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1. Discovery and thermodynamics of granulite in the Caixia mountain, Xinjiang, China
by Liang, Ting and Peng, Ming-Xing and Wang, Lei and Wang, Chong-Li and Hu, Chang-An and Gao, Xiao-Li
Journal of Chengdu University of Technology (Science and Technology Edition), ISSN 1671-9727, 04/2006, Volume 33, Issue 2, pp. 141 - 148
Mineral | Thermodynamics | Rock | Granulite
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2. Full Text Precision Genome Engineering and Agriculture: Opportunities and Regulatory Challenges
by Voytas, Daniel F and Gao, Caixia
PLoS Biology, ISSN 1544-9173, 2014, Volume 12, Issue 6, pp. 1 - 6
Plant agriculture is poised at a technological inflection point. Recent advances in genome engineering make it possible to precisely alter DNA sequences in... 
DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENES | BIOLOGY | PLANT-CELLS | DOUBLE-STRAND BREAKS | CRISPR-CAS SYSTEM | TAL EFFECTOR NUCLEASES | HOMOLOGOUS RECOMBINATION | TARGETED MUTAGENESIS | ZINC-FINGER NUCLEASES | RICE | Genetic Engineering - legislation & jurisprudence | Genetic Engineering - methods | Crops, Agricultural - genetics | Agriculture - methods | Genome, Plant | Agriculture - legislation & jurisprudence | Enzymes | Genes | Genomics | Crops | Genomes | Regulatory approval | Deoxyribonucleic acid | Agriculture | Genetic engineering | Synthetic biology | Food supply | Food | Rice
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3. Full Text The future of CRISPR technologies in agriculture
by Gao, Caixia
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 05/2018, Volume 19, Issue 5, pp. 275 - 276
Conventional plant breeding is unlikely to meet increasing food demands and other environmental challenges. By contrast, CRISPR technology is erasing barriers... 
DNA | ENDONUCLEASE | CELL BIOLOGY | Breeding - methods | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Gene Editing - methods | Agriculture - methods | Plants - genetics | CRISPR-Cas Systems - genetics | Agricultural industry | Technology application | Genetic engineering | Genetic aspects | Plant breeding | Innovations
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4. Full Text Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew
by Wang, Yanpeng and Cheng, Xi and Shan, Qiwei and Zhang, Yi and Liu, Jinxing and Gao, Caixia and Qiu, Jin-Long
Nature Biotechnology, ISSN 1087-0156, 09/2014, Volume 32, Issue 9, pp. 947 - 951
Sequence-specific nucleases have been applied to engineer targeted modifications in polyploid genomes(1), but simultaneous modification of multiple... 
SYSTEM | EFFECTORS | GENE | SPECIFICITY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | TALEN | PLANTS | ARABIDOPSIS | TARGETED MUTAGENESIS | ZINC-FINGER NUCLEASES | RICE | Triticum - genetics | Ascomycota - pathogenicity | RNA Editing | Base Sequence | Alleles | Ascomycota - genetics | Molecular Sequence Data | Sequence Homology, Nucleic Acid | Triticum - microbiology | Allelomorphism | Plant immunology | Diseases and pests | Mildew | Genetic aspects | Wheat | Health aspects | Proteins | Genomes | Mutation | Transgenic plants | Bread
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5. Full Text Genome editing in rice and wheat using the CRISPR/Cas system
by Shan, Qiwei and Wang, Yanpeng and Li, Jun and Gao, Caixia
Nature Protocols, ISSN 1754-2189, 01/2014, Volume 9, Issue 10, pp. 2395 - 2410
Targeted genome editing nucleases, such as zinc-finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs), are powerful tools for... 
DNA CLEAVAGE | ADAPTIVE IMMUNE-SYSTEMS | HUMAN-CELLS | CRISPR-CAS9 SYSTEM | BIOCHEMICAL RESEARCH METHODS | RNA-GUIDED ENDONUCLEASE | PLANTS | CAS SYSTEM | ARABIDOPSIS | TARGETED MUTAGENESIS | ZINC-FINGER NUCLEASES | Protoplasts - physiology | Mutagenesis, Site-Directed - methods | DNA Repair - genetics | Genome, Plant | Polymerase Chain Reaction - methods | Triticum - genetics | Biolistics - methods | Oryza - genetics | Plants, Genetically Modified | Cloning, Molecular | Clustered Regularly Interspaced Short Palindromic Repeats | Gene Expression Regulation, Plant | Mutation | Genomics - methods | Quantitative trait loci | Usage | Genetic aspects | Genetic engineering | Wheat | Methods | Rice | Index Medicus
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6. Full Text Precision plant breeding using genome editing technologies
by Gao, Caixia
Transgenic Research, ISSN 0962-8819, 8/2019, Volume 28, Issue S2, pp. 53 - 55
Life Sciences | Transgenics | Genetic Engineering | Plant Genetics and Genomics | Biomedical Engineering/Biotechnology | Molecular Medicine | Animal Genetics and Genomics | IMMUNITY | ENDONUCLEASE | RNA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | CAS9 | TARGETED MUTAGENESIS | MULTIPLEX | CLEAVAGE | Developmental biology | Genomics | Plant genetics | Genomes | Plant breeding
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7. Full Text Targeted Mutagenesis in Zea mays Using TALENs and the CRISPR/Cas System
by Zhen Liang Kang Zhang Kunling Chen Caixia Gao
遗传学报：英文版, ISSN 1673-8527, 2014, Volume 41, Issue 2, pp. 63 - 68
Transcription activator-like effector nucleases （TALENs） and clustered regularly interspaced short palindromic repeats （CRISPR）/ CRISPR-associated （Cas）... 
玉米 | 体细胞突变 | 塔 | 诱变 | CAS系统 | 原生质体 | 转基因植物 | 基因组功能 | CRISPR/Cas system | TAL-effector nucleases | Zea mays | Knock-out | DNA CLEAVAGE | RNA | SPECIFICITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ZINC-FINGER NUCLEASES | GENOME MODIFICATION | GENES | GENETICS & HEREDITY | MAIZE | CAS9 | ARABIDOPSIS | MULTIPLEX | Genetic Engineering - methods | Zea mays - genetics | Mutagenesis, Site-Directed | DNA Restriction Enzymes - metabolism | Genes, Plant - genetics | Base Sequence | Genomics | Plants, Genetically Modified | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Mutation | CRISPR-Cas Systems - genetics
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8. Full Text Targeted genome modification technologies and their applications in crop improvements
by Chen, Kunling and Gao, Caixia
Plant Cell Reports, ISSN 0721-7714, 4/2014, Volume 33, Issue 4, pp. 575 - 583
Recent advances in genome engineering indicate that innovative crops developed by targeted genome modification (TGM) using site-specific nucleases (SSNs) have... 
Life Sciences | Biotechnology | Plant Biochemistry | CRISPRs | TALENs | ZFNs | Site-specific nucleases (SSNs) | Crop improvement | Targeted genome modification | Plant Sciences | Cell Biology | MUTAGENESIS | RNA | PLANT-CELLS | CRISPR-CAS SYSTEM | TAL EFFECTOR NUCLEASES | ZINC-FINGER NUCLEASES | PLANT SCIENCES | III EFFECTORS | ENDONUCLEASE | DNA | ARABIDOPSIS | Genome, Plant - genetics | Crops, Agricultural - growth & development | Mutagenesis, Site-Directed - methods | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Crops, Agricultural - genetics | Endonucleases - metabolism | Genomics - methods | Genetic engineering | Zinc finger proteins | Developmental biology | Genomics | Genetically modified organisms
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9. Full Text Efficient and transgene-free genome editing in wheat through transient expression of CRISPR/Cas9 DNA or RNA
by Zhang, Yi and Liang, Zhen and Zong, Yuan and Wang, Yanpeng and Liu, Jinxing and Chen, Kunling and Qiu, Jin-Long and Gao, Caixia
Nature Communications, ISSN 2041-1723, 08/2016, Volume 7, Issue 1, p. 12617
Editing plant genomes is technically challenging in hard-to-transform plants and usually involves transgenic intermediates, which causes regulatory concerns.... 
SYSTEM | GENE | SPECIFICITY | NATURAL VARIATION | COMMON WHEAT | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | RIBONUCLEOPROTEINS | CROP PLANTS | CAS9 NUCLEASE | RICE | DNA - genetics | Triticum - genetics | Gene Editing - legislation & jurisprudence | Homozygote | Polyploidy | Plants, Genetically Modified - genetics | Genes, Plant - genetics | Gene Editing - methods | Mutation | CRISPR-Cas Systems - genetics | RNA - genetics
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10. Full Text Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion
by Zong, Yuan and Wang, Yanpeng and Li, Chao and Zhang, Rui and Chen, Kunling and Ran, Yidong and Qiu, Jin-Long and Wang, Daowen and Gao, Caixia
Nature Biotechnology, ISSN 1087-0156, 05/2017, Volume 35, Issue 5, pp. 438 - 440
Targeted base editing in plants without the need for a foreign DNA donor or double-stranded DNA cleavage would accelerate genome modification and breeding in a... 
SYSTEM | RNA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | DNA | CAS9 | TARGETED MUTAGENESIS | MAMMALIAN-CELLS | EFFICIENT | CROP PLANTS | FUNCTIONAL GENOMICS | Zea mays - genetics | Plants, Genetically Modified - genetics | CRISPR-Associated Proteins - genetics | Cytidine Deaminase - genetics | Mutagenesis, Site-Directed - methods | Triticum - genetics | Point Mutation - genetics | Oryza - genetics | Plants - genetics | Genes, Plant - genetics | Base Pairing - genetics | Recombinant Fusion Proteins - genetics | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Gene Editing - methods | DNA, Plant - genetics | Corn | Genetic aspects | Observations | Genetic variation | Wheat | Rice | Genetic engineering | Crop science | Mutation | DNA repair
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11. Full Text Targeted genome modification of crop plants using a CRISPR-Cas system
by Shan, Qiwei and Wang, Yanpeng and Li, Jun and Zhang, Yi and Chen, Kunling and Liang, Zhen and Zhang, Kang and Liu, Jinxing and Xi, Jianzhong Jeff and Qiu, Jin-Long and Gao, Caixia
Nature Biotechnology, ISSN 1087-0156, 2013, Volume 31, Issue 8, pp. 686 - 688
BIOTECHNOLOGY & APPLIED MICROBIOLOGY | Gene Targeting - methods | Endonucleases - genetics | CRISPR-Associated Proteins - genetics | Bacterial Proteins - genetics | Genome, Plant | CRISPR-Cas Systems - genetics | Triticum - genetics | Protoplasts - metabolism | Oryza - genetics | Base Sequence | DNA | Crops, Agricultural - genetics | Gene Editing - methods | Inverted Repeat Sequences | Physiological aspects | Genetic aspects | Zinc finger proteins | Research | Gene mutations | Rice
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12. Full Text Efficient DNA-free genome editing of bread wheat using CRISPR/Cas9 ribonucleoprotein complexes
by Liang, Zhen and Chen, Kunling and Li, Tingdong and Zhang, Yi and Wang, Yanpeng and Zhao, Qian and Liu, Jinxing and Zhang, Huawei and Liu, Cuimin and Ran, Yidong and Gao, Caixia
Nature Communications, ISSN 2041-1723, 01/2017, Volume 8, Issue 1, p. 14261
Substantial efforts are being made to optimize the CRISPR/Cas9 system for precision crop breeding. The avoidance of transgene integration and reduction of... 
SYSTEM | PLANTS | MULTIDISCIPLINARY SCIENCES
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13. Full Text ZnO nanoparticles treatment induces apoptosis by increasing intracellular ROS levels in LTEP-a-2 cells
by Wang, Caixia and Hu, Xiaoke and Gao, Yan and Ji, Yinglu
BioMed Research International, ISSN 2314-6133, 2015, Volume 2015, pp. 423287 - 9
Owing to the wide use of novel nanoparticles (NPs) such as zinc oxide (ZnO) in all aspects of life, toxicological research on ZnO NPs is receiving increasing... 
PATHWAYS | MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE STRESS | BACTERIA | PULMONARY TOXICITY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | Cell Survival - drug effects | Lung Neoplasms - drug therapy | Reactive Oxygen Species - metabolism | Adenocarcinoma of Lung | Apoptosis - drug effects | Glutathione - metabolism | Humans | Metal Nanoparticles - chemistry | Adenocarcinoma - drug therapy | Zinc Oxide - administration & dosage | Metal Nanoparticles - administration & dosage | Zinc Oxide - chemistry | Cell Line, Tumor | Oxidative Stress - drug effects | Cytoplasm - drug effects | Nanoparticles | Adenocarcinoma | Usage | Oncology, Experimental | Cancer cells | Physiological aspects | Zinc oxide | Research | Apoptosis | Cancer | Cell culture | Oxidative stress | Colleges & universities | Clinical trials | Nanomaterials | Cancer therapies | Antioxidants | Metal oxides | Zinc oxides | Morphology | Human | Receiving | Microscopy | Exposure | Assaying
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14. Full Text Anything impossible with CRISPR/Cas9?
by Renjie Jiao Caixia Gao
中国科学：生命科学英文版, ISSN 1674-7305, 2017, Issue 5, pp. 445 - 446
<正>Since the adaptation of the bacterial CRISPR/Cas9 system to eukaryotic cells,this'magic'tool has now been dramatically modified and applied... 
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15. Full Text The OsSPL16-GW7 regulatory module determines grain shape and simultaneously improves rice yield and grain quality
by Wang, Shaokui and Li, Shan and Liu, Qian and Wu, Kun and Zhang, Jianqing and Wang, Shuansuo and Wang, Yi and Chen, Xiangbin and Zhang, Yi and Gao, Caixia and Wang, Feng and Huang, Haixiang and Fu, Xiangdong
Nature Genetics, ISSN 1061-4036, 08/2015, Volume 47, Issue 8, pp. 949 - 954
The deployment of heterosis in the form of hybrid rice varieties has boosted grain yield, but grain quality improvement still remains a challenge. Here we show... 
ORGANIZATION | COMPLEX | PROTEIN | GREEN-REVOLUTION | GENE | ELONGATION | GENETICS & HEREDITY | QTL | ARCHITECTURE | ARABIDOPSIS | EXPRESSION | Endosperm - metabolism | Hybrid Vigor - genetics | Species Specificity | Oryza - metabolism | Starch - metabolism | Phylogeny | Oryza - classification | Endosperm - genetics | Starch - ultrastructure | Edible Grain - genetics | Plant Proteins - classification | Oryza - genetics | Hybridization, Genetic | Base Sequence | Edible Grain - metabolism | Plants, Genetically Modified | Cloning, Molecular | Gene Expression Regulation, Plant | Plant Proteins - metabolism | Amino Acid Sequence | Microscopy, Electron, Scanning | Reverse Transcriptase Polymerase Chain Reaction | Sequence Homology, Nucleic Acid | Sequence Homology, Amino Acid | Plant Proteins - genetics | Two-Hybrid System Techniques | Endosperm - ultrastructure | Protein Binding | Crosses, Genetic | Quantitative Trait Loci - genetics | Quantitative trait loci | Crop yields | Genetic research | Genetic aspects | Research | Genetic regulation | Identification and classification | Health aspects | Rice | Proteins | Gene loci | Transgenic plants | Agricultural production | Genes
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16. Full Text Creation of fragrant rice by targeted knockout of the OsBADH2 gene using TALEN technology
by Shan, Qiwei and Zhang, Yi and Chen, Kunling and Zhang, Kang and Gao, Caixia
Plant Biotechnology Journal, ISSN 1467-7644, 08/2015, Volume 13, Issue 6, pp. 791 - 800
Fragrant rice is favoured worldwide because of its agreeable scent. The presence of a defective badh2 allele encoding betaine aldehyde dehydrogenase ( BADH 2)... 
genome editing | multiplex gene knockout | transcription activator‐like effector nucleases | betaine aldehyde dehydrogenase | Transcription activator-like effector nucleases | 2AP | Betaine aldehyde dehydrogenase | Genome editing | Multiplex gene knockout | TRANSFORMATION | TRANSLOCATIONS | ZINC-FINGER | DOWN-REGULATION | AROMA | 2-ACETYL-1-PYRROLINE | transcription activator-like effector nucleases | GENOME | PLANT SCIENCES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | EFFECTOR NUCLEASES | MUTATIONS | MULTIPLEX | Oryza - genetics | Genes, Plant | Base Sequence | Betaine-Aldehyde Dehydrogenase - genetics | Molecular Sequence Data | Mutation | Oryza - enzymology | Sequence Homology, Nucleic Acid | DNA, Plant | Gene Knockdown Techniques | Genomics | Genetic research | Genetic engineering | Plants | Nucleotide sequencing | Aldehydes | DNA sequencing | Index Medicus | Mutations | Fragrances | Genes | Segregations | Plants (organisms) | Encoding | Rice
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