specificity | Male | Intracellular Signaling Peptides and Proteins - metabolism | Hepatocytes - metabolism | Phosphoproteins - metabolism | Phosphoproteins - chemistry | Insulin Receptor Substrate Proteins | Mitogen-Activated Protein Kinase 8 - genetics | Insulin - genetics | Fatty Acids - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Hepatocytes - drug effects | Amino Acid Sequence | Mitogen-Activated Protein Kinase 8 - metabolism | Cells, Cultured | Gene Expression Regulation | Insulin Resistance | Rats | Phosphoproteins - genetics | Obesity - metabolism | Mitogen-Activated Protein Kinase 8 - deficiency | Insulin - metabolism | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Mice | Enzyme Activation | Transcription, Genetic - genetics | Blood Glucose - metabolism | Receptors | Usage | Genetic transformation | Research | Genetic regulation | Gene expression | Binding sites | Index Medicus | Biological Sciences | Medicinska grundvetenskaper | Basic Medicine
Journal Article
Cancer Discovery, ISSN 2159-8274, 11/2011, Volume 1, Issue 6, pp. 508 - 523
Journal Article
Journal Article
Cell Reports, ISSN 2211-1247, 10/2014, Volume 7, Issue 1, pp. 86 - 93
Journal Article
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 08/2014, Volume 111, Issue 32, pp. E3343 - E3352
Glial cells are an integral part of functional communication in the brain. Here we show that astrocytes contribute to the fast dynamics of neural circuits that... 
Network oscillation | Gliotransmitter | Electroencephalogram | Glia | Glial fibrillary acidic protein | network oscillation | TRIAL OBJECT RECOGNITION | LENTIVIRUS VECTOR | MULTIDISCIPLINARY SCIENCES | CRE RECOMBINASE | gliotransmitter | glia | electroencephalogram | SYNAPTIC-LIKE MICROVESICLES | DEPENDENT GLUTAMATE RELEASE | NETWORK OSCILLATIONS | D-SERINE | IN-VIVO | CHOLINERGIC INDUCTION | glial fibrillary acidic protein | TRANSGENIC MICE | Metalloendopeptidases - genetics | Metalloendopeptidases - metabolism | Electroencephalography | Hippocampus - drug effects | Nerve Net - physiology | Recognition (Psychology) - physiology | Synaptic Transmission | Nerve Net - cytology | Tetanus Toxin - genetics | Brain Waves - drug effects | Glutamic Acid - secretion | Calcium Signaling | Recombinant Proteins - metabolism | Astrocytes - drug effects | Brain Waves - physiology | Gene Expression | Tissue Culture Techniques | Mice, Inbred C57BL | Mice, Transgenic | Recombinant Proteins - genetics | Hippocampus - cytology | Carbachol - pharmacology | Astrocytes - physiology | Animals | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology | Mice | Models, Neurological | Hippocampus - physiology | Tetanus Toxin - metabolism | Brain | Memory | Rodents | Information processing | Cells | Animal cognition | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 05/2012, Volume 18, Issue 9, pp. 2515 - 2525
Purpose: Gene mutations along the Ras pathway (KRAS, NRAS, BRAF, PIK3CA) occur in approximately 50% of colorectal cancers (CRC) and correlate with poor... 
1ST-LINE TREATMENT | CETUXIMAB | LEUCOVORIN | MTOR INHIBITION | ONCOLOGY | WILD-TYPE BRAF | KRAS | MONOCLONAL-ANTIBODIES | FLUOROURACIL | CANCER | CHEMOTHERAPY | TOR Serine-Threonine Kinases - metabolism | Rectum - pathology | Humans | Middle Aged | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Case-Control Studies | Immunoenzyme Techniques | 1-Phosphatidylinositol 4-Kinase - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinase Kinases - metabolism | Aged, 80 and over | Female | Liver Neoplasms - secondary | Colorectal Neoplasms - metabolism | Proto-Oncogene Proteins B-raf - metabolism | Liver Neoplasms - prevention & control | Colon - pathology | Rectum - metabolism | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Colorectal Neoplasms - prevention & control | 1-Phosphatidylinositol 4-Kinase - antagonists & inhibitors | Mice, SCID | Mutation - genetics | Colon - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Liver Neoplasms - metabolism | Cell Line, Tumor | Mice, Inbred NOD | Aged | Mice | Protein Kinase Inhibitors - pharmacology | Colorectal Neoplasms - pathology | Genes, ras | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 05/2011, Volume 17, Issue 10, pp. 3146 - 3156
Journal Article