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1. Full Text Glecaprevir–Pibrentasvir for 8 or 12 Weeks in HCV Genotype 1 or 3 Infection
by Zeuzem, Stefan and Foster, Graham R and Wang, Stanley and Asatryan, Armen and Gane, Edward and Feld, Jordan J and Asselah, Tarik and Bourlière, Marc and Ruane, Peter J and Wedemeyer, Heiner and Pol, Stanislas and Flisiak, Robert and Poordad, Fred and Chuang, Wan-Long and Stedman, Catherine A and Flamm, Steven and Kwo, Paul and Dore, Gregory J and Sepulveda-Arzola, Gladys and Roberts, Stuart K and Soto-Malave, Ruth and Kaita, Kelly and Puoti, Massimo and Vierling, John and Tam, Edward and Vargas, Hugo E and Bruck, Rafi and Fuster, Francisco and Paik, Seung-Woon and Felizarta, Franco and Kort, Jens and Fu, Bo and Liu, Ran and Ng, Teresa I and Pilot-Matias, Tami and Lin, Chih-Wei and Trinh, Roger and Mensa, Federico J
The New England journal of medicine, ISSN 0028-4793, 01/2018, Volume 378, Issue 4, pp. 354 - 369
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Quinoxalines - adverse effects | Humans | Middle Aged | Hepacivirus - genetics | Hepatitis C, Chronic - virology | Male | RNA, Viral - blood | Viral Load | Aged, 80 and over | Adult | Female | Imidazoles - therapeutic use | Sofosbuvir - adverse effects | Benzimidazoles - adverse effects | Benzimidazoles - therapeutic use | Quinoxalines - therapeutic use | Sofosbuvir - therapeutic use | Drug Administration Schedule | Antiviral Agents - therapeutic use | Imidazoles - adverse effects | Genotype | Hepatitis C, Chronic - drug therapy | Sulfonamides - therapeutic use | Antiviral Agents - adverse effects | Sulfonamides - adverse effects | Aged | Drug Combinations | Antiviral agents | Care and treatment | Dosage and administration | Research | Hepatitis C | Medicine | Cirrhosis | Genotype & phenotype | Hepatitis | Clinical trials | Infections | Interferon | Patients | Genotypes | Index Medicus | Abridged Index Medicus
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2. Full Text Inotersen Treatment for Patients with Hereditary Transthyretin Amyloidosis
by Benson, Merrill D and Waddington-Cruz, Márcia and Berk, John L and Polydefkis, Michael and Dyck, Peter J and Wang, Annabel K and Planté-Bordeneuve, Violaine and Barroso, Fabio A and Merlini, Giampaolo and Obici, Laura and Scheinberg, Morton and Brannagan, Thomas H and Litchy, William J and Whelan, Carol and Drachman, Brian M and Adams, David and Heitner, Stephen B and Conceição, Isabel and Schmidt, Hartmut H and Vita, Giuseppe and Campistol, Josep M and Gamez, Josep and Gorevic, Peter D and Gane, Edward and Shah, Amil M and Solomon, Scott D and Monia, Brett P and Hughes, Steven G and Kwoh, T. Jesse and McEvoy, Bradley W and Jung, Shiangtung W and Baker, Brenda F and Ackermann, Elizabeth J and Gertz, Morie A and Coelho, Teresa
The New England journal of medicine, ISSN 0028-4793, 07/2018, Volume 379, Issue 1, pp. 22 - 31
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Glomerulonephritis - chemically induced | Prealbumin - genetics | Humans | Middle Aged | Male | Amyloid Neuropathies, Familial - therapy | Injections, Subcutaneous | Oligonucleotides, Antisense - therapeutic use | Aged, 80 and over | Adult | Female | Prealbumin - analysis | Severity of Illness Index | Double-Blind Method | Amyloid Neuropathies, Familial - complications | Oligonucleotides, Antisense - adverse effects | Thrombocytopenia - chemically induced | Polyneuropathies - therapy | Disease Progression | Prealbumin - antagonists & inhibitors | Polyneuropathies - etiology | Least-Squares Analysis | Quality of Life | Aged | RNAi Therapeutics | Amyloid Neuropathies, Familial - blood | Treatment outcome | Care and treatment | Amyloidosis | Analysis | Quality of life | Glomerulonephritis | Thrombocytopenia | Cardiomyopathy | Diabetes mellitus | Transthyretin | Antisense oligonucleotides | Diabetic neuropathy | Neuropathy | Polyneuropathy | Patients | Proteins | Hospitals | Questionnaires | Amyloid | Diabetes | Mutation | Drug dosages | Index Medicus | Abridged Index Medicus
