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NATURE COMMUNICATIONS, ISSN 2041-1723, 07/2019, Volume 10, Issue 1, pp. 3280 - 14
Somatic mutations in the mitochondrial genome (mtDNA) have been linked to multiple disease conditions and to ageing itself. In Drosophila, knock-in of a... 
POINT MUTATIONS | STRANDED-DNA | STAGE | MULTIDISCIPLINARY SCIENCES | DISEASE | MODEL | MELANOGASTER | DELETIONS | DNA MUTATIONS | GENOME | MOLECULAR-MECHANISMS | Phenotypes | Drosophila | Genomes | Mitochondrial DNA | Polymerase | Mitochondria | Depletion | Insects | Proofreading | Heteroplasmy | Aging | Mutation | Fitness | Cytidine deaminase | Index Medicus
Journal Article
ISSN 0168-9525, 2018
In recent years, mitochondrial DNA has transitioned to greater prominence throughout diverse areas of biology and medicine. The recognition of mitochondria as... 
Journal Article
Nucleic acids research, ISSN 0305-1048, 01/2016, Volume 44, Issue 2, pp. 992 - 992
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 01/2016, Volume 44, Issue 2, p. 992
Journal Article
Nature communications, ISSN 2041-1723, 04/2018, Volume 9, Issue 1, p. 1727
Journal Article
NUCLEIC ACIDS RESEARCH, ISSN 0305-1048, 01/2016, Volume 44, Issue 2, pp. 992 - 992
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1867, pp. 43 - 56
As a platform capable of mtDNA heteroplasmy manipulation, mitochondrially targeted zinc-finger nuclease (mtZFN) technology holds significant potential for the... 
mTUNE | Heteroplasmy | mtDNA | Genetic engineering | Gene therapy | Mitochondrial disease | mtZFN | Index Medicus
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 04/2014, Volume 6, Issue 4, pp. 458 - 466
We designed and engineered mitochondrially targeted obligate heterodimeric zinc finger nucleases (mtZFNs) for site‐specific elimination of pathogenic human... 
Disease | Retinitis pigmentosa | Genomes | Mitochondrial DNA | Neuropathy | Gene deletion | Design | Mitochondria | Clonal deletion | Ataxia | Zinc finger proteins | Nuclease | Pancreas | Localization | Deoxyribonucleic acid--DNA | Enzymes | Phenotypes | Immunoglobulins | Repopulation | Heteroplasmy | Point mutation | Ophthalmoplegia | Retinitis | Mutation | Electron transport
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1 - 11
Emerging gene therapy approaches that aim to eliminate pathogenic mutations of mitochondrial DNA (mtDNA) rely on efficient degradation of linearized mtDNA, but... 
APOPTOSIS | REPAIR | SINGLE | GENOMES | MULTIDISCIPLINARY SCIENCES | POLYMERASE GAMMA | ELIMINATION | MUTATIONS | ACCUMULATION | DELETIONS | STRAND BREAKS | Deactivation | DNA polymerase | Mitochondrial DNA | Inactivation | FEN1 protein | Degradation | DNA helicase | Polymerase | Exonuclease | MRE11 protein | Replication | Mutation | Gene therapy | Endonuclease | Deoxyribonucleic acid--DNA | DNA-directed DNA polymerase | Linearization | Index Medicus
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1867, pp. 215 - 228
Mitochondrial diseases often result from mutations in the mitochondrial genome (mtDNA). In most cases, mutant mtDNA coexists with wild-type mtDNA, resulting in... 
In vitro transcription | Micromanipulation | Mitochondrial disease | mtZFN | Germline | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 11/2018, Volume 24, Issue 11, pp. 1691 - 1695
Journal Article
ISSN 1097-2765, 2018
The bioenergetics and molecular determinants of the metabolic response to mitochondrial dysfunction are incompletely understood, in part due to a lack of... 
Journal Article
Molecular Cell, ISSN 1097-2765, 02/2018, Volume 69, Issue 4, pp. 581 - 593.e7
Journal Article
ISSN 0006-8950, 2018
The m.1555A>G mitochondrial DNA variant causes maternally inherited deafness, but the reasons for the highly variable clinical penetrance are not known. Exome... 
Journal Article
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