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Molecules, ISSN 1420-3049, 05/2019, Volume 24, Issue 10, p. 1959
A novel one-pot multicomponent reaction to synthesize substituted imidazopyrazines is described. In brief, 1H-(imidazol-5-yl)-N-substituted methanamines react... 
Isocyanides | Multicomponent reactions | Interrupted Ugi reactions | multicomponent reactions | interrupted Ugi reactions | isocyanides | MECHANISM | IMINES | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGY | CHEMISTRY | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | REVEALS
Journal Article
Journal of Organic Chemistry, ISSN 0022-3263, 07/2014, Volume 79, Issue 13, pp. 6006 - 6014
(Z)-Arylchlorooximes and α-isocyanoacetamides undergo a smooth reaction to produce 1,3-oxazol-2-oxime derivatives in good yields. Opening of the oxazole ring... 
Oximes - chemistry | Oxazoles - chemical synthesis | Amides - chemical synthesis | Nitriles - chemistry | Amides - chemistry | Molecular Structure | Catalysis | Oximes - chemical synthesis | Oxazoles - chemistry | Oxo compounds | Amides | Chemical properties | Research
Journal Article
Cancer Research, ISSN 0008-5472, 08/2015, Volume 75, Issue 15 Supplement, pp. 393 - 393
Journal Article
Symmetry, ISSN 2073-8994, 06/2019, Volume 11, Issue 6, p. 798
Since the first reports, the Ugi four-component reaction (U-4CR) has been recognized as a keystone transformation enabling the synthesis of peptide mimetics in... 
α-amino acids | Multicomponent reactions | Ugi four-component reaction | Isocyanides | SUBSTRATE SCOPE | DMAP DERIVATIVES | MULTICOMPONENT CASCADE REACTIONS | MULTIDISCIPLINARY SCIENCES | 4-COMPONENT REACTION | EFFICIENT SYNTHESIS | UGI REACTION | THIOLACTONE SCAFFOLD | isocyanides | FACILE SYNTHESIS | alpha-amino acids | MORPHOLIN-2-ONE DERIVATIVES
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2019, Volume 181, p. 111576
The enzyme nicotinamide phosphoribosyltransferase is both a key intracellular enzyme for NAD biosynthesis (iNAMPT) and an extracellular cytokine (eNAMPT). The... 
NAD | Inhibitors | Click chemistry | Nicotinamide phosphoribosyltransferase | Cancer
Journal Article
Journal of Pharmaceutical and Biomedical Analysis, ISSN 0731-7085, 09/2019, Volume 173, pp. 154 - 161
In , the most efficient vector of the malaria parasite , 3-hydroxykynurenine is endowed with a toxic potential. In adult mosquitoes, the excess of... 
LC-MS/MS | Anopheles gambiae | Enzyme assay | Ag-HKT | Kynurenine pathway | TRYPTOPHAN | CHEMISTRY, ANALYTICAL | MOSQUITOS | XANTHURENIC ACID | IDENTIFICATION | MALARIA | PHARMACOLOGY & PHARMACY | HPLC | Enzymes | Anopheles | Malaria | Analysis | Formic acid | Physiological aspects | Mass spectrometry | Methods | Organic acids
Journal Article
Methods in molecular biology (Clifton, N.J.), 2019, Volume 1987, p. 207
Multicomponent transformations, such as Ugi and Passerini reactions, allow for the fast synthesis of libraries of medium complexity, avoiding the formation of... 
Journal Article
Journal of Organic Chemistry, ISSN 0022-3263, 11/2016, Volume 81, Issue 22, pp. 11467 - 11471
Old multicomponent reactions are still a source of inspiration for discovering novel combinations of three or more reactants. A simple idea is to replace one... 
CHEMISTRY, ORGANIC | HINDERED AMINES | ANALOGS | ISOMALYNGAMIDE | 3-COMPONENT REACTION | Isocyanates | Phenols | Chemical properties | Research | Chemical synthesis
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2018, Volume 61, Issue 21, pp. 9756 - 9783
In recent years, channels that mediate store-operated calcium entry (SOCE, i.e., the ability of cells to sense a decrease in endoplasmic reticulum luminal... 
CHEMISTRY, MEDICINAL | 2-AMINOETHOXYDIPHENYL BORATE | CYTOKINE PRODUCTION | CLICK CHEMISTRY | STIM PROTEINS | DRUG DISCOVERY | ACTIVATED CA2+ CHANNELS | ORAI1 | RELEASE | INHIBITORS | CRAC CHANNELS
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 04/2019, Volume 79, Issue 8, pp. 1938 - 1951
Cancer induces alteration of hematopoiesis to fuel disease progression. We report that in tumor-bearing mice the macrophage colony-stimulating factor elevates... 
SUBPOPULATIONS | ONCOLOGY | CHEMOKINE RECEPTOR CXCR4 | MACROPHAGES | RETENTION | NAMPT | DIFFERENTIATION | IDENTIFICATION | HYPOXIA | POLARIZATION | TUMORS
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 09/2017, Volume 58, Issue 36, pp. 3549 - 3553
A library of twenty variously decorated 1,5-disubstituted-(1 -tetrazol-5-yl)methanone oximes was prepared in one single synthetic step exploiting the... 
(1H-Tetrazol-5-yl)methanone oximes | [3+1] cycloaddition | Multicomponent reactions | Z-Chlorooximes | Isocyanides | 3-COMPONENT REACTION | ONE-POT | CHEMISTRY | CHEMISTRY, ORGANIC | Chemical tests and reagents | Oxides
Journal Article
Cancer Research, ISSN 0008-5472, 04/2012, Volume 72, Issue 8 Supplement, pp. 5146 - 5146
Journal Article
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 09/2011, Volume 338, Issue 3, pp. 829 - 840
Journal Article
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