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3. Full Text Efficacy and safety of 12 weeks versus 18 weeks of treatment with grazoprevir (MK-5172) and elbasvir (MK-8742) with or without ribavirin for hepatitis C virus genotype 1 infection in previously untreated patients with cirrhosis and patients with previous null response with or without cirrhosis (C-WORTHY): a randomised, open-label phase 2 trial
by Lawitz, Eric, Prof and Gane, Edward, Prof and Pearlman, Brian, Prof and Tam, Edward, MD and Ghesquiere, Wayne, Prof and Guyader, Dominique, Prof and Alric, Laurent, MD and Bronowicki, Jean-Pierre, Prof and Lester, Laura, MSN and Sievert, William, Prof and Ghalib, Reem, MD and Balart, Luis, MD and Sund, Fredrik, MD and Lagging, Martin, Prof and Dutko, Frank, PhD and Shaughnessy, Melissa, MS and Hwang, Peggy, PhD and Howe, Anita Y M, PhD and Wahl, Janice, MD and Robertson, Michael, MD and Barr, Eliav, MD and Haber, Barbara, MD and Institutionen för biomedicin and Sahlgrenska akademin and Institute of Biomedicine and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy
The Lancet (British edition), ISSN 0140-6736, 2015, Volume 385, Issue 9973, pp. 1075 - 1086
Internal Medicine | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Humans | Middle Aged | Hepacivirus - genetics | Imidazoles - administration & dosage | Benzofurans - administration & dosage | Male | RNA, Viral - blood | Interferons - therapeutic use | Hepatitis C, Chronic - complications | Polyethylene Glycols - therapeutic use | Viral Load | Young Adult | Ribavirin - administration & dosage | Treatment Failure | Aged, 80 and over | Adult | Female | Drug Therapy, Combination | Liver Cirrhosis - etiology | Drug Administration Schedule | Quinoxalines - administration & dosage | Treatment Outcome | Hepatitis C, Chronic - drug therapy | Antiviral Agents - administration & dosage | Adolescent | Aged | Medical colleges | Protease inhibitors | Proteases | Clinical trials | Product development | Biological response modifiers | Hepatitis C virus | Health aspects | Liver cirrhosis | Ribavirin | Comparative studies | Hepatitis | Genotype & phenotype | Interferon | Drug therapy | Index Medicus | Abridged Index Medicus | Life Sciences | UNITED-STATES | SOFOSBUVIR | RIBAVIRIN | Klinisk medicin | SUSTAINED VIROLOGICAL RESPONSE | Medicine | Clinical Medicine | HCV NS5A INHIBITOR | TREATMENT-EXPERIENCED PATIENTS | DISEASE BURDEN | General & Internal | DOUBLE-BLIND | INTERFERON-ALPHA 2A | TREATMENT-NAIVE PATIENTS | PLUS
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4. Full Text One thousand plant transcriptomes and the phylogenomics of green plants
by Leebens-Mack, James H and Barker, Michael S and Carpenter, Eric J and Deyholos, Michael K and Gitzendanner, Matthew A and Graham, Sean W and Grosse, Ivo and Li, Zheng and Melkonian, Michael and Mirarab, Siavash and Porsch, Martin and Quint, Marcel and Rensing, Stefan A and Soltis, Douglas E and Soltis, Pamela S and Stevenson, Dennis W and Ullrich, Kristian K and Wickett, Norman J and DeGironimo, Lisa and Edger, Patrick P and Jordon-Thaden, Ingrid E and Joya, Steve and Liu, Tao and Melkonian, Barbara and Miles, Nicholas W and Pokorny, Lisa and Quigley, Charlotte and Thomas, Philip and Villarreal, Juan Carlos and Augustin, Megan M and Barrett, Matthew D and Baucom, Regina S and Beerling, David J and Benstein, Ruben Maximilian and Biffin, Ed and Brockington, Samuel F and Burge, Dylan O and Burris, Jason N and Burris, Kellie P and Burtet-Sarramegna, Valérie and Caicedo, Ana L and Cannon, Steven B and Çebi, Zehra and Chang, Ying and Chater, Caspar and Cheeseman, John M and Chen, Tao and Clarke, Neil D and Clayton, Harmony and Covshoff, Sarah and Crandall-Stotler, Barbara J and Cross, Hugh and dePamphilis, Claude W and Der, Joshua P and Determann, Ron and Dickson, Rowan C and Di Stilio, Verónica S and Ellis, Shona and Fast, Eva and Feja, Nicole and Field, Katie J and Filatov, Dmitry A and Finnegan, Patrick M and Floyd, Sandra K and Fogliani, Bruno and García, Nicolás and Gâteblé, Gildas and Godden, Grant T and Goh, Falicia (Qi Yun) and Greiner, Stephan and Harkess, Alex and Heaney, James Mike and Helliwell, Katherine E and Heyduk, Karolina and Hibberd, Julian M and Hodel, Richard G. J and Hollingsworth, Peter M and Johnson, Marc T. J and Jost, Ricarda and Joyce, Blake and Kapralov, Maxim V and Kazamia, Elena and Kellogg, Elizabeth A and Koch, Marcus A and Von Konrat, Matt and Könyves, Kálmán and Kutchan, Toni M and Lam, Vivienne and Larsson, Anders and Leitch, Andrew R and Lentz, Roswitha and Li, Fay-Wei and Lowe, Andrew J and Ludwig, Martha and Manos, Paul S and Mavrodiev, Evgeny and McCormick, Melissa K and McKain, Michael and McLellan, Tracy and McNeal, Joel R and ... and One Thousand Plant Transcriptomes and One Thousand Plant Transcriptomes Initiative
Nature (London), ISSN 0028-0836, 10/2019, Volume 574, Issue 7780, pp. 679 - 685
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Biological Evolution | Viridiplantae - genetics | Transcriptome | Databases, Genetic | Genome, Plant | Phylogeny | Evolution, Molecular | Botanical research | Genetic aspects | Plants | Research | Natural history | Trees | Plants (botany) | Polyploidy | Gene families | Genomics | Genes | Terrestrial environments | Algae | Biological evolution | Discordance | Genomes | Gene sequencing | Species diversity | Ferns | Plant diversity | Phylogenetics | Evolution | Flowering | Flowers & plants | Bioinformatics | Species | Speciation | Aquatic ecosystems | Index Medicus | Molecular evolution | Adaptive radiation | Plant evolution | Phylogenomics
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5. Full Text Glecaprevir and Pibrentasvir Yield High response Rates in Patients with HCV Genotype 1-6 without Cirrhosis
by Kwo, Paul Y and Poordad, Fred and Asatryan, Armen and Wang, Stanley and Wyles, David L and Hassanein, Tarek and Felizarta, Franco and Sulkowski, Mark S and Gane, Edward and Maliakkal, Benedict and Scott Overcash, J and Gordon, Stuart C and Muir, Andrew J and Aguilar, Humberto and Agarwal, Kosh and Dore, Gregory J and Lin, Chih-Wei and Liu, Ran and Lovell, Sandra S and Ng, Teresa I and Kort, Jens and Mensa, Federico J
Journal of hepatology, ISSN 0168-8278, 2017, Volume 67, Issue 2, pp. 263 - 271
Gastroenterology and Hepatology | SURVEYOR | ABT-530 | Pangenotypic | D-alanine transaminase | Hepatitis C, chronic | Interferons | Direct-acting antiviral | Genotype | ABT-493 | Sustained virologic response | Liver cirrhosis | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Quinoxalines - adverse effects | Humans | Middle Aged | Hepacivirus - genetics | Hepatitis C, Chronic - virology | Pyrrolidines - administration & dosage | Pyrrolidines - adverse effects | Male | Benzimidazoles - administration & dosage | Ribavirin - administration & dosage | Treatment Failure | Adult | Female | Benzimidazoles - adverse effects | Drug Therapy, Combination | Hepacivirus - drug effects | Drug Administration Schedule | Drug Resistance, Multiple, Viral - genetics | Quinoxalines - administration & dosage | Hepatitis C, Chronic - drug therapy | Antiviral Agents - administration & dosage | Polymorphism, Genetic | Ribavirin - adverse effects | Antiviral Agents - adverse effects | Sulfonamides - adverse effects | Aged | Sustained Virologic Response | Sulfonamides - administration & dosage | Alanine | Clinical trials | Chronic infection | Viruses | Proteinase inhibitors | Patients | Ribavirin | Hepatitis | Genotype & phenotype | Cirrhosis | Alanine transaminase | Interferon | Hepatitis C | Antiviral drugs | Genotypes | Index Medicus
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6. Full Text The natural history of recurrent hepatitis C and what influences this
by Gane, Edward J
Liver transplantation, ISSN 1527-6465, 10/2008, Volume 14, Issue S2, pp. S36 - S44
Gastroenterology & Hepatology | Transplantation | Life Sciences & Biomedicine | Surgery | Science & Technology | Liver Neoplasms - virology | Recurrence | Reoperation | Liver Transplantation | Humans | Risk Factors | Graft Survival | Carcinoma, Hepatocellular - virology | Cholestasis - virology | Hepatitis C - surgery | Immunosuppression | Hepatitis C - complications | Hepatitis C - physiopathology | Index Medicus
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7. Full Text Sofosbuvir and Velpatasvir for HCV Genotype 2 and 3 Infection
by Foster, Graham R and Afdhal, Nezam and Roberts, Stuart K and Bräu, Norbert and Gane, Edward J and Pianko, Stephen and Lawitz, Eric and Thompson, Alex and Shiffman, Mitchell L and Cooper, Curtis and Towner, William J and Conway, Brian and Ruane, Peter and Bourlière, Marc and Asselah, Tarik and Berg, Thomas and Zeuzem, Stefan and Rosenberg, William and Agarwal, Kosh and Stedman, Catherine A.M and Mo, Hongmei and Dvory-Sobol, Hadas and Han, Lingling and Wang, Jing and McNally, John and Osinusi, Anu and Brainard, Diana M and McHutchison, John G and Mazzotta, Francesco and Tran, Tram T and Gordon, Stuart C and Patel, Keyur and Reau, Nancy and Mangia, Alessandra and Sulkowski, Mark and ASTRAL-2 & ASTRAL-3 Investigators and ASTRAL-3 Investigators and ASTRAL-2 Investigators
The New England journal of medicine, ISSN 0028-4793, 12/2015, Volume 373, Issue 27, pp. 2608 - 2617
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Humans | Middle Aged | Drug Resistance, Viral | Hepacivirus - genetics | Hepatitis C, Chronic - virology | Male | Hepatitis C, Chronic - complications | Young Adult | Heterocyclic Compounds, 4 or More Rings - therapeutic use | Aged, 80 and over | Adult | Female | Sofosbuvir - adverse effects | Sofosbuvir - therapeutic use | Liver Cirrhosis - drug therapy | Liver Cirrhosis - etiology | Antiviral Agents - therapeutic use | Genotype | Heterocyclic Compounds, 4 or More Rings - adverse effects | Treatment Outcome | Hepatitis C, Chronic - drug therapy | Antiviral Agents - adverse effects | Carbamates - adverse effects | Aged | Carbamates - therapeutic use | Viral Nonstructural Proteins - antagonists & inhibitors | Drug Combinations | Clinical trials | Usage | Genetic aspects | Research | Hepatitis C virus | Headache | Fatigue | Infections | Nausea | Patients | Ribavirin | Studies | Cirrhosis | Sleep disorders | Genotype & phenotype | Hepatitis | Hepatitis C | Drug therapy | Genotypes | Pharmaceuticals | Index Medicus | Abridged Index Medicus
